Disposition of 3H-cholesteryl ether labeled liposomes following intravenous administration to mice: comparison with an encapsulated 14C-inulin as aqueous phase marker.


:In this study, the blood clearance and organ distribution of intravenously administered liposomes (distearoyl phosphatidylcholine [DSPC] and cholesterol in a ratio of 3:1) was evaluated by utilizing 3H-cholesteryl ether as the lipid phase marker. Also, the ability of liposomes, as a drug delivery system, to alter the distribution and retention of encapsulated agents was investigated by comparing the distribution of intravenously administered free and liposome-encapsulated 14C-inulin within a 48-hr postadministration period. Intravenously administered DSPC liposomes were distributed in all organs examined with the highest levels of 3H-cholesteryl ether and 14C-inulin present in the liver and spleen; peak levels occurred 3 hr postadministration (71.86% +/- 9.39 versus 77.67% +/- 10.30, respectively, in the liver and 5.05% +/- 1.07 versus 5.36% +/- 1.09, respectively, in the spleen) declining gradually during the remaining experimental period. The lowest levels of 3H-cholesteryl ether and 14C-inulin following administration of liposome-encapsulated inulin were found in the lung, kidney, and heart. The area under curve showed much more accumulation of 14C-inulin (6-fold higher) in the body following administration of the liposome-encapsulated drug than the free drug. The ratio of 3H to 14C following administration of liposome-encapsulated inulin was constant throughout the entire observation period, suggesting that the disposition of inulin acquired both the carrier's rate of clearance and tissue distribution. These results indicated that following intravenous administration of liposome-encapsulated inulin, the majority of the radioactively labeled formulation was retained by the organs of the reticuloendothelial system (liver and spleen); liposomes greatly enhanced the retention of inulin in the body; and the liposomal formulation did not destabilize and subsequently did not release the encapsulated inulin to the tissues and organs.


Drug Deliv


Drug delivery


Anderson M,Paradis C,Omri A





Has Abstract


2003-07-01 00:00:00














  • Extension of nasal anti-Staphylococcus aureus efficacy of lysostaphin by its incorporation into a chitosan-o/w cream.

    abstract::Nasal colonization of Staphylococcus aureus (S.aureus) is known as a significant risk factor for nosocomial infections, and clearance of its nasal colonization greatly reduces the risk. In the present study the preparation and characterizations of the chitosan-o/w cream incorporated with lysostaphin (CCL) were describ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Cui F,Li G,Huang J,Zhang J,Lu M,Lu W,Huang Q

    更新日期:2010-11-01 00:00:00

  • A nanoparticulate drug-delivery system for glaucocalyxin A: formulation, characterization, increased in vitro, and vivo antitumor activity.

    abstract::Glaucocalyxin A (GLA) is a phytochemical component with multiple pharmacological activities; however, glaucocalyxin A's wider use has been restricted by its poor solubility. In this study, GLA nanosuspensions were prepared with precipitation-combined ultrasonication and were characterized by dynamic light scattering (...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Han M,Li Z,Guo Y,Zhang J,Wang X

    更新日期:2016-09-01 00:00:00

  • Delivery of antisense oligonucleotide using polyethylenimine-based lipid nanoparticle modified with cell penetrating peptide.

    abstract::Efficient and stable delivery system of antisense oligonucleotide (ASO) is important and urgently needed. Here, an ASO delivery system, Lp-PPRP, which contains a cationic polymer based on PEI (branched, 25 kDa), named PEI-PC and a palmitic acid modified R8 (R8-PA) was prepared to deliver a kind of ASO, LOR-2501. The c...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Yang S,Wang D,Sun Y,Zheng B

    更新日期:2019-12-01 00:00:00

  • Transdermal administration of melatonin coupled to cryopass laser treatment as noninvasive therapy for prostate cancer.

    abstract::Melatonin, a pineal gland hormone, exerts oncostatic activity in several types of human cancer, including prostate, the most common neoplasia and the third most frequent cause of male cancer death in the developed world. The growth of androgen-sensitive LNCaP prostate cancer cells in mice is inhibited by 3 mg/kg/week ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Terraneo L,Bianciardi P,Virgili E,Finati E,Samaja M,Paroni R

    更新日期:2017-11-01 00:00:00

  • Alpha-lipoic acid-loaded nanostructured lipid carrier: sustained release and biocompatibility to HaCaT cells in vitro.

    abstract::ALA-loaded nanostructured lipid carrier (ALA-NLC) was designed to improve physicochemical stability and water solubility, and promote sustained release of ALA as well as determine the biocompatibility of ALA-NLC. The ALA-NLC manufactured using hot high-pressure homogenization technique was investigated in terms of siz...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Wang J,Xia Q

