Abstract:
:Non-ionic surfactant vesicles, simply known as niosomes are synthetic vesicles with potential technological applications. Niosomes have the same potential advantages of phospholipid vesicles (liposomes) of being able to accommodate both water soluble and lipid soluble drug molecules control their release and as such serve as versatile drug delivery devices of numerous applications. Additionally, niosomes can be considered as more economically, chemically, and occasionally physically stable alternatives to liposomes. Niosomes can be fabricated using simple methods of preparations and from widely used surfactants in pharmaceutical technology. Many reports have discussed niosomes in terms of physicochemical properties and their applications as drug delivery systems. In this report, a brief and simplified summary of different theories of self-assembly will be given. Furthermore manufacturing methods, physical characterization techniques, bilayer membrane additives, unconventional niosomes (discomes, proniosomes, elastic and polyhedral niosomes), their recent applications as drug delivery systems, limitations and directions for future research will be discussed.
journal_name
Drug Delivjournal_title
Drug deliveryauthors
Abdelkader H,Alani AW,Alany RGdoi
10.3109/10717544.2013.838077subject
Has Abstractpub_date
2014-03-01 00:00:00pages
87-100issue
2eissn
1071-7544issn
1521-0464journal_volume
21pub_type
杂志文章,评审相关文献
DRUG DELIVERY文献大全abstract::At present, the chemotherapy of advanced inoperable liver cancer is limited with serious side effects. Curcumin possesses multiple cancer preventive activities and low safety concerns. However, its poor solubility and instability in water pose significant pharmacological barriers to its clinical application. In this s...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1526227
更新日期:2018-11-01 00:00:00
abstract::To increase the intra-articular (IA) retention time of osteoarthritis drugs in the synovial cavity and slow down the burst release of microspheres (MPs), we prepared a novel drug delivery system named nanoparticles-in-microspheres (NiMs). The system was constructed by dispersing the brucine-loaded nanoparticle, which ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.848495
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Vorinostat (VRS), a histone deacetylases inhibitor, has significant cytotoxic potential in a large number of human cancer cell lines. OBJECTIVE:To clarify its promising anticancer potential and to improve its drawback related to physical properties and in vivo performance of VRS. METHODS:VRS was successful...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.991432
更新日期:2016-05-01 00:00:00
abstract::Small interfering RNA (siRNA) exhibits great potential as a novel therapeutic option due to its highly sequence-specific ability to silence genes. However, efficient and safe delivery carriers are required for developing novel therapeutic paradigms. Thus, the successful development of efficient delivery platforms for ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2019.1667452
更新日期:2020-12-01 00:00:00
abstract::Combined administration of different drugs is a widely acknowledged approach for effective cancer therapy. However, the limited targeting, as well as inferior drug loading capacities of current drug delivery systems (DDS), are still the bottleneck for better performance in cancer treatment. Herein, we successfully dev...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2019.1710622
更新日期:2020-12-01 00:00:00
abstract::Chitosan, a natural-based polymer obtained by alkaline deacetylation of chitin, is nontoxic, biocompatible, and biodegradable. These properties make chitosan a good candidate for conventional and novel drug delivery systems. This article reviews the approaches aimed to associate bioactive molecules to chitosan in the ...
