Lung cancer combination therapy: co-delivery of paclitaxel and doxorubicin by nanostructured lipid carriers for synergistic effect.

abstract：:In vitro drug release rates from aqueous and oil solutions as well as preformed and in situ formed aqueous and oil suspensions intended for intra-articular delivery have been investigated using the rotating dialysis cell model. Using lidocaine as a model drug substance the release kinetics from aqueous and oil suspens...

journal_title：Drug delivery

authors： Pedersen BT,Larsen SW,Østergaard J,Larsen C

更新日期：2008-01-01 00:00:00

abstract：:The aim of this research was to develop pH-sensitive insulin-loaded NOCC (N,O-carboxymethyl chitosan) nanoparticles for the controlled release of insulin via the oral route. Thus, in this study, insulin-loaded NOCC nanoparticles were prepared by ionic gelation of NOCC with TPP (tripolyphosphate). NOCC nanoparticles we...

journal_title：Drug delivery

authors： Lin CC,Lin CW

更新日期：2009-11-01 00:00:00

abstract：CONTEXT:Designing a sustained release system for Carvedilol to increase its residence time in the stomach. OBJECTIVE:Preparation of floating microsphere by the emulsion solvent diffusion method, studying the effect of various process parameters and optimize the formulation using full factorial design. METHODS:Differe...

journal_title：Drug delivery

authors： Nila MV,Sudhir MR,Cinu TA,Aleykutty NA,Jose S

更新日期：2014-03-01 00:00:00

abstract：:The objective of our study was to formulate and evaluate proliposomes in the form of enteric-coated beads using glyburide as a model drug. The beads were enteric coated with Eudragit L-100 by a fluidized bed coating process using triethyl citrate as plasticizer. Content uniformity of glyburide was estimated using HPLC...

journal_title：Drug delivery

authors： Kumar R,Gupta RB,Betageri GV

更新日期：2001-01-01 00:00:00

abstract：:Gastric cancer is a frequently occurring cancer with high mortality each year worldwide. Finding new and effective therapeutic strategy against human gastric cancer is still urgently required. Hence, we have established a new method to achieve treatment-actuated modifications in a tumor microenvironment by utilizing s...

journal_title：Drug delivery

authors： Xiao Y,Gao Y,Li F,Deng Z

更新日期：2020-12-01 00:00:00

abstract：:Ischemic stroke is one of the major causes of severe disability and death worldwide. It is mainly caused by a sudden reduction in cerebral blood flow due to obstruction of the supplying vessel by thrombi and subsequent initiation of a complex cascade of pathophysiological changes, which ultimately lead to brain ischem...

journal_title：Drug delivery

authors： Ma H,Jiang Z,Xu J,Liu J,Guo ZN

更新日期：2021-12-01 00:00:00

abstract：:Recently, exosomes have been emerged as promising drug delivery carriers, while certain tissues are intrinsically resistant to exosomes. Therapeutically improving the drug delivery efficiency in these tissues/organs would certainly broaden the potential application of exosomes in future. Ultrasound-targeted microbubbl...

journal_title：Drug delivery

authors： Sun W,Li Z,Zhou X,Yang G,Yuan L

更新日期：2019-12-01 00:00:00

abstract：:Carboplatin is a potent anticancer agent that has shown efficacy in clinical trials against malignant glioma, one of the most deadly cancers in humans. However, a high systemic dose is required to achieve an effective concentration in the brain because of the presence of the blood-brain barrier (BBB). Such a high dose...

journal_title：Drug delivery

authors： Chen W,He J,Olson JJ,Lu DR

更新日期：1997-01-01 00:00:00

abstract：:In the present study, six different molecular weight diblock copolymer of methoxy poly (ethylene glycol)-b-poly (ε-caprolactone) (MPEG-PCL) were synthesized and characterized and was used for fabrication of etoposide-loaded micelles by nanoprecipitation technique. The particle size and percentage drug entrapment of pr...

journal_title：Drug delivery

authors： Ukawala M,Rajyaguru T,Chaudhari K,Manjappa AS,Pimple S,Babbar AK,Mathur R,Mishra AK,Murthy RS

更新日期：2012-04-01 00:00:00

abstract：:This research evaluated 7525DLPCL for soft flexible drug delivery systems. The effect of ciprofloxacin hydrochloride (CIP) loading at three levels (10, 20, and 30%), on thermo-mechanical properties was studied. CIP release was monitored for 12 weeks. Addition of CIP to 7525DLPCL caused an increase in compressive modul...

