Alpha-lipoic acid-loaded nanostructured lipid carrier: sustained release and biocompatibility to HaCaT cells in vitro.

abstract：:Gastric cancer is a frequently occurring cancer with high mortality each year worldwide. Finding new and effective therapeutic strategy against human gastric cancer is still urgently required. Hence, we have established a new method to achieve treatment-actuated modifications in a tumor microenvironment by utilizing s...

journal_title：Drug delivery

authors： Xiao Y,Gao Y,Li F,Deng Z

更新日期：2020-12-01 00:00:00

abstract：:In the present study, pluronic lecithin based organogels (PLO gels) were formulated as topical carrier for controlled delivery of mefenamic acid. Ten organogel formulations were prepared by a method employing lecithin as lipophilic phase and pluronic F-127 as hydrophilic phase in varying concentrations to study variou...

journal_title：Drug delivery

authors： Jhawat V,Gupta S,Saini V

更新日期：2016-11-01 00:00:00

abstract：CONTEXT:Terbinafine hydrochloride is an antifungal drug for onychomycosis. Poor permeability of its external preparation leads to poor curative effect. Transfersomes, also known as flexible liposome, could improve transmission of drug for local external use. Terbinafine hydrochloride-loaded liposome is expected to beco...

journal_title：Drug delivery

authors： Yang Y,Ou R,Guan S,Ye X,Hu B,Zhang Y,Lu S,Zhou Y,Yuan Z,Zhang J,Li QG

更新日期：2015-12-01 00:00:00

abstract：:The combination of protein-coated graphene oxide (GO) and microencapsulation technology has moved a step forward in the challenge of improving long-term alginate encapsulated cell survival and sustainable therapeutic protein release, bringing closer its translation from bench to the clinic. Although this new approach ...

journal_title：Drug delivery

authors： Ciriza J,Saenz Del Burgo L,Gurruchaga H,Borras FE,Franquesa M,Orive G,Hernández RM,Pedraz JL

更新日期：2018-11-01 00:00:00

abstract：:Non-ionic surfactant vesicles, simply known as niosomes are synthetic vesicles with potential technological applications. Niosomes have the same potential advantages of phospholipid vesicles (liposomes) of being able to accommodate both water soluble and lipid soluble drug molecules control their release and as such s...

journal_title：Drug delivery

authors： Abdelkader H,Alani AW,Alany RG

更新日期：2014-03-01 00:00:00

abstract：:The purpose of this study was to characterize and evaluate tectorigenin-loaded self-microemulsifying drug delivery system (TG-SMEDDS), a previously studied preparation, and further confirm the improvement of TG in solubility and bioavailability. The appearance of TG-SMEDDS was clear and transparent, with good mobility...

journal_title：Drug delivery

authors： Zhang Y,He L,Yue S,Huang Q,Zhang Y,Yang J

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Vorinostat (VRS), a histone deacetylases inhibitor, has significant cytotoxic potential in a large number of human cancer cell lines. OBJECTIVE:To clarify its promising anticancer potential and to improve its drawback related to physical properties and in vivo performance of VRS. METHODS:VRS was successful...

journal_title：Drug delivery

authors： Tran TH,Chu DT,Truong DH,Tak JW,Jeong JH,Hoang VL,Yong CS,Kim JO

更新日期：2016-05-01 00:00:00

abstract：:Bioadhesive sodium alginate microspheres of Metoprolol tartrate (MT) for intranasal systemic delivery were prepared to avoid the first-pass effect, as an alternative therapy to injection, and to obtain improved therapeutic efficacy in the treatment of hypertension and angina pectoris. The microspheres (Ms) were prepar...

journal_title：Drug delivery

authors： Rajinikanth PS,Sankar C,Mishra B

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:Insulin is a hormone used in the treatment of diabetes mellitus. Multiple injections of insulin every day may causes pain, allergic reactions at injection site, which lead to low patient compliance. The aim of this work was to develop and evaluate an efficient solid lipid nanoparticle (SLN) carrier for oral d...

journal_title：Drug delivery

authors： Ansari MJ,Anwer MK,Jamil S,Al-Shdefat R,Ali BE,Ahmad MM,Ansari MN

更新日期：2016-07-01 00:00:00

abstract：:Pueraria lobata (Willd.) Ohwi is a medicinal and edible homologous plant with a long history in China. Puerarin, the main component isolated from the root of Pueraria lobata, possesses a wide range of pharmacological properties. Daidzein and glucuronides are the main metabolites of puerarin and are excreted in the uri...

