The serious mental illness health improvement profile [HIP]: study protocol for a cluster randomised controlled trial.

abstract：BACKGROUND:Advance care planning (ACP) is a process whereby patients prepare for medical decision-making. The traditional objective of ACP has focused on the completion of advance directives. We have developed a new paradigm of ACP focused on preparing patients and their loved ones for communication and informed medica...

journal_title：Trials

authors： Sudore R,Le GM,McMahan R,Feuz M,Katen M,Barnes DE

更新日期：2015-12-12 00:00:00

abstract：BACKGROUND:An individualized treatment algorithm (Copenhagen Achilles Rupture Treatment Algorithm (CARTA)) based on the ultrasonographic appearance of an acute Achilles tendon rupture has been developed aiming to select the correct patients for operative and non-operative treatment. The objective of this study is to in...

journal_title：Trials

authors： Hansen MS,Vestermark MT,Hölmich P,Kristensen MT,Barfod KW

更新日期：2020-05-12 00:00:00

abstract：BACKGROUND:Incurable cancer does not only affect patients, it also affects the lives of their partners. Many partners take on caregiving responsibilities. The burden of these caregiving tasks are often associated with physical, psychological, and social difficulties and many partners have unmet supportive care needs. O...

journal_title：Trials

authors： Schuit AS,Holtmaat K,Hooghiemstra N,Jansen F,Lissenberg-Witte BI,Coupé VMH,Verdonck-de Leeuw IM

更新日期：2020-01-31 00:00:00

abstract：BACKGROUND:Post-stroke depression (PSD) is the most common psychiatric complication after a stroke. The most frequently used antidepressants are selective serotonin receptor inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), however, these exhibit a series of side effects. Traditional Chin...

journal_title：Trials

authors： Zhao AM,Qiu WR,Mao LJ,Ren JG,Xu L,Yao MJ,Bilinksi K,Chang D,Liu JX

更新日期：2018-05-10 00:00:00

abstract：OBJECTIVES:To investigate the potential efficacy of Acacia Senegal extract Gum Arabic (GA) supplementation as immunomodulatory and anti-inflammatory dietary intervention among newly diagnosed COVID 19 Sudanese patients. To study the effect of GA on the level of cytokines, TNFα, IL8, IL6 IL10, CRP and the viral load. Se...

journal_title：Trials

authors： Kaddam L,Babiker R,Ali S,Satti S,Ali N,Elamin M,Mukhtar M,Elnimeiri M,Saeed A

更新日期：2020-09-05 00:00:00

abstract：BACKGROUND:Earlier vascular healing after drug-eluting stent (DES) implantation may reduce the incidence of late stent thrombosis and provide theoretical evidence to shorten dual antiplatelet therapy duration in patients with high bleeding risks. The BuMA supreme stent is a newly developed DES-coated with the sirolimus...

journal_title：Trials

authors： Li B,Jin QH,Chen YD,Wang CQ,Shi B,Su X,Fu GS,Wu YQ,Zhou XC,Yuan ZY

更新日期：2019-06-07 00:00:00

abstract：BACKGROUND:This is a phase II randomised, double-blind, sham-controlled trial to evaluate the effectiveness and tolerability of repetitive transcranial magnetic stimulation for preventive treatment of episodic migraine amongst migraine subjects. METHODS:Subjects age 18 to 60 years will undergo a baseline evaluation to...

journal_title：Trials

authors： Mohamad Safiai NI,Amir NA,Basri H,Inche Mat LN,Hoo FK,Yusof Khan AHK,Loh WC,Chia PK,Ramachandran V,Mat Din H,Samsudin IN,Fernandez A,Mohamed MH,Ching SM,Hashim HZ,Wan Sulaiman WA

更新日期：2020-11-11 00:00:00

abstract：BACKGROUND:Co-infection with malaria parasite and HIV is an emerging public health problem in tropical areas, particularly in pregnant women, and management of the concurrent effects of these two infections is challenging. Co-trimoxazole is a sulfamide preparation used to prevent opportunistic infections in HIV-infecte...

journal_title：Trials

authors： Manirakiza A,Sepou A,Serdouma E,Gondje S,Bata GG,Moussa S,Boulay A,Moyen JM,Sakanga O,Le-Fouler L,Kazanji M,Vray M

更新日期：2013-08-14 00:00:00

abstract：BACKGROUND:Announcements of interim analyses of a clinical trial convey information about the results beyond the trial's Data Safety Monitoring Board (DSMB). The amount of information conveyed may be minimal, but the fact that none of the trial's stopping boundaries has been crossed implies that the experimental therap...

journal_title：Trials

authors： Broglio KR,Stivers DN,Berry DA

更新日期：2014-03-07 00:00:00

abstract：BACKGROUND:The Northwestern University Center for Education and Research on Therapeutics (CERT), funded by the Agency for Healthcare Research and Quality, is one of seven such centers in the USA. The thematic focus of the Northwestern CERT is 'Tools for Optimizing Medication Safety.' Ensuring drug safety is essential, ...

