Effect of microemulsion in topical sertaconazole hydrogel: in vitro and in vivo study.


PURPOSE:A topical microemulsion (ME)-based hydrogel was developed to enhance permeation of an antifungal drug, sertaconazole (STZL) for effective eradication of cutaneous fungal infection. METHODS:Pseudo-ternary phase diagrams were used to determine the existence of MEs region. ME formulations were prepared with oleic acid, Tween 80, propylene glycol (PG) and water. Carbopol 940 (0.75% w/w) was used for preparation of hydrogel of STZL microemulsion (HSM) and characterized. The in vitro and in vivo evaluation of prepared HSM and commercial cream of STZL were compared. RESULTS:The viscosity, average droplet size and pH of HSM were 154.23 ± 0.54 to 162.52 ± 0.21 Pas, 42.3-91.7 nm and 6.9-7.2, respectively. Permeation rate of STZL from optimized formulation (HSM-4), composed with oleic acid (8.75 % w/w), Tween 80 (33.35% w/w), PG (33.35% w/w) and water (24.55% w/w) was observed higher in compare with other HSMs and commercial cream. HSM-4 was stable, three times higher drug retention capacity in skin than commercial cream and did not caused any erythema or edema based on skin sensitivity study on rabbit. The average zone of inhibition of HSM-4 (23.54 ± 0.72 mm) was higher in compare with commercial cream (16.53 ± 0.63 mm) against Candida albicans. CONCLUSION:The results of study showed that ME played a major role in permeation enhancing and skin retention effect of HSM and the concentration of STZL used for cutaneous fungal infection could be decreased by using ME based hydrogel preparation.


Drug Deliv


Drug delivery


Sahoo S,Pani NR,Sahoo SK




Has Abstract


2016-01-01 00:00:00












  • A local drug delivery system based on visible light-cured glycol chitosan and doxorubicin⋅hydrochloride for thyroid cancer treatment in vitro and in vivo.

    abstract::Systemic drug delivery systems (SDDSs) for thyroid cancer treatment are associated with serious side effects including nausea, anorexia, and hair loss as a result of damage to normal tissues. In this study, we investigated the feasibility of a local DDS (LDDS) based on visible light-cured glycol chitosan (GC) hydrogel...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Yoo Y,Yoon SJ,Kim SY,Lee DW,Um S,Hyun H,Hong SO,Yang DH

    更新日期:2018-11-01 00:00:00

  • In vivo lymphatic targeting of methylene blue with microemulsion and multiple microemulsion.

    abstract::Three formulations including methylene blue solution (MB-S), MB water-in-oil microemulsion (MB-ME), and MB multiple microemulsion (MB-MME) were prepared with the aim to evaluate whether the three formulations can carry MB target to regional lymph nodes and show lymphatic tropism after subcutaneous administration. The ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Wang S,Yang R,Yao H,Zhou G,Zhang Y,Yang B,Ng L,Yan M

    更新日期:2009-10-01 00:00:00

  • Development of artemether and lumefantrine co-loaded nanostructured lipid carriers: physicochemical characterization and in vivo antimalarial activity.

    abstract:CONTEXT:Artemether and lumefantrine combination therapy is well-accepted for uncomplicated malaria treatment. However, the current available formulation has several pharmacokinetic mismatches such as drug degradation in gastrointestinal tract, erratic absorption, etc. Hence, need of the hour is the injectable formulati...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Parashar D,Aditya NP,Murthy RS

    更新日期:2016-01-01 00:00:00

  • Floating microspheres of carvedilol as gastro retentive drug delivery system: 3(2) full factorial design and in vitro evaluation.

    abstract:CONTEXT:Designing a sustained release system for Carvedilol to increase its residence time in the stomach. OBJECTIVE:Preparation of floating microsphere by the emulsion solvent diffusion method, studying the effect of various process parameters and optimize the formulation using full factorial design. METHODS:Differe...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Nila MV,Sudhir MR,Cinu TA,Aleykutty NA,Jose S

    更新日期:2014-03-01 00:00:00

  • Orally delivered polycurcumin responsive to bacterial reduction for targeted therapy of inflammatory bowel disease.

    abstract::Inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis is a chronic autoimmune disease affecting nearly five million people worldwide. Among all drug delivery system, oral administration is the most preferable route for colon-specific targeting and the treatment of IBD. Herein, an amphiphilic ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Qiao H,Fang D,Chen J,Sun Y,Kang C,Di L,Li J,Chen Z,Chen J,Gao Y

    更新日期:2017-11-01 00:00:00

  • Development and in vitro evaluation of pantoprazole-loaded microspheres.

