Abstract:
:Silk was easily dyed in traditional textile industry because of its strong affinity to many colorants. Herein, the biocompatible silk fibroin was firstly extracted from Bombyx mori silkworm cocoons. And SF nanoparticles (SFNPs) were prepared for dyeing indocyanine green (ICG) and construct a therapeutic nano-platform (ICG-SFNPs) for photo-thermal therapy of glioblastoma. ICG was easily encapsulated into SFNPs with a very high encapsulation efficiency reaching to 97.7 ± 1.1%. ICG-SFNPs exhibited a spherical morphology with a mean particle size of 209.4 ± 1.4 nm and a negative zeta potential of -31.9 mV, exhibiting a good stability in physiological medium. Moreover, ICG-SFNPs showed a slow release profile of ICG in vitro, and only 24.51 ± 2.27% of the encapsulated ICG was released even at 72 h. Meanwhile, ICG-SFNPs exhibited a more stable photo-thermal effect than free ICG after exposure to near-infrared irradiation. The temperature of ICG-SFNPs rapidly increased by 33.9 °C within 10 min and maintained for a longer time. ICG-SFNPs were also easily internalized with C6 tumor cells in vitro, and a strong red fluorescence of ICG was observed in cytoplasm for cellular imaging. In vivo imaging showed that ICG-SFNPs were effectively accumulated inside tumor site of C6 glioma-bearing Xenograft nude mice through vein injection. Moreover, the temperature of tumor site was rapidly rising up to kill tumor cells after local NIR irradiation. After treatment, its growth was completely suppressed with the relative tumor volume of 0.55 ± 033 while free ICG of 33.72 ± 1.90. Overall, ICG-SFNPs may be an effective therapeutic means for intraoperative phototherapy and imaging.
journal_name
Drug Delivjournal_title
Drug deliveryauthors
Xu HL,ZhuGe DL,Chen PP,Tong MQ,Lin MT,Jiang X,Zheng YW,Chen B,Li XK,Zhao YZdoi
10.1080/10717544.2018.1428244subject
Has Abstractpub_date
2018-11-01 00:00:00pages
364-375issue
1eissn
1071-7544issn
1521-0464journal_volume
25pub_type
杂志文章相关文献
DRUG DELIVERY文献大全abstract:CONTEXT:MicroRNAs (miRNAs) are important and powerful mediators in a variety of diseases including cardiovascular pathology. Thus, they emerged as interesting new drug targets. However, it is important to develop efficient transfer tools to successfully deliver miRNAs or antisense oligonucleotides (antagomirs) to the t...
journal_title:Drug delivery
pub_type: 杂志文章,评审
doi:10.3109/10717544.2012.738436
更新日期:2012-11-01 00:00:00
abstract::Pulmonary bed can retain microparticles (MP) larger than their capillaries' diameter, hence we offer a promising way for lung passive targeting following intravenous (IV) administration. In this study, enoxaparin (Enox)-albumin microspheres (Enox-Alb MS) were, optimally, developed as lung targeted sustained release MP...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2016.1245368
更新日期:2017-11-01 00:00:00
abstract::The prevalence of childhood dyslipidemia increases and is considered as an important risk factor for the incidence of cardiovascular disease in the adulthood. To improve dosing accuracy and facilitate the determination of dosing regimens in function of the body weight, the proposed study aims at preparing transdermal ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.980896
更新日期:2016-06-01 00:00:00
abstract::Jurkat, an immortalized cell line derived from human leukemic T lymphocytes, has been employed as an excellent surrogate model of human primary T-cells for the advancement of T-cell biology and their applications in medicine. However, presumably due to its T-cell origin, Jurkat cells are very difficult to transfect. T...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1770371
更新日期:2020-12-01 00:00:00
abstract::In order to enhance the interaction between nanocarrier and gastrointestinal epithelial cells, we developed nanoparticles (NPs) modified with targeting ligand FQSIYPpIK (FQS), which specifically interact with integrin αvβ3 receptor expressing on the intestinal epithelium. The targeting NPs were prepared by coating the...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1058433
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:A topical microemulsion (ME)-based hydrogel was developed to enhance permeation of an antifungal drug, sertaconazole (STZL) for effective eradication of cutaneous fungal infection. METHODS:Pseudo-ternary phase diagrams were used to determine the existence of MEs region. ME formulations were prepared with oleic...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.914601
更新日期:2016-01-01 00:00:00
abstract::The purpose of the present study is to develop a new method to prepare magnetite chitosan microspheres conjugated with methotrexate (MTX) for the controlled release of MTX as a magnetic targeting drug delivery system. MTX was first conjugated to the chitosan chain via a peptide bond and then a suspension cross-linking...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540902989555
更新日期:2009-07-01 00:00:00
abstract::Chronic rhinosinusitis (CRS) is a rather prevalent condition with a chronic inflammatory process, which is hard to cure. Herein, a new antibacterial drug, nitric oxide (NO), was used for the attempt on CRS therapy. To achieve this, a star copolymer (β-CD-PAMAM) consisting of the β-cyclodextrin (β-CD) core and seven PA...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2021.1876183
更新日期:2021-12-01 00:00:00
abstract::To prolong the circulation time of drug, PEGylation has been widely used via the enhanced permeability and retention (EPR) effect, thereby providing new hope for better treatment. However, PEGylation also brings the "PEG dilemma", which is difficult for the cellular absorption of drugs and subsequent endosomal escape....
