Characterization of anti-MERS-CoV antibodies against various recombinant structural antigens of MERS-CoV in an imported case in China.

abstract：:A novel equine parvovirus, equine parvovirus-hepatitis (EqPV-H), was first discovered in a horse that died of equine serum hepatitis in the USA in 2018. EqPV-H was shown to be a novel etiological agent associated with equine serum hepatitis. Following this initial report, no additional studies on EqPV-H have been publ...

journal_title：Emerging microbes & infections

authors： Lu G,Sun L,Ou J,Xu H,Wu L,Li S

更新日期：2018-10-23 00:00:00

abstract：:Acinetobacter baumannii is a notorious pathogen that has emerged as a healthcare nightmare in recent years because it causes serious infections that are associated with high morbidity and mortality rates. Due to its exceptional ability to acquire resistance to almost all available antibiotics, A. baumannii is currentl...

journal_title：Emerging microbes & infections

authors： Elhosseiny NM,Attia AS

更新日期：2018-03-21 00:00:00

abstract：:Tigecycline is regarded as a last-resort treatment for carbapenem-resistant Enterobacteriaceae (CRE), however, the emergence of tigecycline heteroresistance has posted the therapeutic challenge to combat this "nightmare bacteria". The primary purpose of this study was to demonstrate the existence of tigecycline hetero...

journal_title：Emerging microbes & infections

authors： Liu H,Jia X,Zou H,Sun S,Li S,Wang Y,Xia Y

更新日期：2019-01-01 00:00:00

abstract：:The progressive anthropization of caves for food resources or economic purposes increases human exposure to pathogens that naturally infect cave-dwelling animals. The presence of wild or domestic animals in the immediate surroundings of caves also may contribute to increasing the risk of emergence of such pathogens. S...

journal_title：Emerging microbes & infections

authors： Obame-Nkoghe J,Leroy EM,Paupy C

更新日期：2017-04-12 00:00:00

abstract：:Shiga toxin-producing Escherichia coli (STEC) are foodborne pathogens causing severe gastroenteritis, which may lead to hemolytic uremic syndrome. The Locus of Enterocyte Effacement (LEE), a Pathogenicity Island (PAI), is a major determinant of intestinal epithelium attachment of a group of STEC strains; however, the ...

journal_title：Emerging microbes & infections

authors： Montero DA,Canto FD,Velasco J,Colello R,Padola NL,Salazar JC,Martin CS,Oñate A,Blanco J,Rasko DA,Contreras C,Puente JL,Scheutz F,Franz E,Vidal RM

更新日期：2019-01-01 00:00:00

abstract：:Serology detection is recognized for its sensitivity in convalescent patients with COVID-19, in comparison with nucleic acid amplification tests (NAATs). This article aimed to evaluate the diagnostic accuracy of serologic methods for COVID-19 based on assay design and post-symptom-onset intervals. Two authors independ...

journal_title：Emerging microbes & infections

authors： Wang H,Ai J,Loeffelholz MJ,Tang YW,Zhang W

更新日期：2020-12-01 00:00:00

abstract：:Macrolides such as erythromycin are the empirical treatment of Bordetella pertussis infections. China has experienced an increase in erythromycin-resistant B. pertussis isolates since they were first reported in 2013. Here, we undertook a genomic study on Chinese B. pertussis isolates from 2012 to 2015 to elucidate th...

journal_title：Emerging microbes & infections

authors： Xu Z,Wang Z,Luan Y,Li Y,Liu X,Peng X,Octavia S,Payne M,Lan R

更新日期：2019-01-01 00:00:00

abstract：:Interleukin 17 (IL-17) and its closest relative, IL-17F, have recently drawn much attention in the field of immunology. IL-17 and IL-17F are expressed by a distinct type of T cells, T helper 17 cells and certain other lymphocytes. These cytokines play key regulatory roles in host defense and inflammatory diseases. In ...

