Abstract:
:The development of mucoadhesive lipidic nanoemulsion based on hyaluronic acid, co-encapsulating two polyphenols (resveratrol and curcumin) for the transnasal treatment of neurodegenerative diseases was attempted in the current manuscript. Nanoemulsions were prepared by the spontaneous emulsification method, and were characterized for their particle size, zeta potential, mucoadhesive strength and morphology. The selected formula was tested for its antioxidant potential, in vitro and ex vivo release of the two polyphenols, safety on nasal mucosa and in vivo quantification of the two drugs in rat brains. Its stability was tested by monitoring the change in particle size, zeta potential, drugs' content and antioxidant potential upon storage for 3 months. The optimized hyaluronic acid based nanoemulsion formula displayed a particle size of 115.2 ± 0.15 and a zeta potential of -23.9 ± 1.7. The formula displayed a spherical morphology and significantly higher mucoadhesive strength compared to its non mucoadhesive counterpart. In addition, the nanoemulsion was able to preserve the antioxidant ability of the two polyphenols and protect them from degradation. Diffusion controlled release of the two drugs was achievable till 6 hours, with an ex vivo flux across sheep nasal mucosa of 2.86 and 2.09 µg/cm(2)hr for resveratrol and curcumin, respectively. Moreover, the mucoadhesive nanoemulsion was safe on nasal mucosa and managed to increase the amounts of the two polypehnols in the brain (about 7 and 9 folds increase in AUC0-7 h for resveratrol and curcumin, respectively). Hyaluronic acid based lipidic nanoemulsion proved itself as a successful carrier enhancing the solubility, stability and brain targetability of polyphenols.
journal_name
Drug Delivjournal_title
Drug deliveryauthors
Nasr Mdoi
10.3109/10717544.2015.1092619subject
Has Abstractpub_date
2016-05-01 00:00:00pages
1444-52issue
4eissn
1071-7544issn
1521-0464journal_volume
23pub_type
杂志文章相关文献
DRUG DELIVERY文献大全abstract::Polysaccharide nucleic acid fractions of bacillus Calmette-Guérin, termed BCG-PSN, have traditionally been used as immunomodulators in the treatment of dermatitis and allergic diseases. While the sales of injectable BCG-PSN have shown steady growth in recent years, no reports of using BCG-PSN powder or its immunothera...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1391892
更新日期:2017-11-01 00:00:00
abstract::The distinct hormone molecules and receptors, such as follicle-stimulating hormone receptor (FSHR) in ovarian cancer, provide opportunities for more precisely targeted therapy. We previously developed FSHR-mediated nanoparticles and found that FSH peptides on the surface of nanoparticles improved the delivery of short...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1440667
更新日期:2018-11-01 00:00:00
abstract::Various ocular diseases like glaucoma, conjunctivitis, and dry eye syndrome require frequent drug administration. Poor ocular bioavailability of drugs (< 1%) from conventional eye drops is due mainly to the precorneal loss factors that include rapid tear turnover, nonproductive absorption, transient residence time in ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540701606426
更新日期:2007-11-01 00:00:00
abstract::The combination of protein-coated graphene oxide (GO) and microencapsulation technology has moved a step forward in the challenge of improving long-term alginate encapsulated cell survival and sustainable therapeutic protein release, bringing closer its translation from bench to the clinic. Although this new approach ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1474966
更新日期:2018-11-01 00:00:00
abstract::A new strategy based on gastric retention is proposed for the treatment of Helicobacter pylori. (H. pylori). A synergism between a floating and a bioadhesive system has been explored. Floating microspheres containing the antiurease drug acetohydroxamic acid (AHA) were prepared by a novel quasi-emulsion solvent diffusi...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540260397837
更新日期:2002-10-01 00:00:00
abstract::Atorvastatin (AT) is a widely used lipid-regulating drug to reduce cholesterol and triglycerides. Its poor aqueous solubility and hepatic metabolism require development of drug delivery systems able to improve its solubility and bypass hepatic effect. For this purpose, atorvastatin nanostructured lipid carriers (AT-NL...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1337823
