Strategies to deliver microRNAs as potential therapeutics in the treatment of cardiovascular pathology.

abstract：:Amphiphilic diblock copolymers composed of methoxy poly ethylene glycol (MePEG) and poly epsilon caprolactone (PCL) were synthesized for the formation of micelles by ring opening mechanism using stannous octoate as a catalyst. The effects of the molecular weight of MePEG and the copolymer ratio on the properties of mi...

journal_title：Drug delivery

authors： Mohanty AK,Dilnawaz F,Mohanty C,Sahoo SK

更新日期：2010-07-01 00:00:00

abstract：:Bevacizumab is an anti-vascular endothelial growth factor drug that can be used to treat choroidal neovascularization (CNV). Bevacizumab-loaded multivesicular liposomes (Bev-MVLs) have been designed and developed to increase the intravitreal retention time of bevacizumab and reduce the number of injection times. In th...

journal_title：Drug delivery

authors： Mu H,Wang Y,Chu Y,Jiang Y,Hua H,Chu L,Wang K,Wang A,Liu W,Li Y,Fu F,Sun K

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:This study introduces the structural design, working principles, performance testing and treatment effects of a newly developed ultrasonic irradiation delivery and treatment catheter system that integrates interventional catheterization technology. BACKGROUND:Systemic administration method needs a high dose...

journal_title：Drug delivery

authors： Yuan QY,Huang J,Li XJ,Peng JB,Li XS,Chen ZP,Si LY

更新日期：2013-08-01 00:00:00

abstract：:This research evaluated 7525DLPCL for soft flexible drug delivery systems. The effect of ciprofloxacin hydrochloride (CIP) loading at three levels (10, 20, and 30%), on thermo-mechanical properties was studied. CIP release was monitored for 12 weeks. Addition of CIP to 7525DLPCL caused an increase in compressive modul...

journal_title：Drug delivery

authors： Waknis V,Jonnalagadda S

更新日期：2011-05-01 00:00:00

abstract：:Chronic rhinosinusitis (CRS) is a rather prevalent condition with a chronic inflammatory process, which is hard to cure. Herein, a new antibacterial drug, nitric oxide (NO), was used for the attempt on CRS therapy. To achieve this, a star copolymer (β-CD-PAMAM) consisting of the β-cyclodextrin (β-CD) core and seven PA...

journal_title：Drug delivery

authors： Liu T,Li G,Wu X,Chen S,Zhang S,Han H,Zhang H,Luo X,Cai X,Ma D

更新日期：2021-12-01 00:00:00

abstract：:Tuberculosis (TB) has gained attention over the past few decades by becoming one of the top ten leading causes of death worldwide. This infectious disease of the lungs is orally treated with a medicinal armamentarium. However, this route of administration passes through the body's first-pass metabolism which reduces t...

journal_title：Drug delivery

authors： Poh W,Ab Rahman N,Ostrovski Y,Sznitman J,Pethe K,Loo SCJ

更新日期：2019-12-01 00:00:00

abstract：:Lung cancer is still the most common cancer globally. Early screening remains the key to improve the prognosis of patients. There is currently a lack of specific and sensitive methods for early screening of lung cancer. In recent years, studies have found that microRNA plays an important role in the occurrence and dev...

journal_title：Drug delivery

authors： Zhu HZ,Hou J,Guo Y,Liu X,Jiang FL,Chen GP,Pang XF,Sun JG,Chen ZT

更新日期：2018-11-01 00:00:00

abstract：:Systemic chemotherapy with the anticancer agent cisplatin is approved for advanced non-melanoma skin cancer (NMSC), but topical treatment is limited by insufficient cutaneous penetration. We studied the impact of ablative fractional laser (AFL) exposure on topical cisplatin's pharmacokinetics and biodistribution in sk...

journal_title：Drug delivery

authors： Wenande E,Olesen UH,Boesen MR,Persson DP,Lerche CM,Stürup S,Gammelgaard B,Husted S,Anderson RR,Haedersdal M

更新日期：2018-11-01 00:00:00

abstract：:In vitro drug release rates from aqueous and oil solutions as well as preformed and in situ formed aqueous and oil suspensions intended for intra-articular delivery have been investigated using the rotating dialysis cell model. Using lidocaine as a model drug substance the release kinetics from aqueous and oil suspens...

journal_title：Drug delivery

authors： Pedersen BT,Larsen SW,Østergaard J,Larsen C

更新日期：2008-01-01 00:00:00

abstract：:Enrofloxacin, a third-generation fluoroquinolone, is a broad-spectrum antimicrobial drug against a lot of veterinary bacterial diseases. However, bactericidal activity of enrofloxacin is concentration-dependent and its poor aqueous solubility and bitter taste limit its development and application. Meanwhile, 2-hydroxy...