journal_title:Drug delivery
pub_type: 杂志文章,评审
doi:10.1080/10717544.2017.1388451
更新日期:2017-12-01 00:00:00
abstract::Over the years, research has focused on strategies to increase benefit/risk ratio of corticoids. However, vehicles intended for topical glucocorticoids delivery with an improved benefit/risk ratio are still on demand. The aim of this work was the in vitro and in vivo characterization of cold processed oil-in-water (o/...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.871086
更新日期:2015-01-01 00:00:00
abstract::Transdermal delivery of non-steroidal anti-inflammatory drugs (NSAIDs) is an effective route of drug administration, as it directs the drug to the inflamed site with reduced incidence of systemic adverse effects such as gastric hemorrhage and ulcers. Tenoxicam (TNX) is a member of NSAIDs that are marketed only as oral...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1803448
更新日期:2020-12-01 00:00:00
abstract::Recently, genkwanin (GKA) has been shown to display in vitro antitumor activity against some cancer cells, but its poor solubility restricted the in vivo study and further investigation of its antitumor therapeutic efficacy. In this paper, genkwanin nanosuspensions (GKA-NSps) were successfully prepared using D-alpha t...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1384519
更新日期:2017-11-01 00:00:00
abstract::Aminoglycoside-induced hair cell (HC) loss is a major cause of hearing impairment, and the effective prevention of HC loss remains an unmet medical need. Epigenetic mechanisms have been reported to be involved in protecting cochlear cells against ototoxic drug injury, and in this study we developed new bioactive compo...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1461277
更新日期:2018-11-01 00:00:00
abstract::The ophthalmic drug delivery is a challenge in the clinical treatment of ocular diseases. The traditional drug administration usually shows apparent limitations, such as the low bioavailability from the reason of low penetration of the cornea and the short survival time of drug in the eyes. To overcome these shortcomi...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1474972
更新日期:2018-11-01 00:00:00
abstract::Reactive oxygen species (ROS)-induced neuronal mitochondrial dysfunction is a key pathologic factor in sporadic Alzheimer's disease (AD). Neuronal mitochondria have been proposed to be a promising therapeutic target for AD, especially for the failures of phase III clinical trials on conventional amyloid-β (Aβ) targete...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1745328
更新日期:2020-12-01 00:00:00
abstract::In the present study, pluronic lecithin based organogels (PLO gels) were formulated as topical carrier for controlled delivery of mefenamic acid. Ten organogel formulations were prepared by a method employing lecithin as lipophilic phase and pluronic F-127 as hydrophilic phase in varying concentrations to study variou...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2016.1212439
更新日期:2016-11-01 00:00:00
abstract::Electro-phonophoresis (EP) has been used as a drug delivery approach in clinical fields. The objective of the present study is to evaluate the skin permeability of isoniazid and rifampin in guinea pigs by EP to provide reference basis for clinical applications of such transdermal delivery system in the treatment of pa...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2016.1267275
更新日期:2017-11-01 00:00:00
abstract::Subcutaneous liraglutide-loaded multivesicular liposomes (Lrg-MVLs) were developed as a sustained drug-delivery system for treating diabetes and their properties were characterized. The Lrg-MVLs prepared using a two-step water-in-oil-in-water double emulsification process had a spherical appearance with a mean diamete...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2016.1180723
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Vorinostat (VRS), a histone deacetylases inhibitor, has significant cytotoxic potential in a large number of human cancer cell lines. OBJECTIVE:To clarify its promising anticancer potential and to improve its drawback related to physical properties and in vivo performance of VRS. METHODS:VRS was successful...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.991432
更新日期:2016-05-01 00:00:00
