Anti-tumor effect of local injectable hydrogel-loaded endostatin alone and in combination with radiotherapy for lung cancer.


:Endostatin (ES) can effectively inhibit neovascularization in most solid tumors and has the potential to make oxygen delivery more efficient and increase the efficacy of radiotherapy (RT). With a short half-life, ES is mainly administered systemically, which leads to low intake in tumor tissue and often toxic systemic side effects. In this study, we used hyaluronic acid-tyramine as a carrier to synthesize an ES-loaded hydrogel drug (ES/HA-Tyr) that can be injected locally. ES/HA-Tyr has a longer half-life and fewer systemic toxic side effects, and it exerts a better anti-angiogenic effect and anti-tumor effect with RT. In vitro, ES/HA-Tyr showed sustained release in the release assay and a stronger ability to inhibit the proliferation of human umbilical vascular endothelial cells (HUVECs) in the MTT assay; it exhibited a more potent effect against HUVEC invasion and a stronger anti-angiogenic effect on HUVECs in tube formation. In vivo, ES/HA-Tyr increased local drug concentration, decreased blood drug concentration, and caused less systemic toxicity. Further, ES/HA-Tyr effectively reduced tumor microvessel density, increased tumor pericyte coverage, decreased tumor hypoxia, and increased RT response. ES/HA-Tyr + RT also had increased anti-tumor and anti-angiogenic effects in Lewis lung cancer (LLC) xenograft models. In conclusion, ES/HA-Tyr showed sustained release, lower systemic toxicity, and better anti-tumor effects than ES. In addition, ES/HA-Tyr + RT enhanced anti-angiogenic effects, reduced tumor hypoxia, and increased the efficacy of RT in LLC-bearing mice.


Drug Deliv


Drug delivery


Wang N,Gao Q,Tang J,Jiang Y,Yang L,Shi X,Chen Y,Zhang Y,Fu S,Lin S




Has Abstract


2021-12-01 00:00:00












  • Recent advances in non-ionic surfactant vesicles (niosomes): self-assembly, fabrication, characterization, drug delivery applications and limitations.

    abstract::Non-ionic surfactant vesicles, simply known as niosomes are synthetic vesicles with potential technological applications. Niosomes have the same potential advantages of phospholipid vesicles (liposomes) of being able to accommodate both water soluble and lipid soluble drug molecules control their release and as such s...

    journal_title:Drug delivery

    pub_type: 杂志文章,评审


    authors: Abdelkader H,Alani AW,Alany RG

    更新日期:2014-03-01 00:00:00

  • Identification and imaging of miR-155 in the early screening of lung cancer by targeted delivery of octreotide-conjugated chitosan-molecular beacon nanoparticles.

    abstract::Lung cancer is still the most common cancer globally. Early screening remains the key to improve the prognosis of patients. There is currently a lack of specific and sensitive methods for early screening of lung cancer. In recent years, studies have found that microRNA plays an important role in the occurrence and dev...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Zhu HZ,Hou J,Guo Y,Liu X,Jiang FL,Chen GP,Pang XF,Sun JG,Chen ZT

    更新日期:2018-11-01 00:00:00

  • Engineering of a novel optimized platform for sublingual delivery with novel characterization tools: in vitro evaluation and in vivo pharmacokinetics study in human.

    abstract::The aim of this work was to develop a novel and more efficient platform for sublingual drug delivery using mosapride citrate (MSP) as a model drug. The engineering of this delivery system had two stages, the first stage was tuning of MSP physicochemical properties by complexation with pure phosphatidylcholine or phosp...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Morsi NM,Abdelbary GA,Elshafeey AH,Ahmed MA

    更新日期:2017-11-01 00:00:00

  • PLA/PEG-PPG-PEG/dexamethasone implant prepared by hot-melt extrusion for controlled release of immunosuppressive drug to implantable medical devices, Part 2: in vivo evaluation.

    abstract::Hot-melt extrusion (HME) plays an important role in preparing implants as local drug delivery systems in pharmaceutical fields. Here, a new PLA/PEG-PPG-PEG/Dexamethasone (PLA/F68/Dex) implant prepared by HME has been developed. Importantly, the implant was successfully achieved to control release of immunosuppressive ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Li D,Guo G,Deng X,Fan R,Guo Q,Fan M,Liang J,Luo F,Qian Z

    更新日期:2013-04-01 00:00:00

  • Silk fibroin nanoparticles dyeing indocyanine green for imaging-guided photo-thermal therapy of glioblastoma.

