Thiopental sodium loaded solid lipid nano-particles attenuates obesity-induced cardiac dysfunction and cardiac hypertrophy via inactivation of inflammatory pathway.

Abstract:

:This work evaluates solid lipid nanoparticles of thiopental sodium against obesity-induced cardiac dysfunction and hypertrophy and explores the possible mechanism of action. TS loaded SLNs were formulated by hot-homogenization and solvent diffusion method. TS-SLNs were scrutinized for entrapment efficiency, drug loading capacity, gastric stability, particle size, in vitro drug release. Mice were feed with the normal chow or high-fat diet for 08 weeks to induce obesity and primary cardiomyocytes. The therapeutic effects of thiopental sodium in the high fat diet (HFD) induced cardiac hypertrophy. Systolic blood pressure (SBP) was estimated at a regular time interval. At the end of the experimental study, systolic pressure left ventricular, LV end-diastolic pressure and rate of increase of LV pressure and antioxidant, apoptosis, cytokines and inflammatory scrutinized. HFD induced group mice exhibited a reduction in the body weight and enhancement of cardiac hypertrophy marker and dose-dependent treatment of thiopental sodium up-regulation the body weight and down-regulated the cardiac hypertrophy. Thiopental sodium significantly (p < .001) dose-dependently altered the antioxidant, biochemical, cardiac parameters and remodeling. Thiopental sodium significantly (p < .001) dose-dependently reduced the SBP. Thiopental sodium altered the apoptosis marker, pro-inflammatory cytokines, inflammatory parameters along with reduced the p38-MAPK level. The cardiac protective effect of thiopental sodium shed light on future therapeutic interventions in obesity and related cardiovascular complications via inflammatory pathway.

journal_name

Drug Deliv

journal_title

Drug delivery

authors

Zhu C,Li W,Wang X,Xue J,Zhao L,Song Y,Zhou T,Zhang M

doi

10.1080/10717544.2020.1803449

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

1188-1200

issue

1

eissn

1071-7544

issn

1521-0464

journal_volume

27

pub_type

杂志文章
  • Chitosan-N-acetyl cysteine conjugates: in vitro evaluation of permeation enhancing and P-glycoprotein inhibiting properties.

    abstract::This study evaluated three chitosan-N-acetyl cysteine (CAC) conjugates of increasing molecular mass as a valuable tool to improve the absorption of drugs by assessing its permeation enhancing effect regarding the active P-gp substrate rhodamine-123 in comparison to the trans- and paracellular marker FD 4 both in rat i...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717540802006708

    authors: Schmitz T,Hombach J,Bernkop-Schnürch A

    更新日期:2008-05-01 00:00:00

  • Etoposide-loaded biodegradable amphiphilic methoxy (poly ethylene glycol) and poly (epsilon caprolactone) copolymeric micelles as drug delivery vehicle for cancer therapy.

    abstract::Amphiphilic diblock copolymers composed of methoxy poly ethylene glycol (MePEG) and poly epsilon caprolactone (PCL) were synthesized for the formation of micelles by ring opening mechanism using stannous octoate as a catalyst. The effects of the molecular weight of MePEG and the copolymer ratio on the properties of mi...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717541003720688

    authors: Mohanty AK,Dilnawaz F,Mohanty C,Sahoo SK

    更新日期:2010-07-01 00:00:00

  • Optimizing novel penetration enhancing hybridized vesicles for augmenting the in-vivo effect of an anti-glaucoma drug.

    abstract::Usually the topical delivery of ocular drugs poses a great challenge. Accordingly, the work in this study comprised the use of different hybrids of generally regarded as safe (GRAS) oils and surfactants in order to develop and optimize novel acetazolamide (AZD) entrapped-vesicular systems aiming at improving its ocula...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2016.1233588

    authors: Naguib SS,Hathout RM,Mansour S

    更新日期:2017-11-01 00:00:00

  • Development of nanoparticles-in-microparticles system for improved local retention after intra-articular injection.

