当前位置： SCI文献检索 > Emerging Microbes & Infections期刊下所有文献 > A host-based whole genome sequencing study reveals novel risk loci associated with severity of influenza A(H1N1)pdm09 infection.

A host-based whole genome sequencing study reveals novel risk loci associated with severity of influenza A(H1N1)pdm09 infection.

Abstract：

:Influenza A(H1N1)pdm09 virus has remained in a seasonal circulation since being recognized in 2009. Although it followed a mild course in most patients, in others it caused a series of severe clinical illnesses. Epidemiologic studies have implicated that host factors have a major influence on the disease severity of influenza A(H1N1)pdm09 infection. However, an understanding of relevant genetic variations and the underlying mechanisms is still limited. In this present study, we used a host-based whole genome sequencing (WGS) method to comprehensively explore the genetic risk loci associated with severity of influenza A(H1N1)pdm09 infection. From the common single-nucleotide variants (SNVs) analysis, we identified the abnormal nominally significant (P < 1 × 10-4) common SNVs enriched in PTBP3 gene. The results of rare functional SNVs analysis supported that there were several novel candidate genes might confer risk of severe influenza A(H1N1)pdm09 diseases, such as FTSJ3, CPVL, BST2, NOD2 and MAVS. Moreover, our results of gene set based analysis indicated that the HIF-1 transcription factor and IFN-γ pathway might play an important role in the underlying mechanism of severe influenza A(H1N1)pdm09. These findings will increase our knowledge about biological mechanism underlying the severe influenza A(H1N1)pdm09 and facilitate to design novel personalized treatments.

journal_name

Emerg Microbes Infect

journal_title

Emerging microbes & infections

authors

Li M,Chen Y,Chen T,Hu S,Chen L,Shen L,Li F,Yang J,Sun Y,Wang D,He L,Qin S,Shu Y

doi

10.1080/22221751.2020.1870412

subject

Has Abstract

pub_date

2021-12-01 00:00:00

pages

123-131

issue

1

issn

2222-1751

journal_volume

10

pub_type

杂志文章

相关文献

Emerging Microbes & Infections文献大全
  • Dengue virus and the host innate immune response.

    abstract：:Dengue virus (DENV) is a mosquito-borne Flavivirus that is endemic in many tropical and sub-tropical countries where the transmission vectors Aedes spp. mosquitoes resides. There are four serotypes of the virus. Each serotype is antigenically different, meaning they elicit heterologous antibodies. Infection with one s...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章,评审

    doi：10.1038/s41426-018-0168-0

    authors： Uno N,Ross TM

    更新日期：2018-10-10 00:00:00

  • Role of domestic ducks in the emergence of a new genotype of highly pathogenic H5N1 avian influenza A viruses in Bangladesh.

    abstract：:Highly pathogenic avian influenza H5N1 viruses were first isolated in Bangladesh in February 2007. Subsequently, clades 2.2.2, 2.3.4.2 and 2.3.2.1a were identified in Bangladesh, and our previous surveillance data revealed that by the end of 2014, the circulating viruses exclusively comprised clade 2.3.2.1a. We recent...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章

    doi：10.1038/emi.2017.60

    authors： Barman S,Marinova-Petkova A,Hasan MK,Akhtar S,El-Shesheny R,Turner JC,Franks J,Walker D,Seiler J,Friedman K,Kercher L,Jeevan T,Darnell D,Kayali G,Jones-Engel L,McKenzie P,Krauss S,Webby RJ,Webster RG,Feeroz MM

    更新日期：2017-08-09 00:00:00

  • miR-1303 regulates BBB permeability and promotes CNS lesions following CA16 infections by directly targeting MMP9.

    abstract：:Coxsackievirus A16 (CA16) is a member of the Picornaviridae family and causes mild and self-limiting hand, foot, and mouth disease (HFMD) in infants and young children. CA16 infection can also progress to central nervous system (CNS) complications; however, the underlying mechanism by which CA16 penetrates the blood-b...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章

    doi：10.1038/s41426-018-0157-3

    authors： Song J,Hu Y,Li H,Huang X,Zheng H,Hu Y,Wang J,Jiang X,Li J,Yang Z,Fan H,Guo L,Shi H,He Z,Yang F,Wang X,Dong S,Li Q,Liu L

    更新日期：2018-09-19 00:00:00

  • Novel reassortant of H1N1 swine influenza virus detected in pig population in Russia.

