Abstract:
:Endostatin (ES) can effectively inhibit neovascularization in most solid tumors and has the potential to make oxygen delivery more efficient and increase the efficacy of radiotherapy (RT). With a short half-life, ES is mainly administered systemically, which leads to low intake in tumor tissue and often toxic systemic side effects. In this study, we used hyaluronic acid-tyramine as a carrier to synthesize an ES-loaded hydrogel drug (ES/HA-Tyr) that can be injected locally. ES/HA-Tyr has a longer half-life and fewer systemic toxic side effects, and it exerts a better anti-angiogenic effect and anti-tumor effect with RT. In vitro, ES/HA-Tyr showed sustained release in the release assay and a stronger ability to inhibit the proliferation of human umbilical vascular endothelial cells (HUVECs) in the MTT assay; it exhibited a more potent effect against HUVEC invasion and a stronger anti-angiogenic effect on HUVECs in tube formation. In vivo, ES/HA-Tyr increased local drug concentration, decreased blood drug concentration, and caused less systemic toxicity. Further, ES/HA-Tyr effectively reduced tumor microvessel density, increased tumor pericyte coverage, decreased tumor hypoxia, and increased RT response. ES/HA-Tyr + RT also had increased anti-tumor and anti-angiogenic effects in Lewis lung cancer (LLC) xenograft models. In conclusion, ES/HA-Tyr showed sustained release, lower systemic toxicity, and better anti-tumor effects than ES. In addition, ES/HA-Tyr + RT enhanced anti-angiogenic effects, reduced tumor hypoxia, and increased the efficacy of RT in LLC-bearing mice.
journal_name
Drug Delivjournal_title
Drug deliveryauthors
Wang N,Gao Q,Tang J,Jiang Y,Yang L,Shi X,Chen Y,Zhang Y,Fu S,Lin Sdoi
10.1080/10717544.2020.1869864subject
Has Abstractpub_date
2021-12-01 00:00:00pages
183-194issue
1eissn
1071-7544issn
1521-0464journal_volume
28pub_type
杂志文章相关文献
DRUG DELIVERY文献大全abstract::The aim of this work was to prepare salts of 6-methoxy-2-naphthylacetic acid (6-MNA) to improve its physicochemical properties for percutaneous application. 6-MNA, an active metabolite of non-steroidal anti-inflammatory drug nabumetone has long half life and has the tendency to penetrate well into synovial fluid. The ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.894595
更新日期:2015-05-01 00:00:00
abstract::A conjugate consisting of streptavidin (biotinylated transferrin)-biotinylated polylysine for DNA delivery to cells was modified by partial nicotinylation of the polylysine component of the conjugate and used for transfection studies. A conjugate of biotin10-nicotinyl60-polylysine250 containing 60 weakly basic nicotin...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/107175400455164
更新日期:2000-10-01 00:00:00
abstract::Etoposide (VP16) is the traditional antitumor agent which has been widely used in a variety of cancers. However, intravenous administration of VP16 was limited in clinical application because of its low aqueous solubility, poor bioavailability and dose-limiting adverse effects. Local chemotherapy with VP16-loaded drug...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1787558
更新日期:2020-12-01 00:00:00
abstract::Although meloxicam (MX) is relatively safer than other NSAIDs, adverse effects relating to the gastro-intestinal tract are still a problem when administrated MX at high doses and on the long-term treatment. Drug delivery via skin provides an attractive alternative to oral administration, but is limited by the first la...