    abstract::To increase the intra-articular (IA) retention time of osteoarthritis drugs in the synovial cavity and slow down the burst release of microspheres (MPs), we prepared a novel drug delivery system named nanoparticles-in-microspheres (NiMs). The system was constructed by dispersing the brucine-loaded nanoparticle, which ...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2013.848495

    authors: Chen Z,Liu D,Wang J,Wu L,Li W,Chen J,Cai BC,Cheng H

    更新日期:2014-08-01 00:00:00

  • Sodium alginate microspheres of metoprolol tartrate for intranasal systemic delivery: development and evaluation.

    abstract::Bioadhesive sodium alginate microspheres of Metoprolol tartrate (MT) for intranasal systemic delivery were prepared to avoid the first-pass effect, as an alternative therapy to injection, and to obtain improved therapeutic efficacy in the treatment of hypertension and angina pectoris. The microspheres (Ms) were prepar...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/713840323

    authors: Rajinikanth PS,Sankar C,Mishra B

    更新日期:2003-01-01 00:00:00

  • Enhancing the chemotherapy effect of Apatinib on gastric cancer by co-treating with salidroside to reprogram the tumor hypoxia micro-environment and induce cell apoptosis.

    abstract::Hypoxic microenvironment commonly occurred in the solid tumors considerably decreases the chemosensitivity of cancer cells. Salidroside (Sal), the main active ingredient of Rhodiola rosea, was shown to be able of regulating the tumor hypoxia micro-environment and enhancing the chemotherapeutic efficacy of drug-resista...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2020.1754528

    authors: Zhang Z,Yang W,Ma F,Ma Q,Zhang B,Zhang Y,Liu Y,Liu H,Hua Y

    更新日期:2020-12-01 00:00:00

  • Controlled-release carbamazepine matrix granules and tablets comprising lipophilic and hydrophilic components.

    abstract::The objective of this study was to investigate the effect of lipophilic (Compritol 888 ATO) and hydrophilic components (combination of HPMC and Avicel) on the release of carbamazepine from granules and corresponding tablet. Wet granulation followed by compression was employed for preparation of granules and tablets. T...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717540802518157

    authors: Barakat NS,Elbagory IM,Almurshedi AS

    更新日期:2009-01-01 00:00:00

  • Pharmacokinetics and anti-hypertensive effect of metoprolol tartrate rectal delivery system.

    abstract::The main aim of this work was to develop rectal suppositories for better delivery of metoprolol tartrate (MT). The various bases used were fatty, water soluble and emulsion bases. The physical properties of the prepared suppositories were characterized such as weight variation, hardness, disintegration time, melting r...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2014.904021

    authors: Abou el Ela Ael S,Allam AA,Ibrahim EH

    更新日期:2016-01-01 00:00:00

  • Development and characterization of mucoadhesive microspheres bearing salbutamol for nasal delivery.

    abstract::Mucoadhesive drug delivery systems are those that provide intimate contact of the drug with the mucosa for an extended period of time. In our present work, mucoadhesive chitosan microspheres were prepared by emulsion solvent method. Formulations were characterized for various physicochemical attributes, shape, surface...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717540490280750

    authors: Jain SK,Chourasia MK,Jain AK,Jain RK,Shrivastava AK

    更新日期:2004-03-01 00:00:00

  • Enhanced oral bioavailability of insulin-loaded solid lipid nanoparticles: pharmacokinetic bioavailability of insulin-loaded solid lipid nanoparticles in diabetic rats.

    abstract:OBJECTIVE:Insulin is a hormone used in the treatment of diabetes mellitus. Multiple injections of insulin every day may causes pain, allergic reactions at injection site, which lead to low patient compliance. The aim of this work was to develop and evaluate an efficient solid lipid nanoparticle (SLN) carrier for oral d...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2015.1039666

    authors: Ansari MJ,Anwer MK,Jamil S,Al-Shdefat R,Ali BE,Ahmad MM,Ansari MN

    更新日期:2016-07-01 00:00:00

  • Enhanced skin permeation of 6-methoxy-2-naphthylacetic acid by salt formation.

