Extruded Soluplus/SIM as an oral delivery system: characterization, interactions, in vitro and in vivo evaluations.

abstract：:Magnetic nanocomposite particles were synthesized by encapsulating nanosized magnetite with an acrylate-based cationic co-polymer made of MMA, BA, and QMA and modifying with MeOPEGMA using the water replacement method. The composition of the co-polymer formulation was optimized based on zeta-potential measurements and...

journal_title：Drug delivery

authors： Phanapavudhikul P,Shen S,Ng WK,Tan RB

更新日期：2008-03-01 00:00:00

abstract：:Three formulations including methylene blue solution (MB-S), MB water-in-oil microemulsion (MB-ME), and MB multiple microemulsion (MB-MME) were prepared with the aim to evaluate whether the three formulations can carry MB target to regional lymph nodes and show lymphatic tropism after subcutaneous administration. The ...

journal_title：Drug delivery

authors： Wang S,Yang R,Yao H,Zhou G,Zhang Y,Yang B,Ng L,Yan M

更新日期：2009-10-01 00:00:00

abstract：:Surface modification of liposomes with polymer to optimize drug delivery was well developed recently. The objective of the present work was to evaluate the feasibility of chitosan-coated liposomes (CSLP) as vehicles for anti-sense oligodeoxynucleotides (ASON). CSLP was obtained by adding chitosan dropwise to liposomes...

journal_title：Drug delivery

authors： Wang WX,Gao JQ,Liang WQ

更新日期：2011-04-01 00:00:00

abstract：CONTEXT:Paclitaxel (PTX) and carboplatin (CBP) are widely used for the combined chemotherapy of non-small cell lung cancer (NSCLC). However, the development of multidrug resistance of cancer cells, as well as systemic toxic side effects resulting from nonspecific localization of anticancer drugs to non-tumor areas are ...

journal_title：Drug delivery

authors： Zhang W,Li C,Shen C,Liu Y,Zhao X,Liu Y,Zou D,Gao Z,Yue C

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVES:This study introduces the structural design, working principles, performance testing and treatment effects of a newly developed ultrasonic irradiation delivery and treatment catheter system that integrates interventional catheterization technology. BACKGROUND:Systemic administration method needs a high dose...

journal_title：Drug delivery

authors： Yuan QY,Huang J,Li XJ,Peng JB,Li XS,Chen ZP,Si LY

更新日期：2013-08-01 00:00:00

abstract：:Among the transcription factors critical for cell cycle regulation is the proto-oncogene c-myc. The expression of c-myc upon vascular injury and its inhibition by antisense oligodeoxynucleotides have demonstrated the importance of this protein in the control of proliferation for many cell types, including vascular smo...

journal_title：Drug delivery

authors： Koo EW,Edelman ER

更新日期：1996-01-01 00:00:00

abstract：:The aim of this work was to prepare salts of 6-methoxy-2-naphthylacetic acid (6-MNA) to improve its physicochemical properties for percutaneous application. 6-MNA, an active metabolite of non-steroidal anti-inflammatory drug nabumetone has long half life and has the tendency to penetrate well into synovial fluid. The ...

journal_title：Drug delivery

authors： Pawar V,Kumar HY,Giridhar R,Yadav MR

更新日期：2015-05-01 00:00:00

abstract：:Boronophenylalanine (BPA)-loaded conventional and stabilized liposomes were prepared by the reversed phase evaporation method to treat liver metastases by boron neutron capture therapy. Conventional vesicles were composed of phosphatidylcholine and cholesterol, molar ratio 1:1. To obtain stealth liposomes, GM1 or PEG ...

journal_title：Drug delivery

authors： Pavanetto F,Perugini P,Genta I,Minoia C,Ronchi A,Prati U,Roveda L,Nano R

更新日期：2000-04-01 00:00:00

abstract：:Effective clinical utilization of non-steroidal anti-inflammatory drugs such as diclofenac sodium (DS) is significantly limited by their ulcerogenic potential and poor bioavailability after oral administration, thus necessitating the need for a better carrier to minimize these obvious limitations. The objective of thi...

journal_title：Drug delivery

authors： Momoh MA,Kenechukwu FC,Adedokun MO,Odo CE,Attama AA

更新日期：2014-05-01 00:00:00

abstract：:Camptothecin (CPT) is an effective anticancer agent against various cancers but the clinical application is limited because of its poor water solubility, low bioavailability and severe toxic side effects. The aim of the present study was to evaluate the feasibility of using targeted NPs as a high-performance CPT deliv...

