Strategies for meloxicam delivery to and across the skin: a review.

Abstract:

:Although meloxicam (MX) is relatively safer than other NSAIDs, adverse effects relating to the gastro-intestinal tract are still a problem when administrated MX at high doses and on the long-term treatment. Drug delivery via skin provides an attractive alternative to oral administration, but is limited by the first layer of the skin-stratum corneum. Studies have been focused on developing effective methods to break the barrier of stratum corneum for enhancing delivery of MX to and across the skin. Strategies including formulation optimizing, chemical modification and physical enhancements to transiently reduce stratum corneum barrier function have been introduced. This article reviews the current state of the techniques in the delivery of MX to and across the skin, and it also includes the profiles of pharmacokinetic and safety related with skin delivery of MX.

journal_name

Drug Deliv

journal_title

Drug delivery

authors

Chen J,Gao Y

doi

10.3109/10717544.2016.1157839

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

3146-3156

issue

8

eissn

1071-7544

issn

1521-0464

journal_volume

23

pub_type

杂志文章,评审
  • Study on the cellular internalization mechanisms and in vivo anti-bone metastasis prostate cancer efficiency of the peptide T7-modified polypeptide nanoparticles.

    abstract::Bone-metastasis prostate cancer (BMPCa)-targeting gene therapy is gaining increasing concern in recent years. The peptide T7-modified polypeptide nanoparticles for delivery DNA (CRD-PEG-T7/pPMEPA1) was prepared as our previous study. However, the feasibility of CRD-PEG-T7/pPMEPA1 for BMPCa treatment, the mechanisms un...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2019.1709923

    authors: Gu Y,Chen X,Zhang H,Wang H,Chen H,Huang S,Xu Y,Zhang Y,Wu X,Chen J

    更新日期:2020-12-01 00:00:00

  • Floating-bioadhesive microspheres containing acetohydroxamic acid for clearance of Helicobacter pylori.

    abstract::A new strategy based on gastric retention is proposed for the treatment of Helicobacter pylori. (H. pylori). A synergism between a floating and a bioadhesive system has been explored. Floating microspheres containing the antiurease drug acetohydroxamic acid (AHA) were prepared by a novel quasi-emulsion solvent diffusi...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717540260397837

    authors: Umamaheswari RB,Jain S,Tripathi PK,Agrawal GP,Jain NK

    更新日期:2002-10-01 00:00:00

  • Chitosan-based liposomal thermogels for the controlled delivery of pingyangmycin: design, optimization and in vitro and in vivo studies.

    abstract::Pingyangmycin (PYM) has been applied clinically for many years to treat vascular malformations (VM) in China. The major limitation of PYM injections is quick diffusion from the injection site, which increases side effects, especially the possibility of pulmonary injury. In this paper, chitosan/glycerophosphate disodiu...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2018.1444684

    authors: Zhang L,Chen F,Zheng J,Wang H,Qin X,Pan W

    更新日期:2018-11-01 00:00:00

  • Effects of phonophoresis with gold nanoparticles on oxidative stress parameters in a traumatic muscle injury model.

    abstract::The aim of this study was to evaluate the effects of therapeutic pulsed ultrasound with gold nanoparticles on oxidative stress parameters after traumatic muscle injury in Wistar rats. The animals were randomly divided into nine groups (n = 6 each): sham (uninjured muscle); muscle injury without treatment; muscle injur...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2014.923063

    authors: Silveira PC,Victor EG,Notoya Fde S,Scheffer Dda L,Silva Ld,Cantú RB,Martínez VH,de Pinho RA,Paula MM

    更新日期:2016-01-01 00:00:00

  • Synthesis, characterization and evaluation of tinidazole-loaded mPEG-PDLLA (10/90) in situ gel forming system for periodontitis treatment.

    abstract::Traditional in situ gel forming systems are potential applications for parenteral administration but always accompanied with burst release. To overcome this limitation, the tinidazole (TNZ)-loaded in situ gel forming system using a diblock copolymer, monomethoxy poly(ethylene glycol)-block-poly(d,l-lactide) (mPEG-PDLL...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2015.1061069

    authors: Tian Y,Shen Y,Jv M

    更新日期:2016-10-01 00:00:00

  • Preparation, characterization, and antitumor activities of folate-decorated docetaxel-loaded human serum albumin nanoparticles.

    abstract:CONTEXT:Docetaxel is now a major antitumor drug in clinical use for the treatment of a variety of tumors. The ethanol/Tween 80 solvent required in the formulation to increase the docetaxel solubility is at least partly responsible for the hypersensitivity reaction, decreased uptake by tumor tissue, and increased exposu...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2013.879964

    authors: Jiang S,Gong X,Zhao X,Zu Y

    更新日期:2015-02-01 00:00:00

  • Pharmacodynamics of diclofenac from novel Eudragit entrapped microspheres.