abstract::Systemic chemotherapy with the anticancer agent cisplatin is approved for advanced non-melanoma skin cancer (NMSC), but topical treatment is limited by insufficient cutaneous penetration. We studied the impact of ablative fractional laser (AFL) exposure on topical cisplatin's pharmacokinetics and biodistribution in sk...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1534896
更新日期:2018-11-01 00:00:00
abstract::Our objective was to evaluate the chemotherapeutic potential of oral poly lactide-co-glycolide (PLG, a synthetic polymer) nanoparticle encapsulated ethambutol in combination with PLG-nanoparticle encapsulated-(rifampicin + isoniazid + pyrazinamide) in a murine tuberculosis (TB) model. Our formulation was prepared by t...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500398076
更新日期:2006-07-01 00:00:00
abstract::Kollicoat SR 30D is a unique 30% aqueous dispersion of polyvinvyl acetate stabilized by polyvinyl-pyrrolidone intended for preparation of sustained release products. Detailed evaluation of this polymer dispersion as a sustained release coating for active pharmaceutical ingredients of two diverse classes of drugs was s...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500313398
更新日期:2006-03-01 00:00:00
abstract:CONTEXT:Docetaxel is now a major antitumor drug in clinical use for the treatment of a variety of tumors. The ethanol/Tween 80 solvent required in the formulation to increase the docetaxel solubility is at least partly responsible for the hypersensitivity reaction, decreased uptake by tumor tissue, and increased exposu...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.879964
更新日期:2015-02-01 00:00:00
abstract::The main aim of this work was to develop rectal suppositories for better delivery of metoprolol tartrate (MT). The various bases used were fatty, water soluble and emulsion bases. The physical properties of the prepared suppositories were characterized such as weight variation, hardness, disintegration time, melting r...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.904021
更新日期:2016-01-01 00:00:00
abstract::Enrofloxacin, a third-generation fluoroquinolone, is a broad-spectrum antimicrobial drug against a lot of veterinary bacterial diseases. However, bactericidal activity of enrofloxacin is concentration-dependent and its poor aqueous solubility and bitter taste limit its development and application. Meanwhile, 2-hydroxy...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1724210
更新日期:2020-12-01 00:00:00
abstract:CONTEXT:Paclitaxel (PTX) and carboplatin (CBP) are widely used for the combined chemotherapy of non-small cell lung cancer (NSCLC). However, the development of multidrug resistance of cancer cells, as well as systemic toxic side effects resulting from nonspecific localization of anticancer drugs to non-tumor areas are ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1035466
更新日期:2016-09-01 00:00:00
abstract::At present, the chemotherapy of advanced inoperable liver cancer is limited with serious side effects. Curcumin possesses multiple cancer preventive activities and low safety concerns. However, its poor solubility and instability in water pose significant pharmacological barriers to its clinical application. In this s...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1526227
更新日期:2018-11-01 00:00:00
abstract::The aim of the current study was to formulate terconazole (TCZ) loaded polymeric mixed micelles (PMMs) incorporating Cremophor EL as a stabilizer and a penetration enhancer. A 23 full factorial design was performed using Design-Expert® software for the optimization of the PMMs which were formulated using Pluronic P123...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1436098
更新日期:2018-11-01 00:00:00
abstract::Administration of influenza vaccines to the lungs could be an attractive alternative to conventional parenteral administration. In this study, we investigated the deposition site of pulmonary delivered liquid and powder influenza vaccine formulations and its relation to their immunogenicity and protective efficacy. In...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1435748
更新日期:2018-11-01 00:00:00
abstract::Ketorolac tromethamine, a potent nonnarcotic analgesic agent and 800 times more potent than aspirin, is indicated for the short-term management of moderate to such severe painful states as post operative pain, acute musculoskeletal pain, and dental pain. It Given every 6 hr intramuscularly in patients for acute pain, ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500398092
更新日期:2008-08-01 00:00:00