journal_title：Emerging microbes & infections

authors： Jin W,Dong C

更新日期：2013-09-01 00:00:00

abstract：:Background: The COVID-19 pandemic represents an unprecedented global challenge and implicates a wide range of burden on medical professionals. Here, we evaluated the perception of the COVID-19 pandemic among medical professionals in Germany. Methods: A total of n = 2827 medical professionals participated in an online ...

journal_title：Emerging microbes & infections

authors： Paffenholz P,Peine A,Hellmich M,Paffenholz SV,Martin L,Luedde M,Haverkamp M,Roderburg C,Marx G,Heidenreich A,Trautwein C,Luedde T,Loosen SH

更新日期：2020-12-01 00:00:00

abstract：:The continuing pandemic threat posed by avian influenza A/H5N1 viruses calls for improved insights into their evolution during human infection. We performed whole genome deep sequencing of respiratory specimens from 44 H5N1-infected individuals from Indonesia and found substantial within-host viral diversity. At nearl...

journal_title：Emerging microbes & infections

authors： Welkers MRA,Pawestri HA,Fonville JM,Sampurno OD,Pater M,Holwerda M,Han AX,Russell CA,Jeeninga RE,Setiawaty V,de Jong MD,Eggink D

更新日期：2019-01-01 00:00:00

abstract：:From September 2015 to March 2016, hepatitis A notifications in Germany increased by 45% to 699 cases compared to 482 cases in the same period of the previous year. Children aged five to nine years were predominantly affected (22% of all cases in this period). We hypothesized that this increase could be explained by t...

journal_title：Emerging microbes & infections

authors： Michaelis K,Wenzel JJ,Stark K,Faber M

更新日期：2017-04-26 00:00:00

abstract：:Influenza has been a long-running health problem and novel antiviral drugs are urgently needed. In pre-clinical studies, we demonstrated broad antiviral activity of D, L-lysine-acetylsalicylate glycine (LASAG) against influenza virus (IV) in cell culture and protection against lethal challenge in mice. LASAG is a comp...

journal_title：Emerging microbes & infections

authors： Scheuch G,Canisius S,Nocker K,Hofmann T,Naumann R,Pleschka S,Ludwig S,Welte T,Planz O

更新日期：2018-03-07 00:00:00

abstract：:The isolation and characterization of monoclonal broadly neutralizing antibodies (nAbs) from natural HIV-1-infected individuals play very important roles in understanding nAb responses to HIV-1 infection and designing vaccines and therapeutics. Many broadly nAbs have been isolated from individuals infected with HIV-1 ...

journal_title：Emerging microbes & infections

authors： Ju B,Li D,Ren L,Hou J,Hao Y,Liang H,Wang S,Zhu J,Wei M,Shao Y

更新日期：2018-11-01 00:00:00

abstract：:Little is known about the processes that enable influenza A viruses to jump into new host species. Here we show that the non-structural protein1 nucleotide substitution, A374G, encoding the D125G(GAT→GGT) mutation, which evolved during the adaptation of a human virus within a mouse host, activates a novel donor splice...

journal_title：Emerging microbes & infections

authors： Selman M,Dankar SK,Forbes NE,Jia JJ,Brown EG

更新日期：2012-11-01 00:00:00

abstract：:Clostridium difficile is the major causative agent of nosocomial antibiotic-associated diarrhea. In a 2009 outbreak of C. difficile-associated diarrhea that was recorded in a major Costa Rican hospital, the hypervirulent NAP1 strain (45%) predominated together with a local genotype variant (NAPCR1, 31%). Both strains ...

journal_title：Emerging microbes & infections

authors： López-Ureña D,Quesada-Gómez C,Montoya-Ramírez M,del Mar Gamboa-Coronado M,Somogyi T,Rodríguez C,Rodríguez-Cavallini E

更新日期：2016-05-11 00:00:00

abstract：:Influenza viruses of the H4 subtype are widespread in wild birds, circulate in domestic poultry, readily infect mammals, and tolerate the insertion of a polybasic cleavage site. In addition, serological evidence suggests that humans working with poultry are exposed to these viruses. While H4 viruses are not of immedia...