更新日期:2017-11-01 00:00:00
abstract::Surface modification of liposomes with polymer to optimize drug delivery was well developed recently. The objective of the present work was to evaluate the feasibility of chitosan-coated liposomes (CSLP) as vehicles for anti-sense oligodeoxynucleotides (ASON). CSLP was obtained by adding chitosan dropwise to liposomes...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2010.549526
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:Insulin is a hormone used in the treatment of diabetes mellitus. Multiple injections of insulin every day may causes pain, allergic reactions at injection site, which lead to low patient compliance. The aim of this work was to develop and evaluate an efficient solid lipid nanoparticle (SLN) carrier for oral d...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1039666
更新日期:2016-07-01 00:00:00
abstract::The aim of this study was to obtain a stable, amorphous solid dispersion (SD) with Soluplus, prepared by hot-melt extrusion (HME) as an effective and stable oral delivery system to improve the physical stability and bioavailability of the poorly water-soluble simvastatin (SIM), a drug with relatively low Tg. The drug ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.960982
更新日期:2016-07-01 00:00:00
abstract::Tuberculosis (TB) has gained attention over the past few decades by becoming one of the top ten leading causes of death worldwide. This infectious disease of the lungs is orally treated with a medicinal armamentarium. However, this route of administration passes through the body's first-pass metabolism which reduces t...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2019.1676841
更新日期:2019-12-01 00:00:00
abstract::Glycyrrhizin or glycyrrhizic acid (GA) - triterpene glycoside extracted from licorice root - has been intensively studied over the past decade and is considered to be a potential drug delivery system. Glycyrrhizin was found to enhance the therapeutic effect of various drugs; however the detailed mechanism of these eff...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.919544
更新日期:2016-01-01 00:00:00
abstract::Among the transcription factors critical for cell cycle regulation is the proto-oncogene c-myc. The expression of c-myc upon vascular injury and its inhibition by antisense oligodeoxynucleotides have demonstrated the importance of this protein in the control of proliferation for many cell types, including vascular smo...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717549609029444
更新日期:1996-01-01 00:00:00
abstract:CONTEXT:Paclitaxel (PTX) and carboplatin (CBP) are widely used for the combined chemotherapy of non-small cell lung cancer (NSCLC). However, the development of multidrug resistance of cancer cells, as well as systemic toxic side effects resulting from nonspecific localization of anticancer drugs to non-tumor areas are ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1035466
更新日期:2016-09-01 00:00:00
abstract::Small interfering RNA (siRNA) exhibits great potential as a novel therapeutic option due to its highly sequence-specific ability to silence genes. However, efficient and safe delivery carriers are required for developing novel therapeutic paradigms. Thus, the successful development of efficient delivery platforms for ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2019.1667452
更新日期:2020-12-01 00:00:00
abstract::Nasal colonization of Staphylococcus aureus (S.aureus) is known as a significant risk factor for nosocomial infections, and clearance of its nasal colonization greatly reduces the risk. In the present study the preparation and characterizations of the chitosan-o/w cream incorporated with lysostaphin (CCL) were describ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2010.509360
更新日期:2010-11-01 00:00:00
abstract::Ocular drug delivery remains challenging because of the complex nature and structure of the eye. Conventional systems, such as eye drops and ointments, are inefficient, whereas systemic administration requires high doses resulting in significant toxicity. There is a need to develop novel drug delivery carriers capable...