    abstract：:Pigs play an important role in interspecies transmission of the influenza virus, particularly as "mixing vessels" for reassortment. Two influenza A/H1N1 virus strains, A/swine/Siberia/1sw/2016 and A/swine/Siberia/4sw/2017, were isolated during a surveillance of pigs from private farms in Russia from 2016 to 2017. Ther...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章

    doi：10.1080/22221751.2019.1673136

    authors： Sobolev I,Kurskaya O,Leonov S,Kabilov M,Alikina T,Alekseev A,Yushkov Y,Saito T,Uchida Y,Mine J,Shestopalov A,Sharshov K

    更新日期：2019-01-01 00:00:00

  • Novel FKS1 and FKS2 modifications in a high-level echinocandin resistant clinical isolate of Candida glabrata.

    abstract：:Echinocandin resistance in Candida glabrata poses a serious clinical challenge. The underlying resistance mechanism of a pan-echinocandin-resistant C. glabrata isolate (strain L74) was investigated in this study. FKS mutants carrying specific mutations found in L74 were reconstructed by the Alt-R CRISPR-Cas9 system (F...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章

    doi：10.1080/22221751.2019.1684209

    authors： Hou X,Healey KR,Shor E,Kordalewska M,Ortigosa CJ,Paderu P,Xiao M,Wang H,Zhao Y,Lin LY,Zhang YH,Li YZ,Xu YC,Perlin DS,Zhao Y

    更新日期：2019-01-01 00:00:00

  • Laboratory diagnosis of emerging human coronavirus infections - the state of the art.

    abstract：:The three unprecedented outbreaks of emerging human coronavirus (HCoV) infections at the beginning of the twenty-first century have highlighted the necessity for readily available, accurate and fast diagnostic testing methods. The laboratory diagnostic methods for human coronavirus infections have evolved substantiall...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章,评审

    doi：10.1080/22221751.2020.1745095

    authors： Loeffelholz MJ,Tang YW

    更新日期：2020-12-01 00:00:00

  • Characterization of anti-MERS-CoV antibodies against various recombinant structural antigens of MERS-CoV in an imported case in China.

    abstract：:The first imported case of Middle East respiratory syndrome (MERS) in China recently occurred, allowing for the characterization of antibody titers in a series of the patient's sera using the following methods based on recombinant viral structural antigens: inactivated MERS coronavirus (MERS-CoV) enzyme-linked immunos...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章

    doi：10.1038/emi.2016.114

    authors： Wang W,Wang H,Deng Y,Song T,Lan J,Wu G,Ke C,Tan W

    更新日期：2016-11-09 00:00:00

  • Culex pipiens quinquefasciatus: a potential vector to transmit Zika virus.

    abstract：:Zika virus (ZIKV) has become a threat to global health since the outbreak in Brazil in 2015. Although ZIKV is generally considered an Aedes-transmitted pathogen, new evidence has shown that parts of the virus closely resemble Culex-transmitted viruses. Therefore, it is important to evaluate the competence of Culex spe...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章

    doi：10.1038/emi.2016.102

    authors： Guo XX,Li CX,Deng YQ,Xing D,Liu QM,Wu Q,Sun AJ,Dong YD,Cao WC,Qin CF,Zhao TY

    更新日期：2016-09-07 00:00:00

  • A new subtype of eastern tick-borne encephalitis virus discovered in Qinghai-Tibet Plateau, China.

    abstract：:Tick-borne encephalitis virus (TBEV) has been classified into three subtypes, namely the European (Eu-TBEV), Far Eastern (FE-TBEV), and Siberian (Sib-TBEV). In this study, we discovered a new subtype of TBEV in wild rodent Marmota himalayana in Qinghai-Tibet Plateau in China, proposed as subtype Himalayan (Him-TBEV). ...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章

    doi：10.1038/s41426-018-0081-6

    authors： Dai X,Shang G,Lu S,Yang J,Xu J

    更新日期：2018-04-25 00:00:00

  • Occult HBV infection in Chinese blood donors: role of N-glycosylation mutations and amino acid substitutions in S protein transmembrane domains.

    abstract：:Occult hepatitis B virus infection (OBI) is a low-level asymptomatic phase of HBV infection. Evidence of OBI clinical relevance is emerging but the mechanisms of its occurrence remain unclear. In this study, the molecular characteristics of 97 confirmed OBI from Chinese blood donors were analyzed and relevant mutation...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章

    doi：10.1080/22221751.2019.1663130

    authors： Zhang L,Chang L,Laperche S,Ji H,Zhao J,Jiang X,Wang L,Candotti D

    更新日期：2019-01-01 00:00:00

  • COVID-19 pandemic - an African perspective.