journal_title：Emerging microbes & infections

authors： Amanat F,Meade P,Strohmeier S,Krammer F

更新日期：2019-01-01 00:00:00

abstract：:Serology is a crucial part of the public health response to the ongoing SARS-CoV-2 pandemic. Here, we describe the development, validation and clinical evaluation of a protein micro-array as a quantitative multiplex immunoassay that can identify S and N-directed SARS-CoV-2 IgG antibodies with high specificity and sens...

journal_title：Emerging microbes & infections

authors： van Tol S,Mögling R,Li W,Godeke GJ,Swart A,Bergmans B,Brandenburg A,Kremer K,Murk JL,van Beek J,Wintermans B,Reimerink J,Bosch BJ,Reusken C

更新日期：2020-12-01 00:00:00

abstract：:Molecular epidemiology of Clostridium difficile infection (CDI) has been extensively studied in North America and Europe; however, limited data on CDI are available in the Asia-Pacific region. A multicentre retrospective study was conducted in this region. C. difficile isolates were subjected to multilocus sequence ty...

journal_title：Emerging microbes & infections

authors： Luo Y,Cheong E,Bian Q,Collins DA,Ye J,Shin JH,Yam WC,Takata T,Song X,Wang X,Kamboj M,Gottlieb T,Jiang J,Riley TV,Tang YW,Jin D

更新日期：2019-01-01 00:00:00

abstract：:The Beijing genotype comprises a highly disseminated strain type that is frequently associated with multidrug resistant (MDR) tuberculosis (TB) and increased transmissibility but, countries such as Portugal and Guinea-Bissau fall outside the regions phylogeographically associated with this specific genotype. Neverthel...

journal_title：Emerging microbes & infections

authors： Perdigão J,Silva C,Maltez F,Machado D,Miranda A,Couto I,Rabna P,Florez de Sessions P,Phelan J,Pain A,McNerney R,Hibberd ML,Mokrousov I,Clark TG,Viveiros M,Portugal I

更新日期：2020-12-01 00:00:00

abstract：:Acute meningoencephalitis (AME) is associated with considerable morbidity and mortality in children in developing countries. Clinical specimens were collected from children presenting with AME at two Cambodian paediatric hospitals to determine the major aetiologies associated with AME in the country. Cerebrospinal flu...

journal_title：Emerging microbes & infections

authors： Horwood PF,Duong V,Laurent D,Mey C,Sothy H,Santy K,Richner B,Heng S,Hem S,Cheval J,Gorman C,Dussart P,de Jong MD,Kerleguer A,Guillard B,Murgue B,Lecuit M,de Lamballerie X,Farrar JJ,Tarantola A,Eloit M,Buchy P

更新日期：2017-05-24 00:00:00

abstract：:Tuberculosis (TB) has been a persistent public health concern for hundreds of years. Despite advances in medicine and science, eliminating this disease has been beyond our reach. Several organizations, including the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Healt...

journal_title：Emerging microbes & infections

authors： Sizemore CF,Schleif AC,Bernstein JB,Heilman CA

更新日期：2012-07-01 00:00:00

abstract：:The three unprecedented outbreaks of emerging human coronavirus (HCoV) infections at the beginning of the twenty-first century have highlighted the necessity for readily available, accurate and fast diagnostic testing methods. The laboratory diagnostic methods for human coronavirus infections have evolved substantiall...

journal_title：Emerging microbes & infections

authors： Loeffelholz MJ,Tang YW

更新日期：2020-12-01 00:00:00

abstract：:We report the discovery and confirmation of 23 novel mutations with previously undocumented role in isoniazid (INH) drug resistance, in catalase-peroxidase (katG) gene of Mycobacterium tuberculosis (Mtb) isolates. With these mutations, a synonymous mutation in fabG1 (g609a), and two canonical mutations, we were able t...

