In vivo lymphatic targeting of methylene blue with microemulsion and multiple microemulsion.

abstract：:The prevalence of childhood dyslipidemia increases and is considered as an important risk factor for the incidence of cardiovascular disease in the adulthood. To improve dosing accuracy and facilitate the determination of dosing regimens in function of the body weight, the proposed study aims at preparing transdermal ...

journal_title：Drug delivery

authors： Zidan AS,Hosny KM,Ahmed OA,Fahmy UA

更新日期：2016-06-01 00:00:00

abstract：:A novel cationic liposome modified with soybean sterylglucoside (SG) and polyethylene glycol-distearoylphosphatidylethanolamine (PEG-DSPE) as a carrier of antisense oligodeoxynucleotide (ODN) for hepatitis B virus (HBV) therapy was constructed. Characteristics of the cationic liposomes modified with SG and PEG (SG/PEG...

journal_title：Drug delivery

authors： Shi J,Yan WW,Qi XR,Maitani Y,Nagai T

更新日期：2005-11-01 00:00:00

abstract：:The objective of this study was to investigate the effect of lipophilic (Compritol 888 ATO) and hydrophilic components (combination of HPMC and Avicel) on the release of carbamazepine from granules and corresponding tablet. Wet granulation followed by compression was employed for preparation of granules and tablets. T...

journal_title：Drug delivery

authors： Barakat NS,Elbagory IM,Almurshedi AS

更新日期：2009-01-01 00:00:00

abstract：:The main aim of this work was to develop rectal suppositories for better delivery of metoprolol tartrate (MT). The various bases used were fatty, water soluble and emulsion bases. The physical properties of the prepared suppositories were characterized such as weight variation, hardness, disintegration time, melting r...

journal_title：Drug delivery

authors： Abou el Ela Ael S,Allam AA,Ibrahim EH

更新日期：2016-01-01 00:00:00

abstract：CONTEXT:Artemether and lumefantrine combination therapy is well-accepted for uncomplicated malaria treatment. However, the current available formulation has several pharmacokinetic mismatches such as drug degradation in gastrointestinal tract, erratic absorption, etc. Hence, need of the hour is the injectable formulati...

journal_title：Drug delivery

authors： Parashar D,Aditya NP,Murthy RS

更新日期：2016-01-01 00:00:00

abstract：:IDEC-CE9.1/SB-210396 is a macaque/human chimeric IgG1 monoclonal antibody (mAb) directed against the human T-cell surface marker, CD4. This antibody has been evaluated as a potential treatment for rheumatoid arthritis and asthma, in which T cell activation is believed to play an important role in orchestrating inflamm...

journal_title：Drug delivery

authors： Davis CB,Bugelski PJ

更新日期：1998-01-01 00:00:00

abstract：:The aim of this study was to obtain a stable, amorphous solid dispersion (SD) with Soluplus, prepared by hot-melt extrusion (HME) as an effective and stable oral delivery system to improve the physical stability and bioavailability of the poorly water-soluble simvastatin (SIM), a drug with relatively low Tg. The drug ...

journal_title：Drug delivery

authors： Zhang Y,Liu Y,Luo Y,Yao Q,Zhong Y,Tian B,Tang X

更新日期：2016-07-01 00:00:00

abstract：:The combination of protein-coated graphene oxide (GO) and microencapsulation technology has moved a step forward in the challenge of improving long-term alginate encapsulated cell survival and sustainable therapeutic protein release, bringing closer its translation from bench to the clinic. Although this new approach ...

journal_title：Drug delivery

authors： Ciriza J,Saenz Del Burgo L,Gurruchaga H,Borras FE,Franquesa M,Orive G,Hernández RM,Pedraz JL

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:In the present study, Curcumin (CU)-loaded nanocarrier (NC) such as nanoemulsion (NE) was developed with the objective of increasing its cytotoxicity and bioavailability through lymphatic transport by enhancing its solubility and intestinal permeability. MATERIALS AND METHODS:Based on the area obtained in ps...

journal_title：Drug delivery

authors： Kumar A,Ahuja A,Ali J,Baboota S

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:A topical microemulsion (ME)-based hydrogel was developed to enhance permeation of an antifungal drug, sertaconazole (STZL) for effective eradication of cutaneous fungal infection. METHODS:Pseudo-ternary phase diagrams were used to determine the existence of MEs region. ME formulations were prepared with oleic...

