Effect of nanostructured lipid carriers on transdermal delivery of tenoxicam in irradiated rats.

abstract：:Surface modification of liposomes with polymer to optimize drug delivery was well developed recently. The objective of the present work was to evaluate the feasibility of chitosan-coated liposomes (CSLP) as vehicles for anti-sense oligodeoxynucleotides (ASON). CSLP was obtained by adding chitosan dropwise to liposomes...

journal_title：Drug delivery

authors： Wang WX,Gao JQ,Liang WQ

更新日期：2011-04-01 00:00:00

abstract：:Novel itraconazole (ITZ)-loaded liposomes (ITZ-LPs) were prepared and their pharmacokinetics and biodistribution were assessed in comparison with commercial formulations (ITZ-CD). The ITZ-LPs were prepared by thin-film hydration method and the physicochemical characterizations of the ITZ-LPs were evaluated. The pharma...

journal_title：Drug delivery

authors： Tang J,Wei H,Liu H,Ji H,Dong D,Zhu D,Wu L

更新日期：2010-05-01 00:00:00

abstract：:In vitro characteristics of the human erythrocytes loaded by enalaprilat have been evaluated. Erythrocytes obtained from a healthy volunteer were loaded by enalaprilat using the hypotonic preswelling method, and the loading parameters, drug-release kinetics, hematological indices, particle size distribution, scanning ...

journal_title：Drug delivery

authors： Hamidi M,Tajerzadeh H,Dehpour AR,Rouini MR,Ejtemaee-Mehr S

更新日期：2001-10-01 00:00:00

abstract：CONTEXT:MicroRNAs (miRNAs) are important and powerful mediators in a variety of diseases including cardiovascular pathology. Thus, they emerged as interesting new drug targets. However, it is important to develop efficient transfer tools to successfully deliver miRNAs or antisense oligonucleotides (antagomirs) to the t...

journal_title：Drug delivery

authors： Chistiakov DA,Sobenin IA,Orekhov AN

更新日期：2012-11-01 00:00:00

abstract：:Polymer nano-sized hydrogels (nanogels) as drug delivery carriers have been investigated over the last few decades. Pullulan, a nontoxic and nonimmunogenic hydrophilic polysaccharide derived from fermentation of black yeast like Aureobasidium pullulans with great biocompatibility and biodegradability, is one of the mo...

journal_title：Drug delivery

authors： Zhang T,Yang R,Yang S,Guan J,Zhang D,Ma Y,Liu H

更新日期：2018-11-01 00:00:00

abstract：:The combined chemotherapy and photodynamic therapy have significant advantages for cancer treatments, which have higher therapeutic effects compared with other medicines. Herein, we focused on the synthesis of carbon quantum dot (CQD) based nanocarrier system. CQD and 5-aminolevulinic acid (5-ALA) were conjugated with...

journal_title：Drug delivery

authors： Li X,Vinothini K,Ramesh T,Rajan M,Ramu A

更新日期：2020-12-01 00:00:00

abstract：:Colon is an ideal absorptive site for oral protein and peptide drug (insulin), and yet it poses multiple barriers against the drug absorption, such as the barriers against the drug diffusion from colon lumen toward the absorptive mucosa and permeation across colon epithelium. In this study, modified nanoparticles (Tat...

journal_title：Drug delivery

authors： Guo F,Zhang M,Gao Y,Zhu S,Chen S,Liu W,Zhong H,Liu J

更新日期：2016-07-01 00:00:00

abstract：:Camptothecin (CPT) is an effective anticancer agent against various cancers but the clinical application is limited because of its poor water solubility, low bioavailability and severe toxic side effects. The aim of the present study was to evaluate the feasibility of using targeted NPs as a high-performance CPT deliv...

journal_title：Drug delivery

authors： Yang A,Liu Z,Yan B,Zhou M,Xiong X

更新日期：2016-06-01 00:00:00

abstract：:Pingyangmycin (PYM) has been applied clinically for many years to treat vascular malformations (VM) in China. The major limitation of PYM injections is quick diffusion from the injection site, which increases side effects, especially the possibility of pulmonary injury. In this paper, chitosan/glycerophosphate disodiu...

journal_title：Drug delivery

authors： Zhang L,Chen F,Zheng J,Wang H,Qin X,Pan W

更新日期：2018-11-01 00:00:00

abstract：:Electro-phonophoresis (EP) has been used in various clinical fields. The objective of present study is to evaluate the skin permeability of isoniazid (INH) and rifampicin (RIF) in patients with tuberculous lymphadenitis with the aid of EP to validate the clinical applications of this transdermal delivery system for th...

