Development and characterization of glimepiride nanocrystal formulation and evaluation of its pharmacokinetic in rats.

abstract：:Bevacizumab is an anti-vascular endothelial growth factor drug that can be used to treat choroidal neovascularization (CNV). Bevacizumab-loaded multivesicular liposomes (Bev-MVLs) have been designed and developed to increase the intravitreal retention time of bevacizumab and reduce the number of injection times. In th...

journal_title：Drug delivery

authors： Mu H,Wang Y,Chu Y,Jiang Y,Hua H,Chu L,Wang K,Wang A,Liu W,Li Y,Fu F,Sun K

更新日期：2018-11-01 00:00:00

abstract：:Chitosan, a natural-based polymer obtained by alkaline deacetylation of chitin, is nontoxic, biocompatible, and biodegradable. These properties make chitosan a good candidate for conventional and novel drug delivery systems. This article reviews the approaches aimed to associate bioactive molecules to chitosan in the ...

journal_title：Drug delivery

authors： Prabaharan M,Mano JF

更新日期：2005-01-01 00:00:00

abstract：:Combined administration of different drugs is a widely acknowledged approach for effective cancer therapy. However, the limited targeting, as well as inferior drug loading capacities of current drug delivery systems (DDS), are still the bottleneck for better performance in cancer treatment. Herein, we successfully dev...

journal_title：Drug delivery

authors： Li D,Cui R,Xu S,Liu Y

更新日期：2020-12-01 00:00:00

abstract：:Nasal colonization of Staphylococcus aureus (S.aureus) is known as a significant risk factor for nosocomial infections, and clearance of its nasal colonization greatly reduces the risk. In the present study the preparation and characterizations of the chitosan-o/w cream incorporated with lysostaphin (CCL) were describ...

journal_title：Drug delivery

authors： Cui F,Li G,Huang J,Zhang J,Lu M,Lu W,Huang Q

更新日期：2010-11-01 00:00:00

abstract：CONTEXT:Bisphosphonates (BPs) are widely used for prevention and treatment of osteoporosis. BPs are known as gold standard for osteoporosis (OP) treatment due to their positive results in clinical studies. But some serious side effects are associated with BPs like gastrointestinal adverse effect i.e. esophagitis and ul...

journal_title：Drug delivery

authors： Fazil M,Baboota S,Sahni JK,Ameeduzzafar,Ali J

更新日期：2015-01-01 00:00:00

abstract：:At present, the chemotherapy of advanced inoperable liver cancer is limited with serious side effects. Curcumin possesses multiple cancer preventive activities and low safety concerns. However, its poor solubility and instability in water pose significant pharmacological barriers to its clinical application. In this s...

journal_title：Drug delivery

authors： Chang M,Wu M,Li H

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:In the present study, Curcumin (CU)-loaded nanocarrier (NC) such as nanoemulsion (NE) was developed with the objective of increasing its cytotoxicity and bioavailability through lymphatic transport by enhancing its solubility and intestinal permeability. MATERIALS AND METHODS:Based on the area obtained in ps...

journal_title：Drug delivery

authors： Kumar A,Ahuja A,Ali J,Baboota S

更新日期：2016-01-01 00:00:00

abstract：:The study was aimed at evaluating the effectiveness of liposomal, micellar, and water-soluble drug forms of diminazene for its localization in cells and selective accumulation at the sites of aggregation of pathogenic organisms. Pharmacological and dynamic properties of a new injection micellar diminazene preparation ...

journal_title：Drug delivery

authors： Staroverov SA,Pristensky DV,Yermilov DN,Gabalov KP,Zhemerichkin DA,Sidorkin VA,Shcherbakov AA,Shchyogolev SY,Dykman LA

更新日期：2006-09-01 00:00:00

abstract：:The oral application of pharmaceuticals is unarguably the most convenient method of application. Especially for protein- or peptide-based drugs, however, the effectiveness is significantly reduced due to enzymatic digestion in the stomach as well as a poor bioavailability in the small intestine. For these difficult fo...

journal_title：Drug delivery

authors： Reinholz J,Landfester K,Mailänder V

更新日期：2018-11-01 00:00:00

abstract：CONTEXT:Artemether and lumefantrine combination therapy is well-accepted for uncomplicated malaria treatment. However, the current available formulation has several pharmacokinetic mismatches such as drug degradation in gastrointestinal tract, erratic absorption, etc. Hence, need of the hour is the injectable formulati...