    abstract::Pantoprazole is a proton pump inhibitor prodrug used in the treatment of gastric ulcers and gastroesophageal disease. Pantoprazole must be absorbed in the gastrointestinal tract and because it is unstable under acidic conditions, enteric delivery systems are required. The purpose of this study was to prepare pantopraz...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Comoglu T,Gonul N,Dogan A,Basci N

    更新日期:2008-06-01 00:00:00

  • Biodistribution of etoposide via intratumoral chemotherapy with etoposide-loaded implants.

    abstract::Etoposide (VP16) is the traditional antitumor agent which has been widely used in a variety of cancers. However, intravenous administration of VP16 was limited in clinical application because of its low aqueous solubility, poor bioavailability and dose-limiting adverse effects. Local chemotherapy with VP16-loaded drug...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Wu C,Yi X,Xu R,Zhang M,Xu Y,Ma Y,Gao L,Zha Z

    更新日期:2020-12-01 00:00:00

  • New synthetic glycolipids for targeted gene transfer: synthesis, formulation in lipoplexes and specific interaction with lectin.

    abstract::Nonviral gene delivery systems are a promising approach for gene therapy applications, despite their low in vivo gene transfer efficiency. One approach to enhance this efficiency is to incorporate targeting elements into cationic lipid/DNA complexes (lipoplexes). Ligand-containing lipoplexes have to retain their effic...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Carrière M,Escriou V,Jollet A,Scherman D,Azoulay M,Monneret C

    更新日期:2004-11-01 00:00:00

  • Multiseed liposomal drug delivery system using micelle gradient as driving force to improve amphiphilic drug retention and its anti-tumor efficacy.

    abstract::To improve drug retention in carriers for amphiphilic asulacrine (ASL), a novel active loading method using micelle gradient was developed to fabricate the ASL-loaded multiseed liposomes (ASL-ML). The empty ML were prepared by hydrating a thin film with empty micelles. Then the micelles in liposomal compartment acting...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Zhang W,Li C,Jin Y,Liu X,Wang Z,Shaw JP,Baguley BC,Wu Z,Liu J

    更新日期:2018-11-01 00:00:00

  • Release of albumin from oligoester plastic matrices: effect of magnesium oxide and bivalent stearates.

    abstract::Biodegradable implantable matrices containing bovine serum albumin were prepared from oligoesters by melting, and subsequently tested on in vitro albumin release. The linear poly (DL-lactic acid) and the branched terpolymer of DL-lactic acid, glycolic acid, and mannitol were synthesized. Products were of similar molec...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Kladnícková I,Dittrich M,Klein T,Pokorová D

    更新日期:2006-01-01 00:00:00

  • Development, characterization, and evaluation of ketorolac tromethamine-loaded biodegradable microspheres as a depot system for parenteral delivery.

    abstract::Ketorolac tromethamine, a potent nonnarcotic analgesic agent and 800 times more potent than aspirin, is indicated for the short-term management of moderate to such severe painful states as post operative pain, acute musculoskeletal pain, and dental pain. It Given every 6 hr intramuscularly in patients for acute pain, ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Sinha VR,Trehan A

    更新日期:2008-08-01 00:00:00

  • Effect of nicotinic acid conjugated to DNA-transfecting complexes targeted at the transferrin receptor of HeLa cells.

    abstract::A conjugate consisting of streptavidin (biotinylated transferrin)-biotinylated polylysine for DNA delivery to cells was modified by partial nicotinylation of the polylysine component of the conjugate and used for transfection studies. A conjugate of biotin10-nicotinyl60-polylysine250 containing 60 weakly basic nicotin...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Quick G,van Zyl J,Hawtrey A,Ariatti M

    更新日期:2000-10-01 00:00:00

  • In vitro evaluation of enrofloxacin-loaded MLV liposomes.

    abstract::Fluoroquinolones are broad-spectrum antimicrobial agents that seem to reach their intracellular target site (DNA gyrase) in Escherichia coli by means of an uptake process through the outer and inner membranes. Delivery of quinolones with liposomes has many advantages than the free form of the drug. Liposomes may repre...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Sezer AD,Akbuğa J,Baş AL

    更新日期:2007-01-01 00:00:00

  • Microencapsulation of superoxide dismutase into biodegradable microparticles by spray-drying.

    abstract::The aim of this work was to encapsulate superoxide dismutase (SOD) into biodegradable microparticles by spray-drying technique. The nature of the organic solvent to dissolve the polymer, the method of incorporation of the drug in the organic phase (with or without a surfactant, namely sucrose ester of HLB = 6), the su...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Youan BB

