Abstract:
:Serology detection is recognized for its sensitivity in convalescent patients with COVID-19, in comparison with nucleic acid amplification tests (NAATs). This article aimed to evaluate the diagnostic accuracy of serologic methods for COVID-19 based on assay design and post-symptom-onset intervals. Two authors independently searched PubMed, Cochrane library, Ovid, EBSCO for case-control, longitudinal and cohort studies that determined the diagnostic accuracy of serology tests in comparison with NAATs in COVID-19 cases and used QUADAS-2 for quality assessment. Pooled accuracy was analysed using INLA method. A total of 27 studies were included in this meta-analysis, with 4 cohort, 16 case-control and 7 longitudinal studies and 4565 participants. Serology tests had the lowest sensitivity at 0-7 days after symptom onset and the highest at >14 days. TAB had a better sensitivity than IgG or IgM only. Using combined nucleocapsid (N) and spike(S) protein had a better sensitivity compared to N or S protein only. Lateral flow immunoassay (LFIA) had a lower sensitivity than enzyme-linked immunoassay (ELISA) and chemiluminescent immunoassay (CLIA). Serology tests will play an important role in the clinical diagnosis for later stage COVID-19 patients. ELISA tests, detecting TAB or targeting combined N and S proteins had a higher diagnostic sensitivity compared to other methods.
journal_name
Emerg Microbes Infectjournal_title
Emerging microbes & infectionsauthors
Wang H,Ai J,Loeffelholz MJ,Tang YW,Zhang Wdoi
10.1080/22221751.2020.1826362subject
Has Abstractpub_date
2020-12-01 00:00:00pages
2200-2211issue
1issn
2222-1751journal_volume
9pub_type
杂志文章,meta分析abstract::Little is known about the processes that enable influenza A viruses to jump into new host species. Here we show that the non-structural protein1 nucleotide substitution, A374G, encoding the D125G(GAT→GGT) mutation, which evolved during the adaptation of a human virus within a mouse host, activates a novel donor splice...
journal_title:Emerging microbes & infections
pub_type: 杂志文章
doi:10.1038/emi.2012.38
更新日期:2012-11-01 00:00:00
abstract::A 78-year-old woman with a long-term ankle spacer with antibacterials developed an intra-articular Candida auris infection. Treatment with systemic antifungal therapy plus an amphotericin B moulded cement spacer was successful. ...
journal_title:Emerging microbes & infections
pub_type: 杂志文章
doi:10.1080/22221751.2019.1625287
更新日期:2019-01-01 00:00:00
abstract::Accumulating evidence indicates that bacterial metabolism plays an important role in virulence. Acetyl phosphate (AcP), the high-energy intermediate of the phosphotransacetylase-acetate kinase pathway, is the major acetyl donor in E. coli. PhoP is an essential transcription factor for bacterial virulence. Here, we sho...
journal_title:Emerging microbes & infections
pub_type: 杂志文章
doi:10.1080/22221751.2018.1558963
更新日期:2019-01-01 00:00:00
abstract::Interleukin 17 (IL-17) and its closest relative, IL-17F, have recently drawn much attention in the field of immunology. IL-17 and IL-17F are expressed by a distinct type of T cells, T helper 17 cells and certain other lymphocytes. These cytokines play key regulatory roles in host defense and inflammatory diseases. In ...
journal_title:Emerging microbes & infections
pub_type: 杂志文章,评审
doi:10.1038/emi.2013.58
更新日期:2013-09-01 00:00:00
abstract::Human papillomaviruses (HPV) contribute to most cervical cancers and are considered to be sexually transmitted. However, papillomaviruses are often found in cancers of internal organs, including the stomach, raising the question as to how the viruses gain access to these sites. A possible connection between blood tran...
journal_title:Emerging microbes & infections
pub_type: 杂志文章
doi:10.1080/22221751.2019.1637072
更新日期:2019-01-01 00:00:00
abstract::The isolation and characterization of monoclonal broadly neutralizing antibodies (nAbs) from natural HIV-1-infected individuals play very important roles in understanding nAb responses to HIV-1 infection and designing vaccines and therapeutics. Many broadly nAbs have been isolated from individuals infected with HIV-1 ...
journal_title:Emerging microbes & infections
pub_type: 杂志文章
doi:10.1038/s41426-018-0175-1
更新日期:2018-11-01 00:00:00
abstract::H7N9 influenza viruses emerged in 2013 and have caused severe disease and deaths in humans in China. Some H7N9 viruses circulating in chickens have mutated to highly pathogenic viruses that have caused several disease outbreaks in chickens. Studies have shown that when the H7N9 highly pathogenic viruses replicate in f...
journal_title:Emerging microbes & infections
pub_type: 杂志文章
doi:10.1038/s41426-018-0154-6
更新日期:2018-09-12 00:00:00
abstract::We report the discovery and confirmation of 23 novel mutations with previously undocumented role in isoniazid (INH) drug resistance, in catalase-peroxidase (katG) gene of Mycobacterium tuberculosis (Mtb) isolates. With these mutations, a synonymous mutation in fabG1 (g609a), and two canonical mutations, we were able t...
