Formulation and evaluation of dextromethorphan hydrobromide sustained release tablets.


:Sustained release (SR) matrix tablets of dextromethorphan hydrobromide were prepared by wet granulation using hydroxypropyl methyl cellulose (HPMC-K-100 CR) as the hydrophilic rate controlling polymer. The effect of the concentration of the polymer and different fillers on the in vitro drug release rate was studied. The studies indicated that the drug release can be modulated by varying the concentration of the polymer and the fillers. A complete cross-over bioavailability study of the optimized formulation of the developed sustained tablets and marketed immediate release tablets was performed on six healthy male volunteers. The extent of absorption of drug from the SR tablets was significantly higher than that for the marketed dextromethorphan hydrobromide tablet because of lower elimination rate and longer half-life.


Drug Deliv


Drug delivery


Meyyanathan SN,Rajan S,Muralidaharan S,Siddaiah MK,Krishnaraj K,Suresh B




Has Abstract


2008-09-01 00:00:00














  • Agomelatine-based in situ gels for brain targeting via the nasal route: statistical optimization, in vitro, and in vivo evaluation.

    abstract::Agomelatine (AGM) is an antidepressant drug with a low absolute bioavailability due to the hepatic first pass metabolism. AGM-loaded solid lipid nanoparticles were formulated in the form of an in situ gel to prolong the intranasal retention time and subsequently to increase the absorbed amount of AGM. The optimized in...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Fatouh AM,Elshafeey AH,Abdelbary A

    更新日期:2017-11-01 00:00:00

  • Formulation and in vivo assessment of terconazole-loaded polymeric mixed micelles enriched with Cremophor EL as dual functioning mediator for augmenting physical stability and skin delivery.

    abstract::The aim of the current study was to formulate terconazole (TCZ) loaded polymeric mixed micelles (PMMs) incorporating Cremophor EL as a stabilizer and a penetration enhancer. A 23 full factorial design was performed using Design-Expert® software for the optimization of the PMMs which were formulated using Pluronic P123...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Abd-Elsalam WH,El-Zahaby SA,Al-Mahallawi AM

    更新日期:2018-11-01 00:00:00

  • Assessment of simvastatin niosomes for pediatric transdermal drug delivery.

    abstract::The prevalence of childhood dyslipidemia increases and is considered as an important risk factor for the incidence of cardiovascular disease in the adulthood. To improve dosing accuracy and facilitate the determination of dosing regimens in function of the body weight, the proposed study aims at preparing transdermal ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Zidan AS,Hosny KM,Ahmed OA,Fahmy UA

    更新日期:2016-06-01 00:00:00

  • Development of nanoparticles-in-microparticles system for improved local retention after intra-articular injection.

    abstract::To increase the intra-articular (IA) retention time of osteoarthritis drugs in the synovial cavity and slow down the burst release of microspheres (MPs), we prepared a novel drug delivery system named nanoparticles-in-microspheres (NiMs). The system was constructed by dispersing the brucine-loaded nanoparticle, which ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Chen Z,Liu D,Wang J,Wu L,Li W,Chen J,Cai BC,Cheng H

    更新日期:2014-08-01 00:00:00

  • Strategies to deliver microRNAs as potential therapeutics in the treatment of cardiovascular pathology.

    abstract:CONTEXT:MicroRNAs (miRNAs) are important and powerful mediators in a variety of diseases including cardiovascular pathology. Thus, they emerged as interesting new drug targets. However, it is important to develop efficient transfer tools to successfully deliver miRNAs or antisense oligonucleotides (antagomirs) to the t...

    journal_title:Drug delivery

    pub_type: 杂志文章,评审


    authors: Chistiakov DA,Sobenin IA,Orekhov AN

    更新日期:2012-11-01 00:00:00

  • Liraglutide-loaded multivesicular liposome as a sustained-delivery reduces blood glucose in SD rats with diabetes.

    abstract::Subcutaneous liraglutide-loaded multivesicular liposomes (Lrg-MVLs) were developed as a sustained drug-delivery system for treating diabetes and their properties were characterized. The Lrg-MVLs prepared using a two-step water-in-oil-in-water double emulsification process had a spherical appearance with a mean diamete...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Zhang L,Ding L,Tang C,Li Y,Yang L

    更新日期:2016-11-01 00:00:00

  • Floating-bioadhesive microspheres containing acetohydroxamic acid for clearance of Helicobacter pylori.

