Comparative epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia and South Korea.

Abstract:

:MERS-CoV infection emerged in the Kingdom of Saudi Arabia (KSA) in 2012 and has spread to 26 countries. However, 80% of all cases have occurred in KSA. The largest outbreak outside KSA occurred in South Korea (SK) in 2015. In this report, we describe an epidemiological comparison of the two outbreaks. Data from 1299 cases in KSA (2012-2015) and 186 cases in SK (2015) were collected from publicly available resources, including FluTrackers, the World Health Organization (WHO) outbreak news and the Saudi MOH (MOH). Descriptive analysis, t-tests, Chi-square tests and binary logistic regression were conducted to compare demographic and other characteristics (comorbidity, contact history) of cases by nationality. Epidemic curves of the outbreaks were generated. The mean age of cases was 51 years in KSA and 54 years in SK. Older males (⩾70 years) were more likely to be infected or to die from MERS-CoV infection, and males exhibited increased rates of comorbidity in both countries. The epidemic pattern in KSA was more complex, with animal-to-human, human-to-human, nosocomial and unknown exposure, whereas the outbreak in SK was more clearly nosocomial. Of the 1186 MERS cases in KSA with reported risk factors, 158 (13.3%) cases were hospital associated compared with 175 (94.1%) in SK, and an increased proportion of cases with unknown exposure risk was found in KSA (710, 59.9%). In a globally connected world, travel is a risk factor for emerging infections, and health systems in all countries should implement better triage systems for potential imported cases of MERS-CoV to prevent large epidemics.

journal_name

Emerg Microbes Infect

authors

Chen X,Chughtai AA,Dyda A,MacIntyre CR

doi

10.1038/emi.2017.40

subject

Has Abstract

pub_date

2017-06-07 00:00:00

pages

e51

issue

6

issn

2222-1751

pii

emi201740

journal_volume

6

pub_type

杂志文章
  • Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors.

    abstract::Since the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, it has rapidly spread across many other countries. While the majority of patients were considered mild, critically ill patients involving respiratory failure and multiple organ dysfunction syndrome are not uncommon, which could result death. We...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章

    doi:10.1080/22221751.2020.1770129

    authors: Han H,Ma Q,Li C,Liu R,Zhao L,Wang W,Zhang P,Liu X,Gao G,Liu F,Jiang Y,Cheng X,Zhu C,Xia Y

    更新日期:2020-12-01 00:00:00

  • Genetic regulation of the development of mating projections in Candida albicans.

    abstract::Candida albicans is a major human fungal pathogen, capable of switching among a range of morphological types, such as the yeast form, including white and opaque cell types and the GUT (gastrointestinally induced transition) cell type, the filamentous form, including hyphal and pseudohyphal cell types, and chlamydospor...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章

    doi:10.1080/22221751.2020.1729067

    authors: Liang W,Guan G,Li C,Nobile CJ,Tao L,Huang G

    更新日期:2020-02-21 00:00:00

  • Enterovirus 71 infection of human airway organoids reveals VP1-145 as a viral infectivity determinant.

    abstract::Human enteroviruses frequently cause severe diseases in children. Human enteroviruses are transmitted via the fecal-oral route and respiratory droplets, and primary replication occurs in the gastro-intestinal and respiratory tracts; however, how enteroviruses infect these sites is largely unknown. Human intestinal org...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章

    doi:10.1038/s41426-018-0077-2

    authors: van der Sanden SMG,Sachs N,Koekkoek SM,Koen G,Pajkrt D,Clevers H,Wolthers KC

    更新日期:2018-05-09 00:00:00

  • Identification and genetic characterization of a novel parvovirus associated with serum hepatitis in horses in China.

    abstract::A novel equine parvovirus, equine parvovirus-hepatitis (EqPV-H), was first discovered in a horse that died of equine serum hepatitis in the USA in 2018. EqPV-H was shown to be a novel etiological agent associated with equine serum hepatitis. Following this initial report, no additional studies on EqPV-H have been publ...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章

    doi:10.1038/s41426-018-0174-2

    authors: Lu G,Sun L,Ou J,Xu H,Wu L,Li S

    更新日期:2018-10-23 00:00:00

  • Avian influenza A H5N1 virus: a continuous threat to humans.