journal_title：Drug delivery

authors： Parashar D,Aditya NP,Murthy RS

更新日期：2016-01-01 00:00:00

abstract：:The present work aimed to apply the liquid antisolvent precipitation (LAP) method for preparing the apigenin nanoparticles and thereby improving the solubility and bioavailability of apigenin. The different experimental parameters on particle size were optimized through central composite design (CCD) using the Design-...

journal_title：Drug delivery

authors： Wu W,Zu Y,Wang L,Wang L,Wang H,Li Y,Wu M,Zhao X,Fu Y

更新日期：2017-11-01 00:00:00

abstract：CONTEXT:Intraoral drug delivery as mucosal delivery pathway provides a huge platform in the pharmaceutical field. OBJECTIVE:Combining mucoadhesiveness and controlled release of thio-poly acrylic acid as advanced excipient for buccal drug delivery. MATERIALS AND METHODS:Mediated by carbodiimide, cysteine was covalentl...

journal_title：Drug delivery

authors： Laffleur F,Leder N,Barthelmes J

更新日期：2016-07-01 00:00:00

abstract：:Aminoglycoside-induced hair cell (HC) loss is a major cause of hearing impairment, and the effective prevention of HC loss remains an unmet medical need. Epigenetic mechanisms have been reported to be involved in protecting cochlear cells against ototoxic drug injury, and in this study we developed new bioactive compo...

journal_title：Drug delivery

authors： Li A,You D,Li W,Cui Y,He Y,Li W,Chen Y,Feng X,Sun S,Chai R,Li H

更新日期：2018-11-01 00:00:00

abstract：:The aim of the current study was to formulate terconazole (TCZ) loaded polymeric mixed micelles (PMMs) incorporating Cremophor EL as a stabilizer and a penetration enhancer. A 23 full factorial design was performed using Design-Expert® software for the optimization of the PMMs which were formulated using Pluronic P123...

journal_title：Drug delivery

authors： Abd-Elsalam WH,El-Zahaby SA,Al-Mahallawi AM

更新日期：2018-11-01 00:00:00

abstract：:The aim of our study was to investigate the enhancing effect of several essential oils in the percutaneous absorption of trazodone hydrochloride (TZN). For this purpose, fennel oil, eucalyptus oil, citronella oil, and mentha oil were applied on the skin membrane in three different ways: included in the transdermal dev...

journal_title：Drug delivery

authors： Das MK,Bhattacharya A,Ghosal SK

更新日期：2006-11-01 00:00:00

abstract：:Among the transcription factors critical for cell cycle regulation is the proto-oncogene c-myc. The expression of c-myc upon vascular injury and its inhibition by antisense oligodeoxynucleotides have demonstrated the importance of this protein in the control of proliferation for many cell types, including vascular smo...

journal_title：Drug delivery

authors： Koo EW,Edelman ER

更新日期：1996-01-01 00:00:00

abstract：:For the treatment of ocular keratitis acyclovir, as a highly specific inhibitor of herpes virus replication, is applied topically into the eye. The objective of this study was to design and evaluate freeze-dried, bioadhesive and biodegredable acyclovir ocular minitablets for prolonged local drug action. The sponge-lik...

journal_title：Drug delivery

authors： Refai H,Tag R

更新日期：2011-01-01 00:00:00

abstract：:Bone metastasis is a devastating complication of cancer that requires an immediate attention. Although our understanding of the metastatic process has improved over the years, yet a number of questions still remain unanswered, and more research is required for complete understanding of the skeletal consequences of met...

journal_title：Drug delivery

authors： Vinay R,KusumDevi V

更新日期：2016-01-01 00:00:00

abstract：:Biodegradable implantable matrices containing bovine serum albumin were prepared from oligoesters by melting, and subsequently tested on in vitro albumin release. The linear poly (DL-lactic acid) and the branched terpolymer of DL-lactic acid, glycolic acid, and mannitol were synthesized. Products were of similar molec...

journal_title：Drug delivery

authors： Kladnícková I,Dittrich M,Klein T,Pokorová D

更新日期：2006-01-01 00:00:00

abstract：:In this study, the blood clearance and organ distribution of intravenously administered liposomes (distearoyl phosphatidylcholine [DSPC] and cholesterol in a ratio of 3:1) was evaluated by utilizing 3H-cholesteryl ether as the lipid phase marker. Also, the ability of liposomes, as a drug delivery system, to alter the ...