journal_title:Emerging microbes & infections
pub_type: 杂志文章
doi:10.1038/emi.2015.42
更新日期:2015-07-01 00:00:00
abstract::The three unprecedented outbreaks of emerging human coronavirus (HCoV) infections at the beginning of the twenty-first century have highlighted the necessity for readily available, accurate and fast diagnostic testing methods. The laboratory diagnostic methods for human coronavirus infections have evolved substantiall...
journal_title:Emerging microbes & infections
pub_type: 杂志文章,评审
doi:10.1080/22221751.2020.1745095
更新日期:2020-12-01 00:00:00
abstract::The highly pathogenic avian influenza A (H5N6) virus has caused sporadic human infections with a high case fatality rate. Due to the continuous evolution of this virus subtype and its ability to transmit to humans, there is an urgent need to develop effective antiviral therapeutics. In this study, a murine monoclonal ...
journal_title:Emerging microbes & infections
pub_type: 杂志文章
doi:10.1080/22221751.2019.1708215
更新日期:2020-01-06 00:00:00
abstract::Saffold virus (SAFV), a newly discovered human cardiovirus of the Picornaviridae family, causes widespread infection among children, as shown by previous seroprevalence studies. To determine the host cell range of SAFV and its cytopathogenicity, eight mammalian cell lines that were available in the laboratory were scr...
journal_title:Emerging microbes & infections
pub_type: 杂志文章
doi:10.1038/emi.2014.15
更新日期:2014-02-01 00:00:00
abstract::We report the first case of severe pneumonia due to co-infection with the emerging avian influenza A (H5N1) virus subclade 2.3.2.1 and Mycoplasma pneumoniae. The patient was a returning traveller who had visited a poultry market in South China. We then review the epidemiology, virology, interspecies barrier limiting p...
journal_title:Emerging microbes & infections
pub_type: 杂志文章,评审
doi:10.1038/emi.2012.24
更新日期:2012-09-01 00:00:00
abstract::The first imported case of Middle East respiratory syndrome (MERS) in China recently occurred, allowing for the characterization of antibody titers in a series of the patient's sera using the following methods based on recombinant viral structural antigens: inactivated MERS coronavirus (MERS-CoV) enzyme-linked immunos...
journal_title:Emerging microbes & infections
pub_type: 杂志文章
doi:10.1038/emi.2016.114
更新日期:2016-11-09 00:00:00
abstract::From September 2015 to March 2016, hepatitis A notifications in Germany increased by 45% to 699 cases compared to 482 cases in the same period of the previous year. Children aged five to nine years were predominantly affected (22% of all cases in this period). We hypothesized that this increase could be explained by t...
journal_title:Emerging microbes & infections
pub_type: 杂志文章
doi:10.1038/emi.2017.11
更新日期:2017-04-26 00:00:00
abstract::Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with droplets and contact as the main means of transmission. Since the first case appeared in Wuhan, China, in December 2019, the outbreak has gradually spread nationwide. Up to now, acco...
journal_title:Emerging microbes & infections
pub_type: 杂志文章
doi:10.1080/22221751.2020.1746199
更新日期:2020-12-01 00:00:00
abstract::We conducted this study to describe the dynamics of the acquisition of respiratory pathogens, their potential interactions and risk factors for possible lower respiratory tract infection symptoms (LRTI) among French pilgrims during the 2018 Hajj. Each participant underwent four successive systematic nasopharyngeal swa...
journal_title:Emerging microbes & infections
pub_type: 杂志文章
doi:10.1080/22221751.2019.1693247
更新日期:2019-01-01 00:00:00
abstract::The progressive anthropization of caves for food resources or economic purposes increases human exposure to pathogens that naturally infect cave-dwelling animals. The presence of wild or domestic animals in the immediate surroundings of caves also may contribute to increasing the risk of emergence of such pathogens. S...
journal_title:Emerging microbes & infections
pub_type: 杂志文章,评审
doi:10.1038/emi.2017.6
更新日期:2017-04-12 00:00:00
abstract::COVID-19, the worst pandemic in 100 years, has rapidly spread to the entire world in 2 months since its early report in January 2020. Based on the publicly available data sources, we developed a simple mathematic modeling approach to track the outbreaks of COVID-19 in the US and three selected states: New York, Michig...
journal_title:Emerging microbes & infections
pub_type: 信件
doi:10.1080/22221751.2020.1760146
更新日期:2020-12-01 00:00:00
abstract::MERS-CoV infection emerged in the Kingdom of Saudi Arabia (KSA) in 2012 and has spread to 26 countries. However, 80% of all cases have occurred in KSA. The largest outbreak outside KSA occurred in South Korea (SK) in 2015. In this report, we describe an epidemiological comparison of the two outbreaks. Data from 1299 c...