journal_title：Trials

authors： Przytula K,Bailey SC,Galanter WL,Lambert BL,Shrestha N,Dickens C,Falck S,Wolf MS

更新日期：2015-01-27 00:00:00

abstract：BACKGROUND:Impairment in social functioning is a key component of personality disorder. Therefore psycho-education and problem solving (PEPS) therapy may benefit people with this disorder. Psycho-education aims to educate, build rapport, and motivate people for problem solving therapy. Problem solving therapy aims to h...

journal_title：Trials

authors： McMurran M,Crawford MJ,Reilly JG,McCrone P,Moran P,Williams H,Adams CE,Duggan C,Delport J,Whitham D,Day F

更新日期：2011-08-24 00:00:00

abstract：BACKGROUND:Recommendations for good clinical practice have been reported to be difficult to apply in real life by primary care clinicians. This could be because the clinical trials at the origin of the guidelines are based on explanatory trials, conducted under ideal conditions not reflecting the reality of primary car...

journal_title：Trials

authors： Ettori-Ajasse I,Tatin E,Forbes G,Eldridge S,Dibao-Dina C

更新日期：2020-03-19 00:00:00

abstract：BACKGROUND:Increasingly, genomics is informing clinical practice, but challenges remain for medical professionals lacking genetics expertise, and in access to and clinical utility of genomic testing for minority and underrepresented populations. The latter is a particularly pernicious problem due to the historical lack...

journal_title：Trials

authors： Odgis JA,Gallagher KM,Suckiel SA,Donohue KE,Ramos MA,Kelly NR,Bertier G,Blackburn C,Brown K,Fielding L,Lopez J,Aguiniga KL,Maria E,Rodriguez JE,Sebastin M,Teitelman N,Watnick D,Yelton NM,Abhyankar A,Abul-Husn NS,B

更新日期：2021-01-14 00:00:00

abstract：BACKGROUND:Exploration and modelling of heterogeneous treatment effects as a function of baseline covariates is an important aspect of precision medicine in randomised controlled trials (RCTs). Randomisation generally guarantees the internal validity of an RCT, but heterogeneity in treatment effect can reduce external ...

journal_title：Trials

authors： Watson JA,Holmes CC

更新日期：2020-05-07 00:00:00

abstract：BACKGROUND:It is widely agreed that triglyceride (TG)-lowering therapy is imperative in early hypertriglyceridemia-induced acute pancreatitis (HTG-AP). Intravenous insulin with or without heparin, and plasmapheresis are available regimens. However, there is no consensus on first-line therapy. METHODS/DESIGN:The Bi-TPA...

journal_title：Trials

authors： Song X,Shi D,Cui Q,Yu S,Yang J,Song P,Walline J,Xu J,Zhu H,Yu X

更新日期：2019-06-18 00:00:00

abstract：:Following publication of the original article [1], we have been notified of a few mistakes in the "Sample size calculations" section, second paragraph. ...

journal_title：Trials

authors： van Oostveen RB,Romero-Palacios A,Whitlock R,Lee SF,Connolly S,Carignan A,Mazer CD,Loeb M,Mertz D

更新日期：2019-10-16 00:00:00

abstract：BACKGROUND:The costs of medical research are a concern. Clinical Trials Units (CTUs) need to better understand variations in the costs of their activities. METHODS:Representatives of ten CTUs and two grant-awarding bodies pooled their experiences in discussions over 1.5 years. Five of the CTUs provided estimates of, a...

journal_title：Trials

authors： Hind D,Reeves BC,Bathers S,Bray C,Corkhill A,Hayward C,Harper L,Napp V,Norrie J,Speed C,Tremain L,Keat N,Bradburn M

更新日期：2017-05-02 00:00:00

abstract：BACKGROUND:Chronic thoracic pain after cardiac surgery is prevalent (11 to 56%) and may affect patients' physical and mental health status. Despite its favorable pharmacokinetic and pharmacodynamic properties, high doses of remifentanil administered during surgery are reported to cause acute postoperative pain and incr...

journal_title：Trials

authors： de Hoogd S,Ahlers SJ,van Dongen EP,Tibboel D,Dahan A,Knibbe CA

更新日期：2014-11-27 00:00:00

abstract：BACKGROUND:In the presence of heterogeneous treatment effects, it is desirable to divide patients into subgroups based on their expected response to treatment. This is formalised via a personalised treatment recommendation: an algorithm that uses biomarker measurements to select treatments. It could be that multiple, r...

journal_title：Trials

authors： Pierce M,Emsley R

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Diabetic distal symmetric polyneuropathy (DSPN) is one of the most common microvascular complications of diabetes mellitus, and it has become a major public health problem worldwide because of its high and increasing prevalence, morbidity, and disability rate. The current medications for DSPN are not entirel...

journal_title：Trials

authors： Jin,Huang WJ,Meng X,Yang F,Zheng YJ,Bao Q,Zhang MZ,Yang YN,Ni Q,Lian FM,Tong XL

更新日期：2017-12-29 00:00:00

abstract：BACKGROUND:The lack of approved treatments for the majority of rare diseases is reflective of the unique challenges of orphan drug development. Novel methodologies, including new functionally relevant endpoints, are needed to render the development process more feasible and appropriate for these rare populations and th...