    abstract::A new strategy based on gastric retention is proposed for the treatment of Helicobacter pylori. (H. pylori). A synergism between a floating and a bioadhesive system has been explored. Floating microspheres containing the antiurease drug acetohydroxamic acid (AHA) were prepared by a novel quasi-emulsion solvent diffusi...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Umamaheswari RB,Jain S,Tripathi PK,Agrawal GP,Jain NK

    更新日期:2002-10-01 00:00:00

  • Multiseed liposomal drug delivery system using micelle gradient as driving force to improve amphiphilic drug retention and its anti-tumor efficacy.

    abstract::To improve drug retention in carriers for amphiphilic asulacrine (ASL), a novel active loading method using micelle gradient was developed to fabricate the ASL-loaded multiseed liposomes (ASL-ML). The empty ML were prepared by hydrating a thin film with empty micelles. Then the micelles in liposomal compartment acting...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Zhang W,Li C,Jin Y,Liu X,Wang Z,Shaw JP,Baguley BC,Wu Z,Liu J

    更新日期:2018-11-01 00:00:00

  • Preparation and characterization of solid lipid nanoparticles containing cloricromene.

    abstract::This article describes the development of solid lipid nanoparticles (SLN) as colloidal carriers for cloricromene. Nanoparticles were prepared by the microemulsion or precipitation technique. In vitro drug release profile from SLN was studied under various experimental conditions mimicking some body fluids. The drug re...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Bondì ML,Fontana G,Carlisi B,Giammona G

    更新日期:2003-10-01 00:00:00

  • Mometasone furoate-loaded cold processed oil-in-water emulsions: in vitro and in vivo studies.

    abstract::Over the years, research has focused on strategies to increase benefit/risk ratio of corticoids. However, vehicles intended for topical glucocorticoids delivery with an improved benefit/risk ratio are still on demand. The aim of this work was the in vitro and in vivo characterization of cold processed oil-in-water (o/...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Raposo S,Tavares R,Gonçalves L,Simões S,Urbano M,Ribeiro HM

    更新日期:2015-01-01 00:00:00

  • In vivo behavior of hydrogel beads based on amidated pectins.

    abstract::Radio-labeled hydrogel beads, based on amidated pectin, have been produced by adding droplets of an amidated pectin solution to calcium chloride. Incorporation of model drugs into the beads and measurement of the dissolution rate showed that the properties of the beads were unaffected by the incorporation of the radio...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Munjeri O,Collett JH,Fell JT,Sharma HL,Smith AM

    更新日期:1998-01-01 00:00:00

  • Development of lipid nanoparticles for a histone deacetylases inhibitor as a promising anticancer therapeutic.

    abstract:BACKGROUND:Vorinostat (VRS), a histone deacetylases inhibitor, has significant cytotoxic potential in a large number of human cancer cell lines. OBJECTIVE:To clarify its promising anticancer potential and to improve its drawback related to physical properties and in vivo performance of VRS. METHODS:VRS was successful...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Tran TH,Chu DT,Truong DH,Tak JW,Jeong JH,Hoang VL,Yong CS,Kim JO

    更新日期:2016-05-01 00:00:00

  • Targeted nano-delivery strategies for facilitating thrombolysis treatment in ischemic stroke.

    abstract::Ischemic stroke is one of the major causes of severe disability and death worldwide. It is mainly caused by a sudden reduction in cerebral blood flow due to obstruction of the supplying vessel by thrombi and subsequent initiation of a complex cascade of pathophysiological changes, which ultimately lead to brain ischem...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Ma H,Jiang Z,Xu J,Liu J,Guo ZN

    更新日期:2021-12-01 00:00:00

  • Solid lipid nanoparticles for ocular drug delivery.

    abstract::Ocular drug delivery remains challenging because of the complex nature and structure of the eye. Conventional systems, such as eye drops and ointments, are inefficient, whereas systemic administration requires high doses resulting in significant toxicity. There is a need to develop novel drug delivery carriers capable...

    journal_title:Drug delivery

    pub_type: 杂志文章,评审


    authors: Seyfoddin A,Shaw J,Al-Kassas R

    更新日期:2010-09-01 00:00:00

  • Potential of targeted drug delivery system for the treatment of bone metastasis.

    abstract::Bone metastasis is a devastating complication of cancer that requires an immediate attention. Although our understanding of the metastatic process has improved over the years, yet a number of questions still remain unanswered, and more research is required for complete understanding of the skeletal consequences of met...