    abstract::Effective clinical utilization of non-steroidal anti-inflammatory drugs such as diclofenac sodium (DS) is significantly limited by their ulcerogenic potential and poor bioavailability after oral administration, thus necessitating the need for a better carrier to minimize these obvious limitations. The objective of thi...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2013.843608

    authors: Momoh MA,Kenechukwu FC,Adedokun MO,Odo CE,Attama AA

    更新日期:2014-05-01 00:00:00

  • Multiseed liposomal drug delivery system using micelle gradient as driving force to improve amphiphilic drug retention and its anti-tumor efficacy.

    abstract::To improve drug retention in carriers for amphiphilic asulacrine (ASL), a novel active loading method using micelle gradient was developed to fabricate the ASL-loaded multiseed liposomes (ASL-ML). The empty ML were prepared by hydrating a thin film with empty micelles. Then the micelles in liposomal compartment acting...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2018.1440669

    authors: Zhang W,Li C,Jin Y,Liu X,Wang Z,Shaw JP,Baguley BC,Wu Z,Liu J

    更新日期:2018-11-01 00:00:00

  • Bisphosphonates: therapeutics potential and recent advances in drug delivery.

    abstract:CONTEXT:Bisphosphonates (BPs) are widely used for prevention and treatment of osteoporosis. BPs are known as gold standard for osteoporosis (OP) treatment due to their positive results in clinical studies. But some serious side effects are associated with BPs like gastrointestinal adverse effect i.e. esophagitis and ul...

    journal_title:Drug delivery

    pub_type: 杂志文章,评审

    doi:10.3109/10717544.2013.870259

    authors: Fazil M,Baboota S,Sahni JK,Ameeduzzafar,Ali J

    更新日期:2015-01-01 00:00:00

  • In vivo behavior of hydrogel beads based on amidated pectins.

    abstract::Radio-labeled hydrogel beads, based on amidated pectin, have been produced by adding droplets of an amidated pectin solution to calcium chloride. Incorporation of model drugs into the beads and measurement of the dissolution rate showed that the properties of the beads were unaffected by the incorporation of the radio...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717549809065753

    authors: Munjeri O,Collett JH,Fell JT,Sharma HL,Smith AM

    更新日期:1998-01-01 00:00:00

  • Development of nanoparticles-in-microparticles system for improved local retention after intra-articular injection.

    abstract::To increase the intra-articular (IA) retention time of osteoarthritis drugs in the synovial cavity and slow down the burst release of microspheres (MPs), we prepared a novel drug delivery system named nanoparticles-in-microspheres (NiMs). The system was constructed by dispersing the brucine-loaded nanoparticle, which ...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2013.848495

    authors: Chen Z,Liu D,Wang J,Wu L,Li W,Chen J,Cai BC,Cheng H

    更新日期:2014-08-01 00:00:00

  • Transdermal administration of melatonin coupled to cryopass laser treatment as noninvasive therapy for prostate cancer.

    abstract::Melatonin, a pineal gland hormone, exerts oncostatic activity in several types of human cancer, including prostate, the most common neoplasia and the third most frequent cause of male cancer death in the developed world. The growth of androgen-sensitive LNCaP prostate cancer cells in mice is inhibited by 3 mg/kg/week ...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2017.1338793

    authors: Terraneo L,Bianciardi P,Virgili E,Finati E,Samaja M,Paroni R

    更新日期:2017-11-01 00:00:00

  • Combined treatment with ultrasound-targeted microbubble destruction technique and NM-aFGF-loaded PEG-nanoliposomes protects against diabetic cardiomyopathy-induced oxidative stress by activating the AKT/GSK-3β1/Nrf-2 pathway.

    abstract::The present study sought to investigate the effect of non-mitogenic acidic fibroblast growth factor (NM-aFGF) loaded PEGylated nanoliposomes (NM-aFGF-PEG-lips) combined with the ultrasound-targeted microbubble destruction (UTMD) technique on modulating diabetic cardiomyopathy (DCM)and the mechanism involved. Animal st...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2020.1785052

    authors: Zhang M,Zhu NW,Ma WC,Chen MJ,Zheng L

    更新日期:2020-12-01 00:00:00

  • Passive targeting and lung tolerability of enoxaparin microspheres for a sustained antithrombotic activity in rats.

