Abstract:
:The effects of various vehicles and adhesives on the percutaneous absorption of isosorbide dinitrate (ISDN) were evaluated. Lauroglycol FCC showed the highest flux among vehicles tested. The flux of ISDN from silicone and acrylic adhesive matrices was found to be higher than that from other types of adhesive matrices. No statistically significant relationship between the flux from acrylic PSA and the flux from a solution formulation was observed. A highly cross-linked acrylic adhesive gave higher permeation rates than the other acrylic adhesives examined. N-decylmethyl sulfoxide showed the highest enhancing effect on the flux of ISDN from acrylic adhesive. The relationship between the HLB values of vehicles and the measured flux showed a decrease of flux at HLB values greater than 12.
journal_name
Drug Delivjournal_title
Drug deliveryauthors
Myoung Y,Choi HKdoi
10.1080/10426500290095430keywords:
subject
Has Abstractpub_date
2002-04-01 00:00:00pages
121-6issue
2eissn
1071-7544issn
1521-0464journal_volume
9pub_type
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