journal_title:Emerging microbes & infections
pub_type: 杂志文章
doi:10.1038/emi.2017.40
更新日期:2017-06-07 00:00:00
abstract::Nontuberculous mycobacterial (NTM) infections in humans have increased in prevalence in recent decades. Mycobacterium kansasii is one of the most prevalent human pathogenic NTM species worldwide. Herein, we report the first isolation of M. kansasii from an indoor domestic cat in Japan. Comparative genome sequence anal...
journal_title:Emerging microbes & infections
pub_type: 信件
doi:10.1080/22221751.2021.1878935
更新日期:2021-01-19 00:00:00
abstract::Human enterovirus 68 (EV-D68) is a rarely reported virus that has been linked to respiratory disease. In recent years, reports about EV-D68 infection have markedly increased worldwide. However, the epidemiological features of this emerging infection are not well understood. To evaluate the emerging EV-D68 epidemic, we...
journal_title:Emerging microbes & infections
pub_type: 杂志文章
doi:10.1038/emi.2017.14
更新日期:2017-05-10 00:00:00
abstract::Molecular epidemiology of Clostridium difficile infection (CDI) has been extensively studied in North America and Europe; however, limited data on CDI are available in the Asia-Pacific region. A multicentre retrospective study was conducted in this region. C. difficile isolates were subjected to multilocus sequence ty...
journal_title:Emerging microbes & infections
pub_type: 杂志文章
doi:10.1080/22221751.2019.1682472
更新日期:2019-01-01 00:00:00
abstract::Zika virus (ZIKV) has become a threat to global health since the outbreak in Brazil in 2015. Although ZIKV is generally considered an Aedes-transmitted pathogen, new evidence has shown that parts of the virus closely resemble Culex-transmitted viruses. Therefore, it is important to evaluate the competence of Culex spe...
journal_title:Emerging microbes & infections
pub_type: 杂志文章
doi:10.1038/emi.2016.102
更新日期:2016-09-07 00:00:00
abstract::Pigs play an important role in interspecies transmission of the influenza virus, particularly as "mixing vessels" for reassortment. Two influenza A/H1N1 virus strains, A/swine/Siberia/1sw/2016 and A/swine/Siberia/4sw/2017, were isolated during a surveillance of pigs from private farms in Russia from 2016 to 2017. Ther...
journal_title:Emerging microbes & infections
pub_type: 杂志文章
doi:10.1080/22221751.2019.1673136
更新日期:2019-01-01 00:00:00
abstract::In March 2013, a patient infected with a novel avian influenza A H7N9 virus was reported in China. Since then, there have been 458 confirmed infection cases and 177 deaths. The virus contains several human-adapted markers, indicating that H7N9 has pandemic potential. The outbreak of this new influenza virus highlighte...
journal_title:Emerging microbes & infections
pub_type: 杂志文章
doi:10.1038/emi.2015.22
更新日期:2015-04-01 00:00:00
abstract::Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has resulted in a pandemic and is continuing to spread rapidly around the globe. No effective vaccine is currently available to prevent COVID-19, and intense efforts are being invested worldwide into vaccine development. In this context, all technolo...
journal_title:Emerging microbes & infections
pub_type: 杂志文章
doi:10.1080/22221751.2020.1791737
更新日期:2020-12-01 00:00:00
abstract::Tick-borne encephalitis virus (TBEV) has been classified into three subtypes, namely the European (Eu-TBEV), Far Eastern (FE-TBEV), and Siberian (Sib-TBEV). In this study, we discovered a new subtype of TBEV in wild rodent Marmota himalayana in Qinghai-Tibet Plateau in China, proposed as subtype Himalayan (Him-TBEV). ...
journal_title:Emerging microbes & infections
pub_type: 杂志文章
doi:10.1038/s41426-018-0081-6
更新日期:2018-04-25 00:00:00
abstract::Avian influenza A(H7N9) virus (A(H7N9)) emerged in February 2013. Liver impairment of unknown cause is present in 29% of patients with A(H7N9) infection, some of whom experience severe liver injury. Hypoxic hepatitis (HH) is a type of acute severe liver injury characterized by an abrupt, massive increase in serum amin...
journal_title:Emerging microbes & infections
pub_type: 杂志文章
doi:10.1038/emi.2016.1
更新日期:2016-01-06 00:00:00
abstract::Shiga toxin-producing Escherichia coli (STEC) are foodborne pathogens causing severe gastroenteritis, which may lead to hemolytic uremic syndrome. The Locus of Enterocyte Effacement (LEE), a Pathogenicity Island (PAI), is a major determinant of intestinal epithelium attachment of a group of STEC strains; however, the ...
journal_title:Emerging microbes & infections
pub_type: 杂志文章
doi:10.1080/22221751.2019.1595985
更新日期:2019-01-01 00:00:00
abstract::Zika virus (ZIKV) infection during pregnancy is associated with congenital brain abnormalities, a finding that highlights the urgent need to understand mother-to-fetus transmission mechanisms. Human umbilical cord mesenchymal stem cells (hUCMSCs) are susceptible to ZIKV infection but the underlying mechanisms of viral...
journal_title:Emerging microbes & infections
pub_type: 杂志文章
doi:10.1080/22221751.2020.1821581
更新日期:2020-12-01 00:00:00