Combinational dual drug delivery system to enhance the care and treatment of gastric cancer patients.

Abstract:

:Gastric cancer is a frequently occurring cancer with high mortality each year worldwide. Finding new and effective therapeutic strategy against human gastric cancer is still urgently required. Hence, we have established a new method to achieve treatment-actuated modifications in a tumor microenvironment by utilizing synergistic activity between two potential anticancer drugs. Dual drug delivery of gemcitabine (GEM) and Camptothecin-11 (CPT-11) exhibits a great anti-cancer potential, as GEM enhances the effect of CPT-11 treatment of human gastric cells by providing microenvironment stability. However, encapsulation of GEM and CPT-11 obsessed by poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles (NPs) is incompetent owing to unsuitability between the binary free GEM and CPT-11 moieties and the polymeric system. Now, we display that CPT-11 can be prepared by hydrophobic covering of the drug centers with dioleoylphosphatidic acid (DOPA). The DOPA-covered CPT-11 can be co-encapsulated in PLGA NPs alongside GEM to stimulate excellent anticancer property. The occurrence of the CPT-11 suggestively enhanced the encapsulations of GEM into PLGA NPs (GEM-CPT-11 NPs). Formation of the nanocomposite (GEM-CPT-11 NPs) was confirmed by FTIR and X-ray spectroscopic techniques. Further, the morphology of GEM NPs, CPT-11 NPs, and GEM-CPT-11 NPs and NP size was examined by transmission electron microscopy (TEM), respectively. Furthermore, GEM-CPT-11 NPs induced significant apoptosis in human gastric NCI-N87 and SGC-791 cancer cells in vitro. The morphological observation and apoptosis were confirmed by the various biochemical assays (AO-EB, nuclear staining, and annexin V-FITC). In addition, evaluation of the hemolysis assay with erythrocytes of human shows excellent biocompatibility of free GEM, free CPT-11, GEM NPs, CPT-11 NPs, and GEM-CPT-11 NPs. The results suggest that GEM-CPT-11 NPs are one of the promising nursing cares for human gastric cancer therapeutic candidates worthy of further investigations.

journal_name

Drug Deliv

journal_title

Drug delivery

authors

Xiao Y,Gao Y,Li F,Deng Z

doi

10.1080/10717544.2020.1822460

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

1491-1500

issue

1

eissn

1071-7544

issn

1521-0464

journal_volume

27

pub_type

杂志文章
  • Multiseed liposomal drug delivery system using micelle gradient as driving force to improve amphiphilic drug retention and its anti-tumor efficacy.

    abstract::To improve drug retention in carriers for amphiphilic asulacrine (ASL), a novel active loading method using micelle gradient was developed to fabricate the ASL-loaded multiseed liposomes (ASL-ML). The empty ML were prepared by hydrating a thin film with empty micelles. Then the micelles in liposomal compartment acting...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2018.1440669

    authors: Zhang W,Li C,Jin Y,Liu X,Wang Z,Shaw JP,Baguley BC,Wu Z,Liu J

    更新日期:2018-11-01 00:00:00

  • In vitro assessment of lidocaine release from aqueous and oil solutions and from preformed and in situ formed aqueous and oil suspensions. Parenteral depots for intra-articular administration.

    abstract::In vitro drug release rates from aqueous and oil solutions as well as preformed and in situ formed aqueous and oil suspensions intended for intra-articular delivery have been investigated using the rotating dialysis cell model. Using lidocaine as a model drug substance the release kinetics from aqueous and oil suspens...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717540701828657

    authors: Pedersen BT,Larsen SW,Østergaard J,Larsen C

    更新日期:2008-01-01 00:00:00

  • New synthetic glycolipids for targeted gene transfer: synthesis, formulation in lipoplexes and specific interaction with lectin.

