Metabolic intermediate acetyl phosphate modulates bacterial virulence via acetylation.

abstract：:MERS-CoV infection emerged in the Kingdom of Saudi Arabia (KSA) in 2012 and has spread to 26 countries. However, 80% of all cases have occurred in KSA. The largest outbreak outside KSA occurred in South Korea (SK) in 2015. In this report, we describe an epidemiological comparison of the two outbreaks. Data from 1299 c...

journal_title：Emerging microbes & infections

authors： Chen X,Chughtai AA,Dyda A,MacIntyre CR

更新日期：2017-06-07 00:00:00

abstract：:Influenza A(H1N1)pdm09 virus has remained in a seasonal circulation since being recognized in 2009. Although it followed a mild course in most patients, in others it caused a series of severe clinical illnesses. Epidemiologic studies have implicated that host factors have a major influence on the disease severity of i...

journal_title：Emerging microbes & infections

authors： Li M,Chen Y,Chen T,Hu S,Chen L,Shen L,Li F,Yang J,Sun Y,Wang D,He L,Qin S,Shu Y

更新日期：2021-12-01 00:00:00

abstract：:Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has resulted in a pandemic and is continuing to spread rapidly around the globe. No effective vaccine is currently available to prevent COVID-19, and intense efforts are being invested worldwide into vaccine development. In this context, all technolo...

journal_title：Emerging microbes & infections

authors： Grenga L,Gallais F,Pible O,Gaillard JC,Gouveia D,Batina H,Bazaline N,Ruat S,Culotta K,Miotello G,Debroas S,Roncato MA,Steinmetz G,Foissard C,Desplan A,Alpha-Bazin B,Almunia C,Gas F,Bellanger L,Armengaud J

更新日期：2020-12-01 00:00:00

abstract：:We report the discovery and confirmation of 23 novel mutations with previously undocumented role in isoniazid (INH) drug resistance, in catalase-peroxidase (katG) gene of Mycobacterium tuberculosis (Mtb) isolates. With these mutations, a synonymous mutation in fabG1 (g609a), and two canonical mutations, we were able t...

journal_title：Emerging microbes & infections

authors： Torres JN,Paul LV,Rodwell TC,Victor TC,Amallraja AM,Elghraoui A,Goodmanson AP,Ramirez-Busby SM,Chawla A,Zadorozhny V,Streicher EM,Sirgel FA,Catanzaro D,Rodrigues C,Gler MT,Crudu V,Catanzaro A,Valafar F

更新日期：2015-07-01 00:00:00

abstract：:Although a number of standardized human immunodeficiency virus 1 (HIV-1) pseudoviruses have been generated to assess neutralizing antibodies, subtype B/B' has not been comprehensively characterized either genotypically or phenotypically. Full-length env genes were isolated from plasma samples derived from B/B'-infecte...

journal_title：Emerging microbes & infections

authors： Xie H,Nie J,Chen Q,Huang W,Wang Y

更新日期：2018-05-16 00:00:00

abstract：:Whooping cough, caused by Bordetella pertussis, has resurged and presents a global health burden worldwide. B. pertussis strains unable to produce the acellular pertussis vaccine component pertactin (Prn), have been emerging and in some countries represent up to 95% of recent clinical isolates. Knowledge on the effect...

journal_title：Emerging microbes & infections

authors： Hovingh ES,Mariman R,Solans L,Hijdra D,Hamstra HJ,Jongerius I,van Gent M,Mooi F,Locht C,Pinelli E

更新日期：2018-03-21 00:00:00

abstract：:Pigs play an important role in interspecies transmission of the influenza virus, particularly as "mixing vessels" for reassortment. Two influenza A/H1N1 virus strains, A/swine/Siberia/1sw/2016 and A/swine/Siberia/4sw/2017, were isolated during a surveillance of pigs from private farms in Russia from 2016 to 2017. Ther...