    abstract：:The recently emerged novel coronavirus, "severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)", caused a highly contagious disease called coronavirus disease 2019 (COVID-19). The virus was first reported from Wuhan city in China in December, 2019, which in less than three months spread throughout the globe and...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章,评审

    doi：10.1080/22221751.2020.1775132

    authors： Lone SA,Ahmad A

    更新日期：2020-12-01 00:00:00

  • Identification and evolutionary dynamics of two novel human coronavirus OC43 genotypes associated with acute respiratory infections: phylogenetic, spatiotemporal and transmission network analyses.

    abstract：:Human coronavirus OC43 (HCoV-OC43) is commonly associated with respiratory tract infections in humans, with five genetically distinct genotypes (A to E) described so far. In this study, we obtained the full-length genomes of HCoV-OC43 strains from two previously unrecognized lineages identified among patients presenti...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章

    doi：10.1038/emi.2016.132

    authors： Oong XY,Ng KT,Takebe Y,Ng LJ,Chan KG,Chook JB,Kamarulzaman A,Tee KK

    更新日期：2017-01-04 00:00:00

  • Prevalence and characteristics of hypoxic hepatitis in the largest single-centre cohort of avian influenza A(H7N9) virus-infected patients with severe liver impairment in the intensive care unit.

    abstract：:Avian influenza A(H7N9) virus (A(H7N9)) emerged in February 2013. Liver impairment of unknown cause is present in 29% of patients with A(H7N9) infection, some of whom experience severe liver injury. Hypoxic hepatitis (HH) is a type of acute severe liver injury characterized by an abrupt, massive increase in serum amin...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章

    doi：10.1038/emi.2016.1

    authors： Zhang Y,Liu J,Yu L,Zhou N,Ding W,Zheng S,Shi D,Li L

    更新日期：2016-01-06 00:00:00

  • Novel katG mutations causing isoniazid resistance in clinical M. tuberculosis isolates.

    abstract：:We report the discovery and confirmation of 23 novel mutations with previously undocumented role in isoniazid (INH) drug resistance, in catalase-peroxidase (katG) gene of Mycobacterium tuberculosis (Mtb) isolates. With these mutations, a synonymous mutation in fabG1 (g609a), and two canonical mutations, we were able t...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章

    doi：10.1038/emi.2015.42

    authors： Torres JN,Paul LV,Rodwell TC,Victor TC,Amallraja AM,Elghraoui A,Goodmanson AP,Ramirez-Busby SM,Chawla A,Zadorozhny V,Streicher EM,Sirgel FA,Catanzaro D,Rodrigues C,Gler MT,Crudu V,Catanzaro A,Valafar F

    更新日期：2015-07-01 00:00:00

  • mRNA and miRNA profiling of Zika virus-infected human umbilical cord mesenchymal stem cells identifies miR-142-5p as an antiviral factor.

    abstract：:Zika virus (ZIKV) infection during pregnancy is associated with congenital brain abnormalities, a finding that highlights the urgent need to understand mother-to-fetus transmission mechanisms. Human umbilical cord mesenchymal stem cells (hUCMSCs) are susceptible to ZIKV infection but the underlying mechanisms of viral...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章

    doi：10.1080/22221751.2020.1821581

    authors： Seong RK,Lee JK,Cho GJ,Kumar M,Shin OS

    更新日期：2020-12-01 00:00:00

  • Contribution of Fc-dependent cell-mediated activity of a vestigial esterase-targeting antibody against H5N6 virus infection.

    abstract：:The highly pathogenic avian influenza A (H5N6) virus has caused sporadic human infections with a high case fatality rate. Due to the continuous evolution of this virus subtype and its ability to transmit to humans, there is an urgent need to develop effective antiviral therapeutics. In this study, a murine monoclonal ...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章

    doi：10.1080/22221751.2019.1708215

    authors： Zheng Z,Teo SHC,Arularasu SC,Liu Z,Mohd-Ismail NK,Mok CK,Ong CB,Chu JJ,Tan YJ

    更新日期：2020-01-06 00:00:00

  • Aetiology of acute meningoencephalitis in Cambodian children, 2010-2013.

    abstract：:Acute meningoencephalitis (AME) is associated with considerable morbidity and mortality in children in developing countries. Clinical specimens were collected from children presenting with AME at two Cambodian paediatric hospitals to determine the major aetiologies associated with AME in the country. Cerebrospinal flu...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章

    doi：10.1038/emi.2017.15

    authors： Horwood PF,Duong V,Laurent D,Mey C,Sothy H,Santy K,Richner B,Heng S,Hem S,Cheval J,Gorman C,Dussart P,de Jong MD,Kerleguer A,Guillard B,Murgue B,Lecuit M,de Lamballerie X,Farrar JJ,Tarantola A,Eloit M,Buchy P