    更新日期:2004-05-01 00:00:00

  • Development of nanoparticles-in-microparticles system for improved local retention after intra-articular injection.

    abstract::To increase the intra-articular (IA) retention time of osteoarthritis drugs in the synovial cavity and slow down the burst release of microspheres (MPs), we prepared a novel drug delivery system named nanoparticles-in-microspheres (NiMs). The system was constructed by dispersing the brucine-loaded nanoparticle, which ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Chen Z,Liu D,Wang J,Wu L,Li W,Chen J,Cai BC,Cheng H

    更新日期:2014-08-01 00:00:00

  • Lung cancer combination therapy: co-delivery of paclitaxel and doxorubicin by nanostructured lipid carriers for synergistic effect.

    abstract:CONTEXT:Paclitaxel (PTX) and doxorubicin (DOX) are widely used for the combined chemotherapy of solid tumors. However, free drug combination has lower antitumor efficiency. It is necessary to design a drug delivery system to carry both of them. OBJECTIVE:This study aimed to engineer a nano-drug delivery system for co-...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Wang Y,Zhang H,Hao J,Li B,Li M,Xiuwen W

    更新日期:2016-05-01 00:00:00

  • Effects of vehicles and pressure sensitive adhesives on the penetration of isosorbide dinitrate across the hairless mouse skin.

    abstract::The effects of various vehicles and adhesives on the percutaneous absorption of isosorbide dinitrate (ISDN) were evaluated. Lauroglycol FCC showed the highest flux among vehicles tested. The flux of ISDN from silicone and acrylic adhesive matrices was found to be higher than that from other types of adhesive matrices....

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Myoung Y,Choi HK

    更新日期:2002-04-01 00:00:00

  • Etoposide-loaded biodegradable amphiphilic methoxy (poly ethylene glycol) and poly (epsilon caprolactone) copolymeric micelles as drug delivery vehicle for cancer therapy.

    abstract::Amphiphilic diblock copolymers composed of methoxy poly ethylene glycol (MePEG) and poly epsilon caprolactone (PCL) were synthesized for the formation of micelles by ring opening mechanism using stannous octoate as a catalyst. The effects of the molecular weight of MePEG and the copolymer ratio on the properties of mi...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Mohanty AK,Dilnawaz F,Mohanty C,Sahoo SK

    更新日期:2010-07-01 00:00:00

  • In vivo behavior of hydrogel beads based on amidated pectins.

    abstract::Radio-labeled hydrogel beads, based on amidated pectin, have been produced by adding droplets of an amidated pectin solution to calcium chloride. Incorporation of model drugs into the beads and measurement of the dissolution rate showed that the properties of the beads were unaffected by the incorporation of the radio...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Munjeri O,Collett JH,Fell JT,Sharma HL,Smith AM

    更新日期:1998-01-01 00:00:00

  • In vitro characterization of human intact erythrocytes loaded by enalaprilat.

    abstract::In vitro characteristics of the human erythrocytes loaded by enalaprilat have been evaluated. Erythrocytes obtained from a healthy volunteer were loaded by enalaprilat using the hypotonic preswelling method, and the loading parameters, drug-release kinetics, hematological indices, particle size distribution, scanning ...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Hamidi M,Tajerzadeh H,Dehpour AR,Rouini MR,Ejtemaee-Mehr S

    更新日期:2001-10-01 00:00:00

  • α-Conotoxin ImI-modified polymeric micelles as potential nanocarriers for targeted docetaxel delivery to α7-nAChR overexpressed non-small cell lung cancer.

    abstract::A micelle system modified with α-Conotoxin ImI (ImI), a potently antagonist for alpha7 nicotinic acetylcholine receptor (α7-nAChR) previously utilized for targeting breast cancer, was constructed. Its targeting efficiency and cytotoxicity against non-small cell lung cancer (NSCLC) highly expressing α7-nAChR was invest...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Mei D,Zhao L,Chen B,Zhang X,Wang X,Yu Z,Ni X,Zhang Q

    更新日期:2018-11-01 00:00:00

  • Research progress of self-assembled nanogel and hybrid hydrogel systems based on pullulan derivatives.

    abstract::Polymer nano-sized hydrogels (nanogels) as drug delivery carriers have been investigated over the last few decades. Pullulan, a nontoxic and nonimmunogenic hydrophilic polysaccharide derived from fermentation of black yeast like Aureobasidium pullulans with great biocompatibility and biodegradability, is one of the mo...

