Examining the effects of a high-protein total diet replacement on energy metabolism, metabolic blood markers, and appetite sensations in healthy adults: protocol for two complementary, randomized, controlled, crossover trials.

abstract：BACKGROUND:Small incision lenticule extraction or SMILE is a novel form of 'flapless' corneal refractive surgery that was adapted from refractive lenticule extraction (ReLEx). SMILE uses only one femtosecond laser to complete the refractive surgery, potentially reducing surgical time, side effects, and cost. If success...

journal_title：Trials

authors： Ang M,Tan D,Mehta JS

更新日期：2012-05-31 00:00:00

abstract：BACKGROUND:Chronic lymphocytic leukaemia (CLL) is the most common adult leukaemia. Combination immunochemotherapy such as fludarabine, cyclophosphamide and rituximab is the standard first line therapy in fit patients, but there is limited evidence regarding the optimal treatment of patients after relapse. Ofatumumab as...

journal_title：Trials

authors： Howard DR,Munir T,Hockaday A,Rawstron AC,Collett L,Oughton JB,Allsup D,Bloor A,Phillips D,Hillmen P

更新日期：2016-09-20 00:00:00

abstract：BACKGROUND:There is no recommendation to screen ferritin level in blood donors, even though several studies have noted the high prevalence of iron deficiency after blood donation, particularly among menstruating females. Furthermore, some clinical trials have shown that non-anaemic women with unexplained fatigue may be...

journal_title：Trials

authors： Pedrazzini B,Waldvogel S,Cornuz J,Vaucher P,Bize R,Tissot JD,Pecoud A,Favrat B

更新日期：2009-01-16 00:00:00

abstract：BACKGROUND:Obesity represents a major public health problem and is the fifth leading risk factor for mortality. Morbid obesity is associated with chronic systemic inflammation which increases the risk of comorbidities. Bariatric surgery (BS) is considered an effective intervention for obese patients. However, BS is ass...

journal_title：Trials

authors： Delgado André L,Basso-Vanelli RP,Di Thommazo-Luporini L,Angélica Ricci P,Cabiddu R,Pilon Jürgensen S,Ricardo de Oliveira C,Arena R,Borghi-Silva A

更新日期：2018-10-31 00:00:00

abstract：BACKGROUND:Acupuncture has been widely applied in the clinic to treat irritable bowel syndrome (IBS), but the underlying mechanism remains unknown. Diffuse noxious inhibitory control (DNIC) is deficient in patients with IBS, which attenuates the systemic analgesic effect elicited by noxious stimulation that is remote f...

journal_title：Trials

authors： Peng Y,You H,Chen X,Chen Y,Yang Y,Huang J,Xu N,Liu J

更新日期：2018-10-16 00:00:00

abstract：BACKGROUND:Generalised anxiety disorder (GAD) is a chronic and debilitating condition characterised by high co-morbidity. Alongside pharmacological treatment, cognitive behavioural therapy (CBT) is an established psychological therapy for GAD. Its effectiveness is limited, however, with only an estimated 50% of clients...

journal_title：Trials

authors： Timulak L,Keogh D,Chigwedere C,Wilson C,Ward F,Hevey D,Griffin P,Jacobs L,Irwin B

更新日期：2018-09-19 00:00:00

abstract：BACKGROUND:Colonoscopy is one of the most effective methods of cancer prevention and detection, particularly for individuals with familial risk. Recruitment of family members to behavioral intervention trials remains uniquely challenging, owing to the intensive process required to identify and contact them. Recruiting ...

journal_title：Trials

authors： Simmons RG,Lee YC,Stroup AM,Edwards SL,Rogers A,Johnson C,Wiggins CL,Hill DA,Cress RD,Lowery J,Walters ST,Jasperson K,Higginbotham JC,Williams MS,Burt RW,Schwartz MD,Kinney AY

更新日期：2013-04-30 00:00:00

abstract：BACKGROUND:Incomplete recovery from facial palsy results in social and physical disabilities, and the medical options for the sequelae of Bell's palsy are limited. Acupuncture is widely used for Bell's palsy patients in East Asia, but its efficacy is unclear. METHODS:We performed a randomized controlled trial includin...

journal_title：Trials

authors： Kwon HJ,Choi JY,Lee MS,Kim YS,Shin BC,Kim JI

更新日期：2015-06-03 00:00:00

abstract：BACKGROUND:A wide range of prophylactic antibiotic regimens are used for patients undergoing open-heart cardiac surgery. This reflects clinical equipoise in choice and duration of antibiotic agents. Although individual-level randomized control trials (RCT) are considered the gold standard when evaluating the efficacy o...

journal_title：Trials

authors： van Oostveen RB,Romero-Palacios A,Whitlock R,Lee SF,Connolly S,Carignan A,Mazer CD,Loeb M,Mertz D

