The challenges of oral drug delivery via nanocarriers.

abstract：:Monoclonal antibodies (mAbs) were generated to the extracellular domain of transcobalamin receptor (TCblR) and used to identify the regions of the receptor protein involved in antibody binding. Based on the effect of transcobalamin bound cobalamin (TC-Cbl) on antibody binding, this study identified both blocking and b...

journal_title：Drug delivery

authors： Jiang W,Nakayama Y,Sequeira JM,Quadros EV

更新日期：2011-01-01 00:00:00

abstract：:Tuberculosis (TB) has gained attention over the past few decades by becoming one of the top ten leading causes of death worldwide. This infectious disease of the lungs is orally treated with a medicinal armamentarium. However, this route of administration passes through the body's first-pass metabolism which reduces t...

journal_title：Drug delivery

authors： Poh W,Ab Rahman N,Ostrovski Y,Sznitman J,Pethe K,Loo SCJ

更新日期：2019-12-01 00:00:00

abstract：:Effective clinical utilization of non-steroidal anti-inflammatory drugs such as diclofenac sodium (DS) is significantly limited by their ulcerogenic potential and poor bioavailability after oral administration, thus necessitating the need for a better carrier to minimize these obvious limitations. The objective of thi...

journal_title：Drug delivery

authors： Momoh MA,Kenechukwu FC,Adedokun MO,Odo CE,Attama AA

更新日期：2014-05-01 00:00:00

abstract：:To increase the intra-articular (IA) retention time of osteoarthritis drugs in the synovial cavity and slow down the burst release of microspheres (MPs), we prepared a novel drug delivery system named nanoparticles-in-microspheres (NiMs). The system was constructed by dispersing the brucine-loaded nanoparticle, which ...

journal_title：Drug delivery

authors： Chen Z,Liu D,Wang J,Wu L,Li W,Chen J,Cai BC,Cheng H

更新日期：2014-08-01 00:00:00

abstract：:Boronophenylalanine (BPA)-loaded conventional and stabilized liposomes were prepared by the reversed phase evaporation method to treat liver metastases by boron neutron capture therapy. Conventional vesicles were composed of phosphatidylcholine and cholesterol, molar ratio 1:1. To obtain stealth liposomes, GM1 or PEG ...

journal_title：Drug delivery

authors： Pavanetto F,Perugini P,Genta I,Minoia C,Ronchi A,Prati U,Roveda L,Nano R

更新日期：2000-04-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to formulate and evaluate the Ibuprofen niosomal formulation as a transdermal drug delivery system. MATERIALS AND METHODS:Niosomes were prepared by a modified ethanol injection method, using Span 60, Tween 60 and Tween 65 as well as cholesterol with various cholesterol:surfact...

journal_title：Drug delivery

authors： Ghanbarzadeh S,Khorrami A,Arami S

更新日期：2015-12-01 00:00:00

abstract：:Usually the topical delivery of ocular drugs poses a great challenge. Accordingly, the work in this study comprised the use of different hybrids of generally regarded as safe (GRAS) oils and surfactants in order to develop and optimize novel acetazolamide (AZD) entrapped-vesicular systems aiming at improving its ocula...

journal_title：Drug delivery

authors： Naguib SS,Hathout RM,Mansour S

更新日期：2017-11-01 00:00:00

abstract：CONTEXT:Propolis has traditionally been used in curing infections and healing wounds and burns. OBJECTIVE:The aim of this study is to formulate pluronic lecithin organogel of propolis to improve its availability and antimicrobial activity. MATERIALS AND METHODS:Different organogels were prepared by using soybean leci...

journal_title：Drug delivery

authors： Balata G,El Nahas HM,Radwan S

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:In the present study, Curcumin (CU)-loaded nanocarrier (NC) such as nanoemulsion (NE) was developed with the objective of increasing its cytotoxicity and bioavailability through lymphatic transport by enhancing its solubility and intestinal permeability. MATERIALS AND METHODS:Based on the area obtained in ps...

journal_title：Drug delivery

authors： Kumar A,Ahuja A,Ali J,Baboota S

更新日期：2016-01-01 00:00:00

abstract：:A macromolecular pro-drug of a known anti-viral agent Zidovudine (AZT) was synthesized and evaluated as a sustained drug delivery system. The pro-drug was synthesized by coupling the drug to 2-hydroxyethyl methacrylate (HEMA) through a succinic spacer to get a monomeric drug conjugate which was polymerized to obtain t...