journal_title:Drug delivery
pub_type: 杂志文章,评审
doi:10.3109/10717544.2016.1157839
更新日期:2016-10-01 00:00:00
abstract::Usually the topical delivery of ocular drugs poses a great challenge. Accordingly, the work in this study comprised the use of different hybrids of generally regarded as safe (GRAS) oils and surfactants in order to develop and optimize novel acetazolamide (AZD) entrapped-vesicular systems aiming at improving its ocula...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2016.1233588
更新日期:2017-11-01 00:00:00
abstract::Mucoadhesive drug delivery systems are those that provide intimate contact of the drug with the mucosa for an extended period of time. In our present work, mucoadhesive chitosan microspheres were prepared by emulsion solvent method. Formulations were characterized for various physicochemical attributes, shape, surface...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540490280750
更新日期:2004-03-01 00:00:00
abstract::The purpose of this study was to characterize and evaluate tectorigenin-loaded self-microemulsifying drug delivery system (TG-SMEDDS), a previously studied preparation, and further confirm the improvement of TG in solubility and bioavailability. The appearance of TG-SMEDDS was clear and transparent, with good mobility...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1284946
更新日期:2017-11-01 00:00:00
abstract:CONTEXT:Humic acid (HA), a natural organic matter is recently being investigated for pharmaceutical purposes. Andrographolide (AGP), a potent hepatoprotective, possesses low aqueous solubility which results in a low bioavailability after oral administration, inappropriate tissue localization and consequently poor thera...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.871602
更新日期:2015-01-01 00:00:00
abstract::The aim of this research was to increase the oral bioavailability of puerarin by N-trimethyl chitosan-modified microemulsions (TMC-MEs) loaded with puerarin. Different concentrations of TMC-modified microemulsions were prepared in our study, and then evaluated for particle size, zeta potential, morphological observati...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.879398
更新日期:2015-01-01 00:00:00
abstract::The conjugation of tunable peptides or materials with nanocarriers represents a promising approach for drug delivery to tumor cells. In this study, we report the development of a novel liposomal carrier system that exploits the cell surface binding synergism between photo-sensitive peptides (PSPs) and targeting ligand...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1008707
更新日期:2016-09-01 00:00:00
abstract::S-nitrosothiols are a class of NO-donors currently under investigation for the treatment of various diseases. In this study, we developed a novel NO-donor (S-nitrosoglutathione-alginate, SNA) by cross-linking alginate with S-nitrosothiols, which can deliver NO in a sustained manner. This compound can be further evalua...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1122676
更新日期:2016-10-01 00:00:00
abstract::Recently, exosomes have been emerged as promising drug delivery carriers, while certain tissues are intrinsically resistant to exosomes. Therapeutically improving the drug delivery efficiency in these tissues/organs would certainly broaden the potential application of exosomes in future. Ultrasound-targeted microbubbl...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1534898
更新日期:2019-12-01 00:00:00
abstract::A new strategy based on gastric retention is proposed for the treatment of Helicobacter pylori. (H. pylori). A synergism between a floating and a bioadhesive system has been explored. Floating microspheres containing the antiurease drug acetohydroxamic acid (AHA) were prepared by a novel quasi-emulsion solvent diffusi...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540260397837
更新日期:2002-10-01 00:00:00
abstract::Nasal colonization of Staphylococcus aureus (S.aureus) is known as a significant risk factor for nosocomial infections, and clearance of its nasal colonization greatly reduces the risk. In the present study the preparation and characterizations of the chitosan-o/w cream incorporated with lysostaphin (CCL) were describ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2010.509360
更新日期:2010-11-01 00:00:00
abstract::In vitro drug release rates from aqueous and oil solutions as well as preformed and in situ formed aqueous and oil suspensions intended for intra-articular delivery have been investigated using the rotating dialysis cell model. Using lidocaine as a model drug substance the release kinetics from aqueous and oil suspens...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540701828657
更新日期:2008-01-01 00:00:00
abstract::This study focused on preparation and evaluation of a thermosensitive and mucoadhesive in situ gelling ophthalmic system of azithromycin (ATM). Poloxamer 407 (P407) and poloxamer 188 (P188) were used as gelling agents. Addition of Carbopol 974P (CP 974P) to the gelling systems could increase the solubility of ATM by s...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2010.483255
更新日期:2010-09-01 00:00:00
abstract::The objective of our study was to formulate and evaluate proliposomes in the form of enteric-coated beads using glyburide as a model drug. The beads were enteric coated with Eudragit L-100 by a fluidized bed coating process using triethyl citrate as plasticizer. Content uniformity of glyburide was estimated using HPLC...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/107175401300002720
更新日期:2001-01-01 00:00:00
abstract::Chitosan, a natural-based polymer obtained by alkaline deacetylation of chitin, is nontoxic, biocompatible, and biodegradable. These properties make chitosan a good candidate for conventional and novel drug delivery systems. This article reviews the approaches aimed to associate bioactive molecules to chitosan in the ...