    journal_title:Drug delivery

    pub_type: 杂志文章,评审


    authors: Vinay R,KusumDevi V

    更新日期:2016-01-01 00:00:00

  • Synergism of cisplatin-oleanolic acid co-loaded hybrid nanoparticles on gastric carcinoma cells for enhanced apoptosis and reversed multidrug resistance.

    abstract::Combined administration of different drugs is a widely acknowledged approach for effective cancer therapy. However, the limited targeting, as well as inferior drug loading capacities of current drug delivery systems (DDS), are still the bottleneck for better performance in cancer treatment. Herein, we successfully dev...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Li D,Cui R,Xu S,Liu Y

    更新日期:2020-12-01 00:00:00

  • The effectivity analysis of accumulation of liposomal, micellar, and water-soluble forms of diminazene in cells and in organs.

    abstract::The study was aimed at evaluating the effectiveness of liposomal, micellar, and water-soluble drug forms of diminazene for its localization in cells and selective accumulation at the sites of aggregation of pathogenic organisms. Pharmacological and dynamic properties of a new injection micellar diminazene preparation ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Staroverov SA,Pristensky DV,Yermilov DN,Gabalov KP,Zhemerichkin DA,Sidorkin VA,Shcherbakov AA,Shchyogolev SY,Dykman LA

    更新日期:2006-09-01 00:00:00

  • Combined photodynamic-chemotherapy investigation of cancer cells using carbon quantum dot-based drug carrier system.

    abstract::The combined chemotherapy and photodynamic therapy have significant advantages for cancer treatments, which have higher therapeutic effects compared with other medicines. Herein, we focused on the synthesis of carbon quantum dot (CQD) based nanocarrier system. CQD and 5-aminolevulinic acid (5-ALA) were conjugated with...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Li X,Vinothini K,Ramesh T,Rajan M,Ramu A

    更新日期:2020-12-01 00:00:00

  • Optimizing novel penetration enhancing hybridized vesicles for augmenting the in-vivo effect of an anti-glaucoma drug.

    abstract::Usually the topical delivery of ocular drugs poses a great challenge. Accordingly, the work in this study comprised the use of different hybrids of generally regarded as safe (GRAS) oils and surfactants in order to develop and optimize novel acetazolamide (AZD) entrapped-vesicular systems aiming at improving its ocula...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Naguib SS,Hathout RM,Mansour S

    更新日期:2017-11-01 00:00:00

  • Propolis organogel as a novel topical delivery system for treating wounds.

    abstract:CONTEXT:Propolis has traditionally been used in curing infections and healing wounds and burns. OBJECTIVE:The aim of this study is to formulate pluronic lecithin organogel of propolis to improve its availability and antimicrobial activity. MATERIALS AND METHODS:Different organogels were prepared by using soybean leci...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Balata G,El Nahas HM,Radwan S

    更新日期:2014-02-01 00:00:00

  • Disposition of 3H-cholesteryl ether labeled liposomes following intravenous administration to mice: comparison with an encapsulated 14C-inulin as aqueous phase marker.

    abstract::In this study, the blood clearance and organ distribution of intravenously administered liposomes (distearoyl phosphatidylcholine [DSPC] and cholesterol in a ratio of 3:1) was evaluated by utilizing 3H-cholesteryl ether as the lipid phase marker. Also, the ability of liposomes, as a drug delivery system, to alter the ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Anderson M,Paradis C,Omri A

    更新日期:2003-07-01 00:00:00

  • Recent advances in non-ionic surfactant vesicles (niosomes): self-assembly, fabrication, characterization, drug delivery applications and limitations.

    abstract::Non-ionic surfactant vesicles, simply known as niosomes are synthetic vesicles with potential technological applications. Niosomes have the same potential advantages of phospholipid vesicles (liposomes) of being able to accommodate both water soluble and lipid soluble drug molecules control their release and as such s...

    journal_title:Drug delivery

    pub_type: 杂志文章,评审


    authors: Abdelkader H,Alani AW,Alany RG

    更新日期:2014-03-01 00:00:00

  • Enhancing the chemotherapy effect of Apatinib on gastric cancer by co-treating with salidroside to reprogram the tumor hypoxia micro-environment and induce cell apoptosis.