journal_title：Drug delivery

authors： Neeraj A,Chandrasekar MJ,Sara UV,Rohini A

更新日期：2011-05-01 00:00:00

abstract：:Hot-melt extrusion (HME) plays an important role in preparing implants as local drug delivery systems in pharmaceutical fields. Here, a new PLA/PEG-PPG-PEG/Dexamethasone (PLA/F68/Dex) implant prepared by HME has been developed. Importantly, the implant was successfully achieved to control release of immunosuppressive ...

journal_title：Drug delivery

authors： Li D,Guo G,Deng X,Fan R,Guo Q,Fan M,Liang J,Luo F,Qian Z

更新日期：2013-04-01 00:00:00

abstract：:Jurkat, an immortalized cell line derived from human leukemic T lymphocytes, has been employed as an excellent surrogate model of human primary T-cells for the advancement of T-cell biology and their applications in medicine. However, presumably due to its T-cell origin, Jurkat cells are very difficult to transfect. T...

journal_title：Drug delivery

authors： Ayyadevara VSSA,Roh KH

更新日期：2020-12-01 00:00:00

abstract：:This work evaluates solid lipid nanoparticles of thiopental sodium against obesity-induced cardiac dysfunction and hypertrophy and explores the possible mechanism of action. TS loaded SLNs were formulated by hot-homogenization and solvent diffusion method. TS-SLNs were scrutinized for entrapment efficiency, drug loadi...

journal_title：Drug delivery

authors： Zhu C,Li W,Wang X,Xue J,Zhao L,Song Y,Zhou T,Zhang M

更新日期：2020-12-01 00:00:00

abstract：:Pantoprazole is a proton pump inhibitor prodrug used in the treatment of gastric ulcers and gastroesophageal disease. Pantoprazole must be absorbed in the gastrointestinal tract and because it is unstable under acidic conditions, enteric delivery systems are required. The purpose of this study was to prepare pantopraz...

journal_title：Drug delivery

authors： Comoglu T,Gonul N,Dogan A,Basci N

更新日期：2008-06-01 00:00:00

abstract：:Kollicoat SR 30D is a unique 30% aqueous dispersion of polyvinvyl acetate stabilized by polyvinyl-pyrrolidone intended for preparation of sustained release products. Detailed evaluation of this polymer dispersion as a sustained release coating for active pharmaceutical ingredients of two diverse classes of drugs was s...

journal_title：Drug delivery

authors： Bordaweka MS,Zia H,Quadir A

更新日期：2006-03-01 00:00:00

abstract：:Combinational therapy is usually considered as a preferable approach for effective cancer therapy. Especially, combinational chemo and photothermal therapy is of particular interest due to its high flexibility as well as efficiency. In this article, we the silica nanoparticles (SLN) were surface conjugated with Cetuxi...

journal_title：Drug delivery

authors： Zhang X,Li Y,Wei M,Liu C,Yu T,Yang J

更新日期：2019-12-01 00:00:00

abstract：:Endostatin (ES) can effectively inhibit neovascularization in most solid tumors and has the potential to make oxygen delivery more efficient and increase the efficacy of radiotherapy (RT). With a short half-life, ES is mainly administered systemically, which leads to low intake in tumor tissue and often toxic systemic...

journal_title：Drug delivery

authors： Wang N,Gao Q,Tang J,Jiang Y,Yang L,Shi X,Chen Y,Zhang Y,Fu S,Lin S

更新日期：2021-12-01 00:00:00

abstract：:The purpose of this work is to use biorelevant media to evaluate the robustness of a poorly water soluble weakly basic drug to variations along the gastrointestinal tract (GIT) after incorporation in liquisolid compacts and to assess the success of these models in predicting the in vivo performance. Liquisolid tablets...

journal_title：Drug delivery

authors： Badawy MA,Kamel AO,Sammour OA

更新日期：2016-01-01 00:00:00

abstract：:Stealth solid lipid nanoparticles (SSLN) were prepared and evaluated for the effect of evading phagocytic uptake by mouse peritoneal macrophages in situ. Fluorescent SSLNs were prepared by emulsion/evaporation with rhodamine B as the fluorescent marker and polyoxyethylene stearate as stealth agent in a stearic acid ma...

journal_title：Drug delivery

authors： Wang Y,Wu W

更新日期：2006-05-01 00:00:00

abstract：:Discovery of novel pharmacological effects of berberine hydrochloride (BH) has made its clinical application valuable. However, further development and applications of BH are hampered by its short half-life and the side effects associated with its intravenous (iv) injection. To improve the hypolipidemia efficacy and r...