journal_title：Emerging microbes & infections

authors： Sobolev I,Kurskaya O,Leonov S,Kabilov M,Alikina T,Alekseev A,Yushkov Y,Saito T,Uchida Y,Mine J,Shestopalov A,Sharshov K

更新日期：2019-01-01 00:00:00

abstract：:Zika virus (ZIKV) infection during pregnancy is associated with congenital brain abnormalities, a finding that highlights the urgent need to understand mother-to-fetus transmission mechanisms. Human umbilical cord mesenchymal stem cells (hUCMSCs) are susceptible to ZIKV infection but the underlying mechanisms of viral...

journal_title：Emerging microbes & infections

authors： Seong RK,Lee JK,Cho GJ,Kumar M,Shin OS

更新日期：2020-12-01 00:00:00

abstract：:H7N9 influenza viruses emerged in 2013 and have caused severe disease and deaths in humans in China. Some H7N9 viruses circulating in chickens have mutated to highly pathogenic viruses that have caused several disease outbreaks in chickens. Studies have shown that when the H7N9 highly pathogenic viruses replicate in f...

journal_title：Emerging microbes & infections

authors： Yang W,Yin X,Guan L,Li M,Ma S,Shi J,Deng G,Suzuki Y,Chen H

更新日期：2018-09-12 00:00:00

abstract：:Echinocandin resistance in Candida glabrata poses a serious clinical challenge. The underlying resistance mechanism of a pan-echinocandin-resistant C. glabrata isolate (strain L74) was investigated in this study. FKS mutants carrying specific mutations found in L74 were reconstructed by the Alt-R CRISPR-Cas9 system (F...

journal_title：Emerging microbes & infections

authors： Hou X,Healey KR,Shor E,Kordalewska M,Ortigosa CJ,Paderu P,Xiao M,Wang H,Zhao Y,Lin LY,Zhang YH,Li YZ,Xu YC,Perlin DS,Zhao Y

更新日期：2019-01-01 00:00:00

abstract：:Dengue virus (DENV) is a mosquito-borne Flavivirus that is endemic in many tropical and sub-tropical countries where the transmission vectors Aedes spp. mosquitoes resides. There are four serotypes of the virus. Each serotype is antigenically different, meaning they elicit heterologous antibodies. Infection with one s...

journal_title：Emerging microbes & infections

authors： Uno N,Ross TM

更新日期：2018-10-10 00:00:00

abstract：:The Beijing genotype comprises a highly disseminated strain type that is frequently associated with multidrug resistant (MDR) tuberculosis (TB) and increased transmissibility but, countries such as Portugal and Guinea-Bissau fall outside the regions phylogeographically associated with this specific genotype. Neverthel...

journal_title：Emerging microbes & infections

authors： Perdigão J,Silva C,Maltez F,Machado D,Miranda A,Couto I,Rabna P,Florez de Sessions P,Phelan J,Pain A,McNerney R,Hibberd ML,Mokrousov I,Clark TG,Viveiros M,Portugal I

更新日期：2020-12-01 00:00:00

abstract：:After three decades of intensive research efforts, an effective vaccine against HIV-1 remains to be developed. Several broadly neutralizing antibodies to HIV-1, such as 10E8, recognize the membrane proximal external region (MPER) of the HIV-1 gp41 protein. Thus, the MPER is considered to be a very important target for...

journal_title：Emerging microbes & infections

authors： Sun Z,Zhu Y,Wang Q,Ye L,Dai Y,Su S,Yu F,Ying T,Yang C,Jiang S,Lu L

更新日期：2016-06-22 00:00:00

abstract：:From September 2015 to March 2016, hepatitis A notifications in Germany increased by 45% to 699 cases compared to 482 cases in the same period of the previous year. Children aged five to nine years were predominantly affected (22% of all cases in this period). We hypothesized that this increase could be explained by t...

