Abstract:
OBJECTIVE:In the present study, Curcumin (CU)-loaded nanocarrier (NC) such as nanoemulsion (NE) was developed with the objective of increasing its cytotoxicity and bioavailability through lymphatic transport by enhancing its solubility and intestinal permeability. MATERIALS AND METHODS:Based on the area obtained in pseudoternary phase diagram, various % combination of Labrafac Lipophile WL 1349, Solutol HS 15, Transcutol HP and distilled water were selected. Formulations which passed physical stability studies were selected for further studies such as globule size, zeta potential, in vitro release, ex vivo permeation, in vitro lipolysis studies, bioavailability studies and cytotoxicity against glioblastoma cells (U-87). RESULT AND DISCUSSION:The optimized NC (NE-SB1) had small average globule diameter of 67 ± 6 nm with zeta potential of -37 ± 2.5 mv which indicated long-term dispersion stability. During in vitro lipolysis study, the digestion rate of medium chain triglycerides increased with decreased globule diameter. Statistically significant difference was found in AUC0-inf of NC formulation (p < 0.05) compared to CU suspension. The relative bioavailability of NC was found 11.88 ± 0.47 with respect to CU suspension. During cytotoxicity studies, IC50 of CU solution on U87 cells was found 24.23 µM, while for the NE- SB1 it was 16.41 µM. The optimized formulation was found to be stable during 6 months of accelerated stability. CONCLUSION:The overall results revealed that the CU-loaded NC is a very effective approach for enhancing the oral absorption of poorly water-soluble drug CU and have great potential for future clinical application.
journal_name
Drug Delivjournal_title
Drug deliveryauthors
Kumar A,Ahuja A,Ali J,Baboota Sdoi
10.3109/10717544.2014.909906subject
Has Abstractpub_date
2016-01-01 00:00:00pages
214-29issue
1eissn
1071-7544issn
1521-0464journal_volume
23pub_type
杂志文章相关文献
DRUG DELIVERY文献大全abstract::Alzheimer's disease is a neurodegenerative disorder mainly characterized by β-amyloid deposit and tau hyperphosphorylation with no curative treatments. Curcumin (Cur) has been proved to have potential use in Alzheimer's disease with its anti-amyloid, anti-inflammatory, and anti-oxidant properties, etc. However, its hy...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1461955
更新日期:2018-11-01 00:00:00
abstract::The combined chemotherapy and photodynamic therapy have significant advantages for cancer treatments, which have higher therapeutic effects compared with other medicines. Herein, we focused on the synthesis of carbon quantum dot (CQD) based nanocarrier system. CQD and 5-aminolevulinic acid (5-ALA) were conjugated with...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1765431
更新日期:2020-12-01 00:00:00
abstract::The aim of this research was to develop pH-sensitive insulin-loaded NOCC (N,O-carboxymethyl chitosan) nanoparticles for the controlled release of insulin via the oral route. Thus, in this study, insulin-loaded NOCC nanoparticles were prepared by ionic gelation of NOCC with TPP (tripolyphosphate). NOCC nanoparticles we...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717540903353090
更新日期:2009-11-01 00:00:00
abstract::Electro-phonophoresis (EP) has been used in various clinical fields. The objective of present study is to evaluate the skin permeability of isoniazid (INH) and rifampicin (RIF) in patients with tuberculous lymphadenitis with the aid of EP to validate the clinical applications of this transdermal delivery system for th...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1124474
更新日期:2016-06-01 00:00:00
abstract::ALA-loaded nanostructured lipid carrier (ALA-NLC) was designed to improve physicochemical stability and water solubility, and promote sustained release of ALA as well as determine the biocompatibility of ALA-NLC. The ALA-NLC manufactured using hot high-pressure homogenization technique was investigated in terms of siz...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.846435
更新日期:2014-08-01 00:00:00
abstract::Agomelatine (AGM) is an antidepressant drug with a low absolute bioavailability due to the hepatic first pass metabolism. AGM-loaded solid lipid nanoparticles were formulated in the form of an in situ gel to prolong the intranasal retention time and subsequently to increase the absorbed amount of AGM. The optimized in...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1357148
更新日期:2017-11-01 00:00:00
abstract::Ischemic stroke is one of the major causes of severe disability and death worldwide. It is mainly caused by a sudden reduction in cerebral blood flow due to obstruction of the supplying vessel by thrombi and subsequent initiation of a complex cascade of pathophysiological changes, which ultimately lead to brain ischem...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2021.1879315