    journal_title:Drug delivery

    pub_type: 杂志文章,评审


    authors: Zhang T,Yang R,Yang S,Guan J,Zhang D,Ma Y,Liu H

    更新日期:2018-11-01 00:00:00

  • The efficiency of a novel delivery system (PEI600-Tat) in development of potent DNA vaccine using HPV16 E7 as a model antigen.

    abstract::DNA vaccination is a promising approach for inducing both humoral and cellular immune responses. The mode of plasmid DNA delivery is critical to make progress in DNA vaccination. Using human papillomavirus type 16 E7 as a model antigen, this study evaluated the effect of peptide-polymer hybrid including PEI600-Tat con...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Bolhassani A,Ghasemi N,Servis C,Taghikhani M,Rafati S

    更新日期:2009-05-01 00:00:00

  • Development of lipid nanoparticles for a histone deacetylases inhibitor as a promising anticancer therapeutic.

    abstract:BACKGROUND:Vorinostat (VRS), a histone deacetylases inhibitor, has significant cytotoxic potential in a large number of human cancer cell lines. OBJECTIVE:To clarify its promising anticancer potential and to improve its drawback related to physical properties and in vivo performance of VRS. METHODS:VRS was successful...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Tran TH,Chu DT,Truong DH,Tak JW,Jeong JH,Hoang VL,Yong CS,Kim JO

    更新日期:2016-05-01 00:00:00

  • In vitro evaluation of thio-poly acrylic acid for intraoral delivery.

    abstract:CONTEXT:Intraoral drug delivery as mucosal delivery pathway provides a huge platform in the pharmaceutical field. OBJECTIVE:Combining mucoadhesiveness and controlled release of thio-poly acrylic acid as advanced excipient for buccal drug delivery. MATERIALS AND METHODS:Mediated by carbodiimide, cysteine was covalentl...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Laffleur F,Leder N,Barthelmes J

    更新日期:2016-07-01 00:00:00

  • Genkwanin nanosuspensions: a novel and potential antitumor drug in breast carcinoma therapy.

    abstract::Recently, genkwanin (GKA) has been shown to display in vitro antitumor activity against some cancer cells, but its poor solubility restricted the in vivo study and further investigation of its antitumor therapeutic efficacy. In this paper, genkwanin nanosuspensions (GKA-NSps) were successfully prepared using D-alpha t...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Li Y,Hong J,Li H,Qi X,Guo Y,Han M,Wang X

    更新日期:2017-11-01 00:00:00

  • Formulation of Fe3O4/acrylate co-polymer nanocomposites as potential drug carriers.

    abstract::Magnetic nanocomposite particles were synthesized by encapsulating nanosized magnetite with an acrylate-based cationic co-polymer made of MMA, BA, and QMA and modifying with MeOPEGMA using the water replacement method. The composition of the co-polymer formulation was optimized based on zeta-potential measurements and...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Phanapavudhikul P,Shen S,Ng WK,Tan RB

    更新日期:2008-03-01 00:00:00

  • Development and characterization of glimepiride nanocrystal formulation and evaluation of its pharmacokinetic in rats.

    abstract::In this paper, orally nanocrystal capsules were produced using nanocrystal formulations in order to optimize dissolution properties of poorly soluble drug glimepiride and improve its bioavailability. The important preparation variables, such as stabilizers, the power input and the time length of ultrasonication on the...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Du B,Shen G,Wang D,Pang L,Chen Z,Liu Z

    更新日期:2013-01-01 00:00:00

  • Solid lipid nanoparticles for ocular drug delivery.

    abstract::Ocular drug delivery remains challenging because of the complex nature and structure of the eye. Conventional systems, such as eye drops and ointments, are inefficient, whereas systemic administration requires high doses resulting in significant toxicity. There is a need to develop novel drug delivery carriers capable...

    journal_title:Drug delivery

    pub_type: 杂志文章,评审


    authors: Seyfoddin A,Shaw J,Al-Kassas R

    更新日期:2010-09-01 00:00:00

  • Preparation of sodium cholate-based micelles through non-covalent ıbonding interaction and application as oral delivery systems for paclitaxel.

    abstract::In present study, two types of micelles based on sodium cholate (NaC) were prepared through non-covalent bonding interaction and the potential of micelles as oral drug delivery systems for paclitaxel (PTX) was evaluated. Pluronic-chitosan (F127-CS) and Pluronic-poly (acrylic acid) (F127-PAA) copolymers were synthesize...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Ge Y,Zhao Y,Li L

    更新日期:2016-09-01 00:00:00