journal_title：Emerging microbes & infections

authors： Michaelis K,Wenzel JJ,Stark K,Faber M

更新日期：2017-04-26 00:00:00

abstract：:Influenza viruses of the H4 subtype are widespread in wild birds, circulate in domestic poultry, readily infect mammals, and tolerate the insertion of a polybasic cleavage site. In addition, serological evidence suggests that humans working with poultry are exposed to these viruses. While H4 viruses are not of immedia...

journal_title：Emerging microbes & infections

authors： Amanat F,Meade P,Strohmeier S,Krammer F

更新日期：2019-01-01 00:00:00

abstract：:The recently emerged novel coronavirus, "severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)", caused a highly contagious disease called coronavirus disease 2019 (COVID-19). The virus was first reported from Wuhan city in China in December, 2019, which in less than three months spread throughout the globe and...

journal_title：Emerging microbes & infections

authors： Lone SA,Ahmad A

更新日期：2020-12-01 00:00:00

abstract：:Histoplasmosis caused by the fungus Histoplasma capsulatum is often lethal in patients with AIDS. Urine antigen testing is highly sensitive and much quicker for diagnosis than culture. Histoplasmosis has a patchy and incompletely appreciated distribution around the world especially in South East Asia. We conducted a s...

journal_title：Emerging microbes & infections

authors： Baker J,Setianingrum F,Wahyuningsih R,Denning DW

更新日期：2019-01-01 00:00:00

abstract：:Acinetobacter baumannii is a notorious pathogen that has emerged as a healthcare nightmare in recent years because it causes serious infections that are associated with high morbidity and mortality rates. Due to its exceptional ability to acquire resistance to almost all available antibiotics, A. baumannii is currentl...

journal_title：Emerging microbes & infections

authors： Elhosseiny NM,Attia AS

更新日期：2018-03-21 00:00:00

abstract：:We report the first case of severe pneumonia due to co-infection with the emerging avian influenza A (H5N1) virus subclade 2.3.2.1 and Mycoplasma pneumoniae. The patient was a returning traveller who had visited a poultry market in South China. We then review the epidemiology, virology, interspecies barrier limiting p...

journal_title：Emerging microbes & infections

authors： To KK,Ng KH,Que TL,Chan JM,Tsang KY,Tsang AK,Chen H,Yuen KY

更新日期：2012-09-01 00:00:00

abstract：:Norovirus (NoV) is now recognized as a leading cause of nonbacterial acute gastroenteritis; however, the NoV GII.17 genotype has rarely been reported as the predominant genotype in clinical diarrhea cases. During the winter of 2014–2015, the GII.17 genotype, together with the NoV GII.4 genotype, dominated in sporadic ...

journal_title：Emerging microbes & infections

authors： Chen H,Qian F,Xu J,Chan M,Shen Z,Zai S,Shan M,Cai J,Zhang W,He J,Liu Y,Zhang J,Yuan Z,Zhu Z,Hu Y

更新日期：2015-11-01 00:00:00

abstract：:Human enteroviruses frequently cause severe diseases in children. Human enteroviruses are transmitted via the fecal-oral route and respiratory droplets, and primary replication occurs in the gastro-intestinal and respiratory tracts; however, how enteroviruses infect these sites is largely unknown. Human intestinal org...

journal_title：Emerging microbes & infections

authors： van der Sanden SMG,Sachs N,Koekkoek SM,Koen G,Pajkrt D,Clevers H,Wolthers KC

更新日期：2018-05-09 00:00:00

abstract：:Infection with a novel H10N8 influenza virus in humans was first described in China in December 2013, which raised concerns related to public health. This novel virus was subsequently confirmed to have originated from a live poultry market. However, whether this virus can infect other mammals remains unclear. In the p...

journal_title：Emerging microbes & infections

authors： Fu X,Huang Y,Fang B,Liu Y,Cai M,Zhong R,Huang J,Wenbao Q,Tian Y,Zhang G

更新日期：2020-01-03 00:00:00

abstract：:Previous studies have shown that livestock (LA)-MRSA ST398 evolved from a human-adapted methicillin-susceptible S. aureus (MSSA) clone. However, detailed information regarding ST9 is still unclear. Here, we characterized a community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) ST9-SCCmec XII isolat...

