Human pathogenic Mycobacterium kansasii (former subtype Ⅰ) with zoonotic potential isolated from a diseased indoor pet cat, Japan.

abstract：:Clostridium difficile is the major causative agent of nosocomial antibiotic-associated diarrhea. In a 2009 outbreak of C. difficile-associated diarrhea that was recorded in a major Costa Rican hospital, the hypervirulent NAP1 strain (45%) predominated together with a local genotype variant (NAPCR1, 31%). Both strains ...

journal_title：Emerging microbes & infections

authors： López-Ureña D,Quesada-Gómez C,Montoya-Ramírez M,del Mar Gamboa-Coronado M,Somogyi T,Rodríguez C,Rodríguez-Cavallini E

更新日期：2016-05-11 00:00:00

abstract：:Human enterovirus 68 (EV-D68) is a rarely reported virus that has been linked to respiratory disease. In recent years, reports about EV-D68 infection have markedly increased worldwide. However, the epidemiological features of this emerging infection are not well understood. To evaluate the emerging EV-D68 epidemic, we...

journal_title：Emerging microbes & infections

authors： Xiang Z,Li L,Ren L,Guo L,Xie Z,Liu C,Li T,Luo M,Paranhos-Baccalà G,Xu W,Wang J

更新日期：2017-05-10 00:00:00

abstract：:COVID-19, the worst pandemic in 100 years, has rapidly spread to the entire world in 2 months since its early report in January 2020. Based on the publicly available data sources, we developed a simple mathematic modeling approach to track the outbreaks of COVID-19 in the US and three selected states: New York, Michig...

journal_title：Emerging microbes & infections

authors： Tang Y,Wang S

更新日期：2020-12-01 00:00:00

abstract：:Echinocandin resistance in Candida glabrata poses a serious clinical challenge. The underlying resistance mechanism of a pan-echinocandin-resistant C. glabrata isolate (strain L74) was investigated in this study. FKS mutants carrying specific mutations found in L74 were reconstructed by the Alt-R CRISPR-Cas9 system (F...

journal_title：Emerging microbes & infections

authors： Hou X,Healey KR,Shor E,Kordalewska M,Ortigosa CJ,Paderu P,Xiao M,Wang H,Zhao Y,Lin LY,Zhang YH,Li YZ,Xu YC,Perlin DS,Zhao Y

更新日期：2019-01-01 00:00:00

abstract：:The first imported case of Middle East respiratory syndrome (MERS) in China recently occurred, allowing for the characterization of antibody titers in a series of the patient's sera using the following methods based on recombinant viral structural antigens: inactivated MERS coronavirus (MERS-CoV) enzyme-linked immunos...

journal_title：Emerging microbes & infections

authors： Wang W,Wang H,Deng Y,Song T,Lan J,Wu G,Ke C,Tan W

更新日期：2016-11-09 00:00:00

abstract：:The continuing pandemic threat posed by avian influenza A/H5N1 viruses calls for improved insights into their evolution during human infection. We performed whole genome deep sequencing of respiratory specimens from 44 H5N1-infected individuals from Indonesia and found substantial within-host viral diversity. At nearl...

journal_title：Emerging microbes & infections

authors： Welkers MRA,Pawestri HA,Fonville JM,Sampurno OD,Pater M,Holwerda M,Han AX,Russell CA,Jeeninga RE,Setiawaty V,de Jong MD,Eggink D

更新日期：2019-01-01 00:00:00

abstract：:Tuberculosis (TB) has been a persistent public health concern for hundreds of years. Despite advances in medicine and science, eliminating this disease has been beyond our reach. Several organizations, including the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Healt...

journal_title：Emerging microbes & infections

authors： Sizemore CF,Schleif AC,Bernstein JB,Heilman CA

更新日期：2012-07-01 00:00:00

abstract：:GRP78/BiP is an endoplasmic reticulum (ER) chaperone protein with the important function of maintaining ER homeostasis, and the overexpression of GRP78/BiP alleviates ER stress. Our previous studies showed that infection with enterovirus 71 (EV71), a (+)RNA picornavirus, induced GRP78/BiP upregulation; however, ectopi...