journal_title：Drug delivery

authors： Anderson M,Paradis C,Omri A

更新日期：2003-07-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) were generated to the extracellular domain of transcobalamin receptor (TCblR) and used to identify the regions of the receptor protein involved in antibody binding. Based on the effect of transcobalamin bound cobalamin (TC-Cbl) on antibody binding, this study identified both blocking and b...

journal_title：Drug delivery

authors： Jiang W,Nakayama Y,Sequeira JM,Quadros EV

更新日期：2011-01-01 00:00:00

abstract：:The aim of this research was to increase the oral bioavailability of puerarin by N-trimethyl chitosan-modified microemulsions (TMC-MEs) loaded with puerarin. Different concentrations of TMC-modified microemulsions were prepared in our study, and then evaluated for particle size, zeta potential, morphological observati...

journal_title：Drug delivery

authors： Liao D,Liu X,Dai W,Tang T,Ou G,Zhang K,Han M,Kang R,Yang S,Xiang D

更新日期：2015-01-01 00:00:00

abstract：:Some cancers such as human breast cancer, prostate cancer, and lung cancer easily metastasize to bone, leading to osteolysis and bone destruction accompanied by a complicated microenvironment. Systemic administration of bisphosphonates (BP) or denosumab is the routine therapy for osteolysis but with non-negligible sid...

journal_title：Drug delivery

authors： Cheng X,Wei J,Ge Q,Xing D,Zhou X,Qian Y,Jiang G

更新日期：2021-12-01 00:00:00

abstract：:Traditional in situ gel forming systems are potential applications for parenteral administration but always accompanied with burst release. To overcome this limitation, the tinidazole (TNZ)-loaded in situ gel forming system using a diblock copolymer, monomethoxy poly(ethylene glycol)-block-poly(d,l-lactide) (mPEG-PDLL...

journal_title：Drug delivery

authors： Tian Y,Shen Y,Jv M

更新日期：2016-10-01 00:00:00

abstract：:Camptothecin (CPT) is an effective anticancer agent against various cancers but the clinical application is limited because of its poor water solubility, low bioavailability and severe toxic side effects. The aim of the present study was to evaluate the feasibility of using targeted NPs as a high-performance CPT deliv...

journal_title：Drug delivery

authors： Yang A,Liu Z,Yan B,Zhou M,Xiong X

更新日期：2016-06-01 00:00:00

abstract：:Ketorolac tromethamine, a potent nonnarcotic analgesic agent and 800 times more potent than aspirin, is indicated for the short-term management of moderate to such severe painful states as post operative pain, acute musculoskeletal pain, and dental pain. It Given every 6 hr intramuscularly in patients for acute pain, ...

journal_title：Drug delivery

authors： Sinha VR,Trehan A

更新日期：2008-08-01 00:00:00

abstract：:Ocular drug delivery remains challenging because of the complex nature and structure of the eye. Conventional systems, such as eye drops and ointments, are inefficient, whereas systemic administration requires high doses resulting in significant toxicity. There is a need to develop novel drug delivery carriers capable...

journal_title：Drug delivery

authors： Seyfoddin A,Shaw J,Al-Kassas R

更新日期：2010-09-01 00:00:00

abstract：:Sustained release (SR) matrix tablets of dextromethorphan hydrobromide were prepared by wet granulation using hydroxypropyl methyl cellulose (HPMC-K-100 CR) as the hydrophilic rate controlling polymer. The effect of the concentration of the polymer and different fillers on the in vitro drug release rate was studied. T...

journal_title：Drug delivery

authors： Meyyanathan SN,Rajan S,Muralidaharan S,Siddaiah MK,Krishnaraj K,Suresh B

更新日期：2008-09-01 00:00:00

abstract：:Discovery of novel pharmacological effects of berberine hydrochloride (BH) has made its clinical application valuable. However, further development and applications of BH are hampered by its short half-life and the side effects associated with its intravenous (iv) injection. To improve the hypolipidemia efficacy and r...

journal_title：Drug delivery

authors： Cheng Z,Liu S,Wu X,Raza F,Li Y,Yuan W,Qiu M,Su J

更新日期：2020-12-01 00:00:00

abstract：:A novel cationic liposome modified with soybean sterylglucoside (SG) and polyethylene glycol-distearoylphosphatidylethanolamine (PEG-DSPE) as a carrier of antisense oligodeoxynucleotide (ODN) for hepatitis B virus (HBV) therapy was constructed. Characteristics of the cationic liposomes modified with SG and PEG (SG/PEG...

journal_title：Drug delivery

authors： Shi J,Yan WW,Qi XR,Maitani Y,Nagai T

更新日期：2005-11-01 00:00:00