Effectiveness and tolerability of repetitive transcranial magnetic stimulation for preventive treatment of episodic migraine: a single-centre, randomised, double-blind, sham-controlled phase 2 trial (Magnet-EM).

abstract：BACKGROUND:Anxiety and affective disorders can be disabling and have a major impact on the ability to work. In Denmark, people with a mental disorder, and mainly non-psychotic disorders, represent a substantial and increasing part of those receiving disability pensions. Previous studies have indicated that Individual P...

journal_title：Trials

authors： Hellström L,Bech P,Nordentoft M,Lindschou J,Eplov LF

更新日期：2013-12-24 00:00:00

abstract：BACKGROUND:Depression occurs in up to 50% of patients after stroke and limits rehabilitation and recovery. Mood disorders are also highly prevalent in carers; their mental health intertwined with the physical and mental wellbeing of the person they are caring for. We argue that working with families, rather than patien...

journal_title：Trials

authors： Gray RJ,Myint PK,Elender F,Barton G,Pfeil M,Price G,Wyatt N,Ravenhill G,Thomas E,Jagger J,Hursey A,Waterfield K,Hardy S

更新日期：2011-04-30 00:00:00

abstract：BACKGROUND:Comprehensive rehabilitation therapy based on traditional Chinese medicine (TCM) has been widely applied in various cancer treatments in China. Thus far, Chinese herbal medicine (CHM) has been shown effective in reducing the adverse effects of chemotherapy and improving the quality of life (QoL) during chemo...

journal_title：Trials

authors： Yao J,Jiao L,Yao Y,Lu Y,Shi J,Li J,Chen P,Xu L,Gong Y

更新日期：2020-04-03 00:00:00

abstract：BACKGROUND:Sharing interim results by the Data Safety Monitoring Board (DSMB) with non-DSMB members is an issue that can affect trial integrity. It is unclear what should be shared. This study assesses the views of professionals to understand what interim information should be shared at interim, with whom and why. MET...

journal_title：Trials

authors： Borg Debono V,Mbuagbaw L,Paul J,Buckley N,Thabane L

更新日期：2018-05-21 00:00:00

abstract：BACKGROUND:During clinical trials in emergency medicine, providing appropriate oral and written information to a patient is usually a challenge. There is little published information regarding patients' opinions and competence to provide informed consent, nor on physicians' attitudes towards the process. We have invest...

journal_title：Trials

authors： Iwanowski P,Budaj A,Członkowska A,Wasek W,Kozłowska-Boszko B,Oledzka U,Masełbas W

更新日期：2008-07-21 00:00:00

abstract：BACKGROUND:Overt chronic metabolic acidosis in patients with chronic kidney disease develops after a drop of glomerular filtration rate to less than approximately 25 mL/min/1.73 m2. The pathogenic mechanism seems to be a lack of tubular bicarbonate production, which in healthy individuals neutralizes the acid net produ...

journal_title：Trials

authors： Gaggl M,Cejka D,Plischke M,Heinze G,Fraunschiel M,Schmidt A,Hörl WH,Sunder-Plassmann G

更新日期：2013-07-04 00:00:00

abstract：:AbstractFollowing publication of the original article [1], the authors notified us of a typing error in spelling Dr. Asario's name. The original publication has been corrected. ...

journal_title：Trials

authors： Curley MAQ,Gedeit RG,Dodson BL,Amling JK,Soetenga DJ,Corriveau CO,Asaro LA,Wypij D,RESTORE Investigative Team.

更新日期：2019-01-07 00:00:00

abstract：BACKGROUND:Indigenous Australian youth (aged 15 to 34) have up to four times the risk of suicide compared with their non-Indigenous counterparts. Barriers to help-seeking include shame, feared loss of autonomy and negative attitudes towards healthcare providers. The use of mobile devices and apps continues to rise amon...

journal_title：Trials

authors： Shand FL,Ridani R,Tighe J,Christensen H

更新日期：2013-11-20 00:00:00

abstract：BACKGROUND:High-protein diets and total diet replacements are becoming increasingly popular for weight regulation; however, further research is needed to elucidate their impact on the physiology of body weight regulation. The aim of this inpatient metabolic balance study is to compare the impact of a high-protein total...

journal_title：Trials

authors： Oliveira CLP,Boulé NG,Sharma AM,Elliott S,Siervo M,Ghosh S,Berg A,Prado CM

更新日期：2019-12-27 00:00:00

abstract：BACKGROUND:Atopic dermatitis (AD) is associated with reduced skin microbial diversity and overgrowth of Staphylococcus (S.) aureus. However, the importance of S. aureus colonisation in the complex pathogenesis remains unclear and studies on the effect of anti-staphylococcal therapy in non-infected AD show contradictory...

