Abstract:
:DNA vaccination is a promising approach for inducing both humoral and cellular immune responses. The mode of plasmid DNA delivery is critical to make progress in DNA vaccination. Using human papillomavirus type 16 E7 as a model antigen, this study evaluated the effect of peptide-polymer hybrid including PEI600-Tat conjugate as a novel gene delivery system on the potency of antigen-specific immunity in mice model. At ratio of 10:50 PEI-Tat/E7DNA (w/w), both humoral and cellular immune responses were significantly enhanced as compared with E7DNA construct and induced Th1 response. Therefore, this new delivery system could have promising applications in gene therapy.
journal_name
Drug Delivjournal_title
Drug deliveryauthors
Bolhassani A,Ghasemi N,Servis C,Taghikhani M,Rafati Sdoi
10.1080/10717540902757721subject
Has Abstractpub_date
2009-05-01 00:00:00pages
196-204issue
4eissn
1071-7544issn
1521-0464journal_volume
16pub_type
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