    abstract::The aim of this work was to prepare salts of 6-methoxy-2-naphthylacetic acid (6-MNA) to improve its physicochemical properties for percutaneous application. 6-MNA, an active metabolite of non-steroidal anti-inflammatory drug nabumetone has long half life and has the tendency to penetrate well into synovial fluid. The ...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2014.894595

    authors: Pawar V,Kumar HY,Giridhar R,Yadav MR

    更新日期:2015-05-01 00:00:00

  • Agomelatine-based in situ gels for brain targeting via the nasal route: statistical optimization, in vitro, and in vivo evaluation.

    abstract::Agomelatine (AGM) is an antidepressant drug with a low absolute bioavailability due to the hepatic first pass metabolism. AGM-loaded solid lipid nanoparticles were formulated in the form of an in situ gel to prolong the intranasal retention time and subsequently to increase the absorbed amount of AGM. The optimized in...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2017.1357148

    authors: Fatouh AM,Elshafeey AH,Abdelbary A

    更新日期:2017-11-01 00:00:00

  • In vivo lymphatic targeting of methylene blue with microemulsion and multiple microemulsion.

    abstract::Three formulations including methylene blue solution (MB-S), MB water-in-oil microemulsion (MB-ME), and MB multiple microemulsion (MB-MME) were prepared with the aim to evaluate whether the three formulations can carry MB target to regional lymph nodes and show lymphatic tropism after subcutaneous administration. The ...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717540903075644

    authors: Wang S,Yang R,Yao H,Zhou G,Zhang Y,Yang B,Ng L,Yan M

    更新日期:2009-10-01 00:00:00

  • In vitro characterization of human intact erythrocytes loaded by enalaprilat.

    abstract::In vitro characteristics of the human erythrocytes loaded by enalaprilat have been evaluated. Erythrocytes obtained from a healthy volunteer were loaded by enalaprilat using the hypotonic preswelling method, and the loading parameters, drug-release kinetics, hematological indices, particle size distribution, scanning ...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/107175401317245903

    authors: Hamidi M,Tajerzadeh H,Dehpour AR,Rouini MR,Ejtemaee-Mehr S

    更新日期:2001-10-01 00:00:00

  • Formulation and evaluation of novel controlled release of topical pluronic lecithin organogel of mefenamic acid.

    abstract::In the present study, pluronic lecithin based organogels (PLO gels) were formulated as topical carrier for controlled delivery of mefenamic acid. Ten organogel formulations were prepared by a method employing lecithin as lipophilic phase and pluronic F-127 as hydrophilic phase in varying concentrations to study variou...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2016.1212439

    authors: Jhawat V,Gupta S,Saini V

    更新日期:2016-11-01 00:00:00

  • The challenges of oral drug delivery via nanocarriers.

    abstract::The oral application of pharmaceuticals is unarguably the most convenient method of application. Especially for protein- or peptide-based drugs, however, the effectiveness is significantly reduced due to enzymatic digestion in the stomach as well as a poor bioavailability in the small intestine. For these difficult fo...

    journal_title:Drug delivery

    pub_type: 杂志文章,评审

    doi:10.1080/10717544.2018.1501119

    authors: Reinholz J,Landfester K,Mailänder V

    更新日期:2018-11-01 00:00:00

  • Formulation and evaluation of dextromethorphan hydrobromide sustained release tablets.

    abstract::Sustained release (SR) matrix tablets of dextromethorphan hydrobromide were prepared by wet granulation using hydroxypropyl methyl cellulose (HPMC-K-100 CR) as the hydrophilic rate controlling polymer. The effect of the concentration of the polymer and different fillers on the in vitro drug release rate was studied. T...

