Enhanced oral bioavailability of insulin-loaded solid lipid nanoparticles: pharmacokinetic bioavailability of insulin-loaded solid lipid nanoparticles in diabetic rats.

abstract：:To develop statistically optimized brain targeted Tween 80 coated chitosan nanoparticulate formulation for oral delivery of doxycycline hydrochloride for the treatment of psychosis and to evaluate its protective effect on ketamine induced behavioral, biochemical, neurochemical and histological alterations in mice. 32 ...

journal_title：Drug delivery

authors： Yadav M,Parle M,Sharma N,Dhingra S,Raina N,Jindal DK

更新日期：2017-11-01 00:00:00

abstract：:The effects of various vehicles and adhesives on the percutaneous absorption of isosorbide dinitrate (ISDN) were evaluated. Lauroglycol FCC showed the highest flux among vehicles tested. The flux of ISDN from silicone and acrylic adhesive matrices was found to be higher than that from other types of adhesive matrices....

journal_title：Drug delivery

authors： Myoung Y,Choi HK

更新日期：2002-04-01 00:00:00

abstract：:To improve drug retention in carriers for amphiphilic asulacrine (ASL), a novel active loading method using micelle gradient was developed to fabricate the ASL-loaded multiseed liposomes (ASL-ML). The empty ML were prepared by hydrating a thin film with empty micelles. Then the micelles in liposomal compartment acting...

journal_title：Drug delivery

authors： Zhang W,Li C,Jin Y,Liu X,Wang Z,Shaw JP,Baguley BC,Wu Z,Liu J

更新日期：2018-11-01 00:00:00

abstract：:Subcutaneous liraglutide-loaded multivesicular liposomes (Lrg-MVLs) were developed as a sustained drug-delivery system for treating diabetes and their properties were characterized. The Lrg-MVLs prepared using a two-step water-in-oil-in-water double emulsification process had a spherical appearance with a mean diamete...

journal_title：Drug delivery

authors： Zhang L,Ding L,Tang C,Li Y,Yang L

更新日期：2016-11-01 00:00:00

abstract：:A mesoporous material based on aluminosilicate mixture was studied to investigate its ability to include drugs and then release them. Nonsteroidal anti-inflammatory agents such as diflunisal, naproxen, ibuprofen and its sodium salt have been used in this study. The preparation of the mesoporous material and its charac...

journal_title：Drug delivery

authors： Cavallaro G,Pierro P,Palumbo FS,Testa F,Pasqua L,Aiello R

更新日期：2004-01-01 00:00:00

abstract：:Polymer nano-sized hydrogels (nanogels) as drug delivery carriers have been investigated over the last few decades. Pullulan, a nontoxic and nonimmunogenic hydrophilic polysaccharide derived from fermentation of black yeast like Aureobasidium pullulans with great biocompatibility and biodegradability, is one of the mo...

journal_title：Drug delivery

authors： Zhang T,Yang R,Yang S,Guan J,Zhang D,Ma Y,Liu H

更新日期：2018-11-01 00:00:00

abstract：:Chitosan, a natural-based polymer obtained by alkaline deacetylation of chitin, is nontoxic, biocompatible, and biodegradable. These properties make chitosan a good candidate for conventional and novel drug delivery systems. This article reviews the approaches aimed to associate bioactive molecules to chitosan in the ...

journal_title：Drug delivery

authors： Prabaharan M,Mano JF

更新日期：2005-01-01 00:00:00

abstract：:Nasal colonization of Staphylococcus aureus (S.aureus) is known as a significant risk factor for nosocomial infections, and clearance of its nasal colonization greatly reduces the risk. In the present study the preparation and characterizations of the chitosan-o/w cream incorporated with lysostaphin (CCL) were describ...

journal_title：Drug delivery

authors： Cui F,Li G,Huang J,Zhang J,Lu M,Lu W,Huang Q

更新日期：2010-11-01 00:00:00

abstract：:Pantoprazole is a proton pump inhibitor prodrug used in the treatment of gastric ulcers and gastroesophageal disease. Pantoprazole must be absorbed in the gastrointestinal tract and because it is unstable under acidic conditions, enteric delivery systems are required. The purpose of this study was to prepare pantopraz...

journal_title：Drug delivery

authors： Comoglu T,Gonul N,Dogan A,Basci N

更新日期：2008-06-01 00:00:00

abstract：CONTEXT:Paclitaxel (PTX) and carboplatin (CBP) are widely used for the combined chemotherapy of non-small cell lung cancer (NSCLC). However, the development of multidrug resistance of cancer cells, as well as systemic toxic side effects resulting from nonspecific localization of anticancer drugs to non-tumor areas are ...

