Abstract:
:Biodegradable implantable matrices containing bovine serum albumin were prepared from oligoesters by melting, and subsequently tested on in vitro albumin release. The linear poly (DL-lactic acid) and the branched terpolymer of DL-lactic acid, glycolic acid, and mannitol were synthesized. Products were of similar molecular weight and possessed different thermal and swelling characteristics. Oligoesters were loaded with 4% albumin and plasticized by 30% triacetin. Other additives added into the matrices as albumin stabilizers were divalent stearates and magnesium oxide. The influences of oligomer molecules constitution, divalent ion stearates or magnesium oxide addition, and triacetin concentration on the albumin release were quantified. SDS-PAGE revealed protein hydrolysis during the dissolution tests.
journal_name
Drug Delivjournal_title
Drug deliveryauthors
Kladnícková I,Dittrich M,Klein T,Pokorová Ddoi
10.1080/10717540500313125keywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
25-30issue
1eissn
1071-7544issn
1521-0464pii
V6473632414243T0journal_volume
13pub_type
杂志文章相关文献
DRUG DELIVERY文献大全abstract:CONTEXT:Artemether and lumefantrine combination therapy is well-accepted for uncomplicated malaria treatment. However, the current available formulation has several pharmacokinetic mismatches such as drug degradation in gastrointestinal tract, erratic absorption, etc. Hence, need of the hour is the injectable formulati...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.905883
更新日期:2016-01-01 00:00:00
abstract::Bone metastasis is a devastating complication of cancer that requires an immediate attention. Although our understanding of the metastatic process has improved over the years, yet a number of questions still remain unanswered, and more research is required for complete understanding of the skeletal consequences of met...
journal_title:Drug delivery
pub_type: 杂志文章,评审
doi:10.3109/10717544.2014.913325
更新日期:2016-01-01 00:00:00
abstract::Fluoroquinolones are broad-spectrum antimicrobial agents that seem to reach their intracellular target site (DNA gyrase) in Escherichia coli by means of an uptake process through the outer and inner membranes. Delivery of quinolones with liposomes has many advantages than the free form of the drug. Liposomes may repre...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540600640146
更新日期:2007-01-01 00:00:00
abstract::Effective clinical utilization of non-steroidal anti-inflammatory drugs such as diclofenac sodium (DS) is significantly limited by their ulcerogenic potential and poor bioavailability after oral administration, thus necessitating the need for a better carrier to minimize these obvious limitations. The objective of thi...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.843608
更新日期:2014-05-01 00:00:00
abstract::Corneal neovascularization (CNV) is one of the major causes of severe disorders in ocular surface. Subconjunctival administration provides a localized and effective delivery of anti-angiogenic agents to inhibit neovascularization. In the present study, the ABA triblock copolymer of poly(D,L-lactic-co-glycolic acid)-bl...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2019.1609623
更新日期:2019-12-01 00:00:00
abstract::The conjugation of tunable peptides or materials with nanocarriers represents a promising approach for drug delivery to tumor cells. In this study, we report the development of a novel liposomal carrier system that exploits the cell surface binding synergism between photo-sensitive peptides (PSPs) and targeting ligand...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1008707
更新日期:2016-09-01 00:00:00
abstract::In order to enhance the interaction between nanocarrier and gastrointestinal epithelial cells, we developed nanoparticles (NPs) modified with targeting ligand FQSIYPpIK (FQS), which specifically interact with integrin αvβ3 receptor expressing on the intestinal epithelium. The targeting NPs were prepared by coating the...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1058433
更新日期:2016-07-01 00:00:00
abstract::Although meloxicam (MX) is relatively safer than other NSAIDs, adverse effects relating to the gastro-intestinal tract are still a problem when administrated MX at high doses and on the long-term treatment. Drug delivery via skin provides an attractive alternative to oral administration, but is limited by the first la...
