Antitumor activities of novel glycyrrhetinic acid-modified curcumin-loaded cationic liposomes in vitro and in H22 tumor-bearing mice.

abstract：:Although convection-enhanced delivery (CED) can successfully facilitate a bypass of the blood brain barrier, its treatment efficacy remains highly limited in clinic. This can be partially attributed to the brain anisotropic characteristics that lead to the difficulties in controlling the drug spatial distribution. Her...

journal_title：Drug delivery

authors： Zhan W,Rodriguez Y Baena F,Dini D

更新日期：2019-12-01 00:00:00

abstract：:Pantoprazole is a proton pump inhibitor prodrug used in the treatment of gastric ulcers and gastroesophageal disease. Pantoprazole must be absorbed in the gastrointestinal tract and because it is unstable under acidic conditions, enteric delivery systems are required. The purpose of this study was to prepare pantopraz...

journal_title：Drug delivery

authors： Comoglu T,Gonul N,Dogan A,Basci N

更新日期：2008-06-01 00:00:00

abstract：:The aim of this work was to prepare salts of 6-methoxy-2-naphthylacetic acid (6-MNA) to improve its physicochemical properties for percutaneous application. 6-MNA, an active metabolite of non-steroidal anti-inflammatory drug nabumetone has long half life and has the tendency to penetrate well into synovial fluid. The ...

journal_title：Drug delivery

authors： Pawar V,Kumar HY,Giridhar R,Yadav MR

更新日期：2015-05-01 00:00:00

abstract：:Systemic drug delivery systems (SDDSs) for thyroid cancer treatment are associated with serious side effects including nausea, anorexia, and hair loss as a result of damage to normal tissues. In this study, we investigated the feasibility of a local DDS (LDDS) based on visible light-cured glycol chitosan (GC) hydrogel...

journal_title：Drug delivery

authors： Yoo Y,Yoon SJ,Kim SY,Lee DW,Um S,Hyun H,Hong SO,Yang DH

更新日期：2018-11-01 00:00:00

abstract：:Corneal neovascularization (CNV) is one of the major causes of severe disorders in ocular surface. Subconjunctival administration provides a localized and effective delivery of anti-angiogenic agents to inhibit neovascularization. In the present study, the ABA triblock copolymer of poly(D,L-lactic-co-glycolic acid)-bl...

journal_title：Drug delivery

authors： Liu D,Wu Q,Zhu Y,Liu Y,Xie X,Li S,Lin H,Chen W,Zhu F

更新日期：2019-12-01 00:00:00

abstract：:Fluoroquinolones are broad-spectrum antimicrobial agents that seem to reach their intracellular target site (DNA gyrase) in Escherichia coli by means of an uptake process through the outer and inner membranes. Delivery of quinolones with liposomes has many advantages than the free form of the drug. Liposomes may repre...

journal_title：Drug delivery

authors： Sezer AD,Akbuğa J,Baş AL

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Vorinostat (VRS), a histone deacetylases inhibitor, has significant cytotoxic potential in a large number of human cancer cell lines. OBJECTIVE:To clarify its promising anticancer potential and to improve its drawback related to physical properties and in vivo performance of VRS. METHODS:VRS was successful...

journal_title：Drug delivery

authors： Tran TH,Chu DT,Truong DH,Tak JW,Jeong JH,Hoang VL,Yong CS,Kim JO

更新日期：2016-05-01 00:00:00

abstract：:HER2-positive breast cancer correlates with more aggressive tumor growth, a poorer prognosis and reduced overall survival. Currently, trastuzumab (Herceptin), which is an anti-HER2 antibody, is one of the key drugs. There is evidence indicating that conjugation of trastuzumab with chemotherapy drugs, such as doxorubic...

journal_title：Drug delivery

authors： You Y,Xu Z,Chen Y

更新日期：2018-11-01 00:00:00

abstract：:Aminoglycoside-induced hair cell (HC) loss is a major cause of hearing impairment, and the effective prevention of HC loss remains an unmet medical need. Epigenetic mechanisms have been reported to be involved in protecting cochlear cells against ototoxic drug injury, and in this study we developed new bioactive compo...

journal_title：Drug delivery

authors： Li A,You D,Li W,Cui Y,He Y,Li W,Chen Y,Feng X,Sun S,Chai R,Li H

更新日期：2018-11-01 00:00:00

abstract：:Hypoxic microenvironment commonly occurred in the solid tumors considerably decreases the chemosensitivity of cancer cells. Salidroside (Sal), the main active ingredient of Rhodiola rosea, was shown to be able of regulating the tumor hypoxia micro-environment and enhancing the chemotherapeutic efficacy of drug-resista...