journal_title：Drug delivery

authors： Zhang W,Li C,Shen C,Liu Y,Zhao X,Liu Y,Zou D,Gao Z,Yue C

更新日期：2016-09-01 00:00:00

abstract：:Hypoxic microenvironment commonly occurred in the solid tumors considerably decreases the chemosensitivity of cancer cells. Salidroside (Sal), the main active ingredient of Rhodiola rosea, was shown to be able of regulating the tumor hypoxia micro-environment and enhancing the chemotherapeutic efficacy of drug-resista...

journal_title：Drug delivery

authors： Zhang Z,Yang W,Ma F,Ma Q,Zhang B,Zhang Y,Liu Y,Liu H,Hua Y

更新日期：2020-12-01 00:00:00

abstract：:A novel cationic liposome modified with soybean sterylglucoside (SG) and polyethylene glycol-distearoylphosphatidylethanolamine (PEG-DSPE) as a carrier of antisense oligodeoxynucleotide (ODN) for hepatitis B virus (HBV) therapy was constructed. Characteristics of the cationic liposomes modified with SG and PEG (SG/PEG...

journal_title：Drug delivery

authors： Shi J,Yan WW,Qi XR,Maitani Y,Nagai T

更新日期：2005-11-01 00:00:00

abstract：:Currently, traumatic brain injury (TBI) is the leading cause of death or disabilities in young individuals worldwide. The multi-complexity of its pathogenesis as well as impermeability of the blood-brain barrier (BBB) makes the drug choice and delivery very challenging. The brain-derived neurotrophic factor (BDNF) reg...

journal_title：Drug delivery

authors： Khalin I,Alyautdin R,Wong TW,Gnanou J,Kocherga G,Kreuter J

更新日期：2016-11-01 00:00:00

abstract：:IDEC-CE9.1/SB-210396 is a macaque/human chimeric IgG1 monoclonal antibody (mAb) directed against the human T-cell surface marker, CD4. This antibody has been evaluated as a potential treatment for rheumatoid arthritis and asthma, in which T cell activation is believed to play an important role in orchestrating inflamm...

journal_title：Drug delivery

authors： Davis CB,Bugelski PJ

更新日期：1998-01-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) were generated to the extracellular domain of transcobalamin receptor (TCblR) and used to identify the regions of the receptor protein involved in antibody binding. Based on the effect of transcobalamin bound cobalamin (TC-Cbl) on antibody binding, this study identified both blocking and b...

journal_title：Drug delivery

authors： Jiang W,Nakayama Y,Sequeira JM,Quadros EV

更新日期：2011-01-01 00:00:00

abstract：:Systemic chemotherapy with the anticancer agent cisplatin is approved for advanced non-melanoma skin cancer (NMSC), but topical treatment is limited by insufficient cutaneous penetration. We studied the impact of ablative fractional laser (AFL) exposure on topical cisplatin's pharmacokinetics and biodistribution in sk...

journal_title：Drug delivery

authors： Wenande E,Olesen UH,Boesen MR,Persson DP,Lerche CM,Stürup S,Gammelgaard B,Husted S,Anderson RR,Haedersdal M

更新日期：2018-11-01 00:00:00

abstract：:Systemic drug delivery systems (SDDSs) for thyroid cancer treatment are associated with serious side effects including nausea, anorexia, and hair loss as a result of damage to normal tissues. In this study, we investigated the feasibility of a local DDS (LDDS) based on visible light-cured glycol chitosan (GC) hydrogel...

journal_title：Drug delivery

authors： Yoo Y,Yoon SJ,Kim SY,Lee DW,Um S,Hyun H,Hong SO,Yang DH

更新日期：2018-11-01 00:00:00

abstract：:A micelle system modified with α-Conotoxin ImI (ImI), a potently antagonist for alpha7 nicotinic acetylcholine receptor (α7-nAChR) previously utilized for targeting breast cancer, was constructed. Its targeting efficiency and cytotoxicity against non-small cell lung cancer (NSCLC) highly expressing α7-nAChR was invest...

journal_title：Drug delivery

authors： Mei D,Zhao L,Chen B,Zhang X,Wang X,Yu Z,Ni X,Zhang Q

更新日期：2018-11-01 00:00:00

abstract：:In the present study, the stability of thymopentin (TP5) in bronchoalveolar lavage fluid (BALF) in presence of potential excipients in inhalation formulation was investigated. The content of TP5 was determined using HPLC method. Commonly used bulking agent, dispersibility enhancers and absorption enhancers in inhalati...

journal_title：Drug delivery

authors： Cai C,Wang L,Dong W,Tang X

更新日期：2014-09-01 00:00:00

abstract：:Pingyangmycin (PYM) has been applied clinically for many years to treat vascular malformations (VM) in China. The major limitation of PYM injections is quick diffusion from the injection site, which increases side effects, especially the possibility of pulmonary injury. In this paper, chitosan/glycerophosphate disodiu...

