α-Conotoxin ImI-modified polymeric micelles as potential nanocarriers for targeted docetaxel delivery to α7-nAChR overexpressed non-small cell lung cancer.

abstract：:The effects of various vehicles and adhesives on the percutaneous absorption of isosorbide dinitrate (ISDN) were evaluated. Lauroglycol FCC showed the highest flux among vehicles tested. The flux of ISDN from silicone and acrylic adhesive matrices was found to be higher than that from other types of adhesive matrices....

journal_title：Drug delivery

authors： Myoung Y,Choi HK

更新日期：2002-04-01 00:00:00

abstract：:Among the transcription factors critical for cell cycle regulation is the proto-oncogene c-myc. The expression of c-myc upon vascular injury and its inhibition by antisense oligodeoxynucleotides have demonstrated the importance of this protein in the control of proliferation for many cell types, including vascular smo...

journal_title：Drug delivery

authors： Koo EW,Edelman ER

更新日期：1996-01-01 00:00:00

abstract：:The purpose of this work is to use biorelevant media to evaluate the robustness of a poorly water soluble weakly basic drug to variations along the gastrointestinal tract (GIT) after incorporation in liquisolid compacts and to assess the success of these models in predicting the in vivo performance. Liquisolid tablets...

journal_title：Drug delivery

authors： Badawy MA,Kamel AO,Sammour OA

更新日期：2016-01-01 00:00:00

abstract：:In the present study, the stability of thymopentin (TP5) in bronchoalveolar lavage fluid (BALF) in presence of potential excipients in inhalation formulation was investigated. The content of TP5 was determined using HPLC method. Commonly used bulking agent, dispersibility enhancers and absorption enhancers in inhalati...

journal_title：Drug delivery

authors： Cai C,Wang L,Dong W,Tang X

更新日期：2014-09-01 00:00:00

abstract：:Systemic chemotherapy with the anticancer agent cisplatin is approved for advanced non-melanoma skin cancer (NMSC), but topical treatment is limited by insufficient cutaneous penetration. We studied the impact of ablative fractional laser (AFL) exposure on topical cisplatin's pharmacokinetics and biodistribution in sk...

journal_title：Drug delivery

authors： Wenande E,Olesen UH,Boesen MR,Persson DP,Lerche CM,Stürup S,Gammelgaard B,Husted S,Anderson RR,Haedersdal M

更新日期：2018-11-01 00:00:00

abstract：:This article describes the development of solid lipid nanoparticles (SLN) as colloidal carriers for cloricromene. Nanoparticles were prepared by the microemulsion or precipitation technique. In vitro drug release profile from SLN was studied under various experimental conditions mimicking some body fluids. The drug re...

journal_title：Drug delivery

authors： Bondì ML,Fontana G,Carlisi B,Giammona G

更新日期：2003-10-01 00:00:00

abstract：:Three formulations including methylene blue solution (MB-S), MB water-in-oil microemulsion (MB-ME), and MB multiple microemulsion (MB-MME) were prepared with the aim to evaluate whether the three formulations can carry MB target to regional lymph nodes and show lymphatic tropism after subcutaneous administration. The ...

journal_title：Drug delivery

authors： Wang S,Yang R,Yao H,Zhou G,Zhang Y,Yang B,Ng L,Yan M

更新日期：2009-10-01 00:00:00

abstract：:In vitro drug release rates from aqueous and oil solutions as well as preformed and in situ formed aqueous and oil suspensions intended for intra-articular delivery have been investigated using the rotating dialysis cell model. Using lidocaine as a model drug substance the release kinetics from aqueous and oil suspens...

journal_title：Drug delivery

authors： Pedersen BT,Larsen SW,Østergaard J,Larsen C

更新日期：2008-01-01 00:00:00

abstract：:The aim of present study was to investigate a pH-responsive and mucoadhesive nanoparticle system for oral bioavailability enhancement of low-molecular weight heparin (LMWH). The thioglycolic acid (TGA) was first covalently attached to chitosan (CS) with 396.97 ± 54.54 μmol thiol groups per gram of polymer and then the...

journal_title：Drug delivery

authors： Fan B,Xing Y,Zheng Y,Sun C,Liang G

更新日期：2016-01-01 00:00:00

abstract：:Mucoadhesive drug delivery systems are those that provide intimate contact of the drug with the mucosa for an extended period of time. In our present work, mucoadhesive chitosan microspheres were prepared by emulsion solvent method. Formulations were characterized for various physicochemical attributes, shape, surface...