    abstract::We report the first case of severe pneumonia due to co-infection with the emerging avian influenza A (H5N1) virus subclade 2.3.2.1 and Mycoplasma pneumoniae. The patient was a returning traveller who had visited a poultry market in South China. We then review the epidemiology, virology, interspecies barrier limiting p...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章,评审

    doi:10.1038/emi.2012.24

    authors: To KK,Ng KH,Que TL,Chan JM,Tsang KY,Tsang AK,Chen H,Yuen KY

    更新日期:2012-09-01 00:00:00

  • Clinical observation and management of COVID-19 patients.

    abstract::Three leading infectious disease experts in China were invited to share their bedside observations in the management of COVID-19 patients. Professor Taisheng Li was sent to Wuhan to provide frontline medical care. He depicts the clinical course of SARS-CoV-2 infection. Furthermore, he observes the significant abnormal...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章

    doi:10.1080/22221751.2020.1741327

    authors: Li T,Lu H,Zhang W

    更新日期:2020-12-01 00:00:00

  • Targeting intracellular signaling as an antiviral strategy: aerosolized LASAG for the treatment of influenza in hospitalized patients.

    abstract::Influenza has been a long-running health problem and novel antiviral drugs are urgently needed. In pre-clinical studies, we demonstrated broad antiviral activity of D, L-lysine-acetylsalicylate glycine (LASAG) against influenza virus (IV) in cell culture and protection against lethal challenge in mice. LASAG is a comp...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1038/s41426-018-0023-3

    authors: Scheuch G,Canisius S,Nocker K,Hofmann T,Naumann R,Pleschka S,Ludwig S,Welte T,Planz O

    更新日期:2018-03-07 00:00:00

  • Molecular characteristics of eae-positive clinical Shiga toxin-producing Escherichia coli in Sweden.

    abstract::Shiga toxin (Stx)-producing Escherichia coli (STEC) can cause a wide range of symptoms from asymptomatic carriage, mild diarrhea to bloody diarrhea (BD) and hemolytic uremic syndrome (HUS). Intimin, encoded by the eae gene, also plays a critical role in STEC pathogenesis. Herein, we investigated the prevalence and gen...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章

    doi:10.1080/22221751.2020.1850182

    authors: Hua Y,Bai X,Zhang J,Jernberg C,Chromek M,Hansson S,Frykman A,Yang X,Xiong Y,Wan C,Matussek A

    更新日期:2020-12-01 00:00:00

  • Tree shrew as a new animal model to study the pathogenesis of avian influenza (H9N2) virus infection.

    abstract::Outbreaks of avian influenza virus continue to pose threats to human health. Animal models such as the mouse, ferret, and macaque are used to understand the pathogenesis of avian influenza virus infection in humans. We previously reported that the tree shrew (Tupaia belangeri, family Tupaiidae), which is regarded as a...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章

    doi:10.1038/s41426-018-0167-1

    authors: Li R,Yuan B,Xia X,Zhang S,Du Q,Yang C,Li N,Zhao J,Zhang Y,Zhang R,Feng Y,Jiao J,Peiris M,Zhong N,Mok CKP,Yang Z

    更新日期:2018-10-10 00:00:00

  • Detection and characterization of an emerging type of Babesia sp. similar to Babesia motasi for the first case of human babesiosis and ticks in Korea.

    abstract::Babesiosis is a tick-transmitted intraerythrocytic zoonosis. In Korea, the first mortalities were reported in 2005 due to Babesia sp. detection in sheep; herein we report epidemiological and genetic characteristics of a second case of babesiosis. Microscopic analysis of patient blood revealed polymorphic merozoites. T...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章

    doi:10.1080/22221751.2019.1622997

    authors: Hong SH,Kim SY,Song BG,Rho JR,Cho CR,Kim CN,Um TH,Kwak YG,Cho SH,Lee SE

    更新日期:2019-01-01 00:00:00

  • Novel reassortant of H1N1 swine influenza virus detected in pig population in Russia.