    更新日期:2014-08-01 00:00:00

  • Evaluation of polyvinyl acetate dispersion as a sustained release polymer for tablets.

    abstract::Kollicoat SR 30D is a unique 30% aqueous dispersion of polyvinvyl acetate stabilized by polyvinyl-pyrrolidone intended for preparation of sustained release products. Detailed evaluation of this polymer dispersion as a sustained release coating for active pharmaceutical ingredients of two diverse classes of drugs was s...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Bordaweka MS,Zia H,Quadir A

    更新日期:2006-03-01 00:00:00

  • In vitro/in vivo evaluation of an optimized fast dissolving oral film containing olanzapine co-amorphous dispersion with selected carboxylic acids.

    abstract::Improvement of water solubility, dissolution rate, oral bioavailability, and reduction of first pass metabolism of OL (OL), were the aims of this research. Co-amorphization of OL carboxylic acid dispersions at various molar ratios was carried out using rapid solvent evaporation. Characterization of the dispersions was...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Maher EM,Ali AM,Salem HF,Abdelrahman AA

    更新日期:2016-10-01 00:00:00

  • Sodium alginate microspheres of metoprolol tartrate for intranasal systemic delivery: development and evaluation.

    abstract::Bioadhesive sodium alginate microspheres of Metoprolol tartrate (MT) for intranasal systemic delivery were prepared to avoid the first-pass effect, as an alternative therapy to injection, and to obtain improved therapeutic efficacy in the treatment of hypertension and angina pectoris. The microspheres (Ms) were prepar...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Rajinikanth PS,Sankar C,Mishra B

    更新日期:2003-01-01 00:00:00

  • PLA/PEG-PPG-PEG/dexamethasone implant prepared by hot-melt extrusion for controlled release of immunosuppressive drug to implantable medical devices, Part 2: in vivo evaluation.

    abstract::Hot-melt extrusion (HME) plays an important role in preparing implants as local drug delivery systems in pharmaceutical fields. Here, a new PLA/PEG-PPG-PEG/Dexamethasone (PLA/F68/Dex) implant prepared by HME has been developed. Importantly, the implant was successfully achieved to control release of immunosuppressive ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Li D,Guo G,Deng X,Fan R,Guo Q,Fan M,Liang J,Luo F,Qian Z

    更新日期:2013-04-01 00:00:00

  • In vivo behavior of hydrogel beads based on amidated pectins.

    abstract::Radio-labeled hydrogel beads, based on amidated pectin, have been produced by adding droplets of an amidated pectin solution to calcium chloride. Incorporation of model drugs into the beads and measurement of the dissolution rate showed that the properties of the beads were unaffected by the incorporation of the radio...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Munjeri O,Collett JH,Fell JT,Sharma HL,Smith AM

    更新日期:1998-01-01 00:00:00

  • Carboplatin-Loaded PLGA Microspheres for Intracerebral Implantation: In Vivo Characterization.

    abstract::Carboplatin is a potent anticancer agent that has shown efficacy in clinical trials against malignant glioma, one of the most deadly cancers in humans. However, a high systemic dose is required to achieve an effective concentration in the brain because of the presence of the blood-brain barrier (BBB). Such a high dose...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Chen W,He J,Olson JJ,Lu DR

    更新日期:1997-01-01 00:00:00

  • Orally delivered polycurcumin responsive to bacterial reduction for targeted therapy of inflammatory bowel disease.

    abstract::Inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis is a chronic autoimmune disease affecting nearly five million people worldwide. Among all drug delivery system, oral administration is the most preferable route for colon-specific targeting and the treatment of IBD. Herein, an amphiphilic ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Qiao H,Fang D,Chen J,Sun Y,Kang C,Di L,Li J,Chen Z,Chen J,Gao Y

    更新日期:2017-11-01 00:00:00

  • In vivo lymphatic targeting of methylene blue with microemulsion and multiple microemulsion.

    abstract::Three formulations including methylene blue solution (MB-S), MB water-in-oil microemulsion (MB-ME), and MB multiple microemulsion (MB-MME) were prepared with the aim to evaluate whether the three formulations can carry MB target to regional lymph nodes and show lymphatic tropism after subcutaneous administration. The ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Wang S,Yang R,Yao H,Zhou G,Zhang Y,Yang B,Ng L,Yan M

    更新日期:2009-10-01 00:00:00

  • Novel poly-DL-lactide-polycaprolactone copolymer based flexible drug delivery system for sustained release of ciprofloxacin.