journal_title：Emerging microbes & infections

authors： Jheng JR,Wang SC,Jheng CR,Horng JT

更新日期：2016-03-23 00:00:00

abstract：:Coxsackievirus A16 (CA16) is a member of the Picornaviridae family and causes mild and self-limiting hand, foot, and mouth disease (HFMD) in infants and young children. CA16 infection can also progress to central nervous system (CNS) complications; however, the underlying mechanism by which CA16 penetrates the blood-b...

journal_title：Emerging microbes & infections

authors： Song J,Hu Y,Li H,Huang X,Zheng H,Hu Y,Wang J,Jiang X,Li J,Yang Z,Fan H,Guo L,Shi H,He Z,Yang F,Wang X,Dong S,Li Q,Liu L

更新日期：2018-09-19 00:00:00

abstract：:Outbreaks of avian influenza virus continue to pose threats to human health. Animal models such as the mouse, ferret, and macaque are used to understand the pathogenesis of avian influenza virus infection in humans. We previously reported that the tree shrew (Tupaia belangeri, family Tupaiidae), which is regarded as a...

journal_title：Emerging microbes & infections

authors： Li R,Yuan B,Xia X,Zhang S,Du Q,Yang C,Li N,Zhao J,Zhang Y,Zhang R,Feng Y,Jiao J,Peiris M,Zhong N,Mok CKP,Yang Z

更新日期：2018-10-10 00:00:00

abstract：:Background: The COVID-19 pandemic represents an unprecedented global challenge and implicates a wide range of burden on medical professionals. Here, we evaluated the perception of the COVID-19 pandemic among medical professionals in Germany. Methods: A total of n = 2827 medical professionals participated in an online ...

journal_title：Emerging microbes & infections

authors： Paffenholz P,Peine A,Hellmich M,Paffenholz SV,Martin L,Luedde M,Haverkamp M,Roderburg C,Marx G,Heidenreich A,Trautwein C,Luedde T,Loosen SH

更新日期：2020-12-01 00:00:00

abstract：:Zika virus (ZIKV) infection during pregnancy is associated with congenital brain abnormalities, a finding that highlights the urgent need to understand mother-to-fetus transmission mechanisms. Human umbilical cord mesenchymal stem cells (hUCMSCs) are susceptible to ZIKV infection but the underlying mechanisms of viral...

journal_title：Emerging microbes & infections

authors： Seong RK,Lee JK,Cho GJ,Kumar M,Shin OS

更新日期：2020-12-01 00:00:00

abstract：:Norovirus (NoV) is now recognized as a leading cause of nonbacterial acute gastroenteritis; however, the NoV GII.17 genotype has rarely been reported as the predominant genotype in clinical diarrhea cases. During the winter of 2014–2015, the GII.17 genotype, together with the NoV GII.4 genotype, dominated in sporadic ...

journal_title：Emerging microbes & infections

authors： Chen H,Qian F,Xu J,Chan M,Shen Z,Zai S,Shan M,Cai J,Zhang W,He J,Liu Y,Zhang J,Yuan Z,Zhu Z,Hu Y

更新日期：2015-11-01 00:00:00

abstract：:Tick-borne encephalitis virus (TBEV) has been classified into three subtypes, namely the European (Eu-TBEV), Far Eastern (FE-TBEV), and Siberian (Sib-TBEV). In this study, we discovered a new subtype of TBEV in wild rodent Marmota himalayana in Qinghai-Tibet Plateau in China, proposed as subtype Himalayan (Him-TBEV). ...

journal_title：Emerging microbes & infections

authors： Dai X,Shang G,Lu S,Yang J,Xu J

更新日期：2018-04-25 00:00:00

abstract：:Little is known about the processes that enable influenza A viruses to jump into new host species. Here we show that the non-structural protein1 nucleotide substitution, A374G, encoding the D125G(GAT→GGT) mutation, which evolved during the adaptation of a human virus within a mouse host, activates a novel donor splice...

