Characteristics and biodistribution of soybean sterylglucoside and polyethylene glycol-modified cationic liposomes and their complexes with antisense oligodeoxynucleotide.

abstract：:The aim of this study was to evaluate the effects of therapeutic pulsed ultrasound with gold nanoparticles on oxidative stress parameters after traumatic muscle injury in Wistar rats. The animals were randomly divided into nine groups (n = 6 each): sham (uninjured muscle); muscle injury without treatment; muscle injur...

journal_title：Drug delivery

authors： Silveira PC,Victor EG,Notoya Fde S,Scheffer Dda L,Silva Ld,Cantú RB,Martínez VH,de Pinho RA,Paula MM

更新日期：2016-01-01 00:00:00

abstract：:This study focused on preparation and evaluation of a thermosensitive and mucoadhesive in situ gelling ophthalmic system of azithromycin (ATM). Poloxamer 407 (P407) and poloxamer 188 (P188) were used as gelling agents. Addition of Carbopol 974P (CP 974P) to the gelling systems could increase the solubility of ATM by s...

journal_title：Drug delivery

authors： Cao F,Zhang X,Ping Q

更新日期：2010-09-01 00:00:00

abstract：:Aminoglycoside-induced hair cell (HC) loss is a major cause of hearing impairment, and the effective prevention of HC loss remains an unmet medical need. Epigenetic mechanisms have been reported to be involved in protecting cochlear cells against ototoxic drug injury, and in this study we developed new bioactive compo...

journal_title：Drug delivery

authors： Li A,You D,Li W,Cui Y,He Y,Li W,Chen Y,Feng X,Sun S,Chai R,Li H

更新日期：2018-11-01 00:00:00

abstract：CONTEXT:Propolis has traditionally been used in curing infections and healing wounds and burns. OBJECTIVE:The aim of this study is to formulate pluronic lecithin organogel of propolis to improve its availability and antimicrobial activity. MATERIALS AND METHODS:Different organogels were prepared by using soybean leci...

journal_title：Drug delivery

authors： Balata G,El Nahas HM,Radwan S

更新日期：2014-02-01 00:00:00

abstract：:Lung cancer is still the most common cancer globally. Early screening remains the key to improve the prognosis of patients. There is currently a lack of specific and sensitive methods for early screening of lung cancer. In recent years, studies have found that microRNA plays an important role in the occurrence and dev...

journal_title：Drug delivery

authors： Zhu HZ,Hou J,Guo Y,Liu X,Jiang FL,Chen GP,Pang XF,Sun JG,Chen ZT

更新日期：2018-11-01 00:00:00

abstract：:For the treatment of ocular keratitis acyclovir, as a highly specific inhibitor of herpes virus replication, is applied topically into the eye. The objective of this study was to design and evaluate freeze-dried, bioadhesive and biodegredable acyclovir ocular minitablets for prolonged local drug action. The sponge-lik...

journal_title：Drug delivery

authors： Refai H,Tag R

更新日期：2011-01-01 00:00:00

abstract：:Silk was easily dyed in traditional textile industry because of its strong affinity to many colorants. Herein, the biocompatible silk fibroin was firstly extracted from Bombyx mori silkworm cocoons. And SF nanoparticles (SFNPs) were prepared for dyeing indocyanine green (ICG) and construct a therapeutic nano-platform ...

journal_title：Drug delivery

authors： Xu HL,ZhuGe DL,Chen PP,Tong MQ,Lin MT,Jiang X,Zheng YW,Chen B,Li XK,Zhao YZ

更新日期：2018-11-01 00:00:00

abstract：:The objective of this study was to investigate the effect of lipophilic (Compritol 888 ATO) and hydrophilic components (combination of HPMC and Avicel) on the release of carbamazepine from granules and corresponding tablet. Wet granulation followed by compression was employed for preparation of granules and tablets. T...

journal_title：Drug delivery

authors： Barakat NS,Elbagory IM,Almurshedi AS

更新日期：2009-01-01 00:00:00

abstract：:Hydrogels based on poly(ethylene glycol)-diacrylate (PEG-DA) and 2-hydroxyethyl methacrylate (HEMA) were polymerized with cross-linking agent ethylene glycol diacrylate (EGDMA) under mild photoinitiating conditions. PEG-DA and HEMA concentrations of disks with 1 +/- 0.3 mm thickness were 30% and 50% w/w and 40% and 60...

journal_title：Drug delivery

authors： Ayhan F,Ozkan S

更新日期：2007-10-01 00:00:00

abstract：:The purpose of this study was to characterize and evaluate tectorigenin-loaded self-microemulsifying drug delivery system (TG-SMEDDS), a previously studied preparation, and further confirm the improvement of TG in solubility and bioavailability. The appearance of TG-SMEDDS was clear and transparent, with good mobility...