journal_title：Drug delivery

authors： Sahoo S,Pani NR,Sahoo SK

更新日期：2016-01-01 00:00:00

abstract：:The aim of the current study was to formulate terconazole (TCZ) loaded polymeric mixed micelles (PMMs) incorporating Cremophor EL as a stabilizer and a penetration enhancer. A 23 full factorial design was performed using Design-Expert® software for the optimization of the PMMs which were formulated using Pluronic P123...

journal_title：Drug delivery

authors： Abd-Elsalam WH,El-Zahaby SA,Al-Mahallawi AM

更新日期：2018-11-01 00:00:00

abstract：:Ketorolac tromethamine, a potent nonnarcotic analgesic agent and 800 times more potent than aspirin, is indicated for the short-term management of moderate to such severe painful states as post operative pain, acute musculoskeletal pain, and dental pain. It Given every 6 hr intramuscularly in patients for acute pain, ...

journal_title：Drug delivery

authors： Sinha VR,Trehan A

更新日期：2008-08-01 00:00:00

abstract：:The present work aimed to apply the liquid antisolvent precipitation (LAP) method for preparing the apigenin nanoparticles and thereby improving the solubility and bioavailability of apigenin. The different experimental parameters on particle size were optimized through central composite design (CCD) using the Design-...

journal_title：Drug delivery

authors： Wu W,Zu Y,Wang L,Wang L,Wang H,Li Y,Wu M,Zhao X,Fu Y

更新日期：2017-11-01 00:00:00

abstract：:Ischemic stroke is one of the major causes of severe disability and death worldwide. It is mainly caused by a sudden reduction in cerebral blood flow due to obstruction of the supplying vessel by thrombi and subsequent initiation of a complex cascade of pathophysiological changes, which ultimately lead to brain ischem...

journal_title：Drug delivery

authors： Ma H,Jiang Z,Xu J,Liu J,Guo ZN

更新日期：2021-12-01 00:00:00

abstract：:In the present study, the stability of thymopentin (TP5) in bronchoalveolar lavage fluid (BALF) in presence of potential excipients in inhalation formulation was investigated. The content of TP5 was determined using HPLC method. Commonly used bulking agent, dispersibility enhancers and absorption enhancers in inhalati...

journal_title：Drug delivery

authors： Cai C,Wang L,Dong W,Tang X

更新日期：2014-09-01 00:00:00

abstract：:Administration of influenza vaccines to the lungs could be an attractive alternative to conventional parenteral administration. In this study, we investigated the deposition site of pulmonary delivered liquid and powder influenza vaccine formulations and its relation to their immunogenicity and protective efficacy. In...

journal_title：Drug delivery

authors： Bhide Y,Tomar J,Dong W,de Vries-Idema J,Frijlink HW,Huckriede A,Hinrichs WLJ

更新日期：2018-11-01 00:00:00

abstract：:Biodegradable implantable matrices containing bovine serum albumin were prepared from oligoesters by melting, and subsequently tested on in vitro albumin release. The linear poly (DL-lactic acid) and the branched terpolymer of DL-lactic acid, glycolic acid, and mannitol were synthesized. Products were of similar molec...

journal_title：Drug delivery

authors： Kladnícková I,Dittrich M,Klein T,Pokorová D

更新日期：2006-01-01 00:00:00

abstract：:Combinational therapy is usually considered as a preferable approach for effective cancer therapy. Especially, combinational chemo and photothermal therapy is of particular interest due to its high flexibility as well as efficiency. In this article, we the silica nanoparticles (SLN) were surface conjugated with Cetuxi...

journal_title：Drug delivery

authors： Zhang X,Li Y,Wei M,Liu C,Yu T,Yang J

更新日期：2019-12-01 00:00:00

abstract：:Traditional in situ gel forming systems are potential applications for parenteral administration but always accompanied with burst release. To overcome this limitation, the tinidazole (TNZ)-loaded in situ gel forming system using a diblock copolymer, monomethoxy poly(ethylene glycol)-block-poly(d,l-lactide) (mPEG-PDLL...

journal_title：Drug delivery

authors： Tian Y,Shen Y,Jv M

更新日期：2016-10-01 00:00:00

abstract：:Sustained release (SR) matrix tablets of dextromethorphan hydrobromide were prepared by wet granulation using hydroxypropyl methyl cellulose (HPMC-K-100 CR) as the hydrophilic rate controlling polymer. The effect of the concentration of the polymer and different fillers on the in vitro drug release rate was studied. T...

journal_title：Drug delivery

authors： Meyyanathan SN,Rajan S,Muralidaharan S,Siddaiah MK,Krishnaraj K,Suresh B