journal_title:Drug delivery
pub_type: 杂志文章,评审
doi:10.3109/10717544.2016.1157839
更新日期:2016-10-01 00:00:00
abstract::Systemic drug delivery systems (SDDSs) for thyroid cancer treatment are associated with serious side effects including nausea, anorexia, and hair loss as a result of damage to normal tissues. In this study, we investigated the feasibility of a local DDS (LDDS) based on visible light-cured glycol chitosan (GC) hydrogel...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1507058
更新日期:2018-11-01 00:00:00
abstract::In the present study, pluronic lecithin based organogels (PLO gels) were formulated as topical carrier for controlled delivery of mefenamic acid. Ten organogel formulations were prepared by a method employing lecithin as lipophilic phase and pluronic F-127 as hydrophilic phase in varying concentrations to study variou...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2016.1212439
更新日期:2016-11-01 00:00:00
abstract::The aim of present study was to investigate a pH-responsive and mucoadhesive nanoparticle system for oral bioavailability enhancement of low-molecular weight heparin (LMWH). The thioglycolic acid (TGA) was first covalently attached to chitosan (CS) with 396.97 ± 54.54 μmol thiol groups per gram of polymer and then the...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.909908
更新日期:2016-01-01 00:00:00
abstract::Hypoxic microenvironment commonly occurred in the solid tumors considerably decreases the chemosensitivity of cancer cells. Salidroside (Sal), the main active ingredient of Rhodiola rosea, was shown to be able of regulating the tumor hypoxia micro-environment and enhancing the chemotherapeutic efficacy of drug-resista...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1754528
更新日期:2020-12-01 00:00:00
abstract::Lung cancer is still the most common cancer globally. Early screening remains the key to improve the prognosis of patients. There is currently a lack of specific and sensitive methods for early screening of lung cancer. In recent years, studies have found that microRNA plays an important role in the occurrence and dev...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1516003
更新日期:2018-11-01 00:00:00
abstract::The objective of this study was to investigate the effect of lipophilic (Compritol 888 ATO) and hydrophilic components (combination of HPMC and Avicel) on the release of carbamazepine from granules and corresponding tablet. Wet granulation followed by compression was employed for preparation of granules and tablets. T...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540802518157
更新日期:2009-01-01 00:00:00
abstract::Glycyrrhizin or glycyrrhizic acid (GA) - triterpene glycoside extracted from licorice root - has been intensively studied over the past decade and is considered to be a potential drug delivery system. Glycyrrhizin was found to enhance the therapeutic effect of various drugs; however the detailed mechanism of these eff...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.919544
更新日期:2016-01-01 00:00:00
abstract::The purpose of this study was to characterize and evaluate tectorigenin-loaded self-microemulsifying drug delivery system (TG-SMEDDS), a previously studied preparation, and further confirm the improvement of TG in solubility and bioavailability. The appearance of TG-SMEDDS was clear and transparent, with good mobility...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1284946
更新日期:2017-11-01 00:00:00
abstract::A new strategy based on gastric retention is proposed for the treatment of Helicobacter pylori. (H. pylori). A synergism between a floating and a bioadhesive system has been explored. Floating microspheres containing the antiurease drug acetohydroxamic acid (AHA) were prepared by a novel quasi-emulsion solvent diffusi...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540260397837
更新日期:2002-10-01 00:00:00
abstract::Bioadhesive sodium alginate microspheres of Metoprolol tartrate (MT) for intranasal systemic delivery were prepared to avoid the first-pass effect, as an alternative therapy to injection, and to obtain improved therapeutic efficacy in the treatment of hypertension and angina pectoris. The microspheres (Ms) were prepar...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/713840323
更新日期:2003-01-01 00:00:00
abstract:CONTEXT:Terbinafine hydrochloride is an antifungal drug for onychomycosis. Poor permeability of its external preparation leads to poor curative effect. Transfersomes, also known as flexible liposome, could improve transmission of drug for local external use. Terbinafine hydrochloride-loaded liposome is expected to beco...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.878856