    journal_title:Drug delivery

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/10717540802035301

    authors: Meyyanathan SN,Rajan S,Muralidaharan S,Siddaiah MK,Krishnaraj K,Suresh B

    更新日期:2008-09-01 00:00:00

  • Targeted nano-delivery strategies for facilitating thrombolysis treatment in ischemic stroke.

    abstract::Ischemic stroke is one of the major causes of severe disability and death worldwide. It is mainly caused by a sudden reduction in cerebral blood flow due to obstruction of the supplying vessel by thrombi and subsequent initiation of a complex cascade of pathophysiological changes, which ultimately lead to brain ischem...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2021.1879315

    authors: Ma H,Jiang Z,Xu J,Liu J,Guo ZN

    更新日期:2021-12-01 00:00:00

  • pH-responsive thiolated chitosan nanoparticles for oral low-molecular weight heparin delivery: in vitro and in vivo evaluation.

    abstract::The aim of present study was to investigate a pH-responsive and mucoadhesive nanoparticle system for oral bioavailability enhancement of low-molecular weight heparin (LMWH). The thioglycolic acid (TGA) was first covalently attached to chitosan (CS) with 396.97 ± 54.54 μmol thiol groups per gram of polymer and then the...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2014.909908

    authors: Fan B,Xing Y,Zheng Y,Sun C,Liang G

    更新日期:2016-01-01 00:00:00

  • The optimized drug delivery systems of treating cancer bone metastatic osteolysis with nanomaterials.

    abstract::Some cancers such as human breast cancer, prostate cancer, and lung cancer easily metastasize to bone, leading to osteolysis and bone destruction accompanied by a complicated microenvironment. Systemic administration of bisphosphonates (BP) or denosumab is the routine therapy for osteolysis but with non-negligible sid...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2020.1856225

    authors: Cheng X,Wei J,Ge Q,Xing D,Zhou X,Qian Y,Jiang G

    更新日期:2021-12-01 00:00:00

  • Formulation of Fe3O4/acrylate co-polymer nanocomposites as potential drug carriers.

    abstract::Magnetic nanocomposite particles were synthesized by encapsulating nanosized magnetite with an acrylate-based cationic co-polymer made of MMA, BA, and QMA and modifying with MeOPEGMA using the water replacement method. The composition of the co-polymer formulation was optimized based on zeta-potential measurements and...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717540801952597

    authors: Phanapavudhikul P,Shen S,Ng WK,Tan RB

    更新日期:2008-03-01 00:00:00

  • Development of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery.

    abstract::The development of mucoadhesive lipidic nanoemulsion based on hyaluronic acid, co-encapsulating two polyphenols (resveratrol and curcumin) for the transnasal treatment of neurodegenerative diseases was attempted in the current manuscript. Nanoemulsions were prepared by the spontaneous emulsification method, and were c...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2015.1092619

    authors: Nasr M

    更新日期:2016-05-01 00:00:00

  • Brain-derived neurotrophic factor delivered to the brain using poly (lactide-co-glycolide) nanoparticles improves neurological and cognitive outcome in mice with traumatic brain injury.

    abstract::Currently, traumatic brain injury (TBI) is the leading cause of death or disabilities in young individuals worldwide. The multi-complexity of its pathogenesis as well as impermeability of the blood-brain barrier (BBB) makes the drug choice and delivery very challenging. The brain-derived neurotrophic factor (BDNF) reg...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2016.1199609

    authors: Khalin I,Alyautdin R,Wong TW,Gnanou J,Kocherga G,Kreuter J

    更新日期:2016-11-01 00:00:00

  • Synthesis, characterization and evaluation of tinidazole-loaded mPEG-PDLLA (10/90) in situ gel forming system for periodontitis treatment.