    abstract::Pulmonary bed can retain microparticles (MP) larger than their capillaries' diameter, hence we offer a promising way for lung passive targeting following intravenous (IV) administration. In this study, enoxaparin (Enox)-albumin microspheres (Enox-Alb MS) were, optimally, developed as lung targeted sustained release MP...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2016.1245368

    authors: Ibrahim SS,Osman R,Mortada ND,Geneidy AS,Awad GA

    更新日期:2017-11-01 00:00:00

  • Bioadhesive polymer/lipid hybrid nanoparticles as oral delivery system of raloxifene with enhancive intestinal retention and bioavailability.

    abstract::Raloxifene (RLX) is a second-generation selective estrogen receptor modulator used to treat osteoporosis in postmenopausal women. RLX fails to be developed into injectable dosage forms due to poor solubility. Although oral formulations are clinically available, the lower bioavailability (<2%) embarrasses the pharmaceu...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2021.1872742

    authors: Du X,Gao N,Song X

    更新日期:2021-12-01 00:00:00

  • Orally delivered polycurcumin responsive to bacterial reduction for targeted therapy of inflammatory bowel disease.

    abstract::Inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis is a chronic autoimmune disease affecting nearly five million people worldwide. Among all drug delivery system, oral administration is the most preferable route for colon-specific targeting and the treatment of IBD. Herein, an amphiphilic ...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2016.1245367

    authors: Qiao H,Fang D,Chen J,Sun Y,Kang C,Di L,Li J,Chen Z,Chen J,Gao Y

    更新日期:2017-11-01 00:00:00

  • Effects of vehicles and pressure sensitive adhesives on the penetration of isosorbide dinitrate across the hairless mouse skin.

    abstract::The effects of various vehicles and adhesives on the percutaneous absorption of isosorbide dinitrate (ISDN) were evaluated. Lauroglycol FCC showed the highest flux among vehicles tested. The flux of ISDN from silicone and acrylic adhesive matrices was found to be higher than that from other types of adhesive matrices....

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10426500290095430

    authors: Myoung Y,Choi HK

    更新日期:2002-04-01 00:00:00

  • Synthesis of S-nitrosoglutathione-alginate for prolonged delivery of nitric oxide in intestines.

    abstract::S-nitrosothiols are a class of NO-donors currently under investigation for the treatment of various diseases. In this study, we developed a novel NO-donor (S-nitrosoglutathione-alginate, SNA) by cross-linking alginate with S-nitrosothiols, which can deliver NO in a sustained manner. This compound can be further evalua...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2015.1122676

    authors: Shah SU,Socha M,Fries I,Gibaud S

    更新日期:2016-10-01 00:00:00

  • Assessment of simvastatin niosomes for pediatric transdermal drug delivery.

    abstract::The prevalence of childhood dyslipidemia increases and is considered as an important risk factor for the incidence of cardiovascular disease in the adulthood. To improve dosing accuracy and facilitate the determination of dosing regimens in function of the body weight, the proposed study aims at preparing transdermal ...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2014.980896

    authors: Zidan AS,Hosny KM,Ahmed OA,Fahmy UA

    更新日期:2016-06-01 00:00:00

  • Formulation and in vivo assessment of terconazole-loaded polymeric mixed micelles enriched with Cremophor EL as dual functioning mediator for augmenting physical stability and skin delivery.

    abstract::The aim of the current study was to formulate terconazole (TCZ) loaded polymeric mixed micelles (PMMs) incorporating Cremophor EL as a stabilizer and a penetration enhancer. A 23 full factorial design was performed using Design-Expert® software for the optimization of the PMMs which were formulated using Pluronic P123...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2018.1436098

    authors: Abd-Elsalam WH,El-Zahaby SA,Al-Mahallawi AM

    更新日期:2018-11-01 00:00:00

  • A novel ligand conjugated nanoparticles for oral insulin delivery.

    abstract::In order to enhance the interaction between nanocarrier and gastrointestinal epithelial cells, we developed nanoparticles (NPs) modified with targeting ligand FQSIYPpIK (FQS), which specifically interact with integrin αvβ3 receptor expressing on the intestinal epithelium. The targeting NPs were prepared by coating the...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2015.1058433

    authors: Liu C,Shan W,Liu M,Zhu X,Xu J,Xu Y,Huang Y

    更新日期:2016-07-01 00:00:00

  • Atorvastatin-loaded nanostructured lipid carriers (NLCs): strategy to overcome oral delivery drawbacks.

