Abstract:
:Monoclonal antibodies (mAbs) were generated to the extracellular domain of transcobalamin receptor (TCblR) and used to identify the regions of the receptor protein involved in antibody binding. Based on the effect of transcobalamin bound cobalamin (TC-Cbl) on antibody binding, this study identified both blocking and binding antibodies. Both types of antibodies bind apo as well as holo receptors, whereas the blocking antibody when bound to the apo receptor prevents the binding and cellular uptake of TC-Cbl. Binding of these antibodies to truncated receptor constructs has identified the peptide domains of the receptor involved in antibody binding. These antibodies have potential utility in blocking cellular uptake of Cbl and delivery of drugs via TCblR, which is over-expressed in many cancers.
journal_name
Drug Delivjournal_title
Drug deliveryauthors
Jiang W,Nakayama Y,Sequeira JM,Quadros EVdoi
10.3109/10717544.2010.509745subject
Has Abstractpub_date
2011-01-01 00:00:00pages
74-8issue
1eissn
1071-7544issn
1521-0464journal_volume
18pub_type
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