    更新日期：2017-05-24 00:00:00

  • Meta-analysis of diagnostic performance of serology tests for COVID-19: impact of assay design and post-symptom-onset intervals.

    abstract：:Serology detection is recognized for its sensitivity in convalescent patients with COVID-19, in comparison with nucleic acid amplification tests (NAATs). This article aimed to evaluate the diagnostic accuracy of serologic methods for COVID-19 based on assay design and post-symptom-onset intervals. Two authors independ...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章,meta分析

    doi：10.1080/22221751.2020.1826362

    authors： Wang H,Ai J,Loeffelholz MJ,Tang YW,Zhang W

    更新日期：2020-12-01 00:00:00

  • Papillomavirus can be transmitted through the blood and produce infections in blood recipients: Evidence from two animal models.

    abstract：:Human papillomaviruses (HPV) contribute to most cervical cancers and are considered to be sexually transmitted. However, papillomaviruses are often found in cancers of internal organs, including the stomach, raising the question as to how the viruses gain access to these sites. A possible connection between blood tran...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章

    doi：10.1080/22221751.2019.1637072

    authors： Cladel NM,Jiang P,Li JJ,Peng X,Cooper TK,Majerciak V,Balogh KK,Meyer TJ,Brendle SA,Budgeon LR,Shearer DA,Munden R,Cam M,Vallur R,Christensen ND,Zheng ZM,Hu J

    更新日期：2019-01-01 00:00:00

  • Accurate serology for SARS-CoV-2 and common human coronaviruses using a multiplex approach.

    abstract：:Serology is a crucial part of the public health response to the ongoing SARS-CoV-2 pandemic. Here, we describe the development, validation and clinical evaluation of a protein micro-array as a quantitative multiplex immunoassay that can identify S and N-directed SARS-CoV-2 IgG antibodies with high specificity and sens...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章

    doi：10.1080/22221751.2020.1813636

    authors： van Tol S,Mögling R,Li W,Godeke GJ,Swart A,Bergmans B,Brandenburg A,Kremer K,Murk JL,van Beek J,Wintermans B,Reimerink J,Bosch BJ,Reusken C

    更新日期：2020-12-01 00:00:00

  • Emergence of human babesiosis along the border of China with Myanmar: detection by PCR and confirmation by sequencing.

    abstract：:Babesiosis is a tick-borne, zoonotic disease caused by Babesia spp. Two cases of babesiosis were detected by nested polymerase chain reaction (PCR) in Yunnan province, China, and further confirmed by molecular assay. The blood smears showed intraerythrocytic ring form and tetrads typical of small B. microti. In both c...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章

    doi：10.1038/emi.2014.55

    authors： Zhou X,Li SG,Wang JZ,Huang JL,Zhou HJ,Chen JH,Zhou XN

    更新日期：2014-08-01 00:00:00

  • Molecular analysis of pyrazinamide resistance in Mycobacterium tuberculosis in Vietnam highlights the high rate of pyrazinamide resistance-associated mutations in clinical isolates.

    abstract：:Pyrazinamide (PZA) is a key antibiotic in current anti-tuberculosis regimens. Although the WHO has stressed the urgent need to obtain data on PZA resistance, in high tuberculosis burden countries, little is known about the level of PZA resistance, the genetic basis of such resistance or its link with Mycobacterium tub...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章

    doi：10.1038/emi.2017.73

    authors： Huy NQ,Lucie C,Hoa TTT,Hung NV,Lan NTN,Son NT,Nhung NV,Anh DD,Anne-Laure B,Van Anh NT

    更新日期：2017-10-11 00:00:00

  • Adaptive mutation F772S-enhanced p7-NS4A cooperation facilitates the assembly and release of hepatitis C virus and is associated with lipid droplet enlargement.

    abstract：:Hepatitis C virus (HCV) infection is a major cause of chronic hepatitis and liver cancer worldwide. Adaptive mutations play important roles in the development of the HCV replicon and its infectious clones. We and others have previously identified the p7 mutation F772S and the co-presence of NS4A mutations in infectiou...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章

    doi：10.1038/s41426-018-0140-z

    authors： Duan X,Anwar MI,Xu Z,Ma L,Yuan G,Chen Y,Liu X,Xia J,Zhou Y,Li YP

    更新日期：2018-08-08 00:00:00

  • The dynamics and interactions of respiratory pathogen carriage among French pilgrims during the 2018 Hajj.

