Abstract:
:Usually the topical delivery of ocular drugs poses a great challenge. Accordingly, the work in this study comprised the use of different hybrids of generally regarded as safe (GRAS) oils and surfactants in order to develop and optimize novel acetazolamide (AZD) entrapped-vesicular systems aiming at improving its ocular delivery and reaching better therapeutic outcomes in the treatment of glaucoma. The phospholipid/cholesterol bilayer of the vesicles was enriched with hybrids of Tween 80, Labrasol, Transcutol and Labrafac lipophile WL in different masses and proportions according to a mixture design viz. D-optimal mixture design. Three models were generated comprising three responses: particles size, percentage of entrapment efficiency and amount of drug released after 24 hours (Q24h). The results demonstrated the ability of the penetration enhancing hybrids in modulating the three responses compared to the conventional liposomes. Transmission electron microscope was used to characterize the selected formulations. Sterilization of selected formulations was carried out using gamma radiation and the effect of gamma radiations on entrapment, particle size and in vitro release were studied. The selected sterilized formulations were tested in-vivo on the eyes of albino rabbits in order to evaluate the efficiency of the novel delivery systems on the intra-ocular pressure reduction (IOP) compared to drug solution and the conventional liposomes. The novel formulations proved their efficiency in reducing the IOP to lower values compared to the conventional liposomes, which pose new successful platform for ocular delivery of AZD and other anti-glaucoma drug analogs.
journal_name
Drug Delivjournal_title
Drug deliveryauthors
Naguib SS,Hathout RM,Mansour Sdoi
10.1080/10717544.2016.1233588subject
Has Abstractpub_date
2017-11-01 00:00:00pages
99-108issue
1eissn
1071-7544issn
1521-0464journal_volume
24pub_type
杂志文章相关文献
DRUG DELIVERY文献大全abstract::The combination of protein-coated graphene oxide (GO) and microencapsulation technology has moved a step forward in the challenge of improving long-term alginate encapsulated cell survival and sustainable therapeutic protein release, bringing closer its translation from bench to the clinic. Although this new approach ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1474966
更新日期:2018-11-01 00:00:00
abstract::The objective of this study was to investigate the effect of lipophilic (Compritol 888 ATO) and hydrophilic components (combination of HPMC and Avicel) on the release of carbamazepine from granules and corresponding tablet. Wet granulation followed by compression was employed for preparation of granules and tablets. T...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540802518157
更新日期:2009-01-01 00:00:00
abstract::The aim of present study was to investigate a pH-responsive and mucoadhesive nanoparticle system for oral bioavailability enhancement of low-molecular weight heparin (LMWH). The thioglycolic acid (TGA) was first covalently attached to chitosan (CS) with 396.97 ± 54.54 μmol thiol groups per gram of polymer and then the...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.909908
更新日期:2016-01-01 00:00:00
abstract::This research evaluated 7525DLPCL for soft flexible drug delivery systems. The effect of ciprofloxacin hydrochloride (CIP) loading at three levels (10, 20, and 30%), on thermo-mechanical properties was studied. CIP release was monitored for 12 weeks. Addition of CIP to 7525DLPCL caused an increase in compressive modul...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2010.528070
更新日期:2011-05-01 00:00:00
abstract::The objective of our study was to formulate and evaluate proliposomes in the form of enteric-coated beads using glyburide as a model drug. The beads were enteric coated with Eudragit L-100 by a fluidized bed coating process using triethyl citrate as plasticizer. Content uniformity of glyburide was estimated using HPLC...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/107175401300002720
更新日期:2001-01-01 00:00:00
abstract::Sustained release (SR) matrix tablets of dextromethorphan hydrobromide were prepared by wet granulation using hydroxypropyl methyl cellulose (HPMC-K-100 CR) as the hydrophilic rate controlling polymer. The effect of the concentration of the polymer and different fillers on the in vitro drug release rate was studied. T...