    abstract::Pigs play an important role in interspecies transmission of the influenza virus, particularly as "mixing vessels" for reassortment. Two influenza A/H1N1 virus strains, A/swine/Siberia/1sw/2016 and A/swine/Siberia/4sw/2017, were isolated during a surveillance of pigs from private farms in Russia from 2016 to 2017. Ther...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章

    doi:10.1080/22221751.2019.1673136

    authors: Sobolev I,Kurskaya O,Leonov S,Kabilov M,Alikina T,Alekseev A,Yushkov Y,Saito T,Uchida Y,Mine J,Shestopalov A,Sharshov K

    更新日期:2019-01-01 00:00:00

  • Aetiology of acute meningoencephalitis in Cambodian children, 2010-2013.

    abstract::Acute meningoencephalitis (AME) is associated with considerable morbidity and mortality in children in developing countries. Clinical specimens were collected from children presenting with AME at two Cambodian paediatric hospitals to determine the major aetiologies associated with AME in the country. Cerebrospinal flu...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章

    doi:10.1038/emi.2017.15

    authors: Horwood PF,Duong V,Laurent D,Mey C,Sothy H,Santy K,Richner B,Heng S,Hem S,Cheval J,Gorman C,Dussart P,de Jong MD,Kerleguer A,Guillard B,Murgue B,Lecuit M,de Lamballerie X,Farrar JJ,Tarantola A,Eloit M,Buchy P

    更新日期:2017-05-24 00:00:00

  • The expanding spectrum of human infections caused by Kocuria species: a case report and literature review.

    abstract::Although not previously known to cause human infections, Kocuria species have now emerged as human pathogens, mostly in compromised hosts with severe underlying disease. Recently, there has been an increasing incidence of different types of Kocuria infections reported, most likely due to the adoption of better identif...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章

    doi:10.1038/emi.2013.71

    authors: Purty S,Saranathan R,Prashanth K,Narayanan K,Asir J,Sheela Devi C,Kumar Amarnath S

    更新日期:2013-10-01 00:00:00

  • Occult HBV infection in Chinese blood donors: role of N-glycosylation mutations and amino acid substitutions in S protein transmembrane domains.

    abstract::Occult hepatitis B virus infection (OBI) is a low-level asymptomatic phase of HBV infection. Evidence of OBI clinical relevance is emerging but the mechanisms of its occurrence remain unclear. In this study, the molecular characteristics of 97 confirmed OBI from Chinese blood donors were analyzed and relevant mutation...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章

    doi:10.1080/22221751.2019.1663130

    authors: Zhang L,Chang L,Laperche S,Ji H,Zhao J,Jiang X,Wang L,Candotti D

    更新日期:2019-01-01 00:00:00

  • The type I-E CRISPR-Cas system influences the acquisition of blaKPC-IncF plasmid in Klebsiella pneumonia.

    abstract::Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) have disseminated worldwide and emerged as major threats to public health. Of epidemiological significance, the international pandemic of KPC-KP is primarily associated with CG258 isolates and blaKPC-IncF plasmids. CRISPR-Cas system is an adapt...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章

    doi:10.1080/22221751.2020.1763209

    authors: Zhou Y,Tang Y,Fu P,Tian D,Yu L,Huang Y,Li G,Li M,Wang Y,Yang Z,Xu X,Yin Z,Zhou D,Poirel L,Jiang X

    更新日期:2020-12-01 00:00:00

  • Cross-reactive antibodies binding to H4 hemagglutinin protect against a lethal H4N6 influenza virus challenge in the mouse model.

    abstract::Influenza viruses of the H4 subtype are widespread in wild birds, circulate in domestic poultry, readily infect mammals, and tolerate the insertion of a polybasic cleavage site. In addition, serological evidence suggests that humans working with poultry are exposed to these viruses. While H4 viruses are not of immedia...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章

    doi:10.1080/22221751.2018.1564369

    authors: Amanat F,Meade P,Strohmeier S,Krammer F

    更新日期:2019-01-01 00:00:00

  • Genetic diversity and host adaptation of avian H5N1 influenza viruses during human infection.

    abstract::The continuing pandemic threat posed by avian influenza A/H5N1 viruses calls for improved insights into their evolution during human infection. We performed whole genome deep sequencing of respiratory specimens from 44 H5N1-infected individuals from Indonesia and found substantial within-host viral diversity. At nearl...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章

    doi:10.1080/22221751.2019.1575700

    authors: Welkers MRA,Pawestri HA,Fonville JM,Sampurno OD,Pater M,Holwerda M,Han AX,Russell CA,Jeeninga RE,Setiawaty V,de Jong MD,Eggink D