journal_title：Drug delivery

authors： Zhang L

更新日期：2019-12-01 00:00:00

abstract：:At present, the chemotherapy of advanced inoperable liver cancer is limited with serious side effects. Curcumin possesses multiple cancer preventive activities and low safety concerns. However, its poor solubility and instability in water pose significant pharmacological barriers to its clinical application. In this s...

journal_title：Drug delivery

authors： Chang M,Wu M,Li H

更新日期：2018-11-01 00:00:00

abstract：:Carboplatin is a potent anticancer agent that has shown efficacy in clinical trials against malignant glioma, one of the most deadly cancers in humans. However, a high systemic dose is required to achieve an effective concentration in the brain because of the presence of the blood-brain barrier (BBB). Such a high dose...

journal_title：Drug delivery

authors： Chen W,He J,Olson JJ,Lu DR

更新日期：1997-01-01 00:00:00

abstract：:Surface modification of liposomes with polymer to optimize drug delivery was well developed recently. The objective of the present work was to evaluate the feasibility of chitosan-coated liposomes (CSLP) as vehicles for anti-sense oligodeoxynucleotides (ASON). CSLP was obtained by adding chitosan dropwise to liposomes...

journal_title：Drug delivery

authors： Wang WX,Gao JQ,Liang WQ

更新日期：2011-04-01 00:00:00

abstract：:Our objective was to evaluate the chemotherapeutic potential of oral poly lactide-co-glycolide (PLG, a synthetic polymer) nanoparticle encapsulated ethambutol in combination with PLG-nanoparticle encapsulated-(rifampicin + isoniazid + pyrazinamide) in a murine tuberculosis (TB) model. Our formulation was prepared by t...

journal_title：Drug delivery

authors： Pandey R,Sharma S,Khuller GK

更新日期：2006-07-01 00:00:00

abstract：:The distinct hormone molecules and receptors, such as follicle-stimulating hormone receptor (FSHR) in ovarian cancer, provide opportunities for more precisely targeted therapy. We previously developed FSHR-mediated nanoparticles and found that FSH peptides on the surface of nanoparticles improved the delivery of short...

journal_title：Drug delivery

authors： Hong SS,Zhang MX,Zhang M,Yu Y,Chen J,Zhang XY,Xu CJ

更新日期：2018-11-01 00:00:00

abstract：:This article describes the development of solid lipid nanoparticles (SLN) as colloidal carriers for cloricromene. Nanoparticles were prepared by the microemulsion or precipitation technique. In vitro drug release profile from SLN was studied under various experimental conditions mimicking some body fluids. The drug re...

journal_title：Drug delivery

authors： Bondì ML,Fontana G,Carlisi B,Giammona G

更新日期：2003-10-01 00:00:00

abstract：:Corneal neovascularization (CNV) is one of the major causes of severe disorders in ocular surface. Subconjunctival administration provides a localized and effective delivery of anti-angiogenic agents to inhibit neovascularization. In the present study, the ABA triblock copolymer of poly(D,L-lactic-co-glycolic acid)-bl...

journal_title：Drug delivery

authors： Liu D,Wu Q,Zhu Y,Liu Y,Xie X,Li S,Lin H,Chen W,Zhu F

更新日期：2019-12-01 00:00:00

abstract：:Glycyrrhizin or glycyrrhizic acid (GA) - triterpene glycoside extracted from licorice root - has been intensively studied over the past decade and is considered to be a potential drug delivery system. Glycyrrhizin was found to enhance the therapeutic effect of various drugs; however the detailed mechanism of these eff...

journal_title：Drug delivery

authors： Selyutina OY,Polyakov NE,Korneev DV,Zaitsev BN

更新日期：2016-01-01 00:00:00

abstract：:Radio-labeled hydrogel beads, based on amidated pectin, have been produced by adding droplets of an amidated pectin solution to calcium chloride. Incorporation of model drugs into the beads and measurement of the dissolution rate showed that the properties of the beads were unaffected by the incorporation of the radio...

journal_title：Drug delivery

authors： Munjeri O,Collett JH,Fell JT,Sharma HL,Smith AM

更新日期：1998-01-01 00:00:00

abstract：:Boronophenylalanine (BPA)-loaded conventional and stabilized liposomes were prepared by the reversed phase evaporation method to treat liver metastases by boron neutron capture therapy. Conventional vesicles were composed of phosphatidylcholine and cholesterol, molar ratio 1:1. To obtain stealth liposomes, GM1 or PEG ...

journal_title：Drug delivery

authors： Pavanetto F,Perugini P,Genta I,Minoia C,Ronchi A,Prati U,Roveda L,Nano R

更新日期：2000-04-01 00:00:00

abstract：:DNA vaccination is a promising approach for inducing both humoral and cellular immune responses. The mode of plasmid DNA delivery is critical to make progress in DNA vaccination. Using human papillomavirus type 16 E7 as a model antigen, this study evaluated the effect of peptide-polymer hybrid including PEI600-Tat con...