journal_title:Drug delivery
pub_type: 杂志文章,随机对照试验
doi:10.1080/10717540802035301
更新日期:2008-09-01 00:00:00
abstract::Ischemic stroke is one of the major causes of severe disability and death worldwide. It is mainly caused by a sudden reduction in cerebral blood flow due to obstruction of the supplying vessel by thrombi and subsequent initiation of a complex cascade of pathophysiological changes, which ultimately lead to brain ischem...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2021.1879315
更新日期:2021-12-01 00:00:00
abstract::Kollicoat SR 30D is a unique 30% aqueous dispersion of polyvinvyl acetate stabilized by polyvinyl-pyrrolidone intended for preparation of sustained release products. Detailed evaluation of this polymer dispersion as a sustained release coating for active pharmaceutical ingredients of two diverse classes of drugs was s...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500313398
更新日期:2006-03-01 00:00:00
abstract::Gastric cancer is a frequently occurring cancer with high mortality each year worldwide. Finding new and effective therapeutic strategy against human gastric cancer is still urgently required. Hence, we have established a new method to achieve treatment-actuated modifications in a tumor microenvironment by utilizing s...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1822460
更新日期:2020-12-01 00:00:00
abstract::Hydroxy genkwanin (HGK), a flavonoid compound from natural resources, showed good inhibition against the growth of breast tumor cells. However, the poor solubility restricted the further study and the in vivo drug delivery of HGK. We prepared HGK nanosuspensions by antisolvent precipitation method and investigated the...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1770372
更新日期:2020-12-01 00:00:00
abstract::Aminoglycoside-induced hair cell (HC) loss is a major cause of hearing impairment, and the effective prevention of HC loss remains an unmet medical need. Epigenetic mechanisms have been reported to be involved in protecting cochlear cells against ototoxic drug injury, and in this study we developed new bioactive compo...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1461277
更新日期:2018-11-01 00:00:00
abstract::Polysaccharide nucleic acid fractions of bacillus Calmette-Guérin, termed BCG-PSN, have traditionally been used as immunomodulators in the treatment of dermatitis and allergic diseases. While the sales of injectable BCG-PSN have shown steady growth in recent years, no reports of using BCG-PSN powder or its immunothera...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1391892
更新日期:2017-11-01 00:00:00
abstract::Systemic chemotherapy with the anticancer agent cisplatin is approved for advanced non-melanoma skin cancer (NMSC), but topical treatment is limited by insufficient cutaneous penetration. We studied the impact of ablative fractional laser (AFL) exposure on topical cisplatin's pharmacokinetics and biodistribution in sk...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1534896
更新日期:2018-11-01 00:00:00
abstract::Pulmonary bed can retain microparticles (MP) larger than their capillaries' diameter, hence we offer a promising way for lung passive targeting following intravenous (IV) administration. In this study, enoxaparin (Enox)-albumin microspheres (Enox-Alb MS) were, optimally, developed as lung targeted sustained release MP...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2016.1245368
更新日期:2017-11-01 00:00:00
abstract::ALA-loaded nanostructured lipid carrier (ALA-NLC) was designed to improve physicochemical stability and water solubility, and promote sustained release of ALA as well as determine the biocompatibility of ALA-NLC. The ALA-NLC manufactured using hot high-pressure homogenization technique was investigated in terms of siz...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.846435
更新日期:2014-08-01 00:00:00
abstract::Monoclonal antibodies (mAbs) were generated to the extracellular domain of transcobalamin receptor (TCblR) and used to identify the regions of the receptor protein involved in antibody binding. Based on the effect of transcobalamin bound cobalamin (TC-Cbl) on antibody binding, this study identified both blocking and b...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2010.509745
更新日期:2011-01-01 00:00:00
abstract::Hydrogels are water swollen networks of polymers and especially hydrogels consisting of poly vinylpyrrolidone/poly ethyleneglycol-dimethacrylate (PVP/PEG-DMA) blends show promising wound care properties. Enhanced functionality of the hydrogels can be achieved by incorporating drugs and other substances that may assist...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540802605129
更新日期:2009-02-01 00:00:00
abstract::The aim of this work was to encapsulate superoxide dismutase (SOD) into biodegradable microparticles by spray-drying technique. The nature of the organic solvent to dissolve the polymer, the method of incorporation of the drug in the organic phase (with or without a surfactant, namely sucrose ester of HLB = 6), the su...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540490280363