journal_title：Emerging microbes & infections

authors： Selman M,Dankar SK,Forbes NE,Jia JJ,Brown EG

更新日期：2012-11-01 00:00:00

abstract：:Interleukin 17 (IL-17) and its closest relative, IL-17F, have recently drawn much attention in the field of immunology. IL-17 and IL-17F are expressed by a distinct type of T cells, T helper 17 cells and certain other lymphocytes. These cytokines play key regulatory roles in host defense and inflammatory diseases. In ...

journal_title：Emerging microbes & infections

authors： Jin W,Dong C

更新日期：2013-09-01 00:00:00

abstract：:Influenza has been a long-running health problem and novel antiviral drugs are urgently needed. In pre-clinical studies, we demonstrated broad antiviral activity of D, L-lysine-acetylsalicylate glycine (LASAG) against influenza virus (IV) in cell culture and protection against lethal challenge in mice. LASAG is a comp...

journal_title：Emerging microbes & infections

authors： Scheuch G,Canisius S,Nocker K,Hofmann T,Naumann R,Pleschka S,Ludwig S,Welte T,Planz O

更新日期：2018-03-07 00:00:00

abstract：:Acute meningoencephalitis (AME) is associated with considerable morbidity and mortality in children in developing countries. Clinical specimens were collected from children presenting with AME at two Cambodian paediatric hospitals to determine the major aetiologies associated with AME in the country. Cerebrospinal flu...

journal_title：Emerging microbes & infections

authors： Horwood PF,Duong V,Laurent D,Mey C,Sothy H,Santy K,Richner B,Heng S,Hem S,Cheval J,Gorman C,Dussart P,de Jong MD,Kerleguer A,Guillard B,Murgue B,Lecuit M,de Lamballerie X,Farrar JJ,Tarantola A,Eloit M,Buchy P

更新日期：2017-05-24 00:00:00

abstract：:Unlike those infected by H5N1, birds infected by the newly discovered H7N9 virus have no observable clinical symptoms. Public health workers in China do not know where the public health threat lies. In this study, we used a distributed focused crawler to analyze online knowledge of the live bird trade in first-wave pr...

journal_title：Emerging microbes & infections

authors： Chen C,Lu S,Du P,Wang H,Yu W,Song H,Xu J

更新日期：2013-12-01 00:00:00

abstract：:MERS-CoV infection emerged in the Kingdom of Saudi Arabia (KSA) in 2012 and has spread to 26 countries. However, 80% of all cases have occurred in KSA. The largest outbreak outside KSA occurred in South Korea (SK) in 2015. In this report, we describe an epidemiological comparison of the two outbreaks. Data from 1299 c...

journal_title：Emerging microbes & infections

authors： Chen X,Chughtai AA,Dyda A,MacIntyre CR

更新日期：2017-06-07 00:00:00

abstract：:Pyrazinamide (PZA) is a key antibiotic in current anti-tuberculosis regimens. Although the WHO has stressed the urgent need to obtain data on PZA resistance, in high tuberculosis burden countries, little is known about the level of PZA resistance, the genetic basis of such resistance or its link with Mycobacterium tub...

journal_title：Emerging microbes & infections

authors： Huy NQ,Lucie C,Hoa TTT,Hung NV,Lan NTN,Son NT,Nhung NV,Anh DD,Anne-Laure B,Van Anh NT

更新日期：2017-10-11 00:00:00

abstract：:Previous studies have shown that livestock (LA)-MRSA ST398 evolved from a human-adapted methicillin-susceptible S. aureus (MSSA) clone. However, detailed information regarding ST9 is still unclear. Here, we characterized a community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) ST9-SCCmec XII isolat...

journal_title：Emerging microbes & infections

authors： Jin Y,Yu X,Chen Y,Chen W,Shen P,Luo Q,Zhang S,Kong X,Zheng B,Xiao Y

更新日期：2020-12-01 00:00:00

abstract：:The recently emerged novel coronavirus, "severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)", caused a highly contagious disease called coronavirus disease 2019 (COVID-19). The virus was first reported from Wuhan city in China in December, 2019, which in less than three months spread throughout the globe and...