journal_title：Trials

authors： Totté J,de Wit J,Pardo L,Schuren F,van Doorn M,Pasmans S

更新日期：2017-08-31 00:00:00

abstract：BACKGROUND:It is generally accepted that an active lifestyle is beneficial for cognition in children, adults and the elderly. Recently, studies using the rat animal model found that the pups of mothers who exercised during pregnancy had increased hippocampal neurogenesis and better memory and learning abilities. The ai...

journal_title：Trials

authors： LeMoyne EL,Curnier D,St-Jacques S,Ellemberg D

更新日期：2012-05-29 00:00:00

abstract：BACKGROUND:Immune function may influence the ability of older adults to maintain or improve muscle mass, strength, and function during aging. Thus, nutritional supplementation that supports the immune system could complement resistance exercise as an intervention for age-associated muscle loss. The current study will d...

journal_title：Trials

authors： Dennis RA,Ponnappan U,Kodell RL,Garner KK,Parkes CM,Bopp MM,Padala KP,Peterson CA,Padala PR,Sullivan DH

更新日期：2015-03-27 00:00:00

abstract：BACKGROUND:Pharmacological therapies of proven efficacy in coronavirus disease 2019 (COVID-19) are still lacking. We have identified IFNβ-1a as the most promising drug to be repurposed for COVID-19. The rationale relies on the evidence of IFNβ anti-viral activity in vitro against SARS-CoV-2 and animal models resembling...

journal_title：Trials

authors： Bosi E,Bosi C,Rovere Querini P,Mancini N,Calori G,Ruggeri A,Canzonieri C,Callegaro L,Clementi M,De Cobelli F,Filippi M,Bregni M

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:Young men in South Africa face concurrent epidemics of HIV, drug and alcohol abuse, and unemployment. Standard HIV prevention programs, located in healthcare settings and/or using counseling models, fail to engage men. Soccer and vocational training are examined as contexts to deliver male-specific, HIV prev...

journal_title：Trials

authors： Rotheram-Borus MJ,Tomlinson M,Mayekiso A,Bantjes J,Harris DM,Stewart J,Weiss RE

更新日期：2018-08-03 00:00:00

abstract：BACKGROUND:The construction of a colostomy is a common procedure, but the evidence for the different parts of the construction of the colostomy is lacking. Parastomal hernia is a common complication of colostomy formation. The aim of this study is to standardise the colostomy formation and to compare three types of col...

journal_title：Trials

authors： Correa Marinez A,Erestam S,Haglind E,Ekelund J,Angerås U,Rosenberg J,Helgstrand F,Angenete E

更新日期：2014-06-27 00:00:00

abstract：BACKGROUND:Individuals with spinal cord injuries (SCI) are prone to pressure ulcers (PUs) because of the loss of sensorimotor function involved as well as increased skin moisture. Treatment of PU after SCI is complicated, involving different specialties and with need for long-lasting follow-up. This study should identi...

journal_title：Trials

authors： Irgens I,Hoff JM,Sørli H,Haugland H,Stanghelle JK,Rekand T

更新日期：2019-01-24 00:00:00

abstract：BACKGROUND:The increasing prevalence and associated cost of treating chronic obstructive pulmonary disease (COPD) is unsustainable, and focus is needed on self-management and prevention of hospital admissions. Telehealth monitoring of patients' vital signs allows clinicians to prioritise their workload and enables pati...

journal_title：Trials

authors： Bentley CL,Mountain GA,Thompson J,Fitzsimmons DA,Lowrie K,Parker SG,Hawley MS

更新日期：2014-08-06 00:00:00

abstract：BACKGROUND:Temporomandibular disorder (TMD) is a condition encompassing clinical symptoms of the temporomandibular joint, masseter muscle, and surrounding structures. Hominis placental pharmacopuncture (HPP), consisting of human placental extract, has been reported as effective for treating chronic musculoskeletal diso...

journal_title：Trials

authors： Kim J,Park KS,Lee YJ,Kim KW,Cho JH,Ha IH

更新日期：2020-06-15 00:00:00

abstract：BACKGROUND:This study is a part of a series of two clinical trials. We consider diabetic polyneuropathy (DPN), a common chronic and progressive complication of diabetes mellitus that has several impacts on individuals' foot health and quality of life. Based on the current trends of self-monitoring and self-care, provid...

journal_title：Trials

authors： Silva EQ,Suda EY,Santos DP,Veríssimo JL,Ferreira JSSP,Cruvinel Júnior RH,Monteiro RL,Sartor CD,Sacco ICN

更新日期：2020-02-13 00:00:00

abstract：BACKGROUND:Spinal manipulative therapy is commonly used in the treatment of adolescent idiopathic scoliosis. Some therapists also rely on physiotherapeutic scoliosis-specific exercise (PSSE). Combining these two modalities seems reasonable, but the effectiveness of this combination has never been rigorously tested. Her...

