Effects of vehicles and pressure sensitive adhesives on the penetration of isosorbide dinitrate across the hairless mouse skin.

Abstract:

:The effects of various vehicles and adhesives on the percutaneous absorption of isosorbide dinitrate (ISDN) were evaluated. Lauroglycol FCC showed the highest flux among vehicles tested. The flux of ISDN from silicone and acrylic adhesive matrices was found to be higher than that from other types of adhesive matrices. No statistically significant relationship between the flux from acrylic PSA and the flux from a solution formulation was observed. A highly cross-linked acrylic adhesive gave higher permeation rates than the other acrylic adhesives examined. N-decylmethyl sulfoxide showed the highest enhancing effect on the flux of ISDN from acrylic adhesive. The relationship between the HLB values of vehicles and the measured flux showed a decrease of flux at HLB values greater than 12.

journal_name

Drug Deliv

journal_title

Drug delivery

authors

Myoung Y,Choi HK

doi

10.1080/10426500290095430

keywords:

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

121-6

issue

2

eissn

1071-7544

issn

1521-0464

journal_volume

9

pub_type

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