    abstract：:We conducted this study to describe the dynamics of the acquisition of respiratory pathogens, their potential interactions and risk factors for possible lower respiratory tract infection symptoms (LRTI) among French pilgrims during the 2018 Hajj. Each participant underwent four successive systematic nasopharyngeal swa...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章

    doi：10.1080/22221751.2019.1693247

    authors： Hoang VT,Dao TL,Ly TDA,Belhouchat K,Chaht KL,Gaudart J,Mrenda BM,Drali T,Yezli S,Alotaibi B,Fournier PE,Raoult D,Parola P,de Santi VP,Gautret P

    更新日期：2019-01-01 00:00:00

  • Human pathogenic Mycobacterium kansasii (former subtype Ⅰ) with zoonotic potential isolated from a diseased indoor pet cat, Japan.

    abstract：:Nontuberculous mycobacterial (NTM) infections in humans have increased in prevalence in recent decades. Mycobacterium kansasii is one of the most prevalent human pathogenic NTM species worldwide. Herein, we report the first isolation of M. kansasii from an indoor domestic cat in Japan. Comparative genome sequence anal...

    journal_title：Emerging microbes & infections

    pub_type： 信件

    doi：10.1080/22221751.2021.1878935

    authors： Fukano H,Terazono T,Hirabayashi A,Yoshida M,Suzuki M,Wada S,Ishii N,Hoshino Y

    更新日期：2021-01-19 00:00:00

  • Different molecular characteristics and antimicrobial resistance profiles of Clostridium difficile in the Asia-Pacific region.

    abstract：:Molecular epidemiology of Clostridium difficile infection (CDI) has been extensively studied in North America and Europe; however, limited data on CDI are available in the Asia-Pacific region. A multicentre retrospective study was conducted in this region. C. difficile isolates were subjected to multilocus sequence ty...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章

    doi：10.1080/22221751.2019.1682472

    authors： Luo Y,Cheong E,Bian Q,Collins DA,Ye J,Shin JH,Yam WC,Takata T,Song X,Wang X,Kamboj M,Gottlieb T,Jiang J,Riley TV,Tang YW,Jin D

    更新日期：2019-01-01 00:00:00

  • Hypothesis for potential pathogenesis of SARS-CoV-2 infection-a review of immune changes in patients with viral pneumonia.

    abstract：:Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with droplets and contact as the main means of transmission. Since the first case appeared in Wuhan, China, in December 2019, the outbreak has gradually spread nationwide. Up to now, acco...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章

    doi：10.1080/22221751.2020.1746199

    authors： Lin L,Lu L,Cao W,Li T

    更新日期：2020-12-01 00:00:00

  • Clinical observation and management of COVID-19 patients.

    abstract：:Three leading infectious disease experts in China were invited to share their bedside observations in the management of COVID-19 patients. Professor Taisheng Li was sent to Wuhan to provide frontline medical care. He depicts the clinical course of SARS-CoV-2 infection. Furthermore, he observes the significant abnormal...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章

    doi：10.1080/22221751.2020.1741327

    authors： Li T,Lu H,Zhang W

    更新日期：2020-12-01 00:00:00

  • The role of biomedical research in global tuberculosis control: gaps and challenges: A perspective from the US National Institute of Allergy and Infectious Diseases, National Institutes of Health.

    abstract：:Tuberculosis (TB) has been a persistent public health concern for hundreds of years. Despite advances in medicine and science, eliminating this disease has been beyond our reach. Several organizations, including the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Healt...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章,评审

    doi：10.1038/emi.2012.21

    authors： Sizemore CF,Schleif AC,Bernstein JB,Heilman CA

    更新日期：2012-07-01 00:00:00

  • A live attenuated vaccine prevents replication and transmission of H7N9 highly pathogenic influenza viruses in mammals.

    abstract：:H7N9 influenza viruses emerged in 2013 and have caused severe disease and deaths in humans in China. Some H7N9 viruses circulating in chickens have mutated to highly pathogenic viruses that have caused several disease outbreaks in chickens. Studies have shown that when the H7N9 highly pathogenic viruses replicate in f...

    journal_title：Emerging microbes & infections

    pub_type： 杂志文章

    doi：10.1038/s41426-018-0154-6

    authors： Yang W,Yin X,Guan L,Li M,Ma S,Shi J,Deng G,Suzuki Y,Chen H

    更新日期：2018-09-12 00:00:00