journal_title：Drug delivery

authors： Yang A,Liu Z,Yan B,Zhou M,Xiong X

更新日期：2016-06-01 00:00:00

abstract：:A novel cationic liposome modified with soybean sterylglucoside (SG) and polyethylene glycol-distearoylphosphatidylethanolamine (PEG-DSPE) as a carrier of antisense oligodeoxynucleotide (ODN) for hepatitis B virus (HBV) therapy was constructed. Characteristics of the cationic liposomes modified with SG and PEG (SG/PEG...

journal_title：Drug delivery

authors： Shi J,Yan WW,Qi XR,Maitani Y,Nagai T

更新日期：2005-11-01 00:00:00

abstract：:A macromolecular pro-drug of a known anti-viral agent Zidovudine (AZT) was synthesized and evaluated as a sustained drug delivery system. The pro-drug was synthesized by coupling the drug to 2-hydroxyethyl methacrylate (HEMA) through a succinic spacer to get a monomeric drug conjugate which was polymerized to obtain t...

journal_title：Drug delivery

authors： Neeraj A,Chandrasekar MJ,Sara UV,Rohini A

更新日期：2011-05-01 00:00:00

abstract：:This study focused on preparation and evaluation of a thermosensitive and mucoadhesive in situ gelling ophthalmic system of azithromycin (ATM). Poloxamer 407 (P407) and poloxamer 188 (P188) were used as gelling agents. Addition of Carbopol 974P (CP 974P) to the gelling systems could increase the solubility of ATM by s...

journal_title：Drug delivery

authors： Cao F,Zhang X,Ping Q

更新日期：2010-09-01 00:00:00

abstract：:Colon is an ideal absorptive site for oral protein and peptide drug (insulin), and yet it poses multiple barriers against the drug absorption, such as the barriers against the drug diffusion from colon lumen toward the absorptive mucosa and permeation across colon epithelium. In this study, modified nanoparticles (Tat...

journal_title：Drug delivery

authors： Guo F,Zhang M,Gao Y,Zhu S,Chen S,Liu W,Zhong H,Liu J

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:A topical microemulsion (ME)-based hydrogel was developed to enhance permeation of an antifungal drug, sertaconazole (STZL) for effective eradication of cutaneous fungal infection. METHODS:Pseudo-ternary phase diagrams were used to determine the existence of MEs region. ME formulations were prepared with oleic...

journal_title：Drug delivery

authors： Sahoo S,Pani NR,Sahoo SK

更新日期：2016-01-01 00:00:00

abstract：:Amphiphilic diblock copolymers composed of methoxy poly ethylene glycol (MePEG) and poly epsilon caprolactone (PCL) were synthesized for the formation of micelles by ring opening mechanism using stannous octoate as a catalyst. The effects of the molecular weight of MePEG and the copolymer ratio on the properties of mi...

journal_title：Drug delivery

authors： Mohanty AK,Dilnawaz F,Mohanty C,Sahoo SK

更新日期：2010-07-01 00:00:00

abstract：:Some cancers such as human breast cancer, prostate cancer, and lung cancer easily metastasize to bone, leading to osteolysis and bone destruction accompanied by a complicated microenvironment. Systemic administration of bisphosphonates (BP) or denosumab is the routine therapy for osteolysis but with non-negligible sid...

journal_title：Drug delivery

authors： Cheng X,Wei J,Ge Q,Xing D,Zhou X,Qian Y,Jiang G

更新日期：2021-12-01 00:00:00

abstract：:Efficient and stable delivery system of antisense oligonucleotide (ASO) is important and urgently needed. Here, an ASO delivery system, Lp-PPRP, which contains a cationic polymer based on PEI (branched, 25 kDa), named PEI-PC and a palmitic acid modified R8 (R8-PA) was prepared to deliver a kind of ASO, LOR-2501. The c...

journal_title：Drug delivery

authors： Yang S,Wang D,Sun Y,Zheng B

更新日期：2019-12-01 00:00:00

abstract：:The development of mucoadhesive lipidic nanoemulsion based on hyaluronic acid, co-encapsulating two polyphenols (resveratrol and curcumin) for the transnasal treatment of neurodegenerative diseases was attempted in the current manuscript. Nanoemulsions were prepared by the spontaneous emulsification method, and were c...

journal_title：Drug delivery

authors： Nasr M

更新日期：2016-05-01 00:00:00

abstract：:Our objective was to evaluate the chemotherapeutic potential of oral poly lactide-co-glycolide (PLG, a synthetic polymer) nanoparticle encapsulated ethambutol in combination with PLG-nanoparticle encapsulated-(rifampicin + isoniazid + pyrazinamide) in a murine tuberculosis (TB) model. Our formulation was prepared by t...