journal_title：Emerging microbes & infections

authors： Lone SA,Ahmad A

更新日期：2020-12-01 00:00:00

abstract：:The Beijing genotype comprises a highly disseminated strain type that is frequently associated with multidrug resistant (MDR) tuberculosis (TB) and increased transmissibility but, countries such as Portugal and Guinea-Bissau fall outside the regions phylogeographically associated with this specific genotype. Neverthel...

journal_title：Emerging microbes & infections

authors： Perdigão J,Silva C,Maltez F,Machado D,Miranda A,Couto I,Rabna P,Florez de Sessions P,Phelan J,Pain A,McNerney R,Hibberd ML,Mokrousov I,Clark TG,Viveiros M,Portugal I

更新日期：2020-12-01 00:00:00

abstract：:Babesiosis is a tick-borne, zoonotic disease caused by Babesia spp. Two cases of babesiosis were detected by nested polymerase chain reaction (PCR) in Yunnan province, China, and further confirmed by molecular assay. The blood smears showed intraerythrocytic ring form and tetrads typical of small B. microti. In both c...

journal_title：Emerging microbes & infections

authors： Zhou X,Li SG,Wang JZ,Huang JL,Zhou HJ,Chen JH,Zhou XN

更新日期：2014-08-01 00:00:00

abstract：:Although a number of standardized human immunodeficiency virus 1 (HIV-1) pseudoviruses have been generated to assess neutralizing antibodies, subtype B/B' has not been comprehensively characterized either genotypically or phenotypically. Full-length env genes were isolated from plasma samples derived from B/B'-infecte...

journal_title：Emerging microbes & infections

authors： Xie H,Nie J,Chen Q,Huang W,Wang Y

更新日期：2018-05-16 00:00:00

abstract：:Occult hepatitis B virus infection (OBI) is a low-level asymptomatic phase of HBV infection. Evidence of OBI clinical relevance is emerging but the mechanisms of its occurrence remain unclear. In this study, the molecular characteristics of 97 confirmed OBI from Chinese blood donors were analyzed and relevant mutation...

journal_title：Emerging microbes & infections

authors： Zhang L,Chang L,Laperche S,Ji H,Zhao J,Jiang X,Wang L,Candotti D

更新日期：2019-01-01 00:00:00

abstract：:Infection with a novel H10N8 influenza virus in humans was first described in China in December 2013, which raised concerns related to public health. This novel virus was subsequently confirmed to have originated from a live poultry market. However, whether this virus can infect other mammals remains unclear. In the p...

journal_title：Emerging microbes & infections

authors： Fu X,Huang Y,Fang B,Liu Y,Cai M,Zhong R,Huang J,Wenbao Q,Tian Y,Zhang G

更新日期：2020-01-03 00:00:00

abstract：:Tigecycline is regarded as a last-resort treatment for carbapenem-resistant Enterobacteriaceae (CRE), however, the emergence of tigecycline heteroresistance has posted the therapeutic challenge to combat this "nightmare bacteria". The primary purpose of this study was to demonstrate the existence of tigecycline hetero...

journal_title：Emerging microbes & infections

authors： Liu H,Jia X,Zou H,Sun S,Li S,Wang Y,Xia Y

更新日期：2019-01-01 00:00:00

abstract：:The highly pathogenic avian influenza A (H5N6) virus has caused sporadic human infections with a high case fatality rate. Due to the continuous evolution of this virus subtype and its ability to transmit to humans, there is an urgent need to develop effective antiviral therapeutics. In this study, a murine monoclonal ...

journal_title：Emerging microbes & infections

authors： Zheng Z,Teo SHC,Arularasu SC,Liu Z,Mohd-Ismail NK,Mok CK,Ong CB,Chu JJ,Tan YJ

更新日期：2020-01-06 00:00:00