journal_title：Emerging microbes & infections

authors： Jin Y,Yu X,Chen Y,Chen W,Shen P,Luo Q,Zhang S,Kong X,Zheng B,Xiao Y

更新日期：2020-12-01 00:00:00

abstract：:West Nile virus (WNV) is an arthropod-borne flavivirus of high medical and veterinary importance. The main vectors for WNV are mosquito species of the Culex genus that transmit WNV among birds, and occasionally to humans and horses, which are 'dead-end' hosts. Recently, several studies have been published that aimed t...

journal_title：Emerging microbes & infections

authors： Vogels CB,Göertz GP,Pijlman GP,Koenraadt CJ

更新日期：2017-11-08 00:00:00

abstract：:Human coronavirus OC43 (HCoV-OC43) is commonly associated with respiratory tract infections in humans, with five genetically distinct genotypes (A to E) described so far. In this study, we obtained the full-length genomes of HCoV-OC43 strains from two previously unrecognized lineages identified among patients presenti...

journal_title：Emerging microbes & infections

authors： Oong XY,Ng KT,Takebe Y,Ng LJ,Chan KG,Chook JB,Kamarulzaman A,Tee KK

更新日期：2017-01-04 00:00:00

abstract：:Serology detection is recognized for its sensitivity in convalescent patients with COVID-19, in comparison with nucleic acid amplification tests (NAATs). This article aimed to evaluate the diagnostic accuracy of serologic methods for COVID-19 based on assay design and post-symptom-onset intervals. Two authors independ...

journal_title：Emerging microbes & infections

authors： Wang H,Ai J,Loeffelholz MJ,Tang YW,Zhang W

更新日期：2020-12-01 00:00:00

abstract：:Nontuberculous mycobacterial (NTM) infections in humans have increased in prevalence in recent decades. Mycobacterium kansasii is one of the most prevalent human pathogenic NTM species worldwide. Herein, we report the first isolation of M. kansasii from an indoor domestic cat in Japan. Comparative genome sequence anal...

journal_title：Emerging microbes & infections

authors： Fukano H,Terazono T,Hirabayashi A,Yoshida M,Suzuki M,Wada S,Ishii N,Hoshino Y

更新日期：2021-01-19 00:00:00

abstract：:A 78-year-old woman with a long-term ankle spacer with antibacterials developed an intra-articular Candida auris infection. Treatment with systemic antifungal therapy plus an amphotericin B moulded cement spacer was successful. ...

journal_title：Emerging microbes & infections

authors： Roberts SC,Zembower TR,Bolon MK,Kadakia AR,Gilley JH,Ko JH,Clark J,Ward-Fore S,Taiwo BO

更新日期：2019-01-01 00:00:00

abstract：:The emergence of SARS-CoV-2 has led to the current global coronavirus pandemic and more than one million infections since December 2019. The exact origin of SARS-CoV-2 remains elusive, but the presence of a distinct motif in the S1/S2 junction region suggests the possible acquisition of cleavage site(s) in the spike p...

journal_title：Emerging microbes & infections

authors： Lau SY,Wang P,Mok BW,Zhang AJ,Chu H,Lee AC,Deng S,Chen P,Chan KH,Song W,Chen Z,To KK,Chan JF,Yuen KY,Chen H

更新日期：2020-12-01 00:00:00

abstract：:Three leading infectious disease experts in China were invited to share their bedside observations in the management of COVID-19 patients. Professor Taisheng Li was sent to Wuhan to provide frontline medical care. He depicts the clinical course of SARS-CoV-2 infection. Furthermore, he observes the significant abnormal...

journal_title：Emerging microbes & infections

authors： Li T,Lu H,Zhang W

更新日期：2020-12-01 00:00:00