journal_title：Drug delivery

authors： Ding Y,Pang Y,Vara Prasad CVNS,Wang B

更新日期：2020-12-01 00:00:00

abstract：:Mucoadhesive drug delivery systems are those that provide intimate contact of the drug with the mucosa for an extended period of time. In our present work, mucoadhesive chitosan microspheres were prepared by emulsion solvent method. Formulations were characterized for various physicochemical attributes, shape, surface...

journal_title：Drug delivery

authors： Jain SK,Chourasia MK,Jain AK,Jain RK,Shrivastava AK

更新日期：2004-03-01 00:00:00

abstract：:The development of mucoadhesive lipidic nanoemulsion based on hyaluronic acid, co-encapsulating two polyphenols (resveratrol and curcumin) for the transnasal treatment of neurodegenerative diseases was attempted in the current manuscript. Nanoemulsions were prepared by the spontaneous emulsification method, and were c...

journal_title：Drug delivery

authors： Nasr M

更新日期：2016-05-01 00:00:00

abstract：CONTEXT:Paclitaxel (PTX) and carboplatin (CBP) are widely used for the combined chemotherapy of non-small cell lung cancer (NSCLC). However, the development of multidrug resistance of cancer cells, as well as systemic toxic side effects resulting from nonspecific localization of anticancer drugs to non-tumor areas are ...

journal_title：Drug delivery

authors： Zhang W,Li C,Shen C,Liu Y,Zhao X,Liu Y,Zou D,Gao Z,Yue C

更新日期：2016-09-01 00:00:00

abstract：:This study aimed to evaluate transdermal delivery of vancomycin hydrochloride using the combination of ethosomes as an encapsulating vesicle and iontophoresis. Ethosomes were prepared and evaluated in terms of electrochemical stability. Cathodal iontophoresis of negatively charged ethosomes and anodal iontophoresis of...

journal_title：Drug delivery

authors： Mohammed MI,Makky AM,Teaima MH,Abdellatif MM,Hamzawy MA,Khalil MA

更新日期：2016-06-01 00:00:00

abstract：:Our objective was to evaluate the chemotherapeutic potential of oral poly lactide-co-glycolide (PLG, a synthetic polymer) nanoparticle encapsulated ethambutol in combination with PLG-nanoparticle encapsulated-(rifampicin + isoniazid + pyrazinamide) in a murine tuberculosis (TB) model. Our formulation was prepared by t...

journal_title：Drug delivery

authors： Pandey R,Sharma S,Khuller GK

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVE:In the present study, Curcumin (CU)-loaded nanocarrier (NC) such as nanoemulsion (NE) was developed with the objective of increasing its cytotoxicity and bioavailability through lymphatic transport by enhancing its solubility and intestinal permeability. MATERIALS AND METHODS:Based on the area obtained in ps...

journal_title：Drug delivery

authors： Kumar A,Ahuja A,Ali J,Baboota S

更新日期：2016-01-01 00:00:00

abstract：:The aim of this research was to increase the oral bioavailability of puerarin by N-trimethyl chitosan-modified microemulsions (TMC-MEs) loaded with puerarin. Different concentrations of TMC-modified microemulsions were prepared in our study, and then evaluated for particle size, zeta potential, morphological observati...

journal_title：Drug delivery

authors： Liao D,Liu X,Dai W,Tang T,Ou G,Zhang K,Han M,Kang R,Yang S,Xiang D

更新日期：2015-01-01 00:00:00

abstract：:The prevalence of childhood dyslipidemia increases and is considered as an important risk factor for the incidence of cardiovascular disease in the adulthood. To improve dosing accuracy and facilitate the determination of dosing regimens in function of the body weight, the proposed study aims at preparing transdermal ...

journal_title：Drug delivery

authors： Zidan AS,Hosny KM,Ahmed OA,Fahmy UA

更新日期：2016-06-01 00:00:00

abstract：:The combined chemotherapy and photodynamic therapy have significant advantages for cancer treatments, which have higher therapeutic effects compared with other medicines. Herein, we focused on the synthesis of carbon quantum dot (CQD) based nanocarrier system. CQD and 5-aminolevulinic acid (5-ALA) were conjugated with...

journal_title：Drug delivery

authors： Li X,Vinothini K,Ramesh T,Rajan M,Ramu A

更新日期：2020-12-01 00:00:00

abstract：:The combination of protein-coated graphene oxide (GO) and microencapsulation technology has moved a step forward in the challenge of improving long-term alginate encapsulated cell survival and sustainable therapeutic protein release, bringing closer its translation from bench to the clinic. Although this new approach ...

journal_title：Drug delivery

authors： Ciriza J,Saenz Del Burgo L,Gurruchaga H,Borras FE,Franquesa M,Orive G,Hernández RM,Pedraz JL

