Abstract:
CONTEXT:Humic acid (HA), a natural organic matter is recently being investigated for pharmaceutical purposes. Andrographolide (AGP), a potent hepatoprotective, possesses low aqueous solubility which results in a low bioavailability after oral administration, inappropriate tissue localization and consequently poor therapeutic application. OBJECTIVE:The present study investigates the complexation of AGP with HA to increase its solubility and hepatoprotective efficacy. MATERIALS AND METHODS:Complexes prepared by solvent evaporation in various weight ratios were characterized using differential scanning calorimetry, Fourier Transform InfraRed spectroscopy, X-ray diffraction, and scanning electron microscopy. RESULTS AND DISCUSSION:The complexed AGP demonstrated improved solubility, dissolution, and permeation across rat intestine. It also displayed better hepatoprotection against carbontetrachloride-induced liver toxicity than the free drug in rats. CONCLUSION:Complexation with HA is a valuable technique to improve solubility and bioavailability of pharmaceuticals.
journal_name
Drug Delivjournal_title
Drug deliveryauthors
Thingale AD,Shaikh KS,Channekar PR,Galgatte UC,Chaudhari PD,Bothiraja Cdoi
10.3109/10717544.2013.871602subject
Has Abstractpub_date
2015-01-01 00:00:00pages
117-24issue
1eissn
1071-7544issn
1521-0464journal_volume
22pub_type
杂志文章相关文献
DRUG DELIVERY文献大全abstract::The aim of our study was to investigate the enhancing effect of several essential oils in the percutaneous absorption of trazodone hydrochloride (TZN). For this purpose, fennel oil, eucalyptus oil, citronella oil, and mentha oil were applied on the skin membrane in three different ways: included in the transdermal dev...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500395064
更新日期:2006-11-01 00:00:00
abstract::Currently, traumatic brain injury (TBI) is the leading cause of death or disabilities in young individuals worldwide. The multi-complexity of its pathogenesis as well as impermeability of the blood-brain barrier (BBB) makes the drug choice and delivery very challenging. The brain-derived neurotrophic factor (BDNF) reg...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2016.1199609
更新日期:2016-11-01 00:00:00
abstract::In the present study, the stability of thymopentin (TP5) in bronchoalveolar lavage fluid (BALF) in presence of potential excipients in inhalation formulation was investigated. The content of TP5 was determined using HPLC method. Commonly used bulking agent, dispersibility enhancers and absorption enhancers in inhalati...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.878002
更新日期:2014-09-01 00:00:00
abstract::Recently, genkwanin (GKA) has been shown to display in vitro antitumor activity against some cancer cells, but its poor solubility restricted the in vivo study and further investigation of its antitumor therapeutic efficacy. In this paper, genkwanin nanosuspensions (GKA-NSps) were successfully prepared using D-alpha t...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1384519
更新日期:2017-11-01 00:00:00
abstract::Piroxicam (PX), a main member of non-steroidal anti-inflammatory drugs (NSAIDs), is mainly used orally, which causes side effects of the gastrointestinal tract. It also has systemic effects when administered intramuscularly. Intra-articular (IA) delivery and encapsulation of PX in biodegradable poly-ε-caprolactone (PC...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1716881
更新日期:2020-12-01 00:00:00
abstract::HER2-positive breast cancer correlates with more aggressive tumor growth, a poorer prognosis and reduced overall survival. Currently, trastuzumab (Herceptin), which is an anti-HER2 antibody, is one of the key drugs. There is evidence indicating that conjugation of trastuzumab with chemotherapy drugs, such as doxorubic...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1435746
更新日期:2018-11-01 00:00:00
abstract::The aim of the current study was to formulate terconazole (TCZ) loaded polymeric mixed micelles (PMMs) incorporating Cremophor EL as a stabilizer and a penetration enhancer. A 23 full factorial design was performed using Design-Expert® software for the optimization of the PMMs which were formulated using Pluronic P123...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1436098
更新日期:2018-11-01 00:00:00
abstract::Silk was easily dyed in traditional textile industry because of its strong affinity to many colorants. Herein, the biocompatible silk fibroin was firstly extracted from Bombyx mori silkworm cocoons. And SF nanoparticles (SFNPs) were prepared for dyeing indocyanine green (ICG) and construct a therapeutic nano-platform ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1428244