    abstract::Atorvastatin (AT) is a widely used lipid-regulating drug to reduce cholesterol and triglycerides. Its poor aqueous solubility and hepatic metabolism require development of drug delivery systems able to improve its solubility and bypass hepatic effect. For this purpose, atorvastatin nanostructured lipid carriers (AT-NL...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2017.1337823

    authors: Elmowafy M,Ibrahim HM,Ahmed MA,Shalaby K,Salama A,Hefesha H

    更新日期:2017-11-01 00:00:00

  • Doxorubicin conjugated with a trastuzumab epitope and an MMP-2 sensitive peptide linker for the treatment of HER2-positive breast cancer.

    abstract::HER2-positive breast cancer correlates with more aggressive tumor growth, a poorer prognosis and reduced overall survival. Currently, trastuzumab (Herceptin), which is an anti-HER2 antibody, is one of the key drugs. There is evidence indicating that conjugation of trastuzumab with chemotherapy drugs, such as doxorubic...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2018.1435746

    authors: You Y,Xu Z,Chen Y

    更新日期:2018-11-01 00:00:00

  • Transdermal delivery of isoniazid and rifampin in guinea pigs by electro-phonophoresis.

    abstract::Electro-phonophoresis (EP) has been used as a drug delivery approach in clinical fields. The objective of the present study is to evaluate the skin permeability of isoniazid and rifampin in guinea pigs by EP to provide reference basis for clinical applications of such transdermal delivery system in the treatment of pa...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2016.1267275

    authors: Chen S,Han Y,Yu D,Huo F,Wang F,Li Y,Dong L,Liu Z,Huang H

    更新日期:2017-11-01 00:00:00

  • Propolis organogel as a novel topical delivery system for treating wounds.

    abstract:CONTEXT:Propolis has traditionally been used in curing infections and healing wounds and burns. OBJECTIVE:The aim of this study is to formulate pluronic lecithin organogel of propolis to improve its availability and antimicrobial activity. MATERIALS AND METHODS:Different organogels were prepared by using soybean leci...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2013.847032

    authors: Balata G,El Nahas HM,Radwan S

    更新日期:2014-02-01 00:00:00

  • Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin.

    abstract::Enrofloxacin, a third-generation fluoroquinolone, is a broad-spectrum antimicrobial drug against a lot of veterinary bacterial diseases. However, bactericidal activity of enrofloxacin is concentration-dependent and its poor aqueous solubility and bitter taste limit its development and application. Meanwhile, 2-hydroxy...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2020.1724210

    authors: Ding Y,Pang Y,Vara Prasad CVNS,Wang B

    更新日期:2020-12-01 00:00:00

  • Cellular effects of antisense c-myc oligodeoxynucleotides are delivery dependent.

    abstract::Among the transcription factors critical for cell cycle regulation is the proto-oncogene c-myc. The expression of c-myc upon vascular injury and its inhibition by antisense oligodeoxynucleotides have demonstrated the importance of this protein in the control of proliferation for many cell types, including vascular smo...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717549609029444

    authors: Koo EW,Edelman ER

    更新日期:1996-01-01 00:00:00

  • Transdermal delivery of vancomycin hydrochloride using combination of nano-ethosomes and iontophoresis: in vitro and in vivo study.

    abstract::This study aimed to evaluate transdermal delivery of vancomycin hydrochloride using the combination of ethosomes as an encapsulating vesicle and iontophoresis. Ethosomes were prepared and evaluated in terms of electrochemical stability. Cathodal iontophoresis of negatively charged ethosomes and anodal iontophoresis of...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2015.1013200

    authors: Mohammed MI,Makky AM,Teaima MH,Abdellatif MM,Hamzawy MA,Khalil MA

    更新日期:2016-06-01 00:00:00

  • Chitosan-based particles as controlled drug delivery systems.

    abstract::Chitosan, a natural-based polymer obtained by alkaline deacetylation of chitin, is nontoxic, biocompatible, and biodegradable. These properties make chitosan a good candidate for conventional and novel drug delivery systems. This article reviews the approaches aimed to associate bioactive molecules to chitosan in the ...

    journal_title:Drug delivery

    pub_type: 杂志文章,评审

    doi:10.1080/10717540590889781

    authors: Prabaharan M,Mano JF

    更新日期:2005-01-01 00:00:00

  • Development and characterization of mucoadhesive microspheres bearing salbutamol for nasal delivery.

    abstract::Mucoadhesive drug delivery systems are those that provide intimate contact of the drug with the mucosa for an extended period of time. In our present work, mucoadhesive chitosan microspheres were prepared by emulsion solvent method. Formulations were characterized for various physicochemical attributes, shape, surface...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717540490280750

    authors: Jain SK,Chourasia MK,Jain AK,Jain RK,Shrivastava AK

    更新日期:2004-03-01 00:00:00