    abstract::Nonviral gene delivery systems are a promising approach for gene therapy applications, despite their low in vivo gene transfer efficiency. One approach to enhance this efficiency is to incorporate targeting elements into cationic lipid/DNA complexes (lipoplexes). Ligand-containing lipoplexes have to retain their effic...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717540490265405

    authors: Carrière M,Escriou V,Jollet A,Scherman D,Azoulay M,Monneret C

    更新日期:2004-11-01 00:00:00

  • Characterizing monoclonal antibodies to antigenic domains of TCblR/CD320, the receptor for cellular uptake of transcobalamin-bound cobalamin.

    abstract::Monoclonal antibodies (mAbs) were generated to the extracellular domain of transcobalamin receptor (TCblR) and used to identify the regions of the receptor protein involved in antibody binding. Based on the effect of transcobalamin bound cobalamin (TC-Cbl) on antibody binding, this study identified both blocking and b...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2010.509745

    authors: Jiang W,Nakayama Y,Sequeira JM,Quadros EV

    更新日期:2011-01-01 00:00:00

  • Influence of potential inhalation carriers on stability of thymopentin in rat bronchoalveolar lavage fluid.

    abstract::In the present study, the stability of thymopentin (TP5) in bronchoalveolar lavage fluid (BALF) in presence of potential excipients in inhalation formulation was investigated. The content of TP5 was determined using HPLC method. Commonly used bulking agent, dispersibility enhancers and absorption enhancers in inhalati...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2013.878002

    authors: Cai C,Wang L,Dong W,Tang X

    更新日期:2014-09-01 00:00:00

  • Curcumin-loaded lipid nanocarrier for improving bioavailability, stability and cytotoxicity against malignant glioma cells.

    abstract:OBJECTIVE:In the present study, Curcumin (CU)-loaded nanocarrier (NC) such as nanoemulsion (NE) was developed with the objective of increasing its cytotoxicity and bioavailability through lymphatic transport by enhancing its solubility and intestinal permeability. MATERIALS AND METHODS:Based on the area obtained in ps...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2014.909906

    authors: Kumar A,Ahuja A,Ali J,Baboota S

    更新日期:2016-01-01 00:00:00

  • Disposition of 3H-cholesteryl ether labeled liposomes following intravenous administration to mice: comparison with an encapsulated 14C-inulin as aqueous phase marker.

    abstract::In this study, the blood clearance and organ distribution of intravenously administered liposomes (distearoyl phosphatidylcholine [DSPC] and cholesterol in a ratio of 3:1) was evaluated by utilizing 3H-cholesteryl ether as the lipid phase marker. Also, the ability of liposomes, as a drug delivery system, to alter the ...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/713840396

    authors: Anderson M,Paradis C,Omri A

    更新日期:2003-07-01 00:00:00

  • Biodistribution of etoposide via intratumoral chemotherapy with etoposide-loaded implants.

    abstract::Etoposide (VP16) is the traditional antitumor agent which has been widely used in a variety of cancers. However, intravenous administration of VP16 was limited in clinical application because of its low aqueous solubility, poor bioavailability and dose-limiting adverse effects. Local chemotherapy with VP16-loaded drug...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2020.1787558

    authors: Wu C,Yi X,Xu R,Zhang M,Xu Y,Ma Y,Gao L,Zha Z

    更新日期:2020-12-01 00:00:00

  • Preparation of hydroxy genkwanin nanosuspensions and their enhanced antitumor efficacy against breast cancer.

    abstract::Hydroxy genkwanin (HGK), a flavonoid compound from natural resources, showed good inhibition against the growth of breast tumor cells. However, the poor solubility restricted the further study and the in vivo drug delivery of HGK. We prepared HGK nanosuspensions by antisolvent precipitation method and investigated the...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2020.1770372

    authors: Ao H,Li Y,Li H,Wang Y,Han M,Guo Y,Shi R,Yue F,Wang X

    更新日期:2020-12-01 00:00:00

  • Cyclodextrin modified hydrogels of PVP/PEG for sustained drug release.