    更新日期:2019-01-01 00:00:00

  • A host-based whole genome sequencing study reveals novel risk loci associated with severity of influenza A(H1N1)pdm09 infection.

    abstract::Influenza A(H1N1)pdm09 virus has remained in a seasonal circulation since being recognized in 2009. Although it followed a mild course in most patients, in others it caused a series of severe clinical illnesses. Epidemiologic studies have implicated that host factors have a major influence on the disease severity of i...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章

    doi:10.1080/22221751.2020.1870412

    authors: Li M,Chen Y,Chen T,Hu S,Chen L,Shen L,Li F,Yang J,Sun Y,Wang D,He L,Qin S,Shu Y

    更新日期:2021-12-01 00:00:00

  • Saffold virus is able to productively infect primate and rodent cell lines and induces apoptosis in these cells.

    abstract::Saffold virus (SAFV), a newly discovered human cardiovirus of the Picornaviridae family, causes widespread infection among children, as shown by previous seroprevalence studies. To determine the host cell range of SAFV and its cytopathogenicity, eight mammalian cell lines that were available in the laboratory were scr...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章

    doi:10.1038/emi.2014.15

    authors: Xu Y,Victorio CB,Ng Q,Tan YJ,Chua KB

    更新日期:2014-02-01 00:00:00

  • Direct evidence of an extra-intestinal cycle of Toxoplasma gondii in tigers (Panthera tigris) by isolation of viable strains.

    abstract::Toxoplasmosis is one of the most common zoonotic diseases in the world. Felines excrete environmentally resistant Toxoplasma gondii oocysts. However, there is no direct evidence to prove tigers are the intermediate host of T. gondii. Here, we show that, IgG antibodies to T. gondii in 80% (8/10) of captive tigers. Two ...

    journal_title:Emerging microbes & infections

    pub_type: 信件

    doi:10.1080/22221751.2019.1682471

    authors: Yang Y,Dong H,Su R,Jiang N,Li T,Su C,Yuan Z,Zhang L

    更新日期:2019-01-01 00:00:00

  • Adaptive mutation in influenza A virus non-structural gene is linked to host switching and induces a novel protein by alternative splicing.

    abstract::Little is known about the processes that enable influenza A viruses to jump into new host species. Here we show that the non-structural protein1 nucleotide substitution, A374G, encoding the D125G(GAT→GGT) mutation, which evolved during the adaptation of a human virus within a mouse host, activates a novel donor splice...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章

    doi:10.1038/emi.2012.38

    authors: Selman M,Dankar SK,Forbes NE,Jia JJ,Brown EG

    更新日期:2012-11-01 00:00:00

  • Mathematic modeling of COVID-19 in the United States.

    abstract::COVID-19, the worst pandemic in 100 years, has rapidly spread to the entire world in 2 months since its early report in January 2020. Based on the publicly available data sources, we developed a simple mathematic modeling approach to track the outbreaks of COVID-19 in the US and three selected states: New York, Michig...

    journal_title:Emerging microbes & infections

    pub_type: 信件

    doi:10.1080/22221751.2020.1760146

    authors: Tang Y,Wang S

    更新日期:2020-12-01 00:00:00

  • Evidence of H10N8 influenza virus infection among swine in southern China and its infectivity and transmissibility in swine.

    abstract::Infection with a novel H10N8 influenza virus in humans was first described in China in December 2013, which raised concerns related to public health. This novel virus was subsequently confirmed to have originated from a live poultry market. However, whether this virus can infect other mammals remains unclear. In the p...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章

    doi:10.1080/22221751.2019.1708811

    authors: Fu X,Huang Y,Fang B,Liu Y,Cai M,Zhong R,Huang J,Wenbao Q,Tian Y,Zhang G

    更新日期:2020-01-03 00:00:00

  • Seroepidemiology of enterovirus D68 infection in China.

