Abstract:
:Kollicoat SR 30D is a unique 30% aqueous dispersion of polyvinvyl acetate stabilized by polyvinyl-pyrrolidone intended for preparation of sustained release products. Detailed evaluation of this polymer dispersion as a sustained release coating for active pharmaceutical ingredients of two diverse classes of drugs was studied. A water insoluble drug (ibuprofen) and a water soluble drug (ascorbic acid) were selected as model active drugs. Ibuprofen was granulated using a GPCG-1 fluid bed processor prior to tableting, to improve the particle size and particle flow properties. In this process a 2(3) factorial design was implemented to evaluate the optimum process parameters such as spray rate, inlet air temperature and the inlet air velocity. The statistical model selected was Y(ijkl) = mu + tau(i) + beta(j) + theta(k) + (taubeta)ij + (betatheta)jk + (tautheta)ik + (taubetatheta)ijk + epsilon(ijkl). The factorial design showed that the spray rate, inlet air temperature, and inlet air velocity had a significant effect (p value <0.05) on the particle size. Significant improvement was observed in the flow properties of the granules. The granules were coated with Kollicoat SR30D dispersion using top spray method in the fluid bed processor. The dissolution studies showed that the release of ibuprofen decreased with an increase in the coating levels of Kollicoat SR 30 D. In the case of ascorbic acid, preparation of sustained release coated commercial granules was not possible due to the difficulty in coating a highly soluble drug particle. However, the coated granules when compressed into tablets showed some sustainability. Ibuprofen tablets manufactured with coated granules with a 15 g polymer for 300 g batch showed dissolution parameters of t50 and t90 at 4.2 hr and 7.5 hr, respectively. An approximate zero-type of release was observed when the polymer content was increased to 45 g for 300 g batch. Ascorbic acid tablets made with coated commercial granules having a total polymer content of 45 g per a 500 g batch showed an average dissolution t50 and t90 at 1.0 hr and 4.55 hr, respectively. When the total polymer content was increased to 60 g, per 500 g, the average dissolution t50 and t90 delayed to 1.40 hr and 7.20 hr, respectively.
journal_name
Drug Delivjournal_title
Drug deliveryauthors
Bordaweka MS,Zia H,Quadir Adoi
10.1080/10717540500313398keywords:
subject
Has Abstractpub_date
2006-03-01 00:00:00pages
121-31issue
2eissn
1071-7544issn
1521-0464pii
J61J2X475Q351742journal_volume
13pub_type
杂志文章相关文献
DRUG DELIVERY文献大全abstract::Magnetic nanocomposite particles were synthesized by encapsulating nanosized magnetite with an acrylate-based cationic co-polymer made of MMA, BA, and QMA and modifying with MeOPEGMA using the water replacement method. The composition of the co-polymer formulation was optimized based on zeta-potential measurements and...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540801952597
更新日期:2008-03-01 00:00:00
abstract:CONTEXT:Terbinafine hydrochloride is an antifungal drug for onychomycosis. Poor permeability of its external preparation leads to poor curative effect. Transfersomes, also known as flexible liposome, could improve transmission of drug for local external use. Terbinafine hydrochloride-loaded liposome is expected to beco...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.878856
更新日期:2015-12-01 00:00:00
abstract::Hydrogels are water swollen networks of polymers and especially hydrogels consisting of poly vinylpyrrolidone/poly ethyleneglycol-dimethacrylate (PVP/PEG-DMA) blends show promising wound care properties. Enhanced functionality of the hydrogels can be achieved by incorporating drugs and other substances that may assist...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540802605129
更新日期:2009-02-01 00:00:00
abstract::To prolong the circulation time of drug, PEGylation has been widely used via the enhanced permeability and retention (EPR) effect, thereby providing new hope for better treatment. However, PEGylation also brings the "PEG dilemma", which is difficult for the cellular absorption of drugs and subsequent endosomal escape....