    abstract::Traditional in situ gel forming systems are potential applications for parenteral administration but always accompanied with burst release. To overcome this limitation, the tinidazole (TNZ)-loaded in situ gel forming system using a diblock copolymer, monomethoxy poly(ethylene glycol)-block-poly(d,l-lactide) (mPEG-PDLL...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2015.1061069

    authors: Tian Y,Shen Y,Jv M

    更新日期:2016-10-01 00:00:00

  • Pulmonary delivery of influenza vaccine formulations in cotton rats: site of deposition plays a minor role in the protective efficacy against clinical isolate of H1N1pdm virus.

    abstract::Administration of influenza vaccines to the lungs could be an attractive alternative to conventional parenteral administration. In this study, we investigated the deposition site of pulmonary delivered liquid and powder influenza vaccine formulations and its relation to their immunogenicity and protective efficacy. In...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2018.1435748

    authors: Bhide Y,Tomar J,Dong W,de Vries-Idema J,Frijlink HW,Huckriede A,Hinrichs WLJ

    更新日期:2018-11-01 00:00:00

  • Microencapsulation of superoxide dismutase into biodegradable microparticles by spray-drying.

    abstract::The aim of this work was to encapsulate superoxide dismutase (SOD) into biodegradable microparticles by spray-drying technique. The nature of the organic solvent to dissolve the polymer, the method of incorporation of the drug in the organic phase (with or without a surfactant, namely sucrose ester of HLB = 6), the su...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717540490280363

    authors: Youan BB

    更新日期:2004-05-01 00:00:00

  • Preparation of camptothecin-loaded targeting nanoparticles and their antitumor effects on hepatocellular carcinoma cell line H22.

    abstract::Camptothecin (CPT) is an effective anticancer agent against various cancers but the clinical application is limited because of its poor water solubility, low bioavailability and severe toxic side effects. The aim of the present study was to evaluate the feasibility of using targeted NPs as a high-performance CPT deliv...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2014.950767

    authors: Yang A,Liu Z,Yan B,Zhou M,Xiong X

    更新日期:2016-06-01 00:00:00

  • Preparation and characterization of novel anti-inflammatory biological agents based on piroxicam-loaded poly-ε-caprolactone nano-particles for sustained NSAID delivery.

    abstract::Piroxicam (PX), a main member of non-steroidal anti-inflammatory drugs (NSAIDs), is mainly used orally, which causes side effects of the gastrointestinal tract. It also has systemic effects when administered intramuscularly. Intra-articular (IA) delivery and encapsulation of PX in biodegradable poly-ε-caprolactone (PC...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2020.1716881

    authors: Rahmani Del Bakhshayesh A,Akbarzadeh A,Alihemmati A,Tayefi Nasrabadi H,Montaseri A,Davaran S,Abedelahi A

    更新日期:2020-12-01 00:00:00

  • Β-Cyclodextrin-graft-poly(amidoamine) dendrons as the nitric oxide deliver system for the chronic rhinosinusitis therapy.

    abstract::Chronic rhinosinusitis (CRS) is a rather prevalent condition with a chronic inflammatory process, which is hard to cure. Herein, a new antibacterial drug, nitric oxide (NO), was used for the attempt on CRS therapy. To achieve this, a star copolymer (β-CD-PAMAM) consisting of the β-cyclodextrin (β-CD) core and seven PA...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2021.1876183

    authors: Liu T,Li G,Wu X,Chen S,Zhang S,Han H,Zhang H,Luo X,Cai X,Ma D

    更新日期:2021-12-01 00:00:00

  • Effects of vehicles and pressure sensitive adhesives on the penetration of isosorbide dinitrate across the hairless mouse skin.

    abstract::The effects of various vehicles and adhesives on the percutaneous absorption of isosorbide dinitrate (ISDN) were evaluated. Lauroglycol FCC showed the highest flux among vehicles tested. The flux of ISDN from silicone and acrylic adhesive matrices was found to be higher than that from other types of adhesive matrices....

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10426500290095430

    authors: Myoung Y,Choi HK

    更新日期:2002-04-01 00:00:00