journal_title：Drug delivery

authors： Bolhassani A,Ghasemi N,Servis C,Taghikhani M,Rafati S

更新日期：2009-05-01 00:00:00

abstract：:The aim of this study was to obtain a stable, amorphous solid dispersion (SD) with Soluplus, prepared by hot-melt extrusion (HME) as an effective and stable oral delivery system to improve the physical stability and bioavailability of the poorly water-soluble simvastatin (SIM), a drug with relatively low Tg. The drug ...

journal_title：Drug delivery

authors： Zhang Y,Liu Y,Luo Y,Yao Q,Zhong Y,Tian B,Tang X

更新日期：2016-07-01 00:00:00

abstract：:Bone-metastasis prostate cancer (BMPCa)-targeting gene therapy is gaining increasing concern in recent years. The peptide T7-modified polypeptide nanoparticles for delivery DNA (CRD-PEG-T7/pPMEPA1) was prepared as our previous study. However, the feasibility of CRD-PEG-T7/pPMEPA1 for BMPCa treatment, the mechanisms un...

journal_title：Drug delivery

authors： Gu Y,Chen X,Zhang H,Wang H,Chen H,Huang S,Xu Y,Zhang Y,Wu X,Chen J

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:Designing a sustained release system for Carvedilol to increase its residence time in the stomach. OBJECTIVE:Preparation of floating microsphere by the emulsion solvent diffusion method, studying the effect of various process parameters and optimize the formulation using full factorial design. METHODS:Differe...

journal_title：Drug delivery

authors： Nila MV,Sudhir MR,Cinu TA,Aleykutty NA,Jose S

更新日期：2014-03-01 00:00:00

abstract：:The aim of this research was to develop pH-sensitive insulin-loaded NOCC (N,O-carboxymethyl chitosan) nanoparticles for the controlled release of insulin via the oral route. Thus, in this study, insulin-loaded NOCC nanoparticles were prepared by ionic gelation of NOCC with TPP (tripolyphosphate). NOCC nanoparticles we...

journal_title：Drug delivery

authors： Lin CC,Lin CW

更新日期：2009-11-01 00:00:00

abstract：:Transdermal delivery of non-steroidal anti-inflammatory drugs (NSAIDs) is an effective route of drug administration, as it directs the drug to the inflamed site with reduced incidence of systemic adverse effects such as gastric hemorrhage and ulcers. Tenoxicam (TNX) is a member of NSAIDs that are marketed only as oral...

journal_title：Drug delivery

authors： Bawazeer S,El-Telbany DFA,Al-Sawahli MM,Zayed G,Keed AAA,Abdelaziz AE,Abdel-Naby DH

更新日期：2020-12-01 00:00:00

abstract：:The ophthalmic drug delivery is a challenge in the clinical treatment of ocular diseases. The traditional drug administration usually shows apparent limitations, such as the low bioavailability from the reason of low penetration of the cornea and the short survival time of drug in the eyes. To overcome these shortcomi...

journal_title：Drug delivery

authors： Li C,Chen R,Xu M,Qiao J,Yan L,Guo XD

更新日期：2018-11-01 00:00:00

abstract：:IDEC-CE9.1/SB-210396 is a macaque/human chimeric IgG1 monoclonal antibody (mAb) directed against the human T-cell surface marker, CD4. This antibody has been evaluated as a potential treatment for rheumatoid arthritis and asthma, in which T cell activation is believed to play an important role in orchestrating inflamm...

journal_title：Drug delivery

authors： Davis CB,Bugelski PJ

更新日期：1998-01-01 00:00:00

abstract：:Novel itraconazole (ITZ)-loaded liposomes (ITZ-LPs) were prepared and their pharmacokinetics and biodistribution were assessed in comparison with commercial formulations (ITZ-CD). The ITZ-LPs were prepared by thin-film hydration method and the physicochemical characterizations of the ITZ-LPs were evaluated. The pharma...

journal_title：Drug delivery

authors： Tang J,Wei H,Liu H,Ji H,Dong D,Zhu D,Wu L

更新日期：2010-05-01 00:00:00

abstract：:The purpose of this work is to use biorelevant media to evaluate the robustness of a poorly water soluble weakly basic drug to variations along the gastrointestinal tract (GIT) after incorporation in liquisolid compacts and to assess the success of these models in predicting the in vivo performance. Liquisolid tablets...

journal_title：Drug delivery

authors： Badawy MA,Kamel AO,Sammour OA

更新日期：2016-01-01 00:00:00