journal_title：Drug delivery

authors： Zhang Z,Yang W,Ma F,Ma Q,Zhang B,Zhang Y,Liu Y,Liu H,Hua Y

更新日期：2020-12-01 00:00:00

abstract：:Endostatin (ES) can effectively inhibit neovascularization in most solid tumors and has the potential to make oxygen delivery more efficient and increase the efficacy of radiotherapy (RT). With a short half-life, ES is mainly administered systemically, which leads to low intake in tumor tissue and often toxic systemic...

journal_title：Drug delivery

authors： Wang N,Gao Q,Tang J,Jiang Y,Yang L,Shi X,Chen Y,Zhang Y,Fu S,Lin S

更新日期：2021-12-01 00:00:00

abstract：:The present work aimed to apply the liquid antisolvent precipitation (LAP) method for preparing the apigenin nanoparticles and thereby improving the solubility and bioavailability of apigenin. The different experimental parameters on particle size were optimized through central composite design (CCD) using the Design-...

journal_title：Drug delivery

authors： Wu W,Zu Y,Wang L,Wang L,Wang H,Li Y,Wu M,Zhao X,Fu Y

更新日期：2017-11-01 00:00:00

abstract：:Kollicoat SR 30D is a unique 30% aqueous dispersion of polyvinvyl acetate stabilized by polyvinyl-pyrrolidone intended for preparation of sustained release products. Detailed evaluation of this polymer dispersion as a sustained release coating for active pharmaceutical ingredients of two diverse classes of drugs was s...

journal_title：Drug delivery

authors： Bordaweka MS,Zia H,Quadir A

更新日期：2006-03-01 00:00:00

abstract：:The combination of protein-coated graphene oxide (GO) and microencapsulation technology has moved a step forward in the challenge of improving long-term alginate encapsulated cell survival and sustainable therapeutic protein release, bringing closer its translation from bench to the clinic. Although this new approach ...

journal_title：Drug delivery

authors： Ciriza J,Saenz Del Burgo L,Gurruchaga H,Borras FE,Franquesa M,Orive G,Hernández RM,Pedraz JL

更新日期：2018-11-01 00:00:00

abstract：:Over the years, research has focused on strategies to increase benefit/risk ratio of corticoids. However, vehicles intended for topical glucocorticoids delivery with an improved benefit/risk ratio are still on demand. The aim of this work was the in vitro and in vivo characterization of cold processed oil-in-water (o/...

journal_title：Drug delivery

authors： Raposo S,Tavares R,Gonçalves L,Simões S,Urbano M,Ribeiro HM

更新日期：2015-01-01 00:00:00

abstract：:The development of mucoadhesive lipidic nanoemulsion based on hyaluronic acid, co-encapsulating two polyphenols (resveratrol and curcumin) for the transnasal treatment of neurodegenerative diseases was attempted in the current manuscript. Nanoemulsions were prepared by the spontaneous emulsification method, and were c...

journal_title：Drug delivery

authors： Nasr M

更新日期：2016-05-01 00:00:00

abstract：:Three formulations including methylene blue solution (MB-S), MB water-in-oil microemulsion (MB-ME), and MB multiple microemulsion (MB-MME) were prepared with the aim to evaluate whether the three formulations can carry MB target to regional lymph nodes and show lymphatic tropism after subcutaneous administration. The ...

journal_title：Drug delivery

authors： Wang S,Yang R,Yao H,Zhou G,Zhang Y,Yang B,Ng L,Yan M

更新日期：2009-10-01 00:00:00

abstract：:Usually the topical delivery of ocular drugs poses a great challenge. Accordingly, the work in this study comprised the use of different hybrids of generally regarded as safe (GRAS) oils and surfactants in order to develop and optimize novel acetazolamide (AZD) entrapped-vesicular systems aiming at improving its ocula...

journal_title：Drug delivery

authors： Naguib SS,Hathout RM,Mansour S

更新日期：2017-11-01 00:00:00

abstract：:To improve drug retention in carriers for amphiphilic asulacrine (ASL), a novel active loading method using micelle gradient was developed to fabricate the ASL-loaded multiseed liposomes (ASL-ML). The empty ML were prepared by hydrating a thin film with empty micelles. Then the micelles in liposomal compartment acting...

journal_title：Drug delivery

authors： Zhang W,Li C,Jin Y,Liu X,Wang Z,Shaw JP,Baguley BC,Wu Z,Liu J

更新日期：2018-11-01 00:00:00

abstract：:Nonviral gene delivery systems are a promising approach for gene therapy applications, despite their low in vivo gene transfer efficiency. One approach to enhance this efficiency is to incorporate targeting elements into cationic lipid/DNA complexes (lipoplexes). Ligand-containing lipoplexes have to retain their effic...