    abstract::Hydrogels are water swollen networks of polymers and especially hydrogels consisting of poly vinylpyrrolidone/poly ethyleneglycol-dimethacrylate (PVP/PEG-DMA) blends show promising wound care properties. Enhanced functionality of the hydrogels can be achieved by incorporating drugs and other substances that may assist...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717540802605129

    authors: Nielsen AL,Madsen F,Larsen KL

    更新日期:2009-02-01 00:00:00

  • Novel poly-DL-lactide-polycaprolactone copolymer based flexible drug delivery system for sustained release of ciprofloxacin.

    abstract::This research evaluated 7525DLPCL for soft flexible drug delivery systems. The effect of ciprofloxacin hydrochloride (CIP) loading at three levels (10, 20, and 30%), on thermo-mechanical properties was studied. CIP release was monitored for 12 weeks. Addition of CIP to 7525DLPCL caused an increase in compressive modul...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2010.528070

    authors: Waknis V,Jonnalagadda S

    更新日期:2011-05-01 00:00:00

  • Antitumor activities of novel glycyrrhetinic acid-modified curcumin-loaded cationic liposomes in vitro and in H22 tumor-bearing mice.

    abstract::At present, the chemotherapy of advanced inoperable liver cancer is limited with serious side effects. Curcumin possesses multiple cancer preventive activities and low safety concerns. However, its poor solubility and instability in water pose significant pharmacological barriers to its clinical application. In this s...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2018.1526227

    authors: Chang M,Wu M,Li H

    更新日期:2018-11-01 00:00:00

  • pH-responsive thiolated chitosan nanoparticles for oral low-molecular weight heparin delivery: in vitro and in vivo evaluation.

    abstract::The aim of present study was to investigate a pH-responsive and mucoadhesive nanoparticle system for oral bioavailability enhancement of low-molecular weight heparin (LMWH). The thioglycolic acid (TGA) was first covalently attached to chitosan (CS) with 396.97 ± 54.54 μmol thiol groups per gram of polymer and then the...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2014.909908

    authors: Fan B,Xing Y,Zheng Y,Sun C,Liang G

    更新日期:2016-01-01 00:00:00

  • Combined treatment with ultrasound-targeted microbubble destruction technique and NM-aFGF-loaded PEG-nanoliposomes protects against diabetic cardiomyopathy-induced oxidative stress by activating the AKT/GSK-3β1/Nrf-2 pathway.

    abstract::The present study sought to investigate the effect of non-mitogenic acidic fibroblast growth factor (NM-aFGF) loaded PEGylated nanoliposomes (NM-aFGF-PEG-lips) combined with the ultrasound-targeted microbubble destruction (UTMD) technique on modulating diabetic cardiomyopathy (DCM)and the mechanism involved. Animal st...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2020.1785052

    authors: Zhang M,Zhu NW,Ma WC,Chen MJ,Zheng L

    更新日期:2020-12-01 00:00:00

  • Preparation, characterization and antitumor activity evaluation of apigenin nanoparticles by the liquid antisolvent precipitation technique.

    abstract::The present work aimed to apply the liquid antisolvent precipitation (LAP) method for preparing the apigenin nanoparticles and thereby improving the solubility and bioavailability of apigenin. The different experimental parameters on particle size were optimized through central composite design (CCD) using the Design-...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2017.1399302

    authors: Wu W,Zu Y,Wang L,Wang L,Wang H,Li Y,Wu M,Zhao X,Fu Y

    更新日期:2017-11-01 00:00:00

  • Efficient exosome delivery in refractory tissues assisted by ultrasound-targeted microbubble destruction.

    abstract::Recently, exosomes have been emerged as promising drug delivery carriers, while certain tissues are intrinsically resistant to exosomes. Therapeutically improving the drug delivery efficiency in these tissues/organs would certainly broaden the potential application of exosomes in future. Ultrasound-targeted microbubbl...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2018.1534898

    authors: Sun W,Li Z,Zhou X,Yang G,Yuan L

    更新日期:2019-12-01 00:00:00

  • In vivo behavior of hydrogel beads based on amidated pectins.