更新日期:2018-11-01 00:00:00
abstract::Chronic rhinosinusitis (CRS) is a rather prevalent condition with a chronic inflammatory process, which is hard to cure. Herein, a new antibacterial drug, nitric oxide (NO), was used for the attempt on CRS therapy. To achieve this, a star copolymer (β-CD-PAMAM) consisting of the β-cyclodextrin (β-CD) core and seven PA...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2021.1876183
更新日期:2021-12-01 00:00:00
abstract::Reactive oxygen species (ROS)-induced neuronal mitochondrial dysfunction is a key pathologic factor in sporadic Alzheimer's disease (AD). Neuronal mitochondria have been proposed to be a promising therapeutic target for AD, especially for the failures of phase III clinical trials on conventional amyloid-β (Aβ) targete...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1745328
更新日期:2020-12-01 00:00:00
abstract::In vitro drug release rates from aqueous and oil solutions as well as preformed and in situ formed aqueous and oil suspensions intended for intra-articular delivery have been investigated using the rotating dialysis cell model. Using lidocaine as a model drug substance the release kinetics from aqueous and oil suspens...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540701828657
更新日期:2008-01-01 00:00:00
abstract::A micelle system modified with α-Conotoxin ImI (ImI), a potently antagonist for alpha7 nicotinic acetylcholine receptor (α7-nAChR) previously utilized for targeting breast cancer, was constructed. Its targeting efficiency and cytotoxicity against non-small cell lung cancer (NSCLC) highly expressing α7-nAChR was invest...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1436097
更新日期:2018-11-01 00:00:00
abstract::Although convection-enhanced delivery (CED) can successfully facilitate a bypass of the blood brain barrier, its treatment efficacy remains highly limited in clinic. This can be partially attributed to the brain anisotropic characteristics that lead to the difficulties in controlling the drug spatial distribution. Her...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2019.1639844
更新日期:2019-12-01 00:00:00
abstract::ALA-loaded nanostructured lipid carrier (ALA-NLC) was designed to improve physicochemical stability and water solubility, and promote sustained release of ALA as well as determine the biocompatibility of ALA-NLC. The ALA-NLC manufactured using hot high-pressure homogenization technique was investigated in terms of siz...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.846435
更新日期:2014-08-01 00:00:00
abstract::Stealth solid lipid nanoparticles (SSLN) were prepared and evaluated for the effect of evading phagocytic uptake by mouse peritoneal macrophages in situ. Fluorescent SSLNs were prepared by emulsion/evaporation with rhodamine B as the fluorescent marker and polyoxyethylene stearate as stealth agent in a stearic acid ma...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500315930
更新日期:2006-05-01 00:00:00
abstract::Systemic drug delivery systems (SDDSs) for thyroid cancer treatment are associated with serious side effects including nausea, anorexia, and hair loss as a result of damage to normal tissues. In this study, we investigated the feasibility of a local DDS (LDDS) based on visible light-cured glycol chitosan (GC) hydrogel...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1507058
更新日期:2018-11-01 00:00:00
abstract::Pantoprazole is a proton pump inhibitor prodrug used in the treatment of gastric ulcers and gastroesophageal disease. Pantoprazole must be absorbed in the gastrointestinal tract and because it is unstable under acidic conditions, enteric delivery systems are required. The purpose of this study was to prepare pantopraz...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540802006864
更新日期:2008-06-01 00:00:00
abstract::Raloxifene (RLX) is a second-generation selective estrogen receptor modulator used to treat osteoporosis in postmenopausal women. RLX fails to be developed into injectable dosage forms due to poor solubility. Although oral formulations are clinically available, the lower bioavailability (<2%) embarrasses the pharmaceu...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2021.1872742
更新日期:2021-12-01 00:00:00
abstract::Hydroxy genkwanin (HGK), a flavonoid compound from natural resources, showed good inhibition against the growth of breast tumor cells. However, the poor solubility restricted the further study and the in vivo drug delivery of HGK. We prepared HGK nanosuspensions by antisolvent precipitation method and investigated the...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1770372
