Abstract:
:Endostatin (ES) can effectively inhibit neovascularization in most solid tumors and has the potential to make oxygen delivery more efficient and increase the efficacy of radiotherapy (RT). With a short half-life, ES is mainly administered systemically, which leads to low intake in tumor tissue and often toxic systemic side effects. In this study, we used hyaluronic acid-tyramine as a carrier to synthesize an ES-loaded hydrogel drug (ES/HA-Tyr) that can be injected locally. ES/HA-Tyr has a longer half-life and fewer systemic toxic side effects, and it exerts a better anti-angiogenic effect and anti-tumor effect with RT. In vitro, ES/HA-Tyr showed sustained release in the release assay and a stronger ability to inhibit the proliferation of human umbilical vascular endothelial cells (HUVECs) in the MTT assay; it exhibited a more potent effect against HUVEC invasion and a stronger anti-angiogenic effect on HUVECs in tube formation. In vivo, ES/HA-Tyr increased local drug concentration, decreased blood drug concentration, and caused less systemic toxicity. Further, ES/HA-Tyr effectively reduced tumor microvessel density, increased tumor pericyte coverage, decreased tumor hypoxia, and increased RT response. ES/HA-Tyr + RT also had increased anti-tumor and anti-angiogenic effects in Lewis lung cancer (LLC) xenograft models. In conclusion, ES/HA-Tyr showed sustained release, lower systemic toxicity, and better anti-tumor effects than ES. In addition, ES/HA-Tyr + RT enhanced anti-angiogenic effects, reduced tumor hypoxia, and increased the efficacy of RT in LLC-bearing mice.
journal_name
Drug Delivjournal_title
Drug deliveryauthors
Wang N,Gao Q,Tang J,Jiang Y,Yang L,Shi X,Chen Y,Zhang Y,Fu S,Lin Sdoi
10.1080/10717544.2020.1869864subject
Has Abstractpub_date
2021-12-01 00:00:00pages
183-194issue
1eissn
1071-7544issn
1521-0464journal_volume
28pub_type
杂志文章相关文献
DRUG DELIVERY文献大全abstract::Non-ionic surfactant vesicles, simply known as niosomes are synthetic vesicles with potential technological applications. Niosomes have the same potential advantages of phospholipid vesicles (liposomes) of being able to accommodate both water soluble and lipid soluble drug molecules control their release and as such s...
journal_title:Drug delivery
pub_type: 杂志文章,评审
doi:10.3109/10717544.2013.838077
更新日期:2014-03-01 00:00:00
abstract::Lung cancer is still the most common cancer globally. Early screening remains the key to improve the prognosis of patients. There is currently a lack of specific and sensitive methods for early screening of lung cancer. In recent years, studies have found that microRNA plays an important role in the occurrence and dev...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1516003
更新日期:2018-11-01 00:00:00
abstract::The aim of this work was to develop a novel and more efficient platform for sublingual drug delivery using mosapride citrate (MSP) as a model drug. The engineering of this delivery system had two stages, the first stage was tuning of MSP physicochemical properties by complexation with pure phosphatidylcholine or phosp...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1334719
更新日期:2017-11-01 00:00:00
abstract::Hot-melt extrusion (HME) plays an important role in preparing implants as local drug delivery systems in pharmaceutical fields. Here, a new PLA/PEG-PPG-PEG/Dexamethasone (PLA/F68/Dex) implant prepared by HME has been developed. Importantly, the implant was successfully achieved to control release of immunosuppressive ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.801049
更新日期:2013-04-01 00:00:00
abstract::Silk was easily dyed in traditional textile industry because of its strong affinity to many colorants. Herein, the biocompatible silk fibroin was firstly extracted from Bombyx mori silkworm cocoons. And SF nanoparticles (SFNPs) were prepared for dyeing indocyanine green (ICG) and construct a therapeutic nano-platform ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1428244
更新日期:2018-11-01 00:00:00
abstract::The combination of protein-coated graphene oxide (GO) and microencapsulation technology has moved a step forward in the challenge of improving long-term alginate encapsulated cell survival and sustainable therapeutic protein release, bringing closer its translation from bench to the clinic. Although this new approach ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1474966
更新日期:2018-11-01 00:00:00
abstract::Ketorolac tromethamine, a potent nonnarcotic analgesic agent and 800 times more potent than aspirin, is indicated for the short-term management of moderate to such severe painful states as post operative pain, acute musculoskeletal pain, and dental pain. It Given every 6 hr intramuscularly in patients for acute pain, ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500398092
更新日期:2008-08-01 00:00:00
abstract:CONTEXT:Propolis has traditionally been used in curing infections and healing wounds and burns. OBJECTIVE:The aim of this study is to formulate pluronic lecithin organogel of propolis to improve its availability and antimicrobial activity. MATERIALS AND METHODS:Different organogels were prepared by using soybean leci...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.847032
更新日期:2014-02-01 00:00:00