    abstract::Silk was easily dyed in traditional textile industry because of its strong affinity to many colorants. Herein, the biocompatible silk fibroin was firstly extracted from Bombyx mori silkworm cocoons. And SF nanoparticles (SFNPs) were prepared for dyeing indocyanine green (ICG) and construct a therapeutic nano-platform ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Xu HL,ZhuGe DL,Chen PP,Tong MQ,Lin MT,Jiang X,Zheng YW,Chen B,Li XK,Zhao YZ

    更新日期:2018-11-01 00:00:00

  • Graphene oxide enhances alginate encapsulated cells viability and functionality while not affecting the foreign body response.

    abstract::The combination of protein-coated graphene oxide (GO) and microencapsulation technology has moved a step forward in the challenge of improving long-term alginate encapsulated cell survival and sustainable therapeutic protein release, bringing closer its translation from bench to the clinic. Although this new approach ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Ciriza J,Saenz Del Burgo L,Gurruchaga H,Borras FE,Franquesa M,Orive G,Hernández RM,Pedraz JL

    更新日期:2018-11-01 00:00:00

  • Development, characterization, and evaluation of ketorolac tromethamine-loaded biodegradable microspheres as a depot system for parenteral delivery.

    abstract::Ketorolac tromethamine, a potent nonnarcotic analgesic agent and 800 times more potent than aspirin, is indicated for the short-term management of moderate to such severe painful states as post operative pain, acute musculoskeletal pain, and dental pain. It Given every 6 hr intramuscularly in patients for acute pain, ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Sinha VR,Trehan A

    更新日期:2008-08-01 00:00:00

  • Propolis organogel as a novel topical delivery system for treating wounds.

    abstract:CONTEXT:Propolis has traditionally been used in curing infections and healing wounds and burns. OBJECTIVE:The aim of this study is to formulate pluronic lecithin organogel of propolis to improve its availability and antimicrobial activity. MATERIALS AND METHODS:Different organogels were prepared by using soybean leci...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Balata G,El Nahas HM,Radwan S

    更新日期:2014-02-01 00:00:00

  • Drug product development and pharmacological evaluation of a sparingly soluble novel camptothecin analog for peroral administration.

    abstract::This work focused on the developmental aspects, pharmacokinetic evaluation, and pharmacological assessment of a drug inclusion complex for a novel camptothecin analog (CA) and 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). Camptothecins analog belong to topoisomerase-I inhibitor class of compounds with proven anti-tumor ac...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Nekkanti V,Karatgi P,Paruchuri S,Pillai R

    更新日期:2011-05-01 00:00:00

  • Modified nanoparticles with cell-penetrating peptide and amphipathic chitosan derivative for enhanced oral colon absorption of insulin: preparation and evaluation.

    abstract::Colon is an ideal absorptive site for oral protein and peptide drug (insulin), and yet it poses multiple barriers against the drug absorption, such as the barriers against the drug diffusion from colon lumen toward the absorptive mucosa and permeation across colon epithelium. In this study, modified nanoparticles (Tat...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Guo F,Zhang M,Gao Y,Zhu S,Chen S,Liu W,Zhong H,Liu J

    更新日期:2016-07-01 00:00:00

  • Multivesicular liposomes for sustained release of bevacizumab in treating laser-induced choroidal neovascularization.

    abstract::Bevacizumab is an anti-vascular endothelial growth factor drug that can be used to treat choroidal neovascularization (CNV). Bevacizumab-loaded multivesicular liposomes (Bev-MVLs) have been designed and developed to increase the intravitreal retention time of bevacizumab and reduce the number of injection times. In th...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Mu H,Wang Y,Chu Y,Jiang Y,Hua H,Chu L,Wang K,Wang A,Liu W,Li Y,Fu F,Sun K

    更新日期:2018-11-01 00:00:00

  • Release of albumin from oligoester plastic matrices: effect of magnesium oxide and bivalent stearates.

    abstract::Biodegradable implantable matrices containing bovine serum albumin were prepared from oligoesters by melting, and subsequently tested on in vitro albumin release. The linear poly (DL-lactic acid) and the branched terpolymer of DL-lactic acid, glycolic acid, and mannitol were synthesized. Products were of similar molec...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Kladnícková I,Dittrich M,Klein T,Pokorová D

    更新日期:2006-01-01 00:00:00

  • Effects of phonophoresis with gold nanoparticles on oxidative stress parameters in a traumatic muscle injury model.

    abstract::The aim of this study was to evaluate the effects of therapeutic pulsed ultrasound with gold nanoparticles on oxidative stress parameters after traumatic muscle injury in Wistar rats. The animals were randomly divided into nine groups (n = 6 each): sham (uninjured muscle); muscle injury without treatment; muscle injur...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Silveira PC,Victor EG,Notoya Fde S,Scheffer Dda L,Silva Ld,Cantú RB,Martínez VH,de Pinho RA,Paula MM