journal_title：Drug delivery

authors： Pandey R,Sharma S,Khuller GK

更新日期：2006-07-01 00:00:00

abstract：:Kollicoat SR 30D is a unique 30% aqueous dispersion of polyvinvyl acetate stabilized by polyvinyl-pyrrolidone intended for preparation of sustained release products. Detailed evaluation of this polymer dispersion as a sustained release coating for active pharmaceutical ingredients of two diverse classes of drugs was s...

journal_title：Drug delivery

authors： Bordaweka MS,Zia H,Quadir A

更新日期：2006-03-01 00:00:00

abstract：:Endostatin (ES) can effectively inhibit neovascularization in most solid tumors and has the potential to make oxygen delivery more efficient and increase the efficacy of radiotherapy (RT). With a short half-life, ES is mainly administered systemically, which leads to low intake in tumor tissue and often toxic systemic...

journal_title：Drug delivery

authors： Wang N,Gao Q,Tang J,Jiang Y,Yang L,Shi X,Chen Y,Zhang Y,Fu S,Lin S

更新日期：2021-12-01 00:00:00

abstract：:Nonviral gene delivery systems are a promising approach for gene therapy applications, despite their low in vivo gene transfer efficiency. One approach to enhance this efficiency is to incorporate targeting elements into cationic lipid/DNA complexes (lipoplexes). Ligand-containing lipoplexes have to retain their effic...

journal_title：Drug delivery

authors： Carrière M,Escriou V,Jollet A,Scherman D,Azoulay M,Monneret C

更新日期：2004-11-01 00:00:00

abstract：:In this study, transdermal etodolac-loaded cubosomes were developed in order to relieve patient pain and joints stiffness by providing stable etodolac concentration at the targeting sites through controlled drug delivery via the noninvasive skin route with more sustaining and less frequent dosing. Different ratios and...

journal_title：Drug delivery

authors： Salah S,Mahmoud AA,Kamel AO

更新日期：2017-11-01 00:00:00

abstract：:This article describes the development of solid lipid nanoparticles (SLN) as colloidal carriers for cloricromene. Nanoparticles were prepared by the microemulsion or precipitation technique. In vitro drug release profile from SLN was studied under various experimental conditions mimicking some body fluids. The drug re...

journal_title：Drug delivery

authors： Bondì ML,Fontana G,Carlisi B,Giammona G

更新日期：2003-10-01 00:00:00

abstract：:S-nitrosothiols are a class of NO-donors currently under investigation for the treatment of various diseases. In this study, we developed a novel NO-donor (S-nitrosoglutathione-alginate, SNA) by cross-linking alginate with S-nitrosothiols, which can deliver NO in a sustained manner. This compound can be further evalua...

journal_title：Drug delivery

authors： Shah SU,Socha M,Fries I,Gibaud S

更新日期：2016-10-01 00:00:00

abstract：:Reactive oxygen species (ROS)-induced neuronal mitochondrial dysfunction is a key pathologic factor in sporadic Alzheimer's disease (AD). Neuronal mitochondria have been proposed to be a promising therapeutic target for AD, especially for the failures of phase III clinical trials on conventional amyloid-β (Aβ) targete...

journal_title：Drug delivery

authors： Han Y,Chu X,Cui L,Fu S,Gao C,Li Y,Sun B

更新日期：2020-12-01 00:00:00

abstract：:Agomelatine (AGM) is an antidepressant drug with a low absolute bioavailability due to the hepatic first pass metabolism. AGM-loaded solid lipid nanoparticles were formulated in the form of an in situ gel to prolong the intranasal retention time and subsequently to increase the absorbed amount of AGM. The optimized in...

journal_title：Drug delivery

authors： Fatouh AM,Elshafeey AH,Abdelbary A

更新日期：2017-11-01 00:00:00

abstract：:In the present study, six different molecular weight diblock copolymer of methoxy poly (ethylene glycol)-b-poly (ε-caprolactone) (MPEG-PCL) were synthesized and characterized and was used for fabrication of etoposide-loaded micelles by nanoprecipitation technique. The particle size and percentage drug entrapment of pr...

journal_title：Drug delivery

authors： Ukawala M,Rajyaguru T,Chaudhari K,Manjappa AS,Pimple S,Babbar AK,Mathur R,Mishra AK,Murthy RS

更新日期：2012-04-01 00:00:00

abstract：:Bone metastasis is a devastating complication of cancer that requires an immediate attention. Although our understanding of the metastatic process has improved over the years, yet a number of questions still remain unanswered, and more research is required for complete understanding of the skeletal consequences of met...

journal_title：Drug delivery

authors： Vinay R,KusumDevi V

更新日期：2016-01-01 00:00:00