journal_title：Drug delivery

authors： Zhang Y,He L,Yue S,Huang Q,Zhang Y,Yang J

更新日期：2017-11-01 00:00:00

abstract：:Improvement of water solubility, dissolution rate, oral bioavailability, and reduction of first pass metabolism of OL (OL), were the aims of this research. Co-amorphization of OL carboxylic acid dispersions at various molar ratios was carried out using rapid solvent evaporation. Characterization of the dispersions was...

journal_title：Drug delivery

authors： Maher EM,Ali AM,Salem HF,Abdelrahman AA

更新日期：2016-10-01 00:00:00

abstract：:In order to enhance the interaction between nanocarrier and gastrointestinal epithelial cells, we developed nanoparticles (NPs) modified with targeting ligand FQSIYPpIK (FQS), which specifically interact with integrin αvβ3 receptor expressing on the intestinal epithelium. The targeting NPs were prepared by coating the...

journal_title：Drug delivery

authors： Liu C,Shan W,Liu M,Zhu X,Xu J,Xu Y,Huang Y

更新日期：2016-07-01 00:00:00

abstract：:Ocular drug delivery remains challenging because of the complex nature and structure of the eye. Conventional systems, such as eye drops and ointments, are inefficient, whereas systemic administration requires high doses resulting in significant toxicity. There is a need to develop novel drug delivery carriers capable...

journal_title：Drug delivery

authors： Seyfoddin A,Shaw J,Al-Kassas R

更新日期：2010-09-01 00:00:00

abstract：:The main aim of this work was to develop rectal suppositories for better delivery of metoprolol tartrate (MT). The various bases used were fatty, water soluble and emulsion bases. The physical properties of the prepared suppositories were characterized such as weight variation, hardness, disintegration time, melting r...

journal_title：Drug delivery

authors： Abou el Ela Ael S,Allam AA,Ibrahim EH

更新日期：2016-01-01 00:00:00

abstract：:Although meloxicam (MX) is relatively safer than other NSAIDs, adverse effects relating to the gastro-intestinal tract are still a problem when administrated MX at high doses and on the long-term treatment. Drug delivery via skin provides an attractive alternative to oral administration, but is limited by the first la...

journal_title：Drug delivery

authors： Chen J,Gao Y

更新日期：2016-10-01 00:00:00

abstract：:Subcutaneous liraglutide-loaded multivesicular liposomes (Lrg-MVLs) were developed as a sustained drug-delivery system for treating diabetes and their properties were characterized. The Lrg-MVLs prepared using a two-step water-in-oil-in-water double emulsification process had a spherical appearance with a mean diamete...

journal_title：Drug delivery

authors： Zhang L,Ding L,Tang C,Li Y,Yang L

更新日期：2016-11-01 00:00:00

abstract：:Reactive oxygen species (ROS)-induced neuronal mitochondrial dysfunction is a key pathologic factor in sporadic Alzheimer's disease (AD). Neuronal mitochondria have been proposed to be a promising therapeutic target for AD, especially for the failures of phase III clinical trials on conventional amyloid-β (Aβ) targete...

journal_title：Drug delivery

authors： Han Y,Chu X,Cui L,Fu S,Gao C,Li Y,Sun B

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:MicroRNAs (miRNAs) are important and powerful mediators in a variety of diseases including cardiovascular pathology. Thus, they emerged as interesting new drug targets. However, it is important to develop efficient transfer tools to successfully deliver miRNAs or antisense oligonucleotides (antagomirs) to the t...

journal_title：Drug delivery

authors： Chistiakov DA,Sobenin IA,Orekhov AN

更新日期：2012-11-01 00:00:00

abstract：CONTEXT:Artemether and lumefantrine combination therapy is well-accepted for uncomplicated malaria treatment. However, the current available formulation has several pharmacokinetic mismatches such as drug degradation in gastrointestinal tract, erratic absorption, etc. Hence, need of the hour is the injectable formulati...

journal_title：Drug delivery

authors： Parashar D,Aditya NP,Murthy RS

更新日期：2016-01-01 00:00:00

abstract：:Ischemic stroke is one of the major causes of severe disability and death worldwide. It is mainly caused by a sudden reduction in cerebral blood flow due to obstruction of the supplying vessel by thrombi and subsequent initiation of a complex cascade of pathophysiological changes, which ultimately lead to brain ischem...

journal_title：Drug delivery

authors： Ma H,Jiang Z,Xu J,Liu J,Guo ZN

更新日期：2021-12-01 00:00:00

abstract：:The combined chemotherapy and photodynamic therapy have significant advantages for cancer treatments, which have higher therapeutic effects compared with other medicines. Herein, we focused on the synthesis of carbon quantum dot (CQD) based nanocarrier system. CQD and 5-aminolevulinic acid (5-ALA) were conjugated with...