journal_title：Drug delivery

authors： Waknis V,Jonnalagadda S

更新日期：2011-05-01 00:00:00

abstract：:Pantoprazole is a proton pump inhibitor prodrug used in the treatment of gastric ulcers and gastroesophageal disease. Pantoprazole must be absorbed in the gastrointestinal tract and because it is unstable under acidic conditions, enteric delivery systems are required. The purpose of this study was to prepare pantopraz...

journal_title：Drug delivery

authors： Comoglu T,Gonul N,Dogan A,Basci N

更新日期：2008-06-01 00:00:00

abstract：:Nonviral gene delivery systems are a promising approach for gene therapy applications, despite their low in vivo gene transfer efficiency. One approach to enhance this efficiency is to incorporate targeting elements into cationic lipid/DNA complexes (lipoplexes). Ligand-containing lipoplexes have to retain their effic...

journal_title：Drug delivery

authors： Carrière M,Escriou V,Jollet A,Scherman D,Azoulay M,Monneret C

更新日期：2004-11-01 00:00:00

abstract：:Enrofloxacin, a third-generation fluoroquinolone, is a broad-spectrum antimicrobial drug against a lot of veterinary bacterial diseases. However, bactericidal activity of enrofloxacin is concentration-dependent and its poor aqueous solubility and bitter taste limit its development and application. Meanwhile, 2-hydroxy...

journal_title：Drug delivery

authors： Ding Y,Pang Y,Vara Prasad CVNS,Wang B

更新日期：2020-12-01 00:00:00

abstract：:ALA-loaded nanostructured lipid carrier (ALA-NLC) was designed to improve physicochemical stability and water solubility, and promote sustained release of ALA as well as determine the biocompatibility of ALA-NLC. The ALA-NLC manufactured using hot high-pressure homogenization technique was investigated in terms of siz...

journal_title：Drug delivery

authors： Wang J,Xia Q

更新日期：2014-08-01 00:00:00

abstract：:Endostatin (ES) can effectively inhibit neovascularization in most solid tumors and has the potential to make oxygen delivery more efficient and increase the efficacy of radiotherapy (RT). With a short half-life, ES is mainly administered systemically, which leads to low intake in tumor tissue and often toxic systemic...

journal_title：Drug delivery

authors： Wang N,Gao Q,Tang J,Jiang Y,Yang L,Shi X,Chen Y,Zhang Y,Fu S,Lin S

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVE:In the present study, Curcumin (CU)-loaded nanocarrier (NC) such as nanoemulsion (NE) was developed with the objective of increasing its cytotoxicity and bioavailability through lymphatic transport by enhancing its solubility and intestinal permeability. MATERIALS AND METHODS:Based on the area obtained in ps...

journal_title：Drug delivery

authors： Kumar A,Ahuja A,Ali J,Baboota S

更新日期：2016-01-01 00:00:00

abstract：CONTEXT:Bisphosphonates (BPs) are widely used for prevention and treatment of osteoporosis. BPs are known as gold standard for osteoporosis (OP) treatment due to their positive results in clinical studies. But some serious side effects are associated with BPs like gastrointestinal adverse effect i.e. esophagitis and ul...

journal_title：Drug delivery

authors： Fazil M,Baboota S,Sahni JK,Ameeduzzafar,Ali J

更新日期：2015-01-01 00:00:00

abstract：:A macromolecular pro-drug of a known anti-viral agent Zidovudine (AZT) was synthesized and evaluated as a sustained drug delivery system. The pro-drug was synthesized by coupling the drug to 2-hydroxyethyl methacrylate (HEMA) through a succinic spacer to get a monomeric drug conjugate which was polymerized to obtain t...

journal_title：Drug delivery

authors： Neeraj A,Chandrasekar MJ,Sara UV,Rohini A

更新日期：2011-05-01 00:00:00

abstract：:Surface modification of liposomes with polymer to optimize drug delivery was well developed recently. The objective of the present work was to evaluate the feasibility of chitosan-coated liposomes (CSLP) as vehicles for anti-sense oligodeoxynucleotides (ASON). CSLP was obtained by adding chitosan dropwise to liposomes...

journal_title：Drug delivery

authors： Wang WX,Gao JQ,Liang WQ

更新日期：2011-04-01 00:00:00

abstract：CONTEXT:Propolis has traditionally been used in curing infections and healing wounds and burns. OBJECTIVE:The aim of this study is to formulate pluronic lecithin organogel of propolis to improve its availability and antimicrobial activity. MATERIALS AND METHODS:Different organogels were prepared by using soybean leci...

journal_title：Drug delivery

authors： Balata G,El Nahas HM,Radwan S

更新日期：2014-02-01 00:00:00

abstract：:Colon is an ideal absorptive site for oral protein and peptide drug (insulin), and yet it poses multiple barriers against the drug absorption, such as the barriers against the drug diffusion from colon lumen toward the absorptive mucosa and permeation across colon epithelium. In this study, modified nanoparticles (Tat...