abstract::This work focused on the developmental aspects, pharmacokinetic evaluation, and pharmacological assessment of a drug inclusion complex for a novel camptothecin analog (CA) and 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). Camptothecins analog belong to topoisomerase-I inhibitor class of compounds with proven anti-tumor ac...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2010.544689
更新日期:2011-05-01 00:00:00
abstract::Colon is an ideal absorptive site for oral protein and peptide drug (insulin), and yet it poses multiple barriers against the drug absorption, such as the barriers against the drug diffusion from colon lumen toward the absorptive mucosa and permeation across colon epithelium. In this study, modified nanoparticles (Tat...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1048489
更新日期:2016-07-01 00:00:00
abstract::Bevacizumab is an anti-vascular endothelial growth factor drug that can be used to treat choroidal neovascularization (CNV). Bevacizumab-loaded multivesicular liposomes (Bev-MVLs) have been designed and developed to increase the intravitreal retention time of bevacizumab and reduce the number of injection times. In th...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1474967
更新日期:2018-11-01 00:00:00
abstract::Biodegradable implantable matrices containing bovine serum albumin were prepared from oligoesters by melting, and subsequently tested on in vitro albumin release. The linear poly (DL-lactic acid) and the branched terpolymer of DL-lactic acid, glycolic acid, and mannitol were synthesized. Products were of similar molec...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500313125
更新日期:2006-01-01 00:00:00
abstract::The aim of this study was to evaluate the effects of therapeutic pulsed ultrasound with gold nanoparticles on oxidative stress parameters after traumatic muscle injury in Wistar rats. The animals were randomly divided into nine groups (n = 6 each): sham (uninjured muscle); muscle injury without treatment; muscle injur...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.923063
更新日期:2016-01-01 00:00:00
abstract::Usually the topical delivery of ocular drugs poses a great challenge. Accordingly, the work in this study comprised the use of different hybrids of generally regarded as safe (GRAS) oils and surfactants in order to develop and optimize novel acetazolamide (AZD) entrapped-vesicular systems aiming at improving its ocula...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2016.1233588
更新日期:2017-11-01 00:00:00
abstract::DNA vaccination is a promising approach for inducing both humoral and cellular immune responses. The mode of plasmid DNA delivery is critical to make progress in DNA vaccination. Using human papillomavirus type 16 E7 as a model antigen, this study evaluated the effect of peptide-polymer hybrid including PEI600-Tat con...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540902757721
更新日期:2009-05-01 00:00:00
abstract::In this study, the blood clearance and organ distribution of intravenously administered liposomes (distearoyl phosphatidylcholine [DSPC] and cholesterol in a ratio of 3:1) was evaluated by utilizing 3H-cholesteryl ether as the lipid phase marker. Also, the ability of liposomes, as a drug delivery system, to alter the ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/713840396
更新日期:2003-07-01 00:00:00
abstract::Radio-labeled hydrogel beads, based on amidated pectin, have been produced by adding droplets of an amidated pectin solution to calcium chloride. Incorporation of model drugs into the beads and measurement of the dissolution rate showed that the properties of the beads were unaffected by the incorporation of the radio...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717549809065753
更新日期:1998-01-01 00:00:00
abstract::Various ocular diseases like glaucoma, conjunctivitis, and dry eye syndrome require frequent drug administration. Poor ocular bioavailability of drugs (< 1%) from conventional eye drops is due mainly to the precorneal loss factors that include rapid tear turnover, nonproductive absorption, transient residence time in ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540701606426
更新日期:2007-11-01 00:00:00
abstract::The study was aimed at evaluating the effectiveness of liposomal, micellar, and water-soluble drug forms of diminazene for its localization in cells and selective accumulation at the sites of aggregation of pathogenic organisms. Pharmacological and dynamic properties of a new injection micellar diminazene preparation ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500459084
更新日期:2006-09-01 00:00:00
abstract::Novel itraconazole (ITZ)-loaded liposomes (ITZ-LPs) were prepared and their pharmacokinetics and biodistribution were assessed in comparison with commercial formulations (ITZ-CD). The ITZ-LPs were prepared by thin-film hydration method and the physicochemical characterizations of the ITZ-LPs were evaluated. The pharma...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717541003667822
更新日期:2010-05-01 00:00:00
abstract::The purpose of this work is to use biorelevant media to evaluate the robustness of a poorly water soluble weakly basic drug to variations along the gastrointestinal tract (GIT) after incorporation in liquisolid compacts and to assess the success of these models in predicting the in vivo performance. Liquisolid tablets...
