Bioadhesive polymer/lipid hybrid nanoparticles as oral delivery system of raloxifene with enhancive intestinal retention and bioavailability.

abstract：:DNA vaccination is a promising approach for inducing both humoral and cellular immune responses. The mode of plasmid DNA delivery is critical to make progress in DNA vaccination. Using human papillomavirus type 16 E7 as a model antigen, this study evaluated the effect of peptide-polymer hybrid including PEI600-Tat con...

journal_title：Drug delivery

authors： Bolhassani A,Ghasemi N,Servis C,Taghikhani M,Rafati S

更新日期：2009-05-01 00:00:00

abstract：:Corneal neovascularization (CNV) is one of the major causes of severe disorders in ocular surface. Subconjunctival administration provides a localized and effective delivery of anti-angiogenic agents to inhibit neovascularization. In the present study, the ABA triblock copolymer of poly(D,L-lactic-co-glycolic acid)-bl...

journal_title：Drug delivery

authors： Liu D,Wu Q,Zhu Y,Liu Y,Xie X,Li S,Lin H,Chen W,Zhu F

更新日期：2019-12-01 00:00:00

abstract：:Ketorolac tromethamine, a potent nonnarcotic analgesic agent and 800 times more potent than aspirin, is indicated for the short-term management of moderate to such severe painful states as post operative pain, acute musculoskeletal pain, and dental pain. It Given every 6 hr intramuscularly in patients for acute pain, ...

journal_title：Drug delivery

authors： Sinha VR,Trehan A

更新日期：2008-08-01 00:00:00

abstract：:Polymer nano-sized hydrogels (nanogels) as drug delivery carriers have been investigated over the last few decades. Pullulan, a nontoxic and nonimmunogenic hydrophilic polysaccharide derived from fermentation of black yeast like Aureobasidium pullulans with great biocompatibility and biodegradability, is one of the mo...

journal_title：Drug delivery

authors： Zhang T,Yang R,Yang S,Guan J,Zhang D,Ma Y,Liu H

更新日期：2018-11-01 00:00:00

abstract：:Over the years, research has focused on strategies to increase benefit/risk ratio of corticoids. However, vehicles intended for topical glucocorticoids delivery with an improved benefit/risk ratio are still on demand. The aim of this work was the in vitro and in vivo characterization of cold processed oil-in-water (o/...

journal_title：Drug delivery

authors： Raposo S,Tavares R,Gonçalves L,Simões S,Urbano M,Ribeiro HM

更新日期：2015-01-01 00:00:00

abstract：:Administration of influenza vaccines to the lungs could be an attractive alternative to conventional parenteral administration. In this study, we investigated the deposition site of pulmonary delivered liquid and powder influenza vaccine formulations and its relation to their immunogenicity and protective efficacy. In...

journal_title：Drug delivery

authors： Bhide Y,Tomar J,Dong W,de Vries-Idema J,Frijlink HW,Huckriede A,Hinrichs WLJ

更新日期：2018-11-01 00:00:00

abstract：:The aim of this work was to prepare salts of 6-methoxy-2-naphthylacetic acid (6-MNA) to improve its physicochemical properties for percutaneous application. 6-MNA, an active metabolite of non-steroidal anti-inflammatory drug nabumetone has long half life and has the tendency to penetrate well into synovial fluid. The ...

journal_title：Drug delivery

authors： Pawar V,Kumar HY,Giridhar R,Yadav MR

更新日期：2015-05-01 00:00:00

abstract：CONTEXT:Paclitaxel (PTX) and carboplatin (CBP) are widely used for the combined chemotherapy of non-small cell lung cancer (NSCLC). However, the development of multidrug resistance of cancer cells, as well as systemic toxic side effects resulting from nonspecific localization of anticancer drugs to non-tumor areas are ...

journal_title：Drug delivery

authors： Zhang W,Li C,Shen C,Liu Y,Zhao X,Liu Y,Zou D,Gao Z,Yue C

更新日期：2016-09-01 00:00:00

abstract：:This work focused on the developmental aspects, pharmacokinetic evaluation, and pharmacological assessment of a drug inclusion complex for a novel camptothecin analog (CA) and 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). Camptothecins analog belong to topoisomerase-I inhibitor class of compounds with proven anti-tumor ac...

journal_title：Drug delivery

authors： Nekkanti V,Karatgi P,Paruchuri S,Pillai R

更新日期：2011-05-01 00:00:00

abstract：:HER2-positive breast cancer correlates with more aggressive tumor growth, a poorer prognosis and reduced overall survival. Currently, trastuzumab (Herceptin), which is an anti-HER2 antibody, is one of the key drugs. There is evidence indicating that conjugation of trastuzumab with chemotherapy drugs, such as doxorubic...

