In vivo behavior of hydrogel beads based on amidated pectins.

Abstract:

:Radio-labeled hydrogel beads, based on amidated pectin, have been produced by adding droplets of an amidated pectin solution to calcium chloride. Incorporation of model drugs into the beads and measurement of the dissolution rate showed that the properties of the beads were unaffected by the incorporation of the radiolabel. The labeled beads were used to carry out an in vivo study of their behavior in the gastrointestinal tract using human volunteers. The volunteers were given the beads after an overnight fast and images were obtained at frequent intervals during transit through the upper gastrointestinal tract and the colon. The beads exhibited rapid gastric emptying and proceeded to pass through the small intestine individually before regrouping at the ileo-caecal junction. Once in the colon, the beads again proceeded as individuals and evidence of the degradation of the beads was observed.

journal_name

Drug Deliv

journal_title

Drug delivery

authors

Munjeri O,Collett JH,Fell JT,Sharma HL,Smith AM

doi

10.3109/10717549809065753

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

239-41

issue

4

eissn

1071-7544

issn

1521-0464

journal_volume

5

pub_type

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