journal_title：Drug delivery

authors： Zhang L,Chen F,Zheng J,Wang H,Qin X,Pan W

更新日期：2018-11-01 00:00:00

abstract：:Fluoroquinolones are broad-spectrum antimicrobial agents that seem to reach their intracellular target site (DNA gyrase) in Escherichia coli by means of an uptake process through the outer and inner membranes. Delivery of quinolones with liposomes has many advantages than the free form of the drug. Liposomes may repre...

journal_title：Drug delivery

authors： Sezer AD,Akbuğa J,Baş AL

更新日期：2007-01-01 00:00:00

abstract：:Melatonin, a pineal gland hormone, exerts oncostatic activity in several types of human cancer, including prostate, the most common neoplasia and the third most frequent cause of male cancer death in the developed world. The growth of androgen-sensitive LNCaP prostate cancer cells in mice is inhibited by 3 mg/kg/week ...

journal_title：Drug delivery

authors： Terraneo L,Bianciardi P,Virgili E,Finati E,Samaja M,Paroni R

更新日期：2017-11-01 00:00:00

abstract：CONTEXT:Terbinafine hydrochloride is an antifungal drug for onychomycosis. Poor permeability of its external preparation leads to poor curative effect. Transfersomes, also known as flexible liposome, could improve transmission of drug for local external use. Terbinafine hydrochloride-loaded liposome is expected to beco...

journal_title：Drug delivery

authors： Yang Y,Ou R,Guan S,Ye X,Hu B,Zhang Y,Lu S,Zhou Y,Yuan Z,Zhang J,Li QG

更新日期：2015-12-01 00:00:00

abstract：:Piroxicam (PX), a main member of non-steroidal anti-inflammatory drugs (NSAIDs), is mainly used orally, which causes side effects of the gastrointestinal tract. It also has systemic effects when administered intramuscularly. Intra-articular (IA) delivery and encapsulation of PX in biodegradable poly-ε-caprolactone (PC...

journal_title：Drug delivery

authors： Rahmani Del Bakhshayesh A,Akbarzadeh A,Alihemmati A,Tayefi Nasrabadi H,Montaseri A,Davaran S,Abedelahi A

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:Intraoral drug delivery as mucosal delivery pathway provides a huge platform in the pharmaceutical field. OBJECTIVE:Combining mucoadhesiveness and controlled release of thio-poly acrylic acid as advanced excipient for buccal drug delivery. MATERIALS AND METHODS:Mediated by carbodiimide, cysteine was covalentl...

journal_title：Drug delivery

authors： Laffleur F,Leder N,Barthelmes J

更新日期：2016-07-01 00:00:00

abstract：CONTEXT:Bisphosphonates (BPs) are widely used for prevention and treatment of osteoporosis. BPs are known as gold standard for osteoporosis (OP) treatment due to their positive results in clinical studies. But some serious side effects are associated with BPs like gastrointestinal adverse effect i.e. esophagitis and ul...

journal_title：Drug delivery

authors： Fazil M,Baboota S,Sahni JK,Ameeduzzafar,Ali J

更新日期：2015-01-01 00:00:00

abstract：:Our objective was to evaluate the chemotherapeutic potential of oral poly lactide-co-glycolide (PLG, a synthetic polymer) nanoparticle encapsulated ethambutol in combination with PLG-nanoparticle encapsulated-(rifampicin + isoniazid + pyrazinamide) in a murine tuberculosis (TB) model. Our formulation was prepared by t...

journal_title：Drug delivery

authors： Pandey R,Sharma S,Khuller GK

更新日期：2006-07-01 00:00:00

abstract：:S-nitrosothiols are a class of NO-donors currently under investigation for the treatment of various diseases. In this study, we developed a novel NO-donor (S-nitrosoglutathione-alginate, SNA) by cross-linking alginate with S-nitrosothiols, which can deliver NO in a sustained manner. This compound can be further evalua...

journal_title：Drug delivery

authors： Shah SU,Socha M,Fries I,Gibaud S

更新日期：2016-10-01 00:00:00

abstract：:In vitro characteristics of the human erythrocytes loaded by enalaprilat have been evaluated. Erythrocytes obtained from a healthy volunteer were loaded by enalaprilat using the hypotonic preswelling method, and the loading parameters, drug-release kinetics, hematological indices, particle size distribution, scanning ...

journal_title：Drug delivery

authors： Hamidi M,Tajerzadeh H,Dehpour AR,Rouini MR,Ejtemaee-Mehr S

更新日期：2001-10-01 00:00:00

abstract：:Efficient and stable delivery system of antisense oligonucleotide (ASO) is important and urgently needed. Here, an ASO delivery system, Lp-PPRP, which contains a cationic polymer based on PEI (branched, 25 kDa), named PEI-PC and a palmitic acid modified R8 (R8-PA) was prepared to deliver a kind of ASO, LOR-2501. The c...

journal_title：Drug delivery

authors： Yang S,Wang D,Sun Y,Zheng B

更新日期：2019-12-01 00:00:00