journal_title：Drug delivery

authors： Chen S,Qin M,Han Y,Zhao L,Fu Y,Shang Y,Liu Z,Huang H

更新日期：2016-06-01 00:00:00

abstract：:Traditional in situ gel forming systems are potential applications for parenteral administration but always accompanied with burst release. To overcome this limitation, the tinidazole (TNZ)-loaded in situ gel forming system using a diblock copolymer, monomethoxy poly(ethylene glycol)-block-poly(d,l-lactide) (mPEG-PDLL...

journal_title：Drug delivery

authors： Tian Y,Shen Y,Jv M

更新日期：2016-10-01 00:00:00

abstract：:Improvement of water solubility, dissolution rate, oral bioavailability, and reduction of first pass metabolism of OL (OL), were the aims of this research. Co-amorphization of OL carboxylic acid dispersions at various molar ratios was carried out using rapid solvent evaporation. Characterization of the dispersions was...

journal_title：Drug delivery

authors： Maher EM,Ali AM,Salem HF,Abdelrahman AA

更新日期：2016-10-01 00:00:00

abstract：:Usually the topical delivery of ocular drugs poses a great challenge. Accordingly, the work in this study comprised the use of different hybrids of generally regarded as safe (GRAS) oils and surfactants in order to develop and optimize novel acetazolamide (AZD) entrapped-vesicular systems aiming at improving its ocula...

journal_title：Drug delivery

authors： Naguib SS,Hathout RM,Mansour S

更新日期：2017-11-01 00:00:00

abstract：:Glaucocalyxin A (GLA) is a phytochemical component with multiple pharmacological activities; however, glaucocalyxin A's wider use has been restricted by its poor solubility. In this study, GLA nanosuspensions were prepared with precipitation-combined ultrasonication and were characterized by dynamic light scattering (...

journal_title：Drug delivery

authors： Han M,Li Z,Guo Y,Zhang J,Wang X

更新日期：2016-09-01 00:00:00

abstract：:Nonviral gene delivery systems are a promising approach for gene therapy applications, despite their low in vivo gene transfer efficiency. One approach to enhance this efficiency is to incorporate targeting elements into cationic lipid/DNA complexes (lipoplexes). Ligand-containing lipoplexes have to retain their effic...

journal_title：Drug delivery

authors： Carrière M,Escriou V,Jollet A,Scherman D,Azoulay M,Monneret C

更新日期：2004-11-01 00:00:00

abstract：:Ischemic stroke is one of the major causes of severe disability and death worldwide. It is mainly caused by a sudden reduction in cerebral blood flow due to obstruction of the supplying vessel by thrombi and subsequent initiation of a complex cascade of pathophysiological changes, which ultimately lead to brain ischem...

journal_title：Drug delivery

authors： Ma H,Jiang Z,Xu J,Liu J,Guo ZN

更新日期：2021-12-01 00:00:00

abstract：:Magnetic nanocomposite particles were synthesized by encapsulating nanosized magnetite with an acrylate-based cationic co-polymer made of MMA, BA, and QMA and modifying with MeOPEGMA using the water replacement method. The composition of the co-polymer formulation was optimized based on zeta-potential measurements and...

journal_title：Drug delivery

authors： Phanapavudhikul P,Shen S,Ng WK,Tan RB

更新日期：2008-03-01 00:00:00

abstract：:Our objective was to evaluate the chemotherapeutic potential of oral poly lactide-co-glycolide (PLG, a synthetic polymer) nanoparticle encapsulated ethambutol in combination with PLG-nanoparticle encapsulated-(rifampicin + isoniazid + pyrazinamide) in a murine tuberculosis (TB) model. Our formulation was prepared by t...

journal_title：Drug delivery

authors： Pandey R,Sharma S,Khuller GK

更新日期：2006-07-01 00:00:00

abstract：:At present, the chemotherapy of advanced inoperable liver cancer is limited with serious side effects. Curcumin possesses multiple cancer preventive activities and low safety concerns. However, its poor solubility and instability in water pose significant pharmacological barriers to its clinical application. In this s...

journal_title：Drug delivery

authors： Chang M,Wu M,Li H

更新日期：2018-11-01 00:00:00

abstract：:Hydrogels are water swollen networks of polymers and especially hydrogels consisting of poly vinylpyrrolidone/poly ethyleneglycol-dimethacrylate (PVP/PEG-DMA) blends show promising wound care properties. Enhanced functionality of the hydrogels can be achieved by incorporating drugs and other substances that may assist...