更新日期：2008-09-01 00:00:00

abstract：:To improve drug retention in carriers for amphiphilic asulacrine (ASL), a novel active loading method using micelle gradient was developed to fabricate the ASL-loaded multiseed liposomes (ASL-ML). The empty ML were prepared by hydrating a thin film with empty micelles. Then the micelles in liposomal compartment acting...

journal_title：Drug delivery

authors： Zhang W,Li C,Jin Y,Liu X,Wang Z,Shaw JP,Baguley BC,Wu Z,Liu J

更新日期：2018-11-01 00:00:00

abstract：:In vitro characteristics of the human erythrocytes loaded by enalaprilat have been evaluated. Erythrocytes obtained from a healthy volunteer were loaded by enalaprilat using the hypotonic preswelling method, and the loading parameters, drug-release kinetics, hematological indices, particle size distribution, scanning ...

journal_title：Drug delivery

authors： Hamidi M,Tajerzadeh H,Dehpour AR,Rouini MR,Ejtemaee-Mehr S

更新日期：2001-10-01 00:00:00

abstract：:Colon is an ideal absorptive site for oral protein and peptide drug (insulin), and yet it poses multiple barriers against the drug absorption, such as the barriers against the drug diffusion from colon lumen toward the absorptive mucosa and permeation across colon epithelium. In this study, modified nanoparticles (Tat...

journal_title：Drug delivery

authors： Guo F,Zhang M,Gao Y,Zhu S,Chen S,Liu W,Zhong H,Liu J

更新日期：2016-07-01 00:00:00

abstract：:Although convection-enhanced delivery (CED) can successfully facilitate a bypass of the blood brain barrier, its treatment efficacy remains highly limited in clinic. This can be partially attributed to the brain anisotropic characteristics that lead to the difficulties in controlling the drug spatial distribution. Her...

journal_title：Drug delivery

authors： Zhan W,Rodriguez Y Baena F,Dini D

更新日期：2019-12-01 00:00:00

abstract：:Usually the topical delivery of ocular drugs poses a great challenge. Accordingly, the work in this study comprised the use of different hybrids of generally regarded as safe (GRAS) oils and surfactants in order to develop and optimize novel acetazolamide (AZD) entrapped-vesicular systems aiming at improving its ocula...

journal_title：Drug delivery

authors： Naguib SS,Hathout RM,Mansour S

更新日期：2017-11-01 00:00:00

abstract：:Efficient and stable delivery system of antisense oligonucleotide (ASO) is important and urgently needed. Here, an ASO delivery system, Lp-PPRP, which contains a cationic polymer based on PEI (branched, 25 kDa), named PEI-PC and a palmitic acid modified R8 (R8-PA) was prepared to deliver a kind of ASO, LOR-2501. The c...

journal_title：Drug delivery

authors： Yang S,Wang D,Sun Y,Zheng B

更新日期：2019-12-01 00:00:00

abstract：:Hydrogels are water swollen networks of polymers and especially hydrogels consisting of poly vinylpyrrolidone/poly ethyleneglycol-dimethacrylate (PVP/PEG-DMA) blends show promising wound care properties. Enhanced functionality of the hydrogels can be achieved by incorporating drugs and other substances that may assist...

journal_title：Drug delivery

authors： Nielsen AL,Madsen F,Larsen KL

更新日期：2009-02-01 00:00:00

abstract：:Surface modification of liposomes with polymer to optimize drug delivery was well developed recently. The objective of the present work was to evaluate the feasibility of chitosan-coated liposomes (CSLP) as vehicles for anti-sense oligodeoxynucleotides (ASON). CSLP was obtained by adding chitosan dropwise to liposomes...

journal_title：Drug delivery

authors： Wang WX,Gao JQ,Liang WQ

更新日期：2011-04-01 00:00:00

abstract：:Gastric cancer is a frequently occurring cancer with high mortality each year worldwide. Finding new and effective therapeutic strategy against human gastric cancer is still urgently required. Hence, we have established a new method to achieve treatment-actuated modifications in a tumor microenvironment by utilizing s...

journal_title：Drug delivery

authors： Xiao Y,Gao Y,Li F,Deng Z

更新日期：2020-12-01 00:00:00

abstract：:Subcutaneous liraglutide-loaded multivesicular liposomes (Lrg-MVLs) were developed as a sustained drug-delivery system for treating diabetes and their properties were characterized. The Lrg-MVLs prepared using a two-step water-in-oil-in-water double emulsification process had a spherical appearance with a mean diamete...

journal_title：Drug delivery

authors： Zhang L,Ding L,Tang C,Li Y,Yang L

更新日期：2016-11-01 00:00:00