    abstract::This research evaluated 7525DLPCL for soft flexible drug delivery systems. The effect of ciprofloxacin hydrochloride (CIP) loading at three levels (10, 20, and 30%), on thermo-mechanical properties was studied. CIP release was monitored for 12 weeks. Addition of CIP to 7525DLPCL caused an increase in compressive modul...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Waknis V,Jonnalagadda S

    更新日期:2011-05-01 00:00:00

  • Preparation of camptothecin-loaded targeting nanoparticles and their antitumor effects on hepatocellular carcinoma cell line H22.

    abstract::Camptothecin (CPT) is an effective anticancer agent against various cancers but the clinical application is limited because of its poor water solubility, low bioavailability and severe toxic side effects. The aim of the present study was to evaluate the feasibility of using targeted NPs as a high-performance CPT deliv...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Yang A,Liu Z,Yan B,Zhou M,Xiong X

    更新日期:2016-06-01 00:00:00

  • Recent advances in non-ionic surfactant vesicles (niosomes): self-assembly, fabrication, characterization, drug delivery applications and limitations.

    abstract::Non-ionic surfactant vesicles, simply known as niosomes are synthetic vesicles with potential technological applications. Niosomes have the same potential advantages of phospholipid vesicles (liposomes) of being able to accommodate both water soluble and lipid soluble drug molecules control their release and as such s...

    journal_title:Drug delivery

    pub_type: 杂志文章,评审


    authors: Abdelkader H,Alani AW,Alany RG

    更新日期:2014-03-01 00:00:00

  • Brain targeted oral delivery of doxycycline hydrochloride encapsulated Tween 80 coated chitosan nanoparticles against ketamine induced psychosis: behavioral, biochemical, neurochemical and histological alterations in mice.

    abstract::To develop statistically optimized brain targeted Tween 80 coated chitosan nanoparticulate formulation for oral delivery of doxycycline hydrochloride for the treatment of psychosis and to evaluate its protective effect on ketamine induced behavioral, biochemical, neurochemical and histological alterations in mice. 32 ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Yadav M,Parle M,Sharma N,Dhingra S,Raina N,Jindal DK

    更新日期:2017-11-01 00:00:00

  • Preparation, characterization, and antitumor activities of folate-decorated docetaxel-loaded human serum albumin nanoparticles.

    abstract:CONTEXT:Docetaxel is now a major antitumor drug in clinical use for the treatment of a variety of tumors. The ethanol/Tween 80 solvent required in the formulation to increase the docetaxel solubility is at least partly responsible for the hypersensitivity reaction, decreased uptake by tumor tissue, and increased exposu...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Jiang S,Gong X,Zhao X,Zu Y

    更新日期:2015-02-01 00:00:00

  • Brain-derived neurotrophic factor delivered to the brain using poly (lactide-co-glycolide) nanoparticles improves neurological and cognitive outcome in mice with traumatic brain injury.

    abstract::Currently, traumatic brain injury (TBI) is the leading cause of death or disabilities in young individuals worldwide. The multi-complexity of its pathogenesis as well as impermeability of the blood-brain barrier (BBB) makes the drug choice and delivery very challenging. The brain-derived neurotrophic factor (BDNF) reg...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Khalin I,Alyautdin R,Wong TW,Gnanou J,Kocherga G,Kreuter J

    更新日期:2016-11-01 00:00:00

  • Development and characterization of mucoadhesive microspheres bearing salbutamol for nasal delivery.

    abstract::Mucoadhesive drug delivery systems are those that provide intimate contact of the drug with the mucosa for an extended period of time. In our present work, mucoadhesive chitosan microspheres were prepared by emulsion solvent method. Formulations were characterized for various physicochemical attributes, shape, surface...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Jain SK,Chourasia MK,Jain AK,Jain RK,Shrivastava AK

    更新日期:2004-03-01 00:00:00

  • A photo-responsive peptide- and asparagine-glycine-arginine (NGR) peptide-mediated liposomal delivery system.

    abstract::The conjugation of tunable peptides or materials with nanocarriers represents a promising approach for drug delivery to tumor cells. In this study, we report the development of a novel liposomal carrier system that exploits the cell surface binding synergism between photo-sensitive peptides (PSPs) and targeting ligand...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Xie X,Yang Y,Yang Y,Zhang H,Li Y,Mei X

    更新日期:2016-09-01 00:00:00

  • Enhanced hepatoprotective activity of andrographolide complexed with a biomaterial.

    abstract:CONTEXT:Humic acid (HA), a natural organic matter is recently being investigated for pharmaceutical purposes. Andrographolide (AGP), a potent hepatoprotective, possesses low aqueous solubility which results in a low bioavailability after oral administration, inappropriate tissue localization and consequently poor thera...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Thingale AD,Shaikh KS,Channekar PR,Galgatte UC,Chaudhari PD,Bothiraja C