    abstract::Hypoxic microenvironment commonly occurred in the solid tumors considerably decreases the chemosensitivity of cancer cells. Salidroside (Sal), the main active ingredient of Rhodiola rosea, was shown to be able of regulating the tumor hypoxia micro-environment and enhancing the chemotherapeutic efficacy of drug-resista...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Zhang Z,Yang W,Ma F,Ma Q,Zhang B,Zhang Y,Liu Y,Liu H,Hua Y

    更新日期:2020-12-01 00:00:00

  • Chitosan-based particles as controlled drug delivery systems.

    abstract::Chitosan, a natural-based polymer obtained by alkaline deacetylation of chitin, is nontoxic, biocompatible, and biodegradable. These properties make chitosan a good candidate for conventional and novel drug delivery systems. This article reviews the approaches aimed to associate bioactive molecules to chitosan in the ...

    journal_title:Drug delivery

    pub_type: 杂志文章,评审


    authors: Prabaharan M,Mano JF

    更新日期:2005-01-01 00:00:00

  • A novel ligand conjugated nanoparticles for oral insulin delivery.

    abstract::In order to enhance the interaction between nanocarrier and gastrointestinal epithelial cells, we developed nanoparticles (NPs) modified with targeting ligand FQSIYPpIK (FQS), which specifically interact with integrin αvβ3 receptor expressing on the intestinal epithelium. The targeting NPs were prepared by coating the...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Liu C,Shan W,Liu M,Zhu X,Xu J,Xu Y,Huang Y

    更新日期:2016-07-01 00:00:00

  • Β-Cyclodextrin-graft-poly(amidoamine) dendrons as the nitric oxide deliver system for the chronic rhinosinusitis therapy.

    abstract::Chronic rhinosinusitis (CRS) is a rather prevalent condition with a chronic inflammatory process, which is hard to cure. Herein, a new antibacterial drug, nitric oxide (NO), was used for the attempt on CRS therapy. To achieve this, a star copolymer (β-CD-PAMAM) consisting of the β-cyclodextrin (β-CD) core and seven PA...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Liu T,Li G,Wu X,Chen S,Zhang S,Han H,Zhang H,Luo X,Cai X,Ma D

    更新日期:2021-12-01 00:00:00

  • Follicle-stimulating hormone peptide-conjugated nanoparticles for targeted shRNA delivery lead to effective gro-α silencing and antitumor activity against ovarian cancer.

    abstract::The distinct hormone molecules and receptors, such as follicle-stimulating hormone receptor (FSHR) in ovarian cancer, provide opportunities for more precisely targeted therapy. We previously developed FSHR-mediated nanoparticles and found that FSH peptides on the surface of nanoparticles improved the delivery of short...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Hong SS,Zhang MX,Zhang M,Yu Y,Chen J,Zhang XY,Xu CJ

    更新日期:2018-11-01 00:00:00

  • Brain targeted oral delivery of doxycycline hydrochloride encapsulated Tween 80 coated chitosan nanoparticles against ketamine induced psychosis: behavioral, biochemical, neurochemical and histological alterations in mice.

    abstract::To develop statistically optimized brain targeted Tween 80 coated chitosan nanoparticulate formulation for oral delivery of doxycycline hydrochloride for the treatment of psychosis and to evaluate its protective effect on ketamine induced behavioral, biochemical, neurochemical and histological alterations in mice. 32 ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Yadav M,Parle M,Sharma N,Dhingra S,Raina N,Jindal DK

    更新日期:2017-11-01 00:00:00

  • The efficiency of a novel delivery system (PEI600-Tat) in development of potent DNA vaccine using HPV16 E7 as a model antigen.

    abstract::DNA vaccination is a promising approach for inducing both humoral and cellular immune responses. The mode of plasmid DNA delivery is critical to make progress in DNA vaccination. Using human papillomavirus type 16 E7 as a model antigen, this study evaluated the effect of peptide-polymer hybrid including PEI600-Tat con...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Bolhassani A,Ghasemi N,Servis C,Taghikhani M,Rafati S

    更新日期:2009-05-01 00:00:00

  • Effect of tissue permeability and drug diffusion anisotropy on convection-enhanced delivery.

    abstract::Although convection-enhanced delivery (CED) can successfully facilitate a bypass of the blood brain barrier, its treatment efficacy remains highly limited in clinic. This can be partially attributed to the brain anisotropic characteristics that lead to the difficulties in controlling the drug spatial distribution. Her...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Zhan W,Rodriguez Y Baena F,Dini D

    更新日期:2019-12-01 00:00:00