Abstract:
:This study evaluated three chitosan-N-acetyl cysteine (CAC) conjugates of increasing molecular mass as a valuable tool to improve the absorption of drugs by assessing its permeation enhancing effect regarding the active P-gp substrate rhodamine-123 in comparison to the trans- and paracellular marker FD 4 both in rat intestine and Caco 2 monolayers. Additional LDH and MTT cytotoxicity tests have attested a non-toxic profile to CAC, which can consequently be seen as a safe and promising novel drug carrier with the ability to enhance drug absorption and to inhibit P-gp efflux transporters.
journal_name
Drug Delivjournal_title
Drug deliveryauthors
Schmitz T,Hombach J,Bernkop-Schnürch Adoi
10.1080/10717540802006708subject
Has Abstractpub_date
2008-05-01 00:00:00pages
245-52issue
4eissn
1071-7544issn
1521-0464pii
792747514journal_volume
15pub_type
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