更新日期:2004-05-01 00:00:00
abstract::In this paper, orally nanocrystal capsules were produced using nanocrystal formulations in order to optimize dissolution properties of poorly soluble drug glimepiride and improve its bioavailability. The important preparation variables, such as stabilizers, the power input and the time length of ultrasonication on the...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2012.742939
更新日期:2013-01-01 00:00:00
abstract::Three formulations including methylene blue solution (MB-S), MB water-in-oil microemulsion (MB-ME), and MB multiple microemulsion (MB-MME) were prepared with the aim to evaluate whether the three formulations can carry MB target to regional lymph nodes and show lymphatic tropism after subcutaneous administration. The ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540903075644
更新日期:2009-10-01 00:00:00
abstract::Transdermal delivery of non-steroidal anti-inflammatory drugs (NSAIDs) is an effective route of drug administration, as it directs the drug to the inflamed site with reduced incidence of systemic adverse effects such as gastric hemorrhage and ulcers. Tenoxicam (TNX) is a member of NSAIDs that are marketed only as oral...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1803448
更新日期:2020-12-01 00:00:00
abstract::A mesoporous material based on aluminosilicate mixture was studied to investigate its ability to include drugs and then release them. Nonsteroidal anti-inflammatory agents such as diflunisal, naproxen, ibuprofen and its sodium salt have been used in this study. The preparation of the mesoporous material and its charac...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540490265252
更新日期:2004-01-01 00:00:00
abstract::In vitro characteristics of the human erythrocytes loaded by enalaprilat have been evaluated. Erythrocytes obtained from a healthy volunteer were loaded by enalaprilat using the hypotonic preswelling method, and the loading parameters, drug-release kinetics, hematological indices, particle size distribution, scanning ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/107175401317245903
更新日期:2001-10-01 00:00:00
abstract::The oral application of pharmaceuticals is unarguably the most convenient method of application. Especially for protein- or peptide-based drugs, however, the effectiveness is significantly reduced due to enzymatic digestion in the stomach as well as a poor bioavailability in the small intestine. For these difficult fo...
journal_title:Drug delivery
pub_type: 杂志文章,评审
doi:10.1080/10717544.2018.1501119
更新日期:2018-11-01 00:00:00
abstract::To prolong the circulation time of drug, PEGylation has been widely used via the enhanced permeability and retention (EPR) effect, thereby providing new hope for better treatment. However, PEGylation also brings the "PEG dilemma", which is difficult for the cellular absorption of drugs and subsequent endosomal escape....
journal_title:Drug delivery
pub_type: 杂志文章,评审
doi:10.1080/10717544.2017.1388451
更新日期:2017-12-01 00:00:00
abstract::In order to enhance the interaction between nanocarrier and gastrointestinal epithelial cells, we developed nanoparticles (NPs) modified with targeting ligand FQSIYPpIK (FQS), which specifically interact with integrin αvβ3 receptor expressing on the intestinal epithelium. The targeting NPs were prepared by coating the...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1058433
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:A topical microemulsion (ME)-based hydrogel was developed to enhance permeation of an antifungal drug, sertaconazole (STZL) for effective eradication of cutaneous fungal infection. METHODS:Pseudo-ternary phase diagrams were used to determine the existence of MEs region. ME formulations were prepared with oleic...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.914601
更新日期:2016-01-01 00:00:00
abstract::Efficient and stable delivery system of antisense oligonucleotide (ASO) is important and urgently needed. Here, an ASO delivery system, Lp-PPRP, which contains a cationic polymer based on PEI (branched, 25 kDa), named PEI-PC and a palmitic acid modified R8 (R8-PA) was prepared to deliver a kind of ASO, LOR-2501. The c...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2019.1667453
更新日期:2019-12-01 00:00:00
abstract::Discovery of novel pharmacological effects of berberine hydrochloride (BH) has made its clinical application valuable. However, further development and applications of BH are hampered by its short half-life and the side effects associated with its intravenous (iv) injection. To improve the hypolipidemia efficacy and r...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1716880
更新日期:2020-12-01 00:00:00
abstract::Combinational therapy is usually considered as a preferable approach for effective cancer therapy. Especially, combinational chemo and photothermal therapy is of particular interest due to its high flexibility as well as efficiency. In this article, we the silica nanoparticles (SLN) were surface conjugated with Cetuxi...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1564403
更新日期:2019-12-01 00:00:00