journal_title:Drug delivery
pub_type: 杂志文章,评审
doi:10.1080/10717540590889781
更新日期:2005-01-01 00:00:00
abstract::Administration of influenza vaccines to the lungs could be an attractive alternative to conventional parenteral administration. In this study, we investigated the deposition site of pulmonary delivered liquid and powder influenza vaccine formulations and its relation to their immunogenicity and protective efficacy. In...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1435748
更新日期:2018-11-01 00:00:00
abstract::The aim of this work was to encapsulate superoxide dismutase (SOD) into biodegradable microparticles by spray-drying technique. The nature of the organic solvent to dissolve the polymer, the method of incorporation of the drug in the organic phase (with or without a surfactant, namely sucrose ester of HLB = 6), the su...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540490280363
更新日期:2004-05-01 00:00:00
abstract::This study aimed to examine the effects of bile salts on pharmacokinetics of lovastatin, which has low bioavailability. Lovastatin solid dispersions were prepared using sodium deoxycholate (NaDC) and sodium glycholate (NaGC) at ratios of 1:19, 1:49, and 1:69. The formulated solid dispersions and control (commercial ta...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2010.512024
更新日期:2011-01-01 00:00:00
abstract::This research evaluated 7525DLPCL for soft flexible drug delivery systems. The effect of ciprofloxacin hydrochloride (CIP) loading at three levels (10, 20, and 30%), on thermo-mechanical properties was studied. CIP release was monitored for 12 weeks. Addition of CIP to 7525DLPCL caused an increase in compressive modul...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2010.528070
更新日期:2011-05-01 00:00:00
abstract::The purpose of the present study is to develop a new method to prepare magnetite chitosan microspheres conjugated with methotrexate (MTX) for the controlled release of MTX as a magnetic targeting drug delivery system. MTX was first conjugated to the chitosan chain via a peptide bond and then a suspension cross-linking...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540902989555
更新日期:2009-07-01 00:00:00
abstract::The combined chemotherapy and photodynamic therapy have significant advantages for cancer treatments, which have higher therapeutic effects compared with other medicines. Herein, we focused on the synthesis of carbon quantum dot (CQD) based nanocarrier system. CQD and 5-aminolevulinic acid (5-ALA) were conjugated with...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1765431
更新日期:2020-12-01 00:00:00
abstract::Our objective was to evaluate the chemotherapeutic potential of oral poly lactide-co-glycolide (PLG, a synthetic polymer) nanoparticle encapsulated ethambutol in combination with PLG-nanoparticle encapsulated-(rifampicin + isoniazid + pyrazinamide) in a murine tuberculosis (TB) model. Our formulation was prepared by t...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500398076
更新日期:2006-07-01 00:00:00
abstract::Fluoroquinolones are broad-spectrum antimicrobial agents that seem to reach their intracellular target site (DNA gyrase) in Escherichia coli by means of an uptake process through the outer and inner membranes. Delivery of quinolones with liposomes has many advantages than the free form of the drug. Liposomes may repre...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540600640146
更新日期:2007-01-01 00:00:00
abstract::Pingyangmycin (PYM) has been applied clinically for many years to treat vascular malformations (VM) in China. The major limitation of PYM injections is quick diffusion from the injection site, which increases side effects, especially the possibility of pulmonary injury. In this paper, chitosan/glycerophosphate disodiu...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1444684
更新日期:2018-11-01 00:00:00
abstract::This study evaluated three chitosan-N-acetyl cysteine (CAC) conjugates of increasing molecular mass as a valuable tool to improve the absorption of drugs by assessing its permeation enhancing effect regarding the active P-gp substrate rhodamine-123 in comparison to the trans- and paracellular marker FD 4 both in rat i...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540802006708
更新日期:2008-05-01 00:00:00
abstract::Inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis is a chronic autoimmune disease affecting nearly five million people worldwide. Among all drug delivery system, oral administration is the most preferable route for colon-specific targeting and the treatment of IBD. Herein, an amphiphilic ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2016.1245367
更新日期:2017-11-01 00:00:00
abstract::A new strategy based on gastric retention is proposed for the treatment of Helicobacter pylori. (H. pylori). A synergism between a floating and a bioadhesive system has been explored. Floating microspheres containing the antiurease drug acetohydroxamic acid (AHA) were prepared by a novel quasi-emulsion solvent diffusi...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540260397837
更新日期:2002-10-01 00:00:00
abstract::Ketorolac tromethamine, a potent nonnarcotic analgesic agent and 800 times more potent than aspirin, is indicated for the short-term management of moderate to such severe painful states as post operative pain, acute musculoskeletal pain, and dental pain. It Given every 6 hr intramuscularly in patients for acute pain, ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500398092
更新日期:2008-08-01 00:00:00
abstract:CONTEXT:Paclitaxel (PTX) and carboplatin (CBP) are widely used for the combined chemotherapy of non-small cell lung cancer (NSCLC). However, the development of multidrug resistance of cancer cells, as well as systemic toxic side effects resulting from nonspecific localization of anticancer drugs to non-tumor areas are ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1035466
更新日期:2016-09-01 00:00:00
abstract::Ischemic stroke is one of the major causes of severe disability and death worldwide. It is mainly caused by a sudden reduction in cerebral blood flow due to obstruction of the supplying vessel by thrombi and subsequent initiation of a complex cascade of pathophysiological changes, which ultimately lead to brain ischem...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2021.1879315
更新日期:2021-12-01 00:00:00
abstract::To prolong the circulation time of drug, PEGylation has been widely used via the enhanced permeability and retention (EPR) effect, thereby providing new hope for better treatment. However, PEGylation also brings the "PEG dilemma", which is difficult for the cellular absorption of drugs and subsequent endosomal escape....