journal_title：Drug delivery

authors： Jain SK,Chourasia MK,Jain AK,Jain RK,Shrivastava AK

更新日期：2004-03-01 00:00:00

abstract：:Non-ionic surfactant vesicles, simply known as niosomes are synthetic vesicles with potential technological applications. Niosomes have the same potential advantages of phospholipid vesicles (liposomes) of being able to accommodate both water soluble and lipid soluble drug molecules control their release and as such s...

journal_title：Drug delivery

authors： Abdelkader H,Alani AW,Alany RG

更新日期：2014-03-01 00:00:00

abstract：:Some cancers such as human breast cancer, prostate cancer, and lung cancer easily metastasize to bone, leading to osteolysis and bone destruction accompanied by a complicated microenvironment. Systemic administration of bisphosphonates (BP) or denosumab is the routine therapy for osteolysis but with non-negligible sid...

journal_title：Drug delivery

authors： Cheng X,Wei J,Ge Q,Xing D,Zhou X,Qian Y,Jiang G

更新日期：2021-12-01 00:00:00

abstract：:Endostatin (ES) can effectively inhibit neovascularization in most solid tumors and has the potential to make oxygen delivery more efficient and increase the efficacy of radiotherapy (RT). With a short half-life, ES is mainly administered systemically, which leads to low intake in tumor tissue and often toxic systemic...

journal_title：Drug delivery

authors： Wang N,Gao Q,Tang J,Jiang Y,Yang L,Shi X,Chen Y,Zhang Y,Fu S,Lin S

更新日期：2021-12-01 00:00:00

abstract：:The aim of this study was to obtain a stable, amorphous solid dispersion (SD) with Soluplus, prepared by hot-melt extrusion (HME) as an effective and stable oral delivery system to improve the physical stability and bioavailability of the poorly water-soluble simvastatin (SIM), a drug with relatively low Tg. The drug ...

journal_title：Drug delivery

authors： Zhang Y,Liu Y,Luo Y,Yao Q,Zhong Y,Tian B,Tang X

更新日期：2016-07-01 00:00:00

abstract：CONTEXT:Paclitaxel (PTX) and doxorubicin (DOX) are widely used for the combined chemotherapy of solid tumors. However, free drug combination has lower antitumor efficiency. It is necessary to design a drug delivery system to carry both of them. OBJECTIVE:This study aimed to engineer a nano-drug delivery system for co-...

journal_title：Drug delivery

authors： Wang Y,Zhang H,Hao J,Li B,Li M,Xiuwen W

更新日期：2016-05-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) were generated to the extracellular domain of transcobalamin receptor (TCblR) and used to identify the regions of the receptor protein involved in antibody binding. Based on the effect of transcobalamin bound cobalamin (TC-Cbl) on antibody binding, this study identified both blocking and b...

journal_title：Drug delivery

authors： Jiang W,Nakayama Y,Sequeira JM,Quadros EV

更新日期：2011-01-01 00:00:00

abstract：CONTEXT:Designing a sustained release system for Carvedilol to increase its residence time in the stomach. OBJECTIVE:Preparation of floating microsphere by the emulsion solvent diffusion method, studying the effect of various process parameters and optimize the formulation using full factorial design. METHODS:Differe...

journal_title：Drug delivery

authors： Nila MV,Sudhir MR,Cinu TA,Aleykutty NA,Jose S

更新日期：2014-03-01 00:00:00

abstract：:Electro-phonophoresis (EP) has been used as a drug delivery approach in clinical fields. The objective of the present study is to evaluate the skin permeability of isoniazid and rifampin in guinea pigs by EP to provide reference basis for clinical applications of such transdermal delivery system in the treatment of pa...

journal_title：Drug delivery

authors： Chen S,Han Y,Yu D,Huo F,Wang F,Li Y,Dong L,Liu Z,Huang H

更新日期：2017-11-01 00:00:00

abstract：:Although convection-enhanced delivery (CED) can successfully facilitate a bypass of the blood brain barrier, its treatment efficacy remains highly limited in clinic. This can be partially attributed to the brain anisotropic characteristics that lead to the difficulties in controlling the drug spatial distribution. Her...

journal_title：Drug delivery

authors： Zhan W,Rodriguez Y Baena F,Dini D

更新日期：2019-12-01 00:00:00

abstract：:At present, the chemotherapy of advanced inoperable liver cancer is limited with serious side effects. Curcumin possesses multiple cancer preventive activities and low safety concerns. However, its poor solubility and instability in water pose significant pharmacological barriers to its clinical application. In this s...

journal_title：Drug delivery

authors： Chang M,Wu M,Li H

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:In the present study, Curcumin (CU)-loaded nanocarrier (NC) such as nanoemulsion (NE) was developed with the objective of increasing its cytotoxicity and bioavailability through lymphatic transport by enhancing its solubility and intestinal permeability. MATERIALS AND METHODS:Based on the area obtained in ps...