journal_title：Drug delivery

authors： Guo F,Zhang M,Gao Y,Zhu S,Chen S,Liu W,Zhong H,Liu J

更新日期：2016-07-01 00:00:00

abstract：:DNA vaccination is a promising approach for inducing both humoral and cellular immune responses. The mode of plasmid DNA delivery is critical to make progress in DNA vaccination. Using human papillomavirus type 16 E7 as a model antigen, this study evaluated the effect of peptide-polymer hybrid including PEI600-Tat con...

journal_title：Drug delivery

authors： Bolhassani A,Ghasemi N,Servis C,Taghikhani M,Rafati S

更新日期：2009-05-01 00:00:00

abstract：:Currently, traumatic brain injury (TBI) is the leading cause of death or disabilities in young individuals worldwide. The multi-complexity of its pathogenesis as well as impermeability of the blood-brain barrier (BBB) makes the drug choice and delivery very challenging. The brain-derived neurotrophic factor (BDNF) reg...

journal_title：Drug delivery

authors： Khalin I,Alyautdin R,Wong TW,Gnanou J,Kocherga G,Kreuter J

更新日期：2016-11-01 00:00:00

abstract：:The objective of this study was to investigate the effect of lipophilic (Compritol 888 ATO) and hydrophilic components (combination of HPMC and Avicel) on the release of carbamazepine from granules and corresponding tablet. Wet granulation followed by compression was employed for preparation of granules and tablets. T...

journal_title：Drug delivery

authors： Barakat NS,Elbagory IM,Almurshedi AS

更新日期：2009-01-01 00:00:00

abstract：:This study focused on preparation and evaluation of a thermosensitive and mucoadhesive in situ gelling ophthalmic system of azithromycin (ATM). Poloxamer 407 (P407) and poloxamer 188 (P188) were used as gelling agents. Addition of Carbopol 974P (CP 974P) to the gelling systems could increase the solubility of ATM by s...

journal_title：Drug delivery

authors： Cao F,Zhang X,Ping Q

更新日期：2010-09-01 00:00:00

abstract：:A micelle system modified with α-Conotoxin ImI (ImI), a potently antagonist for alpha7 nicotinic acetylcholine receptor (α7-nAChR) previously utilized for targeting breast cancer, was constructed. Its targeting efficiency and cytotoxicity against non-small cell lung cancer (NSCLC) highly expressing α7-nAChR was invest...

journal_title：Drug delivery

authors： Mei D,Zhao L,Chen B,Zhang X,Wang X,Yu Z,Ni X,Zhang Q

更新日期：2018-11-01 00:00:00

abstract：:Electro-phonophoresis (EP) has been used in various clinical fields. The objective of present study is to evaluate the skin permeability of isoniazid (INH) and rifampicin (RIF) in patients with tuberculous lymphadenitis with the aid of EP to validate the clinical applications of this transdermal delivery system for th...

journal_title：Drug delivery

authors： Chen S,Qin M,Han Y,Zhao L,Fu Y,Shang Y,Liu Z,Huang H

更新日期：2016-06-01 00:00:00

abstract：:The study was aimed at evaluating the effectiveness of liposomal, micellar, and water-soluble drug forms of diminazene for its localization in cells and selective accumulation at the sites of aggregation of pathogenic organisms. Pharmacological and dynamic properties of a new injection micellar diminazene preparation ...

journal_title：Drug delivery

authors： Staroverov SA,Pristensky DV,Yermilov DN,Gabalov KP,Zhemerichkin DA,Sidorkin VA,Shcherbakov AA,Shchyogolev SY,Dykman LA

更新日期：2006-09-01 00:00:00

abstract：:The main aim of this work was to develop rectal suppositories for better delivery of metoprolol tartrate (MT). The various bases used were fatty, water soluble and emulsion bases. The physical properties of the prepared suppositories were characterized such as weight variation, hardness, disintegration time, melting r...

journal_title：Drug delivery

authors： Abou el Ela Ael S,Allam AA,Ibrahim EH

更新日期：2016-01-01 00:00:00

abstract：:Bone-metastasis prostate cancer (BMPCa)-targeting gene therapy is gaining increasing concern in recent years. The peptide T7-modified polypeptide nanoparticles for delivery DNA (CRD-PEG-T7/pPMEPA1) was prepared as our previous study. However, the feasibility of CRD-PEG-T7/pPMEPA1 for BMPCa treatment, the mechanisms un...

journal_title：Drug delivery

authors： Gu Y,Chen X,Zhang H,Wang H,Chen H,Huang S,Xu Y,Zhang Y,Wu X,Chen J

更新日期：2020-12-01 00:00:00