    更新日期:2016-01-01 00:00:00

  • Optimizing novel penetration enhancing hybridized vesicles for augmenting the in-vivo effect of an anti-glaucoma drug.

    abstract::Usually the topical delivery of ocular drugs poses a great challenge. Accordingly, the work in this study comprised the use of different hybrids of generally regarded as safe (GRAS) oils and surfactants in order to develop and optimize novel acetazolamide (AZD) entrapped-vesicular systems aiming at improving its ocula...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Naguib SS,Hathout RM,Mansour S

    更新日期:2017-11-01 00:00:00

  • The efficiency of a novel delivery system (PEI600-Tat) in development of potent DNA vaccine using HPV16 E7 as a model antigen.

    abstract::DNA vaccination is a promising approach for inducing both humoral and cellular immune responses. The mode of plasmid DNA delivery is critical to make progress in DNA vaccination. Using human papillomavirus type 16 E7 as a model antigen, this study evaluated the effect of peptide-polymer hybrid including PEI600-Tat con...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Bolhassani A,Ghasemi N,Servis C,Taghikhani M,Rafati S

    更新日期:2009-05-01 00:00:00

  • Disposition of 3H-cholesteryl ether labeled liposomes following intravenous administration to mice: comparison with an encapsulated 14C-inulin as aqueous phase marker.

    abstract::In this study, the blood clearance and organ distribution of intravenously administered liposomes (distearoyl phosphatidylcholine [DSPC] and cholesterol in a ratio of 3:1) was evaluated by utilizing 3H-cholesteryl ether as the lipid phase marker. Also, the ability of liposomes, as a drug delivery system, to alter the ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Anderson M,Paradis C,Omri A

    更新日期:2003-07-01 00:00:00

  • In vivo behavior of hydrogel beads based on amidated pectins.

    abstract::Radio-labeled hydrogel beads, based on amidated pectin, have been produced by adding droplets of an amidated pectin solution to calcium chloride. Incorporation of model drugs into the beads and measurement of the dissolution rate showed that the properties of the beads were unaffected by the incorporation of the radio...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Munjeri O,Collett JH,Fell JT,Sharma HL,Smith AM

    更新日期:1998-01-01 00:00:00

  • Sustained ocular drug delivery from a temperature and pH triggered novel in situ gel system.

    abstract::Various ocular diseases like glaucoma, conjunctivitis, and dry eye syndrome require frequent drug administration. Poor ocular bioavailability of drugs (< 1%) from conventional eye drops is due mainly to the precorneal loss factors that include rapid tear turnover, nonproductive absorption, transient residence time in ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Gupta H,Jain S,Mathur R,Mishra P,Mishra AK,Velpandian T

    更新日期:2007-11-01 00:00:00

  • The effectivity analysis of accumulation of liposomal, micellar, and water-soluble forms of diminazene in cells and in organs.

    abstract::The study was aimed at evaluating the effectiveness of liposomal, micellar, and water-soluble drug forms of diminazene for its localization in cells and selective accumulation at the sites of aggregation of pathogenic organisms. Pharmacological and dynamic properties of a new injection micellar diminazene preparation ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Staroverov SA,Pristensky DV,Yermilov DN,Gabalov KP,Zhemerichkin DA,Sidorkin VA,Shcherbakov AA,Shchyogolev SY,Dykman LA

    更新日期:2006-09-01 00:00:00

  • Pharmacokinetics and biodistribution of itraconazole in rats and mice following intravenous administration in a novel liposome formulation.

    abstract::Novel itraconazole (ITZ)-loaded liposomes (ITZ-LPs) were prepared and their pharmacokinetics and biodistribution were assessed in comparison with commercial formulations (ITZ-CD). The ITZ-LPs were prepared by thin-film hydration method and the physicochemical characterizations of the ITZ-LPs were evaluated. The pharma...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Tang J,Wei H,Liu H,Ji H,Dong D,Zhu D,Wu L

    更新日期:2010-05-01 00:00:00

  • Use of biorelevant media for assessment of a poorly soluble weakly basic drug in the form of liquisolid compacts: in vitro and in vivo study.

    abstract::The purpose of this work is to use biorelevant media to evaluate the robustness of a poorly water soluble weakly basic drug to variations along the gastrointestinal tract (GIT) after incorporation in liquisolid compacts and to assess the success of these models in predicting the in vivo performance. Liquisolid tablets...

    journal_title:Drug delivery

    pub_type: 杂志文章,随机对照试验


    authors: Badawy MA,Kamel AO,Sammour OA

    更新日期:2016-01-01 00:00:00

  • Bioadhesive polymer/lipid hybrid nanoparticles as oral delivery system of raloxifene with enhancive intestinal retention and bioavailability.