journal_title:Drug delivery
pub_type: 杂志文章,评审
doi:10.1080/10717540590889781
更新日期:2005-01-01 00:00:00
abstract::Alzheimer's disease is a neurodegenerative disorder mainly characterized by β-amyloid deposit and tau hyperphosphorylation with no curative treatments. Curcumin (Cur) has been proved to have potential use in Alzheimer's disease with its anti-amyloid, anti-inflammatory, and anti-oxidant properties, etc. However, its hy...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1461955
更新日期:2018-11-01 00:00:00
abstract::At present, the chemotherapy of advanced inoperable liver cancer is limited with serious side effects. Curcumin possesses multiple cancer preventive activities and low safety concerns. However, its poor solubility and instability in water pose significant pharmacological barriers to its clinical application. In this s...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1526227
更新日期:2018-11-01 00:00:00
abstract::The aim of this work was to develop a novel and more efficient platform for sublingual drug delivery using mosapride citrate (MSP) as a model drug. The engineering of this delivery system had two stages, the first stage was tuning of MSP physicochemical properties by complexation with pure phosphatidylcholine or phosp...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1334719
更新日期:2017-11-01 00:00:00
abstract::Discovery of novel pharmacological effects of berberine hydrochloride (BH) has made its clinical application valuable. However, further development and applications of BH are hampered by its short half-life and the side effects associated with its intravenous (iv) injection. To improve the hypolipidemia efficacy and r...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1716880
更新日期:2020-12-01 00:00:00
abstract::For the treatment of ocular keratitis acyclovir, as a highly specific inhibitor of herpes virus replication, is applied topically into the eye. The objective of this study was to design and evaluate freeze-dried, bioadhesive and biodegredable acyclovir ocular minitablets for prolonged local drug action. The sponge-lik...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2010.509364
更新日期:2011-01-01 00:00:00
abstract::Silk was easily dyed in traditional textile industry because of its strong affinity to many colorants. Herein, the biocompatible silk fibroin was firstly extracted from Bombyx mori silkworm cocoons. And SF nanoparticles (SFNPs) were prepared for dyeing indocyanine green (ICG) and construct a therapeutic nano-platform ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1428244
更新日期:2018-11-01 00:00:00
abstract::Camptothecin (CPT) is an effective anticancer agent against various cancers but the clinical application is limited because of its poor water solubility, low bioavailability and severe toxic side effects. The aim of the present study was to evaluate the feasibility of using targeted NPs as a high-performance CPT deliv...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.950767
更新日期:2016-06-01 00:00:00
abstract::This work focused on the developmental aspects, pharmacokinetic evaluation, and pharmacological assessment of a drug inclusion complex for a novel camptothecin analog (CA) and 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). Camptothecins analog belong to topoisomerase-I inhibitor class of compounds with proven anti-tumor ac...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2010.544689
更新日期:2011-05-01 00:00:00
abstract:CONTEXT:Docetaxel is now a major antitumor drug in clinical use for the treatment of a variety of tumors. The ethanol/Tween 80 solvent required in the formulation to increase the docetaxel solubility is at least partly responsible for the hypersensitivity reaction, decreased uptake by tumor tissue, and increased exposu...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.879964
更新日期:2015-02-01 00:00:00
abstract::Our objective was to evaluate the chemotherapeutic potential of oral poly lactide-co-glycolide (PLG, a synthetic polymer) nanoparticle encapsulated ethambutol in combination with PLG-nanoparticle encapsulated-(rifampicin + isoniazid + pyrazinamide) in a murine tuberculosis (TB) model. Our formulation was prepared by t...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500398076
更新日期:2006-07-01 00:00:00
abstract::Efficient and stable delivery system of antisense oligonucleotide (ASO) is important and urgently needed. Here, an ASO delivery system, Lp-PPRP, which contains a cationic polymer based on PEI (branched, 25 kDa), named PEI-PC and a palmitic acid modified R8 (R8-PA) was prepared to deliver a kind of ASO, LOR-2501. The c...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2019.1667453
更新日期:2019-12-01 00:00:00
abstract::Hydroxy genkwanin (HGK), a flavonoid compound from natural resources, showed good inhibition against the growth of breast tumor cells. However, the poor solubility restricted the further study and the in vivo drug delivery of HGK. We prepared HGK nanosuspensions by antisolvent precipitation method and investigated the...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1770372
更新日期:2020-12-01 00:00:00