Curcumin-loaded lipid nanocarrier for improving bioavailability, stability and cytotoxicity against malignant glioma cells.

abstract：BACKGROUND:Vorinostat (VRS), a histone deacetylases inhibitor, has significant cytotoxic potential in a large number of human cancer cell lines. OBJECTIVE:To clarify its promising anticancer potential and to improve its drawback related to physical properties and in vivo performance of VRS. METHODS:VRS was successful...

journal_title：Drug delivery

authors： Tran TH,Chu DT,Truong DH,Tak JW,Jeong JH,Hoang VL,Yong CS,Kim JO

更新日期：2016-05-01 00:00:00

abstract：:Over the years, research has focused on strategies to increase benefit/risk ratio of corticoids. However, vehicles intended for topical glucocorticoids delivery with an improved benefit/risk ratio are still on demand. The aim of this work was the in vitro and in vivo characterization of cold processed oil-in-water (o/...

journal_title：Drug delivery

authors： Raposo S,Tavares R,Gonçalves L,Simões S,Urbano M,Ribeiro HM

更新日期：2015-01-01 00:00:00

abstract：:Our objective was to evaluate the chemotherapeutic potential of oral poly lactide-co-glycolide (PLG, a synthetic polymer) nanoparticle encapsulated ethambutol in combination with PLG-nanoparticle encapsulated-(rifampicin + isoniazid + pyrazinamide) in a murine tuberculosis (TB) model. Our formulation was prepared by t...

journal_title：Drug delivery

authors： Pandey R,Sharma S,Khuller GK

更新日期：2006-07-01 00:00:00

abstract：:Various ocular diseases like glaucoma, conjunctivitis, and dry eye syndrome require frequent drug administration. Poor ocular bioavailability of drugs (< 1%) from conventional eye drops is due mainly to the precorneal loss factors that include rapid tear turnover, nonproductive absorption, transient residence time in ...

journal_title：Drug delivery

authors： Gupta H,Jain S,Mathur R,Mishra P,Mishra AK,Velpandian T

更新日期：2007-11-01 00:00:00

abstract：:Tuberculosis (TB) has gained attention over the past few decades by becoming one of the top ten leading causes of death worldwide. This infectious disease of the lungs is orally treated with a medicinal armamentarium. However, this route of administration passes through the body's first-pass metabolism which reduces t...

journal_title：Drug delivery

authors： Poh W,Ab Rahman N,Ostrovski Y,Sznitman J,Pethe K,Loo SCJ

更新日期：2019-12-01 00:00:00

abstract：:The combined chemotherapy and photodynamic therapy have significant advantages for cancer treatments, which have higher therapeutic effects compared with other medicines. Herein, we focused on the synthesis of carbon quantum dot (CQD) based nanocarrier system. CQD and 5-aminolevulinic acid (5-ALA) were conjugated with...

journal_title：Drug delivery

authors： Li X,Vinothini K,Ramesh T,Rajan M,Ramu A

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:This study introduces the structural design, working principles, performance testing and treatment effects of a newly developed ultrasonic irradiation delivery and treatment catheter system that integrates interventional catheterization technology. BACKGROUND:Systemic administration method needs a high dose...

journal_title：Drug delivery

authors： Yuan QY,Huang J,Li XJ,Peng JB,Li XS,Chen ZP,Si LY

更新日期：2013-08-01 00:00:00

abstract：:This research evaluated 7525DLPCL for soft flexible drug delivery systems. The effect of ciprofloxacin hydrochloride (CIP) loading at three levels (10, 20, and 30%), on thermo-mechanical properties was studied. CIP release was monitored for 12 weeks. Addition of CIP to 7525DLPCL caused an increase in compressive modul...

journal_title：Drug delivery

authors： Waknis V,Jonnalagadda S

更新日期：2011-05-01 00:00:00

abstract：:In vitro characteristics of the human erythrocytes loaded by enalaprilat have been evaluated. Erythrocytes obtained from a healthy volunteer were loaded by enalaprilat using the hypotonic preswelling method, and the loading parameters, drug-release kinetics, hematological indices, particle size distribution, scanning ...

journal_title：Drug delivery

authors： Hamidi M,Tajerzadeh H,Dehpour AR,Rouini MR,Ejtemaee-Mehr S

更新日期：2001-10-01 00:00:00

abstract：:The aim of this research was to develop pH-sensitive insulin-loaded NOCC (N,O-carboxymethyl chitosan) nanoparticles for the controlled release of insulin via the oral route. Thus, in this study, insulin-loaded NOCC nanoparticles were prepared by ionic gelation of NOCC with TPP (tripolyphosphate). NOCC nanoparticles we...