    更新日期:2015-01-01 00:00:00

  • Effects of bile salts on the lovastatin pharmacokinetics following oral administration to rats.

    abstract::This study aimed to examine the effects of bile salts on pharmacokinetics of lovastatin, which has low bioavailability. Lovastatin solid dispersions were prepared using sodium deoxycholate (NaDC) and sodium glycholate (NaGC) at ratios of 1:19, 1:49, and 1:69. The formulated solid dispersions and control (commercial ta...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Kim K,Yoon I,Chun I,Lee N,Kim T,Gwak HS

    更新日期:2011-01-01 00:00:00

  • Preparation of hydroxy genkwanin nanosuspensions and their enhanced antitumor efficacy against breast cancer.

    abstract::Hydroxy genkwanin (HGK), a flavonoid compound from natural resources, showed good inhibition against the growth of breast tumor cells. However, the poor solubility restricted the further study and the in vivo drug delivery of HGK. We prepared HGK nanosuspensions by antisolvent precipitation method and investigated the...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Ao H,Li Y,Li H,Wang Y,Han M,Guo Y,Shi R,Yue F,Wang X

    更新日期:2020-12-01 00:00:00

  • Poly(HEMA-Zidovudine) conjugate: a macromolecular pro-drug for improvement in the biopharmaceutical properties of the drug.

    abstract::A macromolecular pro-drug of a known anti-viral agent Zidovudine (AZT) was synthesized and evaluated as a sustained drug delivery system. The pro-drug was synthesized by coupling the drug to 2-hydroxyethyl methacrylate (HEMA) through a succinic spacer to get a monomeric drug conjugate which was polymerized to obtain t...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Neeraj A,Chandrasekar MJ,Sara UV,Rohini A

    更新日期:2011-05-01 00:00:00

  • Cellular effects of antisense c-myc oligodeoxynucleotides are delivery dependent.

    abstract::Among the transcription factors critical for cell cycle regulation is the proto-oncogene c-myc. The expression of c-myc upon vascular injury and its inhibition by antisense oligodeoxynucleotides have demonstrated the importance of this protein in the control of proliferation for many cell types, including vascular smo...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Koo EW,Edelman ER

    更新日期:1996-01-01 00:00:00

  • Development, characterization, and evaluation of ketorolac tromethamine-loaded biodegradable microspheres as a depot system for parenteral delivery.

    abstract::Ketorolac tromethamine, a potent nonnarcotic analgesic agent and 800 times more potent than aspirin, is indicated for the short-term management of moderate to such severe painful states as post operative pain, acute musculoskeletal pain, and dental pain. It Given every 6 hr intramuscularly in patients for acute pain, ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Sinha VR,Trehan A

    更新日期:2008-08-01 00:00:00

  • Identification and imaging of miR-155 in the early screening of lung cancer by targeted delivery of octreotide-conjugated chitosan-molecular beacon nanoparticles.

    abstract::Lung cancer is still the most common cancer globally. Early screening remains the key to improve the prognosis of patients. There is currently a lack of specific and sensitive methods for early screening of lung cancer. In recent years, studies have found that microRNA plays an important role in the occurrence and dev...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Zhu HZ,Hou J,Guo Y,Liu X,Jiang FL,Chen GP,Pang XF,Sun JG,Chen ZT

    更新日期:2018-11-01 00:00:00

  • Sustained ocular drug delivery from a temperature and pH triggered novel in situ gel system.

    abstract::Various ocular diseases like glaucoma, conjunctivitis, and dry eye syndrome require frequent drug administration. Poor ocular bioavailability of drugs (< 1%) from conventional eye drops is due mainly to the precorneal loss factors that include rapid tear turnover, nonproductive absorption, transient residence time in ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Gupta H,Jain S,Mathur R,Mishra P,Mishra AK,Velpandian T

    更新日期:2007-11-01 00:00:00

  • Study on the cellular internalization mechanisms and in vivo anti-bone metastasis prostate cancer efficiency of the peptide T7-modified polypeptide nanoparticles.

    abstract::Bone-metastasis prostate cancer (BMPCa)-targeting gene therapy is gaining increasing concern in recent years. The peptide T7-modified polypeptide nanoparticles for delivery DNA (CRD-PEG-T7/pPMEPA1) was prepared as our previous study. However, the feasibility of CRD-PEG-T7/pPMEPA1 for BMPCa treatment, the mechanisms un...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Gu Y,Chen X,Zhang H,Wang H,Chen H,Huang S,Xu Y,Zhang Y,Wu X,Chen J

    更新日期:2020-12-01 00:00:00