    abstract::Human enterovirus 68 (EV-D68) is a rarely reported virus that has been linked to respiratory disease. In recent years, reports about EV-D68 infection have markedly increased worldwide. However, the epidemiological features of this emerging infection are not well understood. To evaluate the emerging EV-D68 epidemic, we...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章

    doi:10.1038/emi.2017.14

    authors: Xiang Z,Li L,Ren L,Guo L,Xie Z,Liu C,Li T,Luo M,Paranhos-Baccalà G,Xu W,Wang J

    更新日期:2017-05-10 00:00:00

  • Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction.

    abstract::The emergence of SARS-CoV-2 has led to the current global coronavirus pandemic and more than one million infections since December 2019. The exact origin of SARS-CoV-2 remains elusive, but the presence of a distinct motif in the S1/S2 junction region suggests the possible acquisition of cleavage site(s) in the spike p...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章

    doi:10.1080/22221751.2020.1756700

    authors: Lau SY,Wang P,Mok BW,Zhang AJ,Chu H,Lee AC,Deng S,Chen P,Chan KH,Song W,Chen Z,To KK,Chan JF,Yuen KY,Chen H

    更新日期:2020-12-01 00:00:00

  • Vector competence of European mosquitoes for West Nile virus.

    abstract::West Nile virus (WNV) is an arthropod-borne flavivirus of high medical and veterinary importance. The main vectors for WNV are mosquito species of the Culex genus that transmit WNV among birds, and occasionally to humans and horses, which are 'dead-end' hosts. Recently, several studies have been published that aimed t...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章,评审

    doi:10.1038/emi.2017.82

    authors: Vogels CB,Göertz GP,Pijlman GP,Koenraadt CJ

    更新日期:2017-11-08 00:00:00

  • Successful treatment of a Candida auris intra-articular infection.

    abstract::A 78-year-old woman with a long-term ankle spacer with antibacterials developed an intra-articular Candida auris infection. Treatment with systemic antifungal therapy plus an amphotericin B moulded cement spacer was successful. ...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章

    doi:10.1080/22221751.2019.1625287

    authors: Roberts SC,Zembower TR,Bolon MK,Kadakia AR,Gilley JH,Ko JH,Clark J,Ward-Fore S,Taiwo BO

    更新日期:2019-01-01 00:00:00

  • Perception of the 2020 SARS-CoV-2 pandemic among medical professionals in Germany: results from a nationwide online survey.

    abstract::Background: The COVID-19 pandemic represents an unprecedented global challenge and implicates a wide range of burden on medical professionals. Here, we evaluated the perception of the COVID-19 pandemic among medical professionals in Germany. Methods: A total of n = 2827 medical professionals participated in an online ...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章

    doi:10.1080/22221751.2020.1785951

    authors: Paffenholz P,Peine A,Hellmich M,Paffenholz SV,Martin L,Luedde M,Haverkamp M,Roderburg C,Marx G,Heidenreich A,Trautwein C,Luedde T,Loosen SH

    更新日期:2020-12-01 00:00:00

  • Comparison of the virulence and transmissibility of canine H3N2 influenza viruses and characterization of their canine adaptation factors.

    abstract::Recent canine influenza outbreaks have raised concerns about the generation of pathogenic variants that may pose a threat to public health. Here, we examine avian-like H3N2 canine influenza viruses (CIVs) isolated from 2009 to 2013 in South Korea from dogs. Phylogenetic analysis revealed that these viruses are closely...

    journal_title:Emerging microbes & infections

    pub_type: 杂志文章

    doi:10.1038/s41426-017-0013-x

    authors: Lee IW,Kim YI,Lim GJ,Kwon HI,Si YJ,Park SJ,Kim EH,Kim SM,Nguyen HD,Song MS,Choi YK

    更新日期:2018-03-07 00:00:00

  • Emerging colistin resistance in Salmonella enterica serovar Newport isolates from human infections.

    abstract::Worldwide emergence of Salmonella enterica serovar Newport (S. Newport) infection in humans, in parallel with a significant increasing prevalence of antimicrobial resistance (AR), is a serious public health concern. However, the prevalence of S. Newport resistance in China remains largely unknown. A retrospective stud...

    journal_title:Emerging microbes & infections

    pub_type: 信件

    doi:10.1080/22221751.2020.1733439

    authors: Elbediwi M,Pan H,Biswas S,Li Y,Yue M

    更新日期:2020-03-03 00:00:00