journal_title：Drug delivery

authors： Lin CC,Lin CW

更新日期：2009-11-01 00:00:00

abstract：:To develop statistically optimized brain targeted Tween 80 coated chitosan nanoparticulate formulation for oral delivery of doxycycline hydrochloride for the treatment of psychosis and to evaluate its protective effect on ketamine induced behavioral, biochemical, neurochemical and histological alterations in mice. 32 ...

journal_title：Drug delivery

authors： Yadav M,Parle M,Sharma N,Dhingra S,Raina N,Jindal DK

更新日期：2017-11-01 00:00:00

abstract：:Boronophenylalanine (BPA)-loaded conventional and stabilized liposomes were prepared by the reversed phase evaporation method to treat liver metastases by boron neutron capture therapy. Conventional vesicles were composed of phosphatidylcholine and cholesterol, molar ratio 1:1. To obtain stealth liposomes, GM1 or PEG ...

journal_title：Drug delivery

authors： Pavanetto F,Perugini P,Genta I,Minoia C,Ronchi A,Prati U,Roveda L,Nano R

更新日期：2000-04-01 00:00:00

abstract：:The aim of the current study was to formulate terconazole (TCZ) loaded polymeric mixed micelles (PMMs) incorporating Cremophor EL as a stabilizer and a penetration enhancer. A 23 full factorial design was performed using Design-Expert® software for the optimization of the PMMs which were formulated using Pluronic P123...

journal_title：Drug delivery

authors： Abd-Elsalam WH,El-Zahaby SA,Al-Mahallawi AM

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to formulate and evaluate the Ibuprofen niosomal formulation as a transdermal drug delivery system. MATERIALS AND METHODS:Niosomes were prepared by a modified ethanol injection method, using Span 60, Tween 60 and Tween 65 as well as cholesterol with various cholesterol:surfact...

journal_title：Drug delivery

authors： Ghanbarzadeh S,Khorrami A,Arami S

更新日期：2015-12-01 00:00:00

abstract：:Hypoxic microenvironment commonly occurred in the solid tumors considerably decreases the chemosensitivity of cancer cells. Salidroside (Sal), the main active ingredient of Rhodiola rosea, was shown to be able of regulating the tumor hypoxia micro-environment and enhancing the chemotherapeutic efficacy of drug-resista...

journal_title：Drug delivery

authors： Zhang Z,Yang W,Ma F,Ma Q,Zhang B,Zhang Y,Liu Y,Liu H,Hua Y

更新日期：2020-12-01 00:00:00

abstract：:In present study, two types of micelles based on sodium cholate (NaC) were prepared through non-covalent bonding interaction and the potential of micelles as oral drug delivery systems for paclitaxel (PTX) was evaluated. Pluronic-chitosan (F127-CS) and Pluronic-poly (acrylic acid) (F127-PAA) copolymers were synthesize...

journal_title：Drug delivery

authors： Ge Y,Zhao Y,Li L

更新日期：2016-09-01 00:00:00

abstract：:Discovery of novel pharmacological effects of berberine hydrochloride (BH) has made its clinical application valuable. However, further development and applications of BH are hampered by its short half-life and the side effects associated with its intravenous (iv) injection. To improve the hypolipidemia efficacy and r...

journal_title：Drug delivery

authors： Cheng Z,Liu S,Wu X,Raza F,Li Y,Yuan W,Qiu M,Su J

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:Propolis has traditionally been used in curing infections and healing wounds and burns. OBJECTIVE:The aim of this study is to formulate pluronic lecithin organogel of propolis to improve its availability and antimicrobial activity. MATERIALS AND METHODS:Different organogels were prepared by using soybean leci...

journal_title：Drug delivery

authors： Balata G,El Nahas HM,Radwan S

更新日期：2014-02-01 00:00:00

abstract：:A micelle system modified with α-Conotoxin ImI (ImI), a potently antagonist for alpha7 nicotinic acetylcholine receptor (α7-nAChR) previously utilized for targeting breast cancer, was constructed. Its targeting efficiency and cytotoxicity against non-small cell lung cancer (NSCLC) highly expressing α7-nAChR was invest...

journal_title：Drug delivery

authors： Mei D,Zhao L,Chen B,Zhang X,Wang X,Yu Z,Ni X,Zhang Q

更新日期：2018-11-01 00:00:00

abstract：:In order to enhance the interaction between nanocarrier and gastrointestinal epithelial cells, we developed nanoparticles (NPs) modified with targeting ligand FQSIYPpIK (FQS), which specifically interact with integrin αvβ3 receptor expressing on the intestinal epithelium. The targeting NPs were prepared by coating the...