journal_title：Drug delivery

authors： You Y,Xu Z,Chen Y

更新日期：2018-11-01 00:00:00

abstract：:The aim of this work was to develop a novel and more efficient platform for sublingual drug delivery using mosapride citrate (MSP) as a model drug. The engineering of this delivery system had two stages, the first stage was tuning of MSP physicochemical properties by complexation with pure phosphatidylcholine or phosp...

journal_title：Drug delivery

authors： Morsi NM,Abdelbary GA,Elshafeey AH,Ahmed MA

更新日期：2017-11-01 00:00:00

abstract：:The aim of this study was to obtain a stable, amorphous solid dispersion (SD) with Soluplus, prepared by hot-melt extrusion (HME) as an effective and stable oral delivery system to improve the physical stability and bioavailability of the poorly water-soluble simvastatin (SIM), a drug with relatively low Tg. The drug ...

journal_title：Drug delivery

authors： Zhang Y,Liu Y,Luo Y,Yao Q,Zhong Y,Tian B,Tang X

更新日期：2016-07-01 00:00:00

abstract：:Atorvastatin (AT) is a widely used lipid-regulating drug to reduce cholesterol and triglycerides. Its poor aqueous solubility and hepatic metabolism require development of drug delivery systems able to improve its solubility and bypass hepatic effect. For this purpose, atorvastatin nanostructured lipid carriers (AT-NL...

journal_title：Drug delivery

authors： Elmowafy M,Ibrahim HM,Ahmed MA,Shalaby K,Salama A,Hefesha H

更新日期：2017-11-01 00:00:00

abstract：:The prevalence of childhood dyslipidemia increases and is considered as an important risk factor for the incidence of cardiovascular disease in the adulthood. To improve dosing accuracy and facilitate the determination of dosing regimens in function of the body weight, the proposed study aims at preparing transdermal ...

journal_title：Drug delivery

authors： Zidan AS,Hosny KM,Ahmed OA,Fahmy UA

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to formulate and evaluate the Ibuprofen niosomal formulation as a transdermal drug delivery system. MATERIALS AND METHODS:Niosomes were prepared by a modified ethanol injection method, using Span 60, Tween 60 and Tween 65 as well as cholesterol with various cholesterol:surfact...

journal_title：Drug delivery

authors： Ghanbarzadeh S,Khorrami A,Arami S

更新日期：2015-12-01 00:00:00

abstract：:Pueraria lobata (Willd.) Ohwi is a medicinal and edible homologous plant with a long history in China. Puerarin, the main component isolated from the root of Pueraria lobata, possesses a wide range of pharmacological properties. Daidzein and glucuronides are the main metabolites of puerarin and are excreted in the uri...

journal_title：Drug delivery

authors： Zhang L

更新日期：2019-12-01 00:00:00

abstract：:Tuberculosis (TB) has gained attention over the past few decades by becoming one of the top ten leading causes of death worldwide. This infectious disease of the lungs is orally treated with a medicinal armamentarium. However, this route of administration passes through the body's first-pass metabolism which reduces t...

journal_title：Drug delivery

authors： Poh W,Ab Rahman N,Ostrovski Y,Sznitman J,Pethe K,Loo SCJ

更新日期：2019-12-01 00:00:00

abstract：:Chitosan, a natural-based polymer obtained by alkaline deacetylation of chitin, is nontoxic, biocompatible, and biodegradable. These properties make chitosan a good candidate for conventional and novel drug delivery systems. This article reviews the approaches aimed to associate bioactive molecules to chitosan in the ...

journal_title：Drug delivery

authors： Prabaharan M,Mano JF

更新日期：2005-01-01 00:00:00

abstract：:Nasal colonization of Staphylococcus aureus (S.aureus) is known as a significant risk factor for nosocomial infections, and clearance of its nasal colonization greatly reduces the risk. In the present study the preparation and characterizations of the chitosan-o/w cream incorporated with lysostaphin (CCL) were describ...

journal_title：Drug delivery

authors： Cui F,Li G,Huang J,Zhang J,Lu M,Lu W,Huang Q

更新日期：2010-11-01 00:00:00

abstract：:A mesoporous material based on aluminosilicate mixture was studied to investigate its ability to include drugs and then release them. Nonsteroidal anti-inflammatory agents such as diflunisal, naproxen, ibuprofen and its sodium salt have been used in this study. The preparation of the mesoporous material and its charac...

journal_title：Drug delivery

authors： Cavallaro G,Pierro P,Palumbo FS,Testa F,Pasqua L,Aiello R

更新日期：2004-01-01 00:00:00

abstract：:Effective clinical utilization of non-steroidal anti-inflammatory drugs such as diclofenac sodium (DS) is significantly limited by their ulcerogenic potential and poor bioavailability after oral administration, thus necessitating the need for a better carrier to minimize these obvious limitations. The objective of thi...