更新日期：2018-11-01 00:00:00

abstract：:In this study, transdermal etodolac-loaded cubosomes were developed in order to relieve patient pain and joints stiffness by providing stable etodolac concentration at the targeting sites through controlled drug delivery via the noninvasive skin route with more sustaining and less frequent dosing. Different ratios and...

journal_title：Drug delivery

authors： Salah S,Mahmoud AA,Kamel AO

更新日期：2017-11-01 00:00:00

abstract：:Three formulations including methylene blue solution (MB-S), MB water-in-oil microemulsion (MB-ME), and MB multiple microemulsion (MB-MME) were prepared with the aim to evaluate whether the three formulations can carry MB target to regional lymph nodes and show lymphatic tropism after subcutaneous administration. The ...

journal_title：Drug delivery

authors： Wang S,Yang R,Yao H,Zhou G,Zhang Y,Yang B,Ng L,Yan M

更新日期：2009-10-01 00:00:00

abstract：CONTEXT:Humic acid (HA), a natural organic matter is recently being investigated for pharmaceutical purposes. Andrographolide (AGP), a potent hepatoprotective, possesses low aqueous solubility which results in a low bioavailability after oral administration, inappropriate tissue localization and consequently poor thera...

journal_title：Drug delivery

authors： Thingale AD,Shaikh KS,Channekar PR,Galgatte UC,Chaudhari PD,Bothiraja C

更新日期：2015-01-01 00:00:00

abstract：:Novel itraconazole (ITZ)-loaded liposomes (ITZ-LPs) were prepared and their pharmacokinetics and biodistribution were assessed in comparison with commercial formulations (ITZ-CD). The ITZ-LPs were prepared by thin-film hydration method and the physicochemical characterizations of the ITZ-LPs were evaluated. The pharma...

journal_title：Drug delivery

authors： Tang J,Wei H,Liu H,Ji H,Dong D,Zhu D,Wu L

更新日期：2010-05-01 00:00:00

abstract：:Hydrogels based on poly(ethylene glycol)-diacrylate (PEG-DA) and 2-hydroxyethyl methacrylate (HEMA) were polymerized with cross-linking agent ethylene glycol diacrylate (EGDMA) under mild photoinitiating conditions. PEG-DA and HEMA concentrations of disks with 1 +/- 0.3 mm thickness were 30% and 50% w/w and 40% and 60...

journal_title：Drug delivery

authors： Ayhan F,Ozkan S

更新日期：2007-10-01 00:00:00

abstract：:Combined administration of different drugs is a widely acknowledged approach for effective cancer therapy. However, the limited targeting, as well as inferior drug loading capacities of current drug delivery systems (DDS), are still the bottleneck for better performance in cancer treatment. Herein, we successfully dev...

journal_title：Drug delivery

authors： Li D,Cui R,Xu S,Liu Y

更新日期：2020-12-01 00:00:00

abstract：:Some cancers such as human breast cancer, prostate cancer, and lung cancer easily metastasize to bone, leading to osteolysis and bone destruction accompanied by a complicated microenvironment. Systemic administration of bisphosphonates (BP) or denosumab is the routine therapy for osteolysis but with non-negligible sid...

journal_title：Drug delivery

authors： Cheng X,Wei J,Ge Q,Xing D,Zhou X,Qian Y,Jiang G

更新日期：2021-12-01 00:00:00

abstract：:This study evaluated three chitosan-N-acetyl cysteine (CAC) conjugates of increasing molecular mass as a valuable tool to improve the absorption of drugs by assessing its permeation enhancing effect regarding the active P-gp substrate rhodamine-123 in comparison to the trans- and paracellular marker FD 4 both in rat i...

journal_title：Drug delivery

authors： Schmitz T,Hombach J,Bernkop-Schnürch A

更新日期：2008-05-01 00:00:00

abstract：:Systemic drug delivery systems (SDDSs) for thyroid cancer treatment are associated with serious side effects including nausea, anorexia, and hair loss as a result of damage to normal tissues. In this study, we investigated the feasibility of a local DDS (LDDS) based on visible light-cured glycol chitosan (GC) hydrogel...

journal_title：Drug delivery

authors： Yoo Y,Yoon SJ,Kim SY,Lee DW,Um S,Hyun H,Hong SO,Yang DH

更新日期：2018-11-01 00:00:00

abstract：CONTEXT:Docetaxel is now a major antitumor drug in clinical use for the treatment of a variety of tumors. The ethanol/Tween 80 solvent required in the formulation to increase the docetaxel solubility is at least partly responsible for the hypersensitivity reaction, decreased uptake by tumor tissue, and increased exposu...

journal_title：Drug delivery

authors： Jiang S,Gong X,Zhao X,Zu Y

更新日期：2015-02-01 00:00:00