    abstract::Raloxifene (RLX) is a second-generation selective estrogen receptor modulator used to treat osteoporosis in postmenopausal women. RLX fails to be developed into injectable dosage forms due to poor solubility. Although oral formulations are clinically available, the lower bioavailability (<2%) embarrasses the pharmaceu...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Du X,Gao N,Song X

    更新日期:2021-12-01 00:00:00

  • Prodrug-based nano-drug delivery system for co-encapsulate paclitaxel and carboplatin for lung cancer treatment.

    abstract:CONTEXT:Paclitaxel (PTX) and carboplatin (CBP) are widely used for the combined chemotherapy of non-small cell lung cancer (NSCLC). However, the development of multidrug resistance of cancer cells, as well as systemic toxic side effects resulting from nonspecific localization of anticancer drugs to non-tumor areas are ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Zhang W,Li C,Shen C,Liu Y,Zhao X,Liu Y,Zou D,Gao Z,Yue C

    更新日期:2016-09-01 00:00:00

  • Alpha-lipoic acid-loaded nanostructured lipid carrier: sustained release and biocompatibility to HaCaT cells in vitro.

    abstract::ALA-loaded nanostructured lipid carrier (ALA-NLC) was designed to improve physicochemical stability and water solubility, and promote sustained release of ALA as well as determine the biocompatibility of ALA-NLC. The ALA-NLC manufactured using hot high-pressure homogenization technique was investigated in terms of siz...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Wang J,Xia Q

    更新日期:2014-08-01 00:00:00

  • Development and in vitro evaluation of pantoprazole-loaded microspheres.

    abstract::Pantoprazole is a proton pump inhibitor prodrug used in the treatment of gastric ulcers and gastroesophageal disease. Pantoprazole must be absorbed in the gastrointestinal tract and because it is unstable under acidic conditions, enteric delivery systems are required. The purpose of this study was to prepare pantopraz...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Comoglu T,Gonul N,Dogan A,Basci N

    更新日期:2008-06-01 00:00:00

  • Pharmacokinetics and anti-hypertensive effect of metoprolol tartrate rectal delivery system.

    abstract::The main aim of this work was to develop rectal suppositories for better delivery of metoprolol tartrate (MT). The various bases used were fatty, water soluble and emulsion bases. The physical properties of the prepared suppositories were characterized such as weight variation, hardness, disintegration time, melting r...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Abou el Ela Ael S,Allam AA,Ibrahim EH

    更新日期:2016-01-01 00:00:00

  • Etoposide-loaded biodegradable amphiphilic methoxy (poly ethylene glycol) and poly (epsilon caprolactone) copolymeric micelles as drug delivery vehicle for cancer therapy.

    abstract::Amphiphilic diblock copolymers composed of methoxy poly ethylene glycol (MePEG) and poly epsilon caprolactone (PCL) were synthesized for the formation of micelles by ring opening mechanism using stannous octoate as a catalyst. The effects of the molecular weight of MePEG and the copolymer ratio on the properties of mi...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Mohanty AK,Dilnawaz F,Mohanty C,Sahoo SK

    更新日期:2010-07-01 00:00:00

  • N-trimethyl chitosan (TMC)-modified microemulsions for improved oral bioavailability of puerarin: preparation and evaluation.

    abstract::The aim of this research was to increase the oral bioavailability of puerarin by N-trimethyl chitosan-modified microemulsions (TMC-MEs) loaded with puerarin. Different concentrations of TMC-modified microemulsions were prepared in our study, and then evaluated for particle size, zeta potential, morphological observati...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Liao D,Liu X,Dai W,Tang T,Ou G,Zhang K,Han M,Kang R,Yang S,Xiang D

    更新日期:2015-01-01 00:00:00

  • Enhanced skin permeation of 6-methoxy-2-naphthylacetic acid by salt formation.

    abstract::The aim of this work was to prepare salts of 6-methoxy-2-naphthylacetic acid (6-MNA) to improve its physicochemical properties for percutaneous application. 6-MNA, an active metabolite of non-steroidal anti-inflammatory drug nabumetone has long half life and has the tendency to penetrate well into synovial fluid. The ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Pawar V,Kumar HY,Giridhar R,Yadav MR

    更新日期:2015-05-01 00:00:00

  • Development and characterization of sponge-like acyclovir ocular minitablets.

    abstract::For the treatment of ocular keratitis acyclovir, as a highly specific inhibitor of herpes virus replication, is applied topically into the eye. The objective of this study was to design and evaluate freeze-dried, bioadhesive and biodegredable acyclovir ocular minitablets for prolonged local drug action. The sponge-lik...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Refai H,Tag R

    更新日期:2011-01-01 00:00:00