journal_title:Drug delivery
pub_type: 杂志文章,评审
doi:10.1080/10717544.2017.1388451
更新日期:2017-12-01 00:00:00
abstract::S-nitrosothiols are a class of NO-donors currently under investigation for the treatment of various diseases. In this study, we developed a novel NO-donor (S-nitrosoglutathione-alginate, SNA) by cross-linking alginate with S-nitrosothiols, which can deliver NO in a sustained manner. This compound can be further evalua...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1122676
更新日期:2016-10-01 00:00:00
abstract:CONTEXT:Paclitaxel (PTX) and doxorubicin (DOX) are widely used for the combined chemotherapy of solid tumors. However, free drug combination has lower antitumor efficiency. It is necessary to design a drug delivery system to carry both of them. OBJECTIVE:This study aimed to engineer a nano-drug delivery system for co-...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1055619
更新日期:2016-05-01 00:00:00
abstract::The present work aimed to apply the liquid antisolvent precipitation (LAP) method for preparing the apigenin nanoparticles and thereby improving the solubility and bioavailability of apigenin. The different experimental parameters on particle size were optimized through central composite design (CCD) using the Design-...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1399302
更新日期:2017-11-01 00:00:00
abstract::Hydrogels based on poly(ethylene glycol)-diacrylate (PEG-DA) and 2-hydroxyethyl methacrylate (HEMA) were polymerized with cross-linking agent ethylene glycol diacrylate (EGDMA) under mild photoinitiating conditions. PEG-DA and HEMA concentrations of disks with 1 +/- 0.3 mm thickness were 30% and 50% w/w and 40% and 60...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540701202911
更新日期:2007-10-01 00:00:00
abstract::Some cancers such as human breast cancer, prostate cancer, and lung cancer easily metastasize to bone, leading to osteolysis and bone destruction accompanied by a complicated microenvironment. Systemic administration of bisphosphonates (BP) or denosumab is the routine therapy for osteolysis but with non-negligible sid...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1856225
更新日期:2021-12-01 00:00:00
abstract::Systemic drug delivery systems (SDDSs) for thyroid cancer treatment are associated with serious side effects including nausea, anorexia, and hair loss as a result of damage to normal tissues. In this study, we investigated the feasibility of a local DDS (LDDS) based on visible light-cured glycol chitosan (GC) hydrogel...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1507058
更新日期:2018-11-01 00:00:00
abstract::The effects of pressure-sensitive adhesives and vehicles on the in vitro permeation of ketorolac and in vivo pharmacokinetics were studied. Duro-Tak 87-2196 showed the highest in vitro permeation profiles, and propylene glycol monolaurate-diethylene glycol monoethyl ether (DGME) (60:40, v/v) and propylene glycol monoc...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540600640336
更新日期:2007-02-01 00:00:00
abstract::A conjugate consisting of streptavidin (biotinylated transferrin)-biotinylated polylysine for DNA delivery to cells was modified by partial nicotinylation of the polylysine component of the conjugate and used for transfection studies. A conjugate of biotin10-nicotinyl60-polylysine250 containing 60 weakly basic nicotin...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/107175400455164
更新日期:2000-10-01 00:00:00
abstract::Various ocular diseases like glaucoma, conjunctivitis, and dry eye syndrome require frequent drug administration. Poor ocular bioavailability of drugs (< 1%) from conventional eye drops is due mainly to the precorneal loss factors that include rapid tear turnover, nonproductive absorption, transient residence time in ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540701606426
更新日期:2007-11-01 00:00:00
abstract::In order to enhance the interaction between nanocarrier and gastrointestinal epithelial cells, we developed nanoparticles (NPs) modified with targeting ligand FQSIYPpIK (FQS), which specifically interact with integrin αvβ3 receptor expressing on the intestinal epithelium. The targeting NPs were prepared by coating the...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1058433
更新日期:2016-07-01 00:00:00
abstract::Amphiphilic diblock copolymers composed of methoxy poly ethylene glycol (MePEG) and poly epsilon caprolactone (PCL) were synthesized for the formation of micelles by ring opening mechanism using stannous octoate as a catalyst. The effects of the molecular weight of MePEG and the copolymer ratio on the properties of mi...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717541003720688
更新日期:2010-07-01 00:00:00
abstract::Bioadhesive sodium alginate microspheres of Metoprolol tartrate (MT) for intranasal systemic delivery were prepared to avoid the first-pass effect, as an alternative therapy to injection, and to obtain improved therapeutic efficacy in the treatment of hypertension and angina pectoris. The microspheres (Ms) were prepar...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/713840323
更新日期:2003-01-01 00:00:00
abstract::The aim of this study was to obtain a stable, amorphous solid dispersion (SD) with Soluplus, prepared by hot-melt extrusion (HME) as an effective and stable oral delivery system to improve the physical stability and bioavailability of the poorly water-soluble simvastatin (SIM), a drug with relatively low Tg. The drug ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.960982
更新日期:2016-07-01 00:00:00
abstract::The aim of this work was to encapsulate superoxide dismutase (SOD) into biodegradable microparticles by spray-drying technique. The nature of the organic solvent to dissolve the polymer, the method of incorporation of the drug in the organic phase (with or without a surfactant, namely sucrose ester of HLB = 6), the su...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540490280363
更新日期:2004-05-01 00:00:00
abstract::Subcutaneous liraglutide-loaded multivesicular liposomes (Lrg-MVLs) were developed as a sustained drug-delivery system for treating diabetes and their properties were characterized. The Lrg-MVLs prepared using a two-step water-in-oil-in-water double emulsification process had a spherical appearance with a mean diamete...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2016.1180723
更新日期:2016-11-01 00:00:00
abstract::Efficient and stable delivery system of antisense oligonucleotide (ASO) is important and urgently needed. Here, an ASO delivery system, Lp-PPRP, which contains a cationic polymer based on PEI (branched, 25 kDa), named PEI-PC and a palmitic acid modified R8 (R8-PA) was prepared to deliver a kind of ASO, LOR-2501. The c...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2019.1667453
更新日期:2019-12-01 00:00:00
abstract::Ocular drug delivery remains challenging because of the complex nature and structure of the eye. Conventional systems, such as eye drops and ointments, are inefficient, whereas systemic administration requires high doses resulting in significant toxicity. There is a need to develop novel drug delivery carriers capable...