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Intraoral drug delivery as mucosal delivery pathway provides a huge platform in the pharmaceutical field. OBJECTIVE:Combining mucoadhesiveness and controlled release of thio-poly acrylic acid as advanced excipient for buccal drug delivery. MATERIALS AND METHODS:Mediated by carbodiimide, cysteine was covalentl...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1122673
更新日期:2016-07-01 00:00:00
abstract:CONTEXT:Humic acid (HA), a natural organic matter is recently being investigated for pharmaceutical purposes. Andrographolide (AGP), a potent hepatoprotective, possesses low aqueous solubility which results in a low bioavailability after oral administration, inappropriate tissue localization and consequently poor thera...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.871602
更新日期:2015-01-01 00:00:00
abstract::In the present study, the stability of thymopentin (TP5) in bronchoalveolar lavage fluid (BALF) in presence of potential excipients in inhalation formulation was investigated. The content of TP5 was determined using HPLC method. Commonly used bulking agent, dispersibility enhancers and absorption enhancers in inhalati...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.878002
更新日期:2014-09-01 00:00:00
abstract::Recently, genkwanin (GKA) has been shown to display in vitro antitumor activity against some cancer cells, but its poor solubility restricted the in vivo study and further investigation of its antitumor therapeutic efficacy. In this paper, genkwanin nanosuspensions (GKA-NSps) were successfully prepared using D-alpha t...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1384519
更新日期:2017-11-01 00:00:00
abstract::A novel niosomal delivery system was designed and investigated for the targeted delivery of daunorubicin (DNR) against acute myeloid leukemia (AML). Anti-CD123 antibodies conjugated to Mal-PEG2000-DSPE were incorporated into normal niosomes (NS) via a post insertion method to afford antibody-modified niosomes (CD123-N...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1333170
更新日期:2017-11-01 00:00:00
abstract::Surface modification of liposomes with polymer to optimize drug delivery was well developed recently. The objective of the present work was to evaluate the feasibility of chitosan-coated liposomes (CSLP) as vehicles for anti-sense oligodeoxynucleotides (ASON). CSLP was obtained by adding chitosan dropwise to liposomes...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2010.549526
更新日期:2011-04-01 00:00:00
abstract::In this paper, orally nanocrystal capsules were produced using nanocrystal formulations in order to optimize dissolution properties of poorly soluble drug glimepiride and improve its bioavailability. The important preparation variables, such as stabilizers, the power input and the time length of ultrasonication on the...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2012.742939
更新日期:2013-01-01 00:00:00
abstract::Three formulations including methylene blue solution (MB-S), MB water-in-oil microemulsion (MB-ME), and MB multiple microemulsion (MB-MME) were prepared with the aim to evaluate whether the three formulations can carry MB target to regional lymph nodes and show lymphatic tropism after subcutaneous administration. The ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540903075644
更新日期:2009-10-01 00:00:00
abstract::Pulmonary bed can retain microparticles (MP) larger than their capillaries' diameter, hence we offer a promising way for lung passive targeting following intravenous (IV) administration. In this study, enoxaparin (Enox)-albumin microspheres (Enox-Alb MS) were, optimally, developed as lung targeted sustained release MP...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2016.1245368
更新日期:2017-11-01 00:00:00
abstract::Although convection-enhanced delivery (CED) can successfully facilitate a bypass of the blood brain barrier, its treatment efficacy remains highly limited in clinic. This can be partially attributed to the brain anisotropic characteristics that lead to the difficulties in controlling the drug spatial distribution. Her...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2019.1639844
更新日期:2019-12-01 00:00:00
abstract::Atorvastatin (AT) is a widely used lipid-regulating drug to reduce cholesterol and triglycerides. Its poor aqueous solubility and hepatic metabolism require development of drug delivery systems able to improve its solubility and bypass hepatic effect. For this purpose, atorvastatin nanostructured lipid carriers (AT-NL...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1337823
更新日期:2017-11-01 00:00:00
abstract::The study was aimed at evaluating the effectiveness of liposomal, micellar, and water-soluble drug forms of diminazene for its localization in cells and selective accumulation at the sites of aggregation of pathogenic organisms. Pharmacological and dynamic properties of a new injection micellar diminazene preparation ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500459084