    abstract::Radio-labeled hydrogel beads, based on amidated pectin, have been produced by adding droplets of an amidated pectin solution to calcium chloride. Incorporation of model drugs into the beads and measurement of the dissolution rate showed that the properties of the beads were unaffected by the incorporation of the radio...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717549809065753

    authors: Munjeri O,Collett JH,Fell JT,Sharma HL,Smith AM

    更新日期:1998-01-01 00:00:00

  • Immunotherapeutic effect of BCG-polysaccharide nucleic acid powder on Mycobacterium tuberculosis-infected mice using microneedle patches.

    abstract::Polysaccharide nucleic acid fractions of bacillus Calmette-Guérin, termed BCG-PSN, have traditionally been used as immunomodulators in the treatment of dermatitis and allergic diseases. While the sales of injectable BCG-PSN have shown steady growth in recent years, no reports of using BCG-PSN powder or its immunothera...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2017.1391892

    authors: Yan Q,Liu H,Cheng Z,Xue Y,Cheng Z,Dai X,Shan W,Chen F

    更新日期:2017-11-01 00:00:00

  • Etodolac transdermal cubosomes for the treatment of rheumatoid arthritis: ex vivo permeation and in vivo pharmacokinetic studies.

    abstract::In this study, transdermal etodolac-loaded cubosomes were developed in order to relieve patient pain and joints stiffness by providing stable etodolac concentration at the targeting sites through controlled drug delivery via the noninvasive skin route with more sustaining and less frequent dosing. Different ratios and...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2017.1326539

    authors: Salah S,Mahmoud AA,Kamel AO

    更新日期:2017-11-01 00:00:00

  • Preparation and characterization of novel anti-inflammatory biological agents based on piroxicam-loaded poly-ε-caprolactone nano-particles for sustained NSAID delivery.

    abstract::Piroxicam (PX), a main member of non-steroidal anti-inflammatory drugs (NSAIDs), is mainly used orally, which causes side effects of the gastrointestinal tract. It also has systemic effects when administered intramuscularly. Intra-articular (IA) delivery and encapsulation of PX in biodegradable poly-ε-caprolactone (PC...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2020.1716881

    authors: Rahmani Del Bakhshayesh A,Akbarzadeh A,Alihemmati A,Tayefi Nasrabadi H,Montaseri A,Davaran S,Abedelahi A

    更新日期:2020-12-01 00:00:00

  • The effectivity analysis of accumulation of liposomal, micellar, and water-soluble forms of diminazene in cells and in organs.

    abstract::The study was aimed at evaluating the effectiveness of liposomal, micellar, and water-soluble drug forms of diminazene for its localization in cells and selective accumulation at the sites of aggregation of pathogenic organisms. Pharmacological and dynamic properties of a new injection micellar diminazene preparation ...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717540500459084

    authors: Staroverov SA,Pristensky DV,Yermilov DN,Gabalov KP,Zhemerichkin DA,Sidorkin VA,Shcherbakov AA,Shchyogolev SY,Dykman LA

    更新日期:2006-09-01 00:00:00

  • Cetuximab-modified silica nanoparticle loaded with ICG for tumor-targeted combinational therapy of breast cancer.

    abstract::Combinational therapy is usually considered as a preferable approach for effective cancer therapy. Especially, combinational chemo and photothermal therapy is of particular interest due to its high flexibility as well as efficiency. In this article, we the silica nanoparticles (SLN) were surface conjugated with Cetuxi...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2018.1564403

    authors: Zhang X,Li Y,Wei M,Liu C,Yu T,Yang J

    更新日期:2019-12-01 00:00:00

  • Formulation of Fe3O4/acrylate co-polymer nanocomposites as potential drug carriers.

    abstract::Magnetic nanocomposite particles were synthesized by encapsulating nanosized magnetite with an acrylate-based cationic co-polymer made of MMA, BA, and QMA and modifying with MeOPEGMA using the water replacement method. The composition of the co-polymer formulation was optimized based on zeta-potential measurements and...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717540801952597

    authors: Phanapavudhikul P,Shen S,Ng WK,Tan RB

    更新日期:2008-03-01 00:00:00

  • Development of lipid nanoparticles for a histone deacetylases inhibitor as a promising anticancer therapeutic.