journal_title：Emerging microbes & infections

authors： Torres JN,Paul LV,Rodwell TC,Victor TC,Amallraja AM,Elghraoui A,Goodmanson AP,Ramirez-Busby SM,Chawla A,Zadorozhny V,Streicher EM,Sirgel FA,Catanzaro D,Rodrigues C,Gler MT,Crudu V,Catanzaro A,Valafar F

更新日期：2015-07-01 00:00:00

abstract：:Monoclonal antibodies (mAbs), which currently constitute the main class of biotherapeutics, are now recognized as major medical tools that are increasingly being considered to fight severe viral infections. Indeed, the number of antiviral mAbs developed in recent years has grown exponentially. Although their direct ef...

journal_title：Emerging microbes & infections

authors： Lambour J,Naranjo-Gomez M,Piechaczyk M,Pelegrin M

更新日期：2016-08-17 00:00:00

abstract：:Avian influenza A(H7N9) virus (A(H7N9)) emerged in February 2013. Liver impairment of unknown cause is present in 29% of patients with A(H7N9) infection, some of whom experience severe liver injury. Hypoxic hepatitis (HH) is a type of acute severe liver injury characterized by an abrupt, massive increase in serum amin...

journal_title：Emerging microbes & infections

authors： Zhang Y,Liu J,Yu L,Zhou N,Ding W,Zheng S,Shi D,Li L

更新日期：2016-01-06 00:00:00

abstract：:Previous studies have shown that livestock (LA)-MRSA ST398 evolved from a human-adapted methicillin-susceptible S. aureus (MSSA) clone. However, detailed information regarding ST9 is still unclear. Here, we characterized a community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) ST9-SCCmec XII isolat...

journal_title：Emerging microbes & infections

authors： Jin Y,Yu X,Chen Y,Chen W,Shen P,Luo Q,Zhang S,Kong X,Zheng B,Xiao Y

更新日期：2020-12-01 00:00:00

abstract：:Zika virus (ZIKV) infection during pregnancy is associated with congenital brain abnormalities, a finding that highlights the urgent need to understand mother-to-fetus transmission mechanisms. Human umbilical cord mesenchymal stem cells (hUCMSCs) are susceptible to ZIKV infection but the underlying mechanisms of viral...

journal_title：Emerging microbes & infections

authors： Seong RK,Lee JK,Cho GJ,Kumar M,Shin OS

更新日期：2020-12-01 00:00:00

abstract：:Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) have disseminated worldwide and emerged as major threats to public health. Of epidemiological significance, the international pandemic of KPC-KP is primarily associated with CG258 isolates and blaKPC-IncF plasmids. CRISPR-Cas system is an adapt...

journal_title：Emerging microbes & infections

authors： Zhou Y,Tang Y,Fu P,Tian D,Yu L,Huang Y,Li G,Li M,Wang Y,Yang Z,Xu X,Yin Z,Zhou D,Poirel L,Jiang X

更新日期：2020-12-01 00:00:00

abstract：:Pyrazinamide (PZA) is a key antibiotic in current anti-tuberculosis regimens. Although the WHO has stressed the urgent need to obtain data on PZA resistance, in high tuberculosis burden countries, little is known about the level of PZA resistance, the genetic basis of such resistance or its link with Mycobacterium tub...

journal_title：Emerging microbes & infections

authors： Huy NQ,Lucie C,Hoa TTT,Hung NV,Lan NTN,Son NT,Nhung NV,Anh DD,Anne-Laure B,Van Anh NT

更新日期：2017-10-11 00:00:00

abstract：:In March 2013, a patient infected with a novel avian influenza A H7N9 virus was reported in China. Since then, there have been 458 confirmed infection cases and 177 deaths. The virus contains several human-adapted markers, indicating that H7N9 has pandemic potential. The outbreak of this new influenza virus highlighte...

journal_title：Emerging microbes & infections

authors： Leung HC,Chan CC,Poon VK,Zhao HJ,Cheung CY,Ng F,Huang JD,Zheng BJ

更新日期：2015-04-01 00:00:00