更新日期:2020-12-01 00:00:00
abstract::S-nitrosothiols are a class of NO-donors currently under investigation for the treatment of various diseases. In this study, we developed a novel NO-donor (S-nitrosoglutathione-alginate, SNA) by cross-linking alginate with S-nitrosothiols, which can deliver NO in a sustained manner. This compound can be further evalua...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1122676
更新日期:2016-10-01 00:00:00
abstract::Aminoglycoside-induced hair cell (HC) loss is a major cause of hearing impairment, and the effective prevention of HC loss remains an unmet medical need. Epigenetic mechanisms have been reported to be involved in protecting cochlear cells against ototoxic drug injury, and in this study we developed new bioactive compo...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1461277
更新日期:2018-11-01 00:00:00
abstract::Pingyangmycin (PYM) has been applied clinically for many years to treat vascular malformations (VM) in China. The major limitation of PYM injections is quick diffusion from the injection site, which increases side effects, especially the possibility of pulmonary injury. In this paper, chitosan/glycerophosphate disodiu...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1444684
更新日期:2018-11-01 00:00:00
abstract::Ocular drug delivery remains challenging because of the complex nature and structure of the eye. Conventional systems, such as eye drops and ointments, are inefficient, whereas systemic administration requires high doses resulting in significant toxicity. There is a need to develop novel drug delivery carriers capable...
journal_title:Drug delivery
pub_type: 杂志文章,评审
doi:10.3109/10717544.2010.483257
更新日期:2010-09-01 00:00:00
abstract::To develop statistically optimized brain targeted Tween 80 coated chitosan nanoparticulate formulation for oral delivery of doxycycline hydrochloride for the treatment of psychosis and to evaluate its protective effect on ketamine induced behavioral, biochemical, neurochemical and histological alterations in mice. 32 ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1377315
更新日期:2017-11-01 00:00:00
abstract::The aim of this study was to obtain a stable, amorphous solid dispersion (SD) with Soluplus, prepared by hot-melt extrusion (HME) as an effective and stable oral delivery system to improve the physical stability and bioavailability of the poorly water-soluble simvastatin (SIM), a drug with relatively low Tg. The drug ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.960982
更新日期:2016-07-01 00:00:00
abstract::Bone metastasis is a devastating complication of cancer that requires an immediate attention. Although our understanding of the metastatic process has improved over the years, yet a number of questions still remain unanswered, and more research is required for complete understanding of the skeletal consequences of met...
journal_title:Drug delivery
pub_type: 杂志文章,评审
doi:10.3109/10717544.2014.913325
更新日期:2016-01-01 00:00:00
abstract::This study evaluated three chitosan-N-acetyl cysteine (CAC) conjugates of increasing molecular mass as a valuable tool to improve the absorption of drugs by assessing its permeation enhancing effect regarding the active P-gp substrate rhodamine-123 in comparison to the trans- and paracellular marker FD 4 both in rat i...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540802006708
更新日期:2008-05-01 00:00:00
abstract::Mucoadhesive drug delivery systems are those that provide intimate contact of the drug with the mucosa for an extended period of time. In our present work, mucoadhesive chitosan microspheres were prepared by emulsion solvent method. Formulations were characterized for various physicochemical attributes, shape, surface...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540490280750
更新日期:2004-03-01 00:00:00
abstract::The objective of this study was to establish a drug transport study using human nasal epithelial (HNE) cell monolayers cultured by the air-liquid interface (ALI) method using serum-free medium (BEGM:DME/F12, 50:50). The cells were developed and characterized in comparison to those that have been previously cultured by...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500177009
更新日期:2005-09-01 00:00:00
abstract::The aim of this study was to evaluate the effects of therapeutic pulsed ultrasound with gold nanoparticles on oxidative stress parameters after traumatic muscle injury in Wistar rats. The animals were randomly divided into nine groups (n = 6 each): sham (uninjured muscle); muscle injury without treatment; muscle injur...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.923063
更新日期:2016-01-01 00:00:00