journal_title：Trials

authors： Fields T,Patterson M,Bremova-Ertl T,Belcher G,Billington I,Churchill GC,Davis W,Evans W,Flint S,Galione A,Granzer U,Greenfield J,Karl R,Kay R,Lewi D,Mathieson T,Meyer T,Pangonis D,Platt FM,Tsang L,Verburg C,Fact

更新日期：2021-01-22 00:00:00

abstract：BACKGROUND:Tinnitus is the perception of a sound in the absence of an objective physical source. Up to now, there is no generally accepted view how these phantom sounds come about, and also no efficient treatment. Patients are turning to complementary or alternative medical therapies, such as acupuncture. Based on the ...

journal_title：Trials

authors： Shi GX,Han LL,Liu LY,Li QQ,Liu CZ,Wang LP

更新日期：2012-11-23 00:00:00

abstract：BACKGROUND:Postpartum haemorrhage (PPH) is a major cause of maternal morbidity. Bleeding is caused by a combination of physical causes, such as failure of the uterus to contract or operations, and is made worse by impairment of the blood clotting system. A number of studies have shown that low levels of the blood clott...

journal_title：Trials

authors： Aawar N,Alikhan R,Bruynseels D,Cannings-John R,Collis R,Dick J,Elton C,Fernando R,Hall J,Hood K,Lack N,Mallaiah S,Maybury H,Nuttall J,Paranjothy S,Rayment R,Rees A,Sanders J,Townson J,Weeks A,Collins P

更新日期：2015-04-17 00:00:00

abstract：BACKGROUND:Comprehensive rehabilitation therapy based on traditional Chinese medicine (TCM) has been widely applied in various cancer treatments in China. Thus far, Chinese herbal medicine (CHM) has been shown effective in reducing the adverse effects of chemotherapy and improving the quality of life (QoL) during chemo...

journal_title：Trials

authors： Yao J,Jiao L,Yao Y,Lu Y,Shi J,Li J,Chen P,Xu L,Gong Y

更新日期：2020-04-03 00:00:00

abstract：BACKGROUND:Knee osteoarthritis (KOA) is one of the most common bone and joint diseases. As one of the main non-drug therapies, acupuncture is widely used to treat KOA, although the evidence for its efficacy is inconclusive. The objective of this pilot trial is to clarify the clinical efficacy and safety of fire acupunc...

journal_title：Trials

authors： Fu YB,Li B,Sun SF,Liu HL,Wang X,Wang SS,Zhang F,Du X,Ge DJ,Shang L,Liang RL,Wang LN,Yuan F,Sun JQ,Chen JW

更新日期：2019-12-04 00:00:00

abstract：BACKGROUND:Ascites is one of the most common complications of cirrhosis. Umbilical therapy with traditional Chinese medicines has been increasingly prescribed to treat cirrhotic ascites. However, high-quality evidence from clinical trials supporting such application of traditional Chinese medicines remains limited. The...

journal_title：Trials

authors： Yang X,Ru S,Luo L,Lv X,Bai W,Zhang F,Jiang F

更新日期：2019-02-13 00:00:00

abstract：BACKGROUND:A wound that does not heal in the orderly stages of the healing process or does not heal within 3 months is considered a chronic wound. Wound healing is impaired when the wound remains in the inflammatory stage for too long. A range of factors can delay the healing process: imbalance between proteases and pr...

journal_title：Trials

authors： Comino-Sanz IM,López-Franco MD,Castro B,Pancorbo-Hidalgo PL

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:Incomplete recovery from facial palsy results in social and physical disabilities, and the medical options for the sequelae of Bell's palsy are limited. Acupuncture is widely used for Bell's palsy patients in East Asia, but its efficacy is unclear. METHODS:We performed a randomized controlled trial includin...

journal_title：Trials

authors： Kwon HJ,Choi JY,Lee MS,Kim YS,Shin BC,Kim JI

更新日期：2015-06-03 00:00:00

abstract：BACKGROUND:Spine surgery is associated with considerable postoperative pain and can be challenging to treat. A loco-regional technique suitable for spine surgery should cover the dorsal root of the spinal nerves at the levels where surgery is performed. The erector spinae block is a loco-regional technique with promisi...

journal_title：Trials

authors： Breebaart MB,Van Aken D,De Fré O,Sermeus L,Kamerling N,de Jong L,Michielsen J,Roelant E,Saldien V,Versyck B

更新日期：2019-07-17 00:00:00

abstract：BACKGROUND:Maintaining adequate oxygenation during rapid sequence intubation (RSI) is imperative to prevent peri-intubation adverse events that can lead to increased duration of hospital and intensive care unit stay, or a prolonged vegetative state requiring long-term institutionalisation. Despite employing current bes...

journal_title：Trials

authors： Chua MT,Khan FA,Ng WM,Lu Q,Low MJW,Yau YW,Punyadasa A,Kuan WS

更新日期：2019-04-04 00:00:00