journal_title:Drug delivery
pub_type: 杂志文章,评审
doi:10.1080/10717544.2017.1388451
更新日期:2017-12-01 00:00:00
abstract::Chronic rhinosinusitis (CRS) is a rather prevalent condition with a chronic inflammatory process, which is hard to cure. Herein, a new antibacterial drug, nitric oxide (NO), was used for the attempt on CRS therapy. To achieve this, a star copolymer (β-CD-PAMAM) consisting of the β-cyclodextrin (β-CD) core and seven PA...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2021.1876183
更新日期:2021-12-01 00:00:00
abstract::Over the years, research has focused on strategies to increase benefit/risk ratio of corticoids. However, vehicles intended for topical glucocorticoids delivery with an improved benefit/risk ratio are still on demand. The aim of this work was the in vitro and in vivo characterization of cold processed oil-in-water (o/...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.871086
更新日期:2015-01-01 00:00:00
abstract::Sustained release (SR) matrix tablets of dextromethorphan hydrobromide were prepared by wet granulation using hydroxypropyl methyl cellulose (HPMC-K-100 CR) as the hydrophilic rate controlling polymer. The effect of the concentration of the polymer and different fillers on the in vitro drug release rate was studied. T...
journal_title:Drug delivery
pub_type: 杂志文章,随机对照试验
doi:10.1080/10717540802035301
更新日期:2008-09-01 00:00:00
abstract::Polysaccharide nucleic acid fractions of bacillus Calmette-Guérin, termed BCG-PSN, have traditionally been used as immunomodulators in the treatment of dermatitis and allergic diseases. While the sales of injectable BCG-PSN have shown steady growth in recent years, no reports of using BCG-PSN powder or its immunothera...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1391892
更新日期:2017-11-01 00:00:00
abstract::The prevalence of childhood dyslipidemia increases and is considered as an important risk factor for the incidence of cardiovascular disease in the adulthood. To improve dosing accuracy and facilitate the determination of dosing regimens in function of the body weight, the proposed study aims at preparing transdermal ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.980896
更新日期:2016-06-01 00:00:00
abstract::DNA vaccination is a promising approach for inducing both humoral and cellular immune responses. The mode of plasmid DNA delivery is critical to make progress in DNA vaccination. Using human papillomavirus type 16 E7 as a model antigen, this study evaluated the effect of peptide-polymer hybrid including PEI600-Tat con...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540902757721
更新日期:2009-05-01 00:00:00
abstract::Recently, exosomes have been emerged as promising drug delivery carriers, while certain tissues are intrinsically resistant to exosomes. Therapeutically improving the drug delivery efficiency in these tissues/organs would certainly broaden the potential application of exosomes in future. Ultrasound-targeted microbubbl...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1534898
更新日期:2019-12-01 00:00:00
abstract:CONTEXT:Designing a sustained release system for Carvedilol to increase its residence time in the stomach. OBJECTIVE:Preparation of floating microsphere by the emulsion solvent diffusion method, studying the effect of various process parameters and optimize the formulation using full factorial design. METHODS:Differe...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.834414
更新日期:2014-03-01 00:00:00