journal_title：Drug delivery

authors： Carrière M,Escriou V,Jollet A,Scherman D,Azoulay M,Monneret C

更新日期：2004-11-01 00:00:00

abstract：:Radio-labeled hydrogel beads, based on amidated pectin, have been produced by adding droplets of an amidated pectin solution to calcium chloride. Incorporation of model drugs into the beads and measurement of the dissolution rate showed that the properties of the beads were unaffected by the incorporation of the radio...

journal_title：Drug delivery

authors： Munjeri O,Collett JH,Fell JT,Sharma HL,Smith AM

更新日期：1998-01-01 00:00:00

abstract：:Hydroxy genkwanin (HGK), a flavonoid compound from natural resources, showed good inhibition against the growth of breast tumor cells. However, the poor solubility restricted the further study and the in vivo drug delivery of HGK. We prepared HGK nanosuspensions by antisolvent precipitation method and investigated the...

journal_title：Drug delivery

authors： Ao H,Li Y,Li H,Wang Y,Han M,Guo Y,Shi R,Yue F,Wang X

更新日期：2020-12-01 00:00:00

abstract：:Camptothecin (CPT) is an effective anticancer agent against various cancers but the clinical application is limited because of its poor water solubility, low bioavailability and severe toxic side effects. The aim of the present study was to evaluate the feasibility of using targeted NPs as a high-performance CPT deliv...

journal_title：Drug delivery

authors： Yang A,Liu Z,Yan B,Zhou M,Xiong X

更新日期：2016-06-01 00:00:00

abstract：:The ophthalmic drug delivery is a challenge in the clinical treatment of ocular diseases. The traditional drug administration usually shows apparent limitations, such as the low bioavailability from the reason of low penetration of the cornea and the short survival time of drug in the eyes. To overcome these shortcomi...

journal_title：Drug delivery

authors： Li C,Chen R,Xu M,Qiao J,Yan L,Guo XD

更新日期：2018-11-01 00:00:00

abstract：:A conjugate consisting of streptavidin (biotinylated transferrin)-biotinylated polylysine for DNA delivery to cells was modified by partial nicotinylation of the polylysine component of the conjugate and used for transfection studies. A conjugate of biotin10-nicotinyl60-polylysine250 containing 60 weakly basic nicotin...

journal_title：Drug delivery

authors： Quick G,van Zyl J,Hawtrey A,Ariatti M

更新日期：2000-10-01 00:00:00

abstract：:This work focused on the developmental aspects, pharmacokinetic evaluation, and pharmacological assessment of a drug inclusion complex for a novel camptothecin analog (CA) and 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). Camptothecins analog belong to topoisomerase-I inhibitor class of compounds with proven anti-tumor ac...

journal_title：Drug delivery

authors： Nekkanti V,Karatgi P,Paruchuri S,Pillai R

更新日期：2011-05-01 00:00:00

abstract：CONTEXT:Designing a sustained release system for Carvedilol to increase its residence time in the stomach. OBJECTIVE:Preparation of floating microsphere by the emulsion solvent diffusion method, studying the effect of various process parameters and optimize the formulation using full factorial design. METHODS:Differe...

journal_title：Drug delivery

authors： Nila MV,Sudhir MR,Cinu TA,Aleykutty NA,Jose S

更新日期：2014-03-01 00:00:00

abstract：:The main aim of this work was to develop rectal suppositories for better delivery of metoprolol tartrate (MT). The various bases used were fatty, water soluble and emulsion bases. The physical properties of the prepared suppositories were characterized such as weight variation, hardness, disintegration time, melting r...

journal_title：Drug delivery

authors： Abou el Ela Ael S,Allam AA,Ibrahim EH

更新日期：2016-01-01 00:00:00

abstract：:A novel niosomal delivery system was designed and investigated for the targeted delivery of daunorubicin (DNR) against acute myeloid leukemia (AML). Anti-CD123 antibodies conjugated to Mal-PEG2000-DSPE were incorporated into normal niosomes (NS) via a post insertion method to afford antibody-modified niosomes (CD123-N...

journal_title：Drug delivery

authors： Liu FR,Jin H,Wang Y,Chen C,Li M,Mao SJ,Wang Q,Li H

更新日期：2017-11-01 00:00:00

abstract：:Glycyrrhizin or glycyrrhizic acid (GA) - triterpene glycoside extracted from licorice root - has been intensively studied over the past decade and is considered to be a potential drug delivery system. Glycyrrhizin was found to enhance the therapeutic effect of various drugs; however the detailed mechanism of these eff...

journal_title：Drug delivery

authors： Selyutina OY,Polyakov NE,Korneev DV,Zaitsev BN

更新日期：2016-01-01 00:00:00