journal_title：Drug delivery

authors： Kumar A,Ahuja A,Ali J,Baboota S

更新日期：2016-01-01 00:00:00

abstract：CONTEXT:Propolis has traditionally been used in curing infections and healing wounds and burns. OBJECTIVE:The aim of this study is to formulate pluronic lecithin organogel of propolis to improve its availability and antimicrobial activity. MATERIALS AND METHODS:Different organogels were prepared by using soybean leci...

journal_title：Drug delivery

authors： Balata G,El Nahas HM,Radwan S

更新日期：2014-02-01 00:00:00

abstract：:Our objective was to evaluate the chemotherapeutic potential of oral poly lactide-co-glycolide (PLG, a synthetic polymer) nanoparticle encapsulated ethambutol in combination with PLG-nanoparticle encapsulated-(rifampicin + isoniazid + pyrazinamide) in a murine tuberculosis (TB) model. Our formulation was prepared by t...

journal_title：Drug delivery

authors： Pandey R,Sharma S,Khuller GK

更新日期：2006-07-01 00:00:00

abstract：:The aim of this work was to prepare salts of 6-methoxy-2-naphthylacetic acid (6-MNA) to improve its physicochemical properties for percutaneous application. 6-MNA, an active metabolite of non-steroidal anti-inflammatory drug nabumetone has long half life and has the tendency to penetrate well into synovial fluid. The ...

journal_title：Drug delivery

authors： Pawar V,Kumar HY,Giridhar R,Yadav MR

更新日期：2015-05-01 00:00:00

abstract：:The aim of this research was to increase the oral bioavailability of puerarin by N-trimethyl chitosan-modified microemulsions (TMC-MEs) loaded with puerarin. Different concentrations of TMC-modified microemulsions were prepared in our study, and then evaluated for particle size, zeta potential, morphological observati...

journal_title：Drug delivery

authors： Liao D,Liu X,Dai W,Tang T,Ou G,Zhang K,Han M,Kang R,Yang S,Xiang D

更新日期：2015-01-01 00:00:00

abstract：:Carboplatin is a potent anticancer agent that has shown efficacy in clinical trials against malignant glioma, one of the most deadly cancers in humans. However, a high systemic dose is required to achieve an effective concentration in the brain because of the presence of the blood-brain barrier (BBB). Such a high dose...

journal_title：Drug delivery

authors： Chen W,He J,Olson JJ,Lu DR

更新日期：1997-01-01 00:00:00

abstract：:Silk was easily dyed in traditional textile industry because of its strong affinity to many colorants. Herein, the biocompatible silk fibroin was firstly extracted from Bombyx mori silkworm cocoons. And SF nanoparticles (SFNPs) were prepared for dyeing indocyanine green (ICG) and construct a therapeutic nano-platform ...

journal_title：Drug delivery

authors： Xu HL,ZhuGe DL,Chen PP,Tong MQ,Lin MT,Jiang X,Zheng YW,Chen B,Li XK,Zhao YZ

更新日期：2018-11-01 00:00:00

abstract：:Stealth solid lipid nanoparticles (SSLN) were prepared and evaluated for the effect of evading phagocytic uptake by mouse peritoneal macrophages in situ. Fluorescent SSLNs were prepared by emulsion/evaporation with rhodamine B as the fluorescent marker and polyoxyethylene stearate as stealth agent in a stearic acid ma...

journal_title：Drug delivery

authors： Wang Y,Wu W

更新日期：2006-05-01 00:00:00

abstract：:Melatonin, a pineal gland hormone, exerts oncostatic activity in several types of human cancer, including prostate, the most common neoplasia and the third most frequent cause of male cancer death in the developed world. The growth of androgen-sensitive LNCaP prostate cancer cells in mice is inhibited by 3 mg/kg/week ...

journal_title：Drug delivery

authors： Terraneo L,Bianciardi P,Virgili E,Finati E,Samaja M,Paroni R

更新日期：2017-11-01 00:00:00

abstract：:The study was aimed at evaluating the effectiveness of liposomal, micellar, and water-soluble drug forms of diminazene for its localization in cells and selective accumulation at the sites of aggregation of pathogenic organisms. Pharmacological and dynamic properties of a new injection micellar diminazene preparation ...

journal_title：Drug delivery

authors： Staroverov SA,Pristensky DV,Yermilov DN,Gabalov KP,Zhemerichkin DA,Sidorkin VA,Shcherbakov AA,Shchyogolev SY,Dykman LA

更新日期：2006-09-01 00:00:00