journal_title：Drug delivery

authors： Cheng Z,Liu S,Wu X,Raza F,Li Y,Yuan W,Qiu M,Su J

更新日期：2020-12-01 00:00:00

abstract：:Radio-labeled hydrogel beads, based on amidated pectin, have been produced by adding droplets of an amidated pectin solution to calcium chloride. Incorporation of model drugs into the beads and measurement of the dissolution rate showed that the properties of the beads were unaffected by the incorporation of the radio...

journal_title：Drug delivery

authors： Munjeri O,Collett JH,Fell JT,Sharma HL,Smith AM

更新日期：1998-01-01 00:00:00

abstract：:Enrofloxacin, a third-generation fluoroquinolone, is a broad-spectrum antimicrobial drug against a lot of veterinary bacterial diseases. However, bactericidal activity of enrofloxacin is concentration-dependent and its poor aqueous solubility and bitter taste limit its development and application. Meanwhile, 2-hydroxy...

journal_title：Drug delivery

authors： Ding Y,Pang Y,Vara Prasad CVNS,Wang B

更新日期：2020-12-01 00:00:00

abstract：:Electro-phonophoresis (EP) has been used in various clinical fields. The objective of present study is to evaluate the skin permeability of isoniazid (INH) and rifampicin (RIF) in patients with tuberculous lymphadenitis with the aid of EP to validate the clinical applications of this transdermal delivery system for th...

journal_title：Drug delivery

authors： Chen S,Qin M,Han Y,Zhao L,Fu Y,Shang Y,Liu Z,Huang H

更新日期：2016-06-01 00:00:00

abstract：:Mucoadhesive drug delivery systems are those that provide intimate contact of the drug with the mucosa for an extended period of time. In our present work, mucoadhesive chitosan microspheres were prepared by emulsion solvent method. Formulations were characterized for various physicochemical attributes, shape, surface...

journal_title：Drug delivery

authors： Jain SK,Chourasia MK,Jain AK,Jain RK,Shrivastava AK

更新日期：2004-03-01 00:00:00

abstract：:The aim of this work was to develop a novel and more efficient platform for sublingual drug delivery using mosapride citrate (MSP) as a model drug. The engineering of this delivery system had two stages, the first stage was tuning of MSP physicochemical properties by complexation with pure phosphatidylcholine or phosp...

journal_title：Drug delivery

authors： Morsi NM,Abdelbary GA,Elshafeey AH,Ahmed MA

更新日期：2017-11-01 00:00:00

abstract：CONTEXT:Paclitaxel (PTX) and carboplatin (CBP) are widely used for the combined chemotherapy of non-small cell lung cancer (NSCLC). However, the development of multidrug resistance of cancer cells, as well as systemic toxic side effects resulting from nonspecific localization of anticancer drugs to non-tumor areas are ...

journal_title：Drug delivery

authors： Zhang W,Li C,Shen C,Liu Y,Zhao X,Liu Y,Zou D,Gao Z,Yue C

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVES:This study introduces the structural design, working principles, performance testing and treatment effects of a newly developed ultrasonic irradiation delivery and treatment catheter system that integrates interventional catheterization technology. BACKGROUND:Systemic administration method needs a high dose...

journal_title：Drug delivery

authors： Yuan QY,Huang J,Li XJ,Peng JB,Li XS,Chen ZP,Si LY

更新日期：2013-08-01 00:00:00

abstract：:Among the transcription factors critical for cell cycle regulation is the proto-oncogene c-myc. The expression of c-myc upon vascular injury and its inhibition by antisense oligodeoxynucleotides have demonstrated the importance of this protein in the control of proliferation for many cell types, including vascular smo...

journal_title：Drug delivery

authors： Koo EW,Edelman ER

更新日期：1996-01-01 00:00:00

abstract：:The conjugation of tunable peptides or materials with nanocarriers represents a promising approach for drug delivery to tumor cells. In this study, we report the development of a novel liposomal carrier system that exploits the cell surface binding synergism between photo-sensitive peptides (PSPs) and targeting ligand...

journal_title：Drug delivery

authors： Xie X,Yang Y,Yang Y,Zhang H,Li Y,Mei X

更新日期：2016-09-01 00:00:00

abstract：:Piroxicam (PX), a main member of non-steroidal anti-inflammatory drugs (NSAIDs), is mainly used orally, which causes side effects of the gastrointestinal tract. It also has systemic effects when administered intramuscularly. Intra-articular (IA) delivery and encapsulation of PX in biodegradable poly-ε-caprolactone (PC...

journal_title：Drug delivery

authors： Rahmani Del Bakhshayesh A,Akbarzadeh A,Alihemmati A,Tayefi Nasrabadi H,Montaseri A,Davaran S,Abedelahi A

更新日期：2020-12-01 00:00:00