journal_title:Drug delivery
pub_type: 杂志文章,评审
doi:10.3109/10717544.2010.483257
更新日期:2010-09-01 00:00:00
abstract::Mucoadhesive drug delivery systems are those that provide intimate contact of the drug with the mucosa for an extended period of time. In our present work, mucoadhesive chitosan microspheres were prepared by emulsion solvent method. Formulations were characterized for various physicochemical attributes, shape, surface...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540490280750
更新日期:2004-03-01 00:00:00
abstract::Agomelatine (AGM) is an antidepressant drug with a low absolute bioavailability due to the hepatic first pass metabolism. AGM-loaded solid lipid nanoparticles were formulated in the form of an in situ gel to prolong the intranasal retention time and subsequently to increase the absorbed amount of AGM. The optimized in...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1357148
更新日期:2017-11-01 00:00:00
abstract:CONTEXT:Humic acid (HA), a natural organic matter is recently being investigated for pharmaceutical purposes. Andrographolide (AGP), a potent hepatoprotective, possesses low aqueous solubility which results in a low bioavailability after oral administration, inappropriate tissue localization and consequently poor thera...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.871602
更新日期:2015-01-01 00:00:00
abstract::Hydrogels based on poly(ethylene glycol)-diacrylate (PEG-DA) and 2-hydroxyethyl methacrylate (HEMA) were polymerized with cross-linking agent ethylene glycol diacrylate (EGDMA) under mild photoinitiating conditions. PEG-DA and HEMA concentrations of disks with 1 +/- 0.3 mm thickness were 30% and 50% w/w and 40% and 60...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540701202911
更新日期:2007-10-01 00:00:00
abstract:CONTEXT:Propolis has traditionally been used in curing infections and healing wounds and burns. OBJECTIVE:The aim of this study is to formulate pluronic lecithin organogel of propolis to improve its availability and antimicrobial activity. MATERIALS AND METHODS:Different organogels were prepared by using soybean leci...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.847032
更新日期:2014-02-01 00:00:00
abstract::Chitosan, a natural-based polymer obtained by alkaline deacetylation of chitin, is nontoxic, biocompatible, and biodegradable. These properties make chitosan a good candidate for conventional and novel drug delivery systems. This article reviews the approaches aimed to associate bioactive molecules to chitosan in the ...
journal_title:Drug delivery
pub_type: 杂志文章,评审
doi:10.1080/10717540590889781
更新日期:2005-01-01 00:00:00
abstract::Ketorolac tromethamine, a potent nonnarcotic analgesic agent and 800 times more potent than aspirin, is indicated for the short-term management of moderate to such severe painful states as post operative pain, acute musculoskeletal pain, and dental pain. It Given every 6 hr intramuscularly in patients for acute pain, ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500398092
更新日期:2008-08-01 00:00:00
abstract::Endostatin (ES) can effectively inhibit neovascularization in most solid tumors and has the potential to make oxygen delivery more efficient and increase the efficacy of radiotherapy (RT). With a short half-life, ES is mainly administered systemically, which leads to low intake in tumor tissue and often toxic systemic...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1869864
更新日期:2021-12-01 00:00:00
abstract::In this study, the blood clearance and organ distribution of intravenously administered liposomes (distearoyl phosphatidylcholine [DSPC] and cholesterol in a ratio of 3:1) was evaluated by utilizing 3H-cholesteryl ether as the lipid phase marker. Also, the ability of liposomes, as a drug delivery system, to alter the ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/713840396
更新日期:2003-07-01 00:00:00
abstract::To improve drug retention in carriers for amphiphilic asulacrine (ASL), a novel active loading method using micelle gradient was developed to fabricate the ASL-loaded multiseed liposomes (ASL-ML). The empty ML were prepared by hydrating a thin film with empty micelles. Then the micelles in liposomal compartment acting...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1440669
更新日期:2018-11-01 00:00:00
abstract::Nonviral gene delivery systems are a promising approach for gene therapy applications, despite their low in vivo gene transfer efficiency. One approach to enhance this efficiency is to incorporate targeting elements into cationic lipid/DNA complexes (lipoplexes). Ligand-containing lipoplexes have to retain their effic...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540490265405
更新日期:2004-11-01 00:00:00
abstract::Sustained release (SR) matrix tablets of dextromethorphan hydrobromide were prepared by wet granulation using hydroxypropyl methyl cellulose (HPMC-K-100 CR) as the hydrophilic rate controlling polymer. The effect of the concentration of the polymer and different fillers on the in vitro drug release rate was studied. T...
journal_title:Drug delivery
pub_type: 杂志文章,随机对照试验
doi:10.1080/10717540802035301
更新日期:2008-09-01 00:00:00
abstract::The objective of this study was to establish a drug transport study using human nasal epithelial (HNE) cell monolayers cultured by the air-liquid interface (ALI) method using serum-free medium (BEGM:DME/F12, 50:50). The cells were developed and characterized in comparison to those that have been previously cultured by...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500177009
更新日期:2005-09-01 00:00:00
abstract::Kollicoat SR 30D is a unique 30% aqueous dispersion of polyvinvyl acetate stabilized by polyvinyl-pyrrolidone intended for preparation of sustained release products. Detailed evaluation of this polymer dispersion as a sustained release coating for active pharmaceutical ingredients of two diverse classes of drugs was s...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500313398
更新日期:2006-03-01 00:00:00