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to formulate and evaluate the Ibuprofen niosomal formulation as a transdermal drug delivery system. MATERIALS AND METHODS:Niosomes were prepared by a modified ethanol injection method, using Span 60, Tween 60 and Tween 65 as well as cholesterol with various cholesterol:surfact...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.873837
更新日期:2015-12-01 00:00:00
abstract:CONTEXT:Propolis has traditionally been used in curing infections and healing wounds and burns. OBJECTIVE:The aim of this study is to formulate pluronic lecithin organogel of propolis to improve its availability and antimicrobial activity. MATERIALS AND METHODS:Different organogels were prepared by using soybean leci...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.847032
更新日期:2014-02-01 00:00:00
abstract:CONTEXT:Intraoral drug delivery as mucosal delivery pathway provides a huge platform in the pharmaceutical field. OBJECTIVE:Combining mucoadhesiveness and controlled release of thio-poly acrylic acid as advanced excipient for buccal drug delivery. MATERIALS AND METHODS:Mediated by carbodiimide, cysteine was covalentl...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1122673
更新日期:2016-07-01 00:00:00
abstract::To prolong the circulation time of drug, PEGylation has been widely used via the enhanced permeability and retention (EPR) effect, thereby providing new hope for better treatment. However, PEGylation also brings the "PEG dilemma", which is difficult for the cellular absorption of drugs and subsequent endosomal escape....
journal_title:Drug delivery
pub_type: 杂志文章,评审
doi:10.1080/10717544.2017.1388451
更新日期:2017-12-01 00:00:00
abstract::Efficient and stable delivery system of antisense oligonucleotide (ASO) is important and urgently needed. Here, an ASO delivery system, Lp-PPRP, which contains a cationic polymer based on PEI (branched, 25 kDa), named PEI-PC and a palmitic acid modified R8 (R8-PA) was prepared to deliver a kind of ASO, LOR-2501. The c...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2019.1667453
更新日期:2019-12-01 00:00:00
abstract::Silk was easily dyed in traditional textile industry because of its strong affinity to many colorants. Herein, the biocompatible silk fibroin was firstly extracted from Bombyx mori silkworm cocoons. And SF nanoparticles (SFNPs) were prepared for dyeing indocyanine green (ICG) and construct a therapeutic nano-platform ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1428244
更新日期:2018-11-01 00:00:00
abstract::To improve drug retention in carriers for amphiphilic asulacrine (ASL), a novel active loading method using micelle gradient was developed to fabricate the ASL-loaded multiseed liposomes (ASL-ML). The empty ML were prepared by hydrating a thin film with empty micelles. Then the micelles in liposomal compartment acting...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1440669
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Vorinostat (VRS), a histone deacetylases inhibitor, has significant cytotoxic potential in a large number of human cancer cell lines. OBJECTIVE:To clarify its promising anticancer potential and to improve its drawback related to physical properties and in vivo performance of VRS. METHODS:VRS was successful...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.991432
更新日期:2016-05-01 00:00:00
abstract::Piroxicam (PX), a main member of non-steroidal anti-inflammatory drugs (NSAIDs), is mainly used orally, which causes side effects of the gastrointestinal tract. It also has systemic effects when administered intramuscularly. Intra-articular (IA) delivery and encapsulation of PX in biodegradable poly-ε-caprolactone (PC...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1716881
更新日期:2020-12-01 00:00:00
abstract::Nonviral gene delivery systems are a promising approach for gene therapy applications, despite their low in vivo gene transfer efficiency. One approach to enhance this efficiency is to incorporate targeting elements into cationic lipid/DNA complexes (lipoplexes). Ligand-containing lipoplexes have to retain their effic...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540490265405
更新日期:2004-11-01 00:00:00
abstract::The effects of pressure-sensitive adhesives and vehicles on the in vitro permeation of ketorolac and in vivo pharmacokinetics were studied. Duro-Tak 87-2196 showed the highest in vitro permeation profiles, and propylene glycol monolaurate-diethylene glycol monoethyl ether (DGME) (60:40, v/v) and propylene glycol monoc...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540600640336
更新日期:2007-02-01 00:00:00