Abstract:
:Radio-labeled hydrogel beads, based on amidated pectin, have been produced by adding droplets of an amidated pectin solution to calcium chloride. Incorporation of model drugs into the beads and measurement of the dissolution rate showed that the properties of the beads were unaffected by the incorporation of the radiolabel. The labeled beads were used to carry out an in vivo study of their behavior in the gastrointestinal tract using human volunteers. The volunteers were given the beads after an overnight fast and images were obtained at frequent intervals during transit through the upper gastrointestinal tract and the colon. The beads exhibited rapid gastric emptying and proceeded to pass through the small intestine individually before regrouping at the ileo-caecal junction. Once in the colon, the beads again proceeded as individuals and evidence of the degradation of the beads was observed.
journal_name
Drug Delivjournal_title
Drug deliveryauthors
Munjeri O,Collett JH,Fell JT,Sharma HL,Smith AMdoi
10.3109/10717549809065753subject
Has Abstractpub_date
1998-01-01 00:00:00pages
239-41issue
4eissn
1071-7544issn
1521-0464journal_volume
5pub_type
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