journal_title：Drug delivery

authors： Liu C,Shan W,Liu M,Zhu X,Xu J,Xu Y,Huang Y

更新日期：2016-07-01 00:00:00

abstract：:Polymer nano-sized hydrogels (nanogels) as drug delivery carriers have been investigated over the last few decades. Pullulan, a nontoxic and nonimmunogenic hydrophilic polysaccharide derived from fermentation of black yeast like Aureobasidium pullulans with great biocompatibility and biodegradability, is one of the mo...

journal_title：Drug delivery

authors： Zhang T,Yang R,Yang S,Guan J,Zhang D,Ma Y,Liu H

更新日期：2018-11-01 00:00:00

abstract：:The present work aimed to apply the liquid antisolvent precipitation (LAP) method for preparing the apigenin nanoparticles and thereby improving the solubility and bioavailability of apigenin. The different experimental parameters on particle size were optimized through central composite design (CCD) using the Design-...

journal_title：Drug delivery

authors： Wu W,Zu Y,Wang L,Wang L,Wang H,Li Y,Wu M,Zhao X,Fu Y

更新日期：2017-11-01 00:00:00

abstract：:The objective of this study was to establish a drug transport study using human nasal epithelial (HNE) cell monolayers cultured by the air-liquid interface (ALI) method using serum-free medium (BEGM:DME/F12, 50:50). The cells were developed and characterized in comparison to those that have been previously cultured by...

journal_title：Drug delivery

authors： Lee MK,Yoo JW,Lin H,Kim YS,Kim DD,Choi YM,Park SK,Lee CH,Roh HJ

更新日期：2005-09-01 00:00:00

abstract：:In this study, transdermal etodolac-loaded cubosomes were developed in order to relieve patient pain and joints stiffness by providing stable etodolac concentration at the targeting sites through controlled drug delivery via the noninvasive skin route with more sustaining and less frequent dosing. Different ratios and...

journal_title：Drug delivery

authors： Salah S,Mahmoud AA,Kamel AO

更新日期：2017-11-01 00:00:00

abstract：:The aim of this research was to increase the oral bioavailability of puerarin by N-trimethyl chitosan-modified microemulsions (TMC-MEs) loaded with puerarin. Different concentrations of TMC-modified microemulsions were prepared in our study, and then evaluated for particle size, zeta potential, morphological observati...

journal_title：Drug delivery

authors： Liao D,Liu X,Dai W,Tang T,Ou G,Zhang K,Han M,Kang R,Yang S,Xiang D

更新日期：2015-01-01 00:00:00

abstract：:The main aim of this work was to develop rectal suppositories for better delivery of metoprolol tartrate (MT). The various bases used were fatty, water soluble and emulsion bases. The physical properties of the prepared suppositories were characterized such as weight variation, hardness, disintegration time, melting r...

journal_title：Drug delivery

authors： Abou el Ela Ael S,Allam AA,Ibrahim EH

更新日期：2016-01-01 00:00:00

abstract：:Transdermal delivery of non-steroidal anti-inflammatory drugs (NSAIDs) is an effective route of drug administration, as it directs the drug to the inflamed site with reduced incidence of systemic adverse effects such as gastric hemorrhage and ulcers. Tenoxicam (TNX) is a member of NSAIDs that are marketed only as oral...

journal_title：Drug delivery

authors： Bawazeer S,El-Telbany DFA,Al-Sawahli MM,Zayed G,Keed AAA,Abdelaziz AE,Abdel-Naby DH

更新日期：2020-12-01 00:00:00

abstract：:Systemic drug delivery systems (SDDSs) for thyroid cancer treatment are associated with serious side effects including nausea, anorexia, and hair loss as a result of damage to normal tissues. In this study, we investigated the feasibility of a local DDS (LDDS) based on visible light-cured glycol chitosan (GC) hydrogel...

journal_title：Drug delivery

authors： Yoo Y,Yoon SJ,Kim SY,Lee DW,Um S,Hyun H,Hong SO,Yang DH

更新日期：2018-11-01 00:00:00

abstract：:Combined administration of different drugs is a widely acknowledged approach for effective cancer therapy. However, the limited targeting, as well as inferior drug loading capacities of current drug delivery systems (DDS), are still the bottleneck for better performance in cancer treatment. Herein, we successfully dev...

journal_title：Drug delivery

authors： Li D,Cui R,Xu S,Liu Y

更新日期：2020-12-01 00:00:00

abstract：:This study evaluated three chitosan-N-acetyl cysteine (CAC) conjugates of increasing molecular mass as a valuable tool to improve the absorption of drugs by assessing its permeation enhancing effect regarding the active P-gp substrate rhodamine-123 in comparison to the trans- and paracellular marker FD 4 both in rat i...

journal_title：Drug delivery

authors： Schmitz T,Hombach J,Bernkop-Schnürch A

更新日期：2008-05-01 00:00:00