journal_title：Drug delivery

authors： Momoh MA,Kenechukwu FC,Adedokun MO,Odo CE,Attama AA

更新日期：2014-05-01 00:00:00

abstract：:This study aimed to evaluate transdermal delivery of vancomycin hydrochloride using the combination of ethosomes as an encapsulating vesicle and iontophoresis. Ethosomes were prepared and evaluated in terms of electrochemical stability. Cathodal iontophoresis of negatively charged ethosomes and anodal iontophoresis of...

journal_title：Drug delivery

authors： Mohammed MI,Makky AM,Teaima MH,Abdellatif MM,Hamzawy MA,Khalil MA

更新日期：2016-06-01 00:00:00

abstract：:Enrofloxacin, a third-generation fluoroquinolone, is a broad-spectrum antimicrobial drug against a lot of veterinary bacterial diseases. However, bactericidal activity of enrofloxacin is concentration-dependent and its poor aqueous solubility and bitter taste limit its development and application. Meanwhile, 2-hydroxy...

journal_title：Drug delivery

authors： Ding Y,Pang Y,Vara Prasad CVNS,Wang B

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Vorinostat (VRS), a histone deacetylases inhibitor, has significant cytotoxic potential in a large number of human cancer cell lines. OBJECTIVE:To clarify its promising anticancer potential and to improve its drawback related to physical properties and in vivo performance of VRS. METHODS:VRS was successful...

journal_title：Drug delivery

authors： Tran TH,Chu DT,Truong DH,Tak JW,Jeong JH,Hoang VL,Yong CS,Kim JO

更新日期：2016-05-01 00:00:00

abstract：:Melatonin, a pineal gland hormone, exerts oncostatic activity in several types of human cancer, including prostate, the most common neoplasia and the third most frequent cause of male cancer death in the developed world. The growth of androgen-sensitive LNCaP prostate cancer cells in mice is inhibited by 3 mg/kg/week ...

journal_title：Drug delivery

authors： Terraneo L,Bianciardi P,Virgili E,Finati E,Samaja M,Paroni R

更新日期：2017-11-01 00:00:00

abstract：:Recently, exosomes have been emerged as promising drug delivery carriers, while certain tissues are intrinsically resistant to exosomes. Therapeutically improving the drug delivery efficiency in these tissues/organs would certainly broaden the potential application of exosomes in future. Ultrasound-targeted microbubbl...

journal_title：Drug delivery

authors： Sun W,Li Z,Zhou X,Yang G,Yuan L

更新日期：2019-12-01 00:00:00

abstract：:This study focused on preparation and evaluation of a thermosensitive and mucoadhesive in situ gelling ophthalmic system of azithromycin (ATM). Poloxamer 407 (P407) and poloxamer 188 (P188) were used as gelling agents. Addition of Carbopol 974P (CP 974P) to the gelling systems could increase the solubility of ATM by s...

journal_title：Drug delivery

authors： Cao F,Zhang X,Ping Q

更新日期：2010-09-01 00:00:00

abstract：:Bone-metastasis prostate cancer (BMPCa)-targeting gene therapy is gaining increasing concern in recent years. The peptide T7-modified polypeptide nanoparticles for delivery DNA (CRD-PEG-T7/pPMEPA1) was prepared as our previous study. However, the feasibility of CRD-PEG-T7/pPMEPA1 for BMPCa treatment, the mechanisms un...

journal_title：Drug delivery

authors： Gu Y,Chen X,Zhang H,Wang H,Chen H,Huang S,Xu Y,Zhang Y,Wu X,Chen J

更新日期：2020-12-01 00:00:00

abstract：:Glycyrrhizin or glycyrrhizic acid (GA) - triterpene glycoside extracted from licorice root - has been intensively studied over the past decade and is considered to be a potential drug delivery system. Glycyrrhizin was found to enhance the therapeutic effect of various drugs; however the detailed mechanism of these eff...

journal_title：Drug delivery

authors： Selyutina OY,Polyakov NE,Korneev DV,Zaitsev BN

更新日期：2016-01-01 00:00:00

abstract：:ALA-loaded nanostructured lipid carrier (ALA-NLC) was designed to improve physicochemical stability and water solubility, and promote sustained release of ALA as well as determine the biocompatibility of ALA-NLC. The ALA-NLC manufactured using hot high-pressure homogenization technique was investigated in terms of siz...

journal_title：Drug delivery

authors： Wang J,Xia Q

更新日期：2014-08-01 00:00:00