Abstract:
:This article describes the development of solid lipid nanoparticles (SLN) as colloidal carriers for cloricromene. Nanoparticles were prepared by the microemulsion or precipitation technique. In vitro drug release profile from SLN was studied under various experimental conditions mimicking some body fluids. The drug release rate of drug at pH 7.4 and human plasma is high. In plasma, after 15 min, about 70% of drug was released. The cloricromene that was not released within 4 hr was found in the SLN. This result suggests that this colloidal system could be useful for targeted drug delivery to the central nervous system after intravenous administration.
journal_name
Drug Delivjournal_title
Drug deliveryauthors
Bondì ML,Fontana G,Carlisi B,Giammona Gdoi
10.1080/drd_10_4_245keywords:
subject
Has Abstractpub_date
2003-10-01 00:00:00pages
245-50issue
4eissn
1071-7544issn
1521-0464pii
DQF5QB284UVF7NTAjournal_volume
10pub_type
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