Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin.

Abstract:

:Enrofloxacin, a third-generation fluoroquinolone, is a broad-spectrum antimicrobial drug against a lot of veterinary bacterial diseases. However, bactericidal activity of enrofloxacin is concentration-dependent and its poor aqueous solubility and bitter taste limit its development and application. Meanwhile, 2-hydroxypropyl-β-cyclodextrin (HP-β-CD), a widely used cyclodextrin analog, is a safe and an effective drug carrier. It forms inclusion complexes with its drug substrates and improves their physiochemical and pharmacokinetic properties. Enrofloxacin was also found to form a stable inclusion complex with HP-β-CD and different research groups have shown improved solubility for enrofloxacin by 32.5%, 9.25 and 165-fold. Our own efforts in this direction resulted in manifold improvement (916-fold) in its solubility compared to the previous studies. It was further shown that pharmaceutical properties, absorption and bioavailability, of enrofloxacin have also been significantly improved by complexation with HP-β-CD.

journal_name

Drug Deliv

journal_title

Drug delivery

authors

Ding Y,Pang Y,Vara Prasad CVNS,Wang B

doi

10.1080/10717544.2020.1724210

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

334-343

issue

1

eissn

1071-7544

issn

1521-0464

journal_volume

27

pub_type

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