journal_title：Drug delivery

authors： Nielsen AL,Madsen F,Larsen KL

更新日期：2009-02-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) were generated to the extracellular domain of transcobalamin receptor (TCblR) and used to identify the regions of the receptor protein involved in antibody binding. Based on the effect of transcobalamin bound cobalamin (TC-Cbl) on antibody binding, this study identified both blocking and b...

journal_title：Drug delivery

authors： Jiang W,Nakayama Y,Sequeira JM,Quadros EV

更新日期：2011-01-01 00:00:00

abstract：:Some cancers such as human breast cancer, prostate cancer, and lung cancer easily metastasize to bone, leading to osteolysis and bone destruction accompanied by a complicated microenvironment. Systemic administration of bisphosphonates (BP) or denosumab is the routine therapy for osteolysis but with non-negligible sid...

journal_title：Drug delivery

authors： Cheng X,Wei J,Ge Q,Xing D,Zhou X,Qian Y,Jiang G

更新日期：2021-12-01 00:00:00

abstract：:Systemic chemotherapy with the anticancer agent cisplatin is approved for advanced non-melanoma skin cancer (NMSC), but topical treatment is limited by insufficient cutaneous penetration. We studied the impact of ablative fractional laser (AFL) exposure on topical cisplatin's pharmacokinetics and biodistribution in sk...

journal_title：Drug delivery

authors： Wenande E,Olesen UH,Boesen MR,Persson DP,Lerche CM,Stürup S,Gammelgaard B,Husted S,Anderson RR,Haedersdal M

更新日期：2018-11-01 00:00:00

abstract：:Systemic drug delivery systems (SDDSs) for thyroid cancer treatment are associated with serious side effects including nausea, anorexia, and hair loss as a result of damage to normal tissues. In this study, we investigated the feasibility of a local DDS (LDDS) based on visible light-cured glycol chitosan (GC) hydrogel...

journal_title：Drug delivery

authors： Yoo Y,Yoon SJ,Kim SY,Lee DW,Um S,Hyun H,Hong SO,Yang DH

更新日期：2018-11-01 00:00:00

abstract：:Although convection-enhanced delivery (CED) can successfully facilitate a bypass of the blood brain barrier, its treatment efficacy remains highly limited in clinic. This can be partially attributed to the brain anisotropic characteristics that lead to the difficulties in controlling the drug spatial distribution. Her...

journal_title：Drug delivery

authors： Zhan W,Rodriguez Y Baena F,Dini D

更新日期：2019-12-01 00:00:00

abstract：:Various ocular diseases like glaucoma, conjunctivitis, and dry eye syndrome require frequent drug administration. Poor ocular bioavailability of drugs (< 1%) from conventional eye drops is due mainly to the precorneal loss factors that include rapid tear turnover, nonproductive absorption, transient residence time in ...

journal_title：Drug delivery

authors： Gupta H,Jain S,Mathur R,Mishra P,Mishra AK,Velpandian T

更新日期：2007-11-01 00:00:00

abstract：:Lung cancer is still the most common cancer globally. Early screening remains the key to improve the prognosis of patients. There is currently a lack of specific and sensitive methods for early screening of lung cancer. In recent years, studies have found that microRNA plays an important role in the occurrence and dev...

journal_title：Drug delivery

authors： Zhu HZ,Hou J,Guo Y,Liu X,Jiang FL,Chen GP,Pang XF,Sun JG,Chen ZT

更新日期：2018-11-01 00:00:00

abstract：:Tuberculosis (TB) has gained attention over the past few decades by becoming one of the top ten leading causes of death worldwide. This infectious disease of the lungs is orally treated with a medicinal armamentarium. However, this route of administration passes through the body's first-pass metabolism which reduces t...

journal_title：Drug delivery

authors： Poh W,Ab Rahman N,Ostrovski Y,Sznitman J,Pethe K,Loo SCJ

更新日期：2019-12-01 00:00:00

abstract：:Etoposide (VP16) is the traditional antitumor agent which has been widely used in a variety of cancers. However, intravenous administration of VP16 was limited in clinical application because of its low aqueous solubility, poor bioavailability and dose-limiting adverse effects. Local chemotherapy with VP16-loaded drug...

journal_title：Drug delivery

authors： Wu C,Yi X,Xu R,Zhang M,Xu Y,Ma Y,Gao L,Zha Z

更新日期：2020-12-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis is a chronic autoimmune disease affecting nearly five million people worldwide. Among all drug delivery system, oral administration is the most preferable route for colon-specific targeting and the treatment of IBD. Herein, an amphiphilic ...

journal_title：Drug delivery

authors： Qiao H,Fang D,Chen J,Sun Y,Kang C,Di L,Li J,Chen Z,Chen J,Gao Y

更新日期：2017-11-01 00:00:00