journal_title：Drug delivery

authors： Li X,Vinothini K,Ramesh T,Rajan M,Ramu A

更新日期：2020-12-01 00:00:00

abstract：:Boronophenylalanine (BPA)-loaded conventional and stabilized liposomes were prepared by the reversed phase evaporation method to treat liver metastases by boron neutron capture therapy. Conventional vesicles were composed of phosphatidylcholine and cholesterol, molar ratio 1:1. To obtain stealth liposomes, GM1 or PEG ...

journal_title：Drug delivery

authors： Pavanetto F,Perugini P,Genta I,Minoia C,Ronchi A,Prati U,Roveda L,Nano R

更新日期：2000-04-01 00:00:00

abstract：:Polymer nano-sized hydrogels (nanogels) as drug delivery carriers have been investigated over the last few decades. Pullulan, a nontoxic and nonimmunogenic hydrophilic polysaccharide derived from fermentation of black yeast like Aureobasidium pullulans with great biocompatibility and biodegradability, is one of the mo...

journal_title：Drug delivery

authors： Zhang T,Yang R,Yang S,Guan J,Zhang D,Ma Y,Liu H

更新日期：2018-11-01 00:00:00

abstract：:To improve drug retention in carriers for amphiphilic asulacrine (ASL), a novel active loading method using micelle gradient was developed to fabricate the ASL-loaded multiseed liposomes (ASL-ML). The empty ML were prepared by hydrating a thin film with empty micelles. Then the micelles in liposomal compartment acting...

journal_title：Drug delivery

authors： Zhang W,Li C,Jin Y,Liu X,Wang Z,Shaw JP,Baguley BC,Wu Z,Liu J

更新日期：2018-11-01 00:00:00

abstract：:The distinct hormone molecules and receptors, such as follicle-stimulating hormone receptor (FSHR) in ovarian cancer, provide opportunities for more precisely targeted therapy. We previously developed FSHR-mediated nanoparticles and found that FSH peptides on the surface of nanoparticles improved the delivery of short...

journal_title：Drug delivery

authors： Hong SS,Zhang MX,Zhang M,Yu Y,Chen J,Zhang XY,Xu CJ

更新日期：2018-11-01 00:00:00

abstract：:Among the transcription factors critical for cell cycle regulation is the proto-oncogene c-myc. The expression of c-myc upon vascular injury and its inhibition by antisense oligodeoxynucleotides have demonstrated the importance of this protein in the control of proliferation for many cell types, including vascular smo...

journal_title：Drug delivery

authors： Koo EW,Edelman ER

更新日期：1996-01-01 00:00:00

abstract：:The combination of protein-coated graphene oxide (GO) and microencapsulation technology has moved a step forward in the challenge of improving long-term alginate encapsulated cell survival and sustainable therapeutic protein release, bringing closer its translation from bench to the clinic. Although this new approach ...

journal_title：Drug delivery

authors： Ciriza J,Saenz Del Burgo L,Gurruchaga H,Borras FE,Franquesa M,Orive G,Hernández RM,Pedraz JL

更新日期：2018-11-01 00:00:00

abstract：:The present study sought to investigate the effect of non-mitogenic acidic fibroblast growth factor (NM-aFGF) loaded PEGylated nanoliposomes (NM-aFGF-PEG-lips) combined with the ultrasound-targeted microbubble destruction (UTMD) technique on modulating diabetic cardiomyopathy (DCM)and the mechanism involved. Animal st...

journal_title：Drug delivery

authors： Zhang M,Zhu NW,Ma WC,Chen MJ,Zheng L

更新日期：2020-12-01 00:00:00

abstract：:Three formulations including methylene blue solution (MB-S), MB water-in-oil microemulsion (MB-ME), and MB multiple microemulsion (MB-MME) were prepared with the aim to evaluate whether the three formulations can carry MB target to regional lymph nodes and show lymphatic tropism after subcutaneous administration. The ...

journal_title：Drug delivery

authors： Wang S,Yang R,Yao H,Zhou G,Zhang Y,Yang B,Ng L,Yan M

更新日期：2009-10-01 00:00:00

abstract：:A micelle system modified with α-Conotoxin ImI (ImI), a potently antagonist for alpha7 nicotinic acetylcholine receptor (α7-nAChR) previously utilized for targeting breast cancer, was constructed. Its targeting efficiency and cytotoxicity against non-small cell lung cancer (NSCLC) highly expressing α7-nAChR was invest...

journal_title：Drug delivery

authors： Mei D,Zhao L,Chen B,Zhang X,Wang X,Yu Z,Ni X,Zhang Q

更新日期：2018-11-01 00:00:00