journal_title：Trials

authors： Wang L,Wang C,Youssef ASA,Xu J,Huang X,Xia N

更新日期：2021-01-14 00:00:00

abstract：BACKGROUND:Angulated fractures of the distal forearm are very frequent lesions in childhood. Currently, there are no standard guidelines on whether these children should be treated conservatively with a cast; with reduction and a cast; or with reduction, pinning and a cast under anesthesia. Minor prospective and retros...

journal_title：Trials

authors： Adrian M,Wachtlin D,Kronfeld K,Sommerfeldt D,Wessel LM

更新日期：2015-09-30 00:00:00

abstract：BACKGROUND:Amnestic mild cognitive impairment (aMCI) is a syndrome characterized by significant forgetfulness that does not meet the criteria of dementia. Individuals with aMCI are at greater risk of progressing to dementia. Current studies suggest that good sleep quality is linked with preserved cognition in the elder...

journal_title：Trials

authors： Yue S,He T,Li B,Qu Y,Peng H,Chen J,Lei M,Chen C,Wu W

更新日期：2019-08-20 00:00:00

abstract：BACKGROUND:Multiple pregnancies are one of the major safety concerns of in vitro fertilization (IVF) due to the increased risk of maternal and neonatal complications. Single embryo transfer is the most effective way to reduce the risk of multiple pregnancies. Selection of the embryo and optimization of the implantation...

journal_title：Trials

authors： Wei D,Sun Y,Liu J,Liang X,Zhu Y,Shi Y,Chen ZJ

更新日期：2017-06-05 00:00:00

abstract：BACKGROUND:Granulomatosis with polyangiitis (GPA, Wegener's) and microscopic polyangiitis (MPA) are small vessel vasculitides collectively referred to as anti-neutrophil cytoplasm antibody-associated vasculitis (AAV). AAV is associated with high rates of morbidity and mortality due to uncontrolled disease and treatment...

journal_title：Trials

authors： Walsh M,Merkel PA,Peh CA,Szpirt W,Guillevin L,Pusey CD,De Zoysa J,Ives N,Clark WF,Quillen K,Winters JL,Wheatley K,Jayne D,PEXIVAS Investigators.

更新日期：2013-03-14 00:00:00

abstract：BACKGROUND:The traditional Chinese theory of acupuncture emphasizes that the intensity of acupuncture must reach a threshold to generate de qi (a specific and compound sensation during the acupuncture), which is necessary to achieve the best therapeutic effect. However, the notion that de qi must be achieved for maximu...

journal_title：Trials

authors： Chen Q,Zhang Q,Jiang L,Li X,Liu Y,Xie Y,Mu S,Liu Y,Wang X,Yu Y,Li M

更新日期：2014-07-24 00:00:00

abstract：BACKGROUND:In Germany, clinical trials and comparative effectiveness studies in primary care are still very rare, while their usefulness has been recognised in many other countries. A network of researchers from German academic general practice has explored the reasons for this discrepancy. METHODS:Based on a comprehe...

journal_title：Trials

authors： Hummers-Pradier E,Bleidorn J,Schmiemann G,Joos S,Becker A,Altiner A,Chenot JF,Scherer M,German ‘Clinical Trials in German General Practice Network’.

更新日期：2012-11-08 00:00:00

abstract：BACKGROUND:A high intake of salt is a major risk factor for cardiovascular diseases. Despite decades of effort to reduce salt consumption, the salt intake in China is still considerably above the recommended level. Thus, this study aims to design and implement an intelligent household added salt monitoring system (SALT...

journal_title：Trials

authors： Xian J,Zeng M,Zhu R,Cai Z,Shi Z,Abdullah AS,Zhao Y

更新日期：2020-04-21 00:00:00

abstract：BACKGROUND:Post-stroke depression (PSD) is the most common psychiatric complication after a stroke. The most frequently used antidepressants are selective serotonin receptor inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), however, these exhibit a series of side effects. Traditional Chin...

journal_title：Trials

authors： Zhao AM,Qiu WR,Mao LJ,Ren JG,Xu L,Yao MJ,Bilinksi K,Chang D,Liu JX

更新日期：2018-05-10 00:00:00

abstract：BACKGROUND:As intensive care mortality is high, end of life is a subject of major concern for intensivists. In this context, relatives are particularly vulnerable and prone to post-ICU syndrome, in the form of high levels of anxiety, depression, post-traumatic stress, and complicated grief. Grieving families suffer fro...

journal_title：Trials

authors： Kentish-Barnes N,Chevret S,Azoulay E

更新日期：2016-02-20 00:00:00

abstract：BACKGROUND:Individuals with chronic lung disease are more susceptible to present reduction in exercise tolerance and muscles strength not only due to pulmonary limitations but also due systemic repercussions of the pulmonary disease. The aim of this study is to assess the physical capacity, peripheral muscle function, ...

journal_title：Trials

authors： Reimberg MM,Castro RA,Selman JP,Meneses AS,Politti F,Mallozi MC,Wandalsen GF,Solé D,De Angelis K,Dal Corso S,Lanza FC

更新日期：2015-08-13 00:00:00