    abstract:BACKGROUND:Vorinostat (VRS), a histone deacetylases inhibitor, has significant cytotoxic potential in a large number of human cancer cell lines. OBJECTIVE:To clarify its promising anticancer potential and to improve its drawback related to physical properties and in vivo performance of VRS. METHODS:VRS was successful...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2014.991432

    authors: Tran TH,Chu DT,Truong DH,Tak JW,Jeong JH,Hoang VL,Yong CS,Kim JO

    更新日期:2016-05-01 00:00:00

  • Sodium alginate microspheres of metoprolol tartrate for intranasal systemic delivery: development and evaluation.

    abstract::Bioadhesive sodium alginate microspheres of Metoprolol tartrate (MT) for intranasal systemic delivery were prepared to avoid the first-pass effect, as an alternative therapy to injection, and to obtain improved therapeutic efficacy in the treatment of hypertension and angina pectoris. The microspheres (Ms) were prepar...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/713840323

    authors: Rajinikanth PS,Sankar C,Mishra B

    更新日期:2003-01-01 00:00:00

  • Strategies for meloxicam delivery to and across the skin: a review.

    abstract::Although meloxicam (MX) is relatively safer than other NSAIDs, adverse effects relating to the gastro-intestinal tract are still a problem when administrated MX at high doses and on the long-term treatment. Drug delivery via skin provides an attractive alternative to oral administration, but is limited by the first la...

    journal_title:Drug delivery

    pub_type: 杂志文章,评审

    doi:10.3109/10717544.2016.1157839

    authors: Chen J,Gao Y

    更新日期:2016-10-01 00:00:00

  • Effects of bile salts on the lovastatin pharmacokinetics following oral administration to rats.

    abstract::This study aimed to examine the effects of bile salts on pharmacokinetics of lovastatin, which has low bioavailability. Lovastatin solid dispersions were prepared using sodium deoxycholate (NaDC) and sodium glycholate (NaGC) at ratios of 1:19, 1:49, and 1:69. The formulated solid dispersions and control (commercial ta...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2010.512024

    authors: Kim K,Yoon I,Chun I,Lee N,Kim T,Gwak HS

    更新日期:2011-01-01 00:00:00

  • A photo-responsive peptide- and asparagine-glycine-arginine (NGR) peptide-mediated liposomal delivery system.

    abstract::The conjugation of tunable peptides or materials with nanocarriers represents a promising approach for drug delivery to tumor cells. In this study, we report the development of a novel liposomal carrier system that exploits the cell surface binding synergism between photo-sensitive peptides (PSPs) and targeting ligand...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2015.1008707

    authors: Xie X,Yang Y,Yang Y,Zhang H,Li Y,Mei X

    更新日期:2016-09-01 00:00:00

  • Cellular effects of antisense c-myc oligodeoxynucleotides are delivery dependent.

    abstract::Among the transcription factors critical for cell cycle regulation is the proto-oncogene c-myc. The expression of c-myc upon vascular injury and its inhibition by antisense oligodeoxynucleotides have demonstrated the importance of this protein in the control of proliferation for many cell types, including vascular smo...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717549609029444

    authors: Koo EW,Edelman ER

    更新日期:1996-01-01 00:00:00

  • Research progress of self-assembled nanogel and hybrid hydrogel systems based on pullulan derivatives.

    abstract::Polymer nano-sized hydrogels (nanogels) as drug delivery carriers have been investigated over the last few decades. Pullulan, a nontoxic and nonimmunogenic hydrophilic polysaccharide derived from fermentation of black yeast like Aureobasidium pullulans with great biocompatibility and biodegradability, is one of the mo...

    journal_title:Drug delivery

    pub_type: 杂志文章,评审

    doi:10.1080/10717544.2018.1425776

    authors: Zhang T,Yang R,Yang S,Guan J,Zhang D,Ma Y,Liu H

    更新日期:2018-11-01 00:00:00