更新日期:2006-09-01 00:00:00
abstract::This work evaluates solid lipid nanoparticles of thiopental sodium against obesity-induced cardiac dysfunction and hypertrophy and explores the possible mechanism of action. TS loaded SLNs were formulated by hot-homogenization and solvent diffusion method. TS-SLNs were scrutinized for entrapment efficiency, drug loadi...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1803449
更新日期:2020-12-01 00:00:00
abstract::IDEC-CE9.1/SB-210396 is a macaque/human chimeric IgG1 monoclonal antibody (mAb) directed against the human T-cell surface marker, CD4. This antibody has been evaluated as a potential treatment for rheumatoid arthritis and asthma, in which T cell activation is believed to play an important role in orchestrating inflamm...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717549809031384
更新日期:1998-01-01 00:00:00
abstract::Amphiphilic diblock copolymers composed of methoxy poly ethylene glycol (MePEG) and poly epsilon caprolactone (PCL) were synthesized for the formation of micelles by ring opening mechanism using stannous octoate as a catalyst. The effects of the molecular weight of MePEG and the copolymer ratio on the properties of mi...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717541003720688
更新日期:2010-07-01 00:00:00
abstract::The purpose of this work is to use biorelevant media to evaluate the robustness of a poorly water soluble weakly basic drug to variations along the gastrointestinal tract (GIT) after incorporation in liquisolid compacts and to assess the success of these models in predicting the in vivo performance. Liquisolid tablets...
journal_title:Drug delivery
pub_type: 杂志文章,随机对照试验
doi:10.3109/10717544.2014.917442
更新日期:2016-01-01 00:00:00
abstract::Ocular drug delivery remains challenging because of the complex nature and structure of the eye. Conventional systems, such as eye drops and ointments, are inefficient, whereas systemic administration requires high doses resulting in significant toxicity. There is a need to develop novel drug delivery carriers capable...
journal_title:Drug delivery
pub_type: 杂志文章,评审
doi:10.3109/10717544.2010.483257
更新日期:2010-09-01 00:00:00
abstract::The present work aimed to apply the liquid antisolvent precipitation (LAP) method for preparing the apigenin nanoparticles and thereby improving the solubility and bioavailability of apigenin. The different experimental parameters on particle size were optimized through central composite design (CCD) using the Design-...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1399302
更新日期:2017-11-01 00:00:00
abstract::Hypoxic microenvironment commonly occurred in the solid tumors considerably decreases the chemosensitivity of cancer cells. Salidroside (Sal), the main active ingredient of Rhodiola rosea, was shown to be able of regulating the tumor hypoxia micro-environment and enhancing the chemotherapeutic efficacy of drug-resista...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1754528
更新日期:2020-12-01 00:00:00
abstract::In vitro characteristics of the human erythrocytes loaded by enalaprilat have been evaluated. Erythrocytes obtained from a healthy volunteer were loaded by enalaprilat using the hypotonic preswelling method, and the loading parameters, drug-release kinetics, hematological indices, particle size distribution, scanning ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/107175401317245903
更新日期:2001-10-01 00:00:00
abstract::The aim of this study was to obtain a stable, amorphous solid dispersion (SD) with Soluplus, prepared by hot-melt extrusion (HME) as an effective and stable oral delivery system to improve the physical stability and bioavailability of the poorly water-soluble simvastatin (SIM), a drug with relatively low Tg. The drug ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.960982
更新日期:2016-07-01 00:00:00
abstract::Kollicoat SR 30D is a unique 30% aqueous dispersion of polyvinvyl acetate stabilized by polyvinyl-pyrrolidone intended for preparation of sustained release products. Detailed evaluation of this polymer dispersion as a sustained release coating for active pharmaceutical ingredients of two diverse classes of drugs was s...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500313398
更新日期:2006-03-01 00:00:00
abstract:CONTEXT:Docetaxel is now a major antitumor drug in clinical use for the treatment of a variety of tumors. The ethanol/Tween 80 solvent required in the formulation to increase the docetaxel solubility is at least partly responsible for the hypersensitivity reaction, decreased uptake by tumor tissue, and increased exposu...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.879964
更新日期:2015-02-01 00:00:00