journal_title:Drug delivery
pub_type: 杂志文章,随机对照试验
doi:10.3109/10717544.2014.917442
更新日期:2016-01-01 00:00:00
abstract::Raloxifene (RLX) is a second-generation selective estrogen receptor modulator used to treat osteoporosis in postmenopausal women. RLX fails to be developed into injectable dosage forms due to poor solubility. Although oral formulations are clinically available, the lower bioavailability (<2%) embarrasses the pharmaceu...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2021.1872742
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Paclitaxel (PTX) and carboplatin (CBP) are widely used for the combined chemotherapy of non-small cell lung cancer (NSCLC). However, the development of multidrug resistance of cancer cells, as well as systemic toxic side effects resulting from nonspecific localization of anticancer drugs to non-tumor areas are ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1035466
更新日期:2016-09-01 00:00:00
abstract::ALA-loaded nanostructured lipid carrier (ALA-NLC) was designed to improve physicochemical stability and water solubility, and promote sustained release of ALA as well as determine the biocompatibility of ALA-NLC. The ALA-NLC manufactured using hot high-pressure homogenization technique was investigated in terms of siz...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.846435
更新日期:2014-08-01 00:00:00
abstract::Pantoprazole is a proton pump inhibitor prodrug used in the treatment of gastric ulcers and gastroesophageal disease. Pantoprazole must be absorbed in the gastrointestinal tract and because it is unstable under acidic conditions, enteric delivery systems are required. The purpose of this study was to prepare pantopraz...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540802006864
更新日期:2008-06-01 00:00:00
abstract::The main aim of this work was to develop rectal suppositories for better delivery of metoprolol tartrate (MT). The various bases used were fatty, water soluble and emulsion bases. The physical properties of the prepared suppositories were characterized such as weight variation, hardness, disintegration time, melting r...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.904021
更新日期:2016-01-01 00:00:00
abstract::Amphiphilic diblock copolymers composed of methoxy poly ethylene glycol (MePEG) and poly epsilon caprolactone (PCL) were synthesized for the formation of micelles by ring opening mechanism using stannous octoate as a catalyst. The effects of the molecular weight of MePEG and the copolymer ratio on the properties of mi...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717541003720688
更新日期:2010-07-01 00:00:00
abstract::The aim of this research was to increase the oral bioavailability of puerarin by N-trimethyl chitosan-modified microemulsions (TMC-MEs) loaded with puerarin. Different concentrations of TMC-modified microemulsions were prepared in our study, and then evaluated for particle size, zeta potential, morphological observati...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.879398
更新日期:2015-01-01 00:00:00
abstract::The aim of this work was to prepare salts of 6-methoxy-2-naphthylacetic acid (6-MNA) to improve its physicochemical properties for percutaneous application. 6-MNA, an active metabolite of non-steroidal anti-inflammatory drug nabumetone has long half life and has the tendency to penetrate well into synovial fluid. The ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.894595
更新日期:2015-05-01 00:00:00
abstract::For the treatment of ocular keratitis acyclovir, as a highly specific inhibitor of herpes virus replication, is applied topically into the eye. The objective of this study was to design and evaluate freeze-dried, bioadhesive and biodegredable acyclovir ocular minitablets for prolonged local drug action. The sponge-lik...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2010.509364
更新日期:2011-01-01 00:00:00