journal_title:Drug delivery
pub_type: 杂志文章,评审
doi:10.3109/10717544.2010.483257
更新日期:2010-09-01 00:00:00
abstract::The study was aimed at evaluating the effectiveness of liposomal, micellar, and water-soluble drug forms of diminazene for its localization in cells and selective accumulation at the sites of aggregation of pathogenic organisms. Pharmacological and dynamic properties of a new injection micellar diminazene preparation ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500459084
更新日期:2006-09-01 00:00:00
abstract::Camptothecin (CPT) is an effective anticancer agent against various cancers but the clinical application is limited because of its poor water solubility, low bioavailability and severe toxic side effects. The aim of the present study was to evaluate the feasibility of using targeted NPs as a high-performance CPT deliv...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.950767
更新日期:2016-06-01 00:00:00
abstract::Nonviral gene delivery systems are a promising approach for gene therapy applications, despite their low in vivo gene transfer efficiency. One approach to enhance this efficiency is to incorporate targeting elements into cationic lipid/DNA complexes (lipoplexes). Ligand-containing lipoplexes have to retain their effic...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540490265405
更新日期:2004-11-01 00:00:00
abstract::The purpose of this study was to characterize and evaluate tectorigenin-loaded self-microemulsifying drug delivery system (TG-SMEDDS), a previously studied preparation, and further confirm the improvement of TG in solubility and bioavailability. The appearance of TG-SMEDDS was clear and transparent, with good mobility...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1284946
更新日期:2017-11-01 00:00:00
abstract::The prevalence of childhood dyslipidemia increases and is considered as an important risk factor for the incidence of cardiovascular disease in the adulthood. To improve dosing accuracy and facilitate the determination of dosing regimens in function of the body weight, the proposed study aims at preparing transdermal ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.980896
更新日期:2016-06-01 00:00:00
abstract::This work evaluates solid lipid nanoparticles of thiopental sodium against obesity-induced cardiac dysfunction and hypertrophy and explores the possible mechanism of action. TS loaded SLNs were formulated by hot-homogenization and solvent diffusion method. TS-SLNs were scrutinized for entrapment efficiency, drug loadi...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1803449
更新日期:2020-12-01 00:00:00
abstract::Over the years, research has focused on strategies to increase benefit/risk ratio of corticoids. However, vehicles intended for topical glucocorticoids delivery with an improved benefit/risk ratio are still on demand. The aim of this work was the in vitro and in vivo characterization of cold processed oil-in-water (o/...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.871086
更新日期:2015-01-01 00:00:00
abstract::A micelle system modified with α-Conotoxin ImI (ImI), a potently antagonist for alpha7 nicotinic acetylcholine receptor (α7-nAChR) previously utilized for targeting breast cancer, was constructed. Its targeting efficiency and cytotoxicity against non-small cell lung cancer (NSCLC) highly expressing α7-nAChR was invest...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1436097
更新日期:2018-11-01 00:00:00
abstract::IDEC-CE9.1/SB-210396 is a macaque/human chimeric IgG1 monoclonal antibody (mAb) directed against the human T-cell surface marker, CD4. This antibody has been evaluated as a potential treatment for rheumatoid arthritis and asthma, in which T cell activation is believed to play an important role in orchestrating inflamm...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717549809031384
更新日期:1998-01-01 00:00:00