更新日期：2018-12-17 00:00:00

abstract：BACKGROUND:Diabetes mellitus is associated with risk of sudden sensorineural hearing loss (SSNHL). Systemic and intratympanic corticosteroids are the two primary treatments for SSNHL in patients with diabetes mellitus. The benefit of intratympanic compared to systemic treatment is the reduced systemic steroid exposure ...

journal_title：Trials

authors： Yang W,Li X,Zhong J,Mei X,Liu H,Yang L,Lu L,Hu H

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:Delirium prevalence in the intensive care unit (ICU) is high. Numerous psychotropic agents are used to manage delirium in the ICU with limited data regarding their efficacy or harms. METHODS/DESIGN:This is a randomized controlled trial of 428 patients aged 18 and older suffering from delirium and admitted t...

journal_title：Trials

authors： Campbell NL,Khan BA,Farber M,Campbell T,Perkins AJ,Hui SL,Abernathy G,Buckley J,Sing R,Tricker J,Zawahiri M,Boustani MA

更新日期：2011-06-06 00:00:00

abstract：BACKGROUND:Approximately 50% of heart failure patients are readmitted to hospital within 6 months, owing to deterioration of their condition. Thus, symptomatic treatment of heart failure requires significant improvement. The aim of this study is to compare the effects of torasemide and furosemide on biochemical paramet...

journal_title：Trials

authors： Balsam P,Ozierański K,Tymińska A,Główczyńska R,Peller M,Fojt A,Cacko A,Sieradzki B,Bakuła E,Markulis M,Kowalik R,Huczek Z,Filipiak KJ,Opolski G,Grabowski M

更新日期：2017-01-23 00:00:00

abstract：BACKGROUND:Exercise-based cardiac rehabilitation is a beneficial therapy for patients with chronic heart failure. The delivery of exercise-based cardiac rehabilitation should adopt an evidence-based approach, as well as be culturally appropriate and sensitive to individual needs and preferences. The Baduanjin Eight-Sil...

journal_title：Trials

authors： Chen X,Jiang W,Lin X,Lundborg CS,Wen Z,Lu W,Marrone G

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Spleen qi deficiency (SQD), a syndrome based on traditional Chinese medicine (TCM) theory, is common in patients after radical gastrectomy. SQD manifests with chronic gastrointestinal disorders and systemic symptoms and is challenging to manage. Hou Gu Mi Xi (HGMX) is a dietary TCM formula for SQD. This stud...

journal_title：Trials

authors： Zhou X,Yan DM,Zhu WF,Liu WJ,Nie HY,Xu S,Jiang YP,Zhang KH,Fu Y,Wan YY,Yu XY,Li H,Sun X,Chen XF

更新日期：2019-06-10 00:00:00

abstract：BACKGROUND:A variety of videolaryngoscopes with angulated blade have been recently introduced into clinical practice. They provide an indirect view of the glottic structures in normal and challenging clinical settings. Despite the very good visualization of the laryngeal structures by these devices, the insertion and a...

journal_title：Trials

authors： Al-Qasmi A,Al-Alawi W,Malik AM,Khan RM,Kaul N

更新日期：2013-09-16 00:00:00

abstract：BACKGROUND:Adaptive servo-ventilation (ASV) therapy, which is a form of noninvasive positive pressure ventilation therapy and uses an innovative ventilator that has simple operability and provides good patient adherence, potentially has therapeutic benefits-suppression of the deterioration and progression of chronic he...

journal_title：Trials

authors： Seino Y,Momomura S,Kihara Y,Adachi H,Yasumura Y,Yokoyama H,SAVIOR-C investigators.

更新日期：2015-01-16 00:00:00

abstract：BACKGROUND:Currently, there still is no treatment that eliminates tinnitus in all patients. Recent studies have shown that Tinnitus Retraining Therapy (TRT) significantly improves quality of life for tinnitus patients. Also, several studies have reported that transcranial Direct Current Stimulation (tDCS) has a positiv...

journal_title：Trials

authors： Rabau S,Van Rompaey V,Van de Heyning P

更新日期：2015-11-10 00:00:00

abstract：BACKGROUND:Chronic subdural hematoma (cSDH) is one of the most common conditions encountered in neurosurgical practice. Recurrence, observed in 5-30% of patients, is a major clinical problem. The temperature of the irrigation fluid used during evacuation of the hematoma might theoretically influence recurrence rates si...

journal_title：Trials

authors： Bartley A,Jakola AS,Bartek J Jr,Sundblom J,Förander P,Marklund N,Tisell M

更新日期：2017-10-11 00:00:00

abstract：BACKGROUND:Many funding bodies require researchers to actively involve service users in research to improve relevance, accountability and quality. Current guidance to researchers mainly discusses general principles. Formal guidance about how to involve service users operationally in the conduct of trials is lacking. We...

journal_title：Trials

authors： Evans BA,Bedson E,Bell P,Hutchings H,Lowes L,Rea D,Seagrove A,Siebert S,Smith G,Snooks H,Thomas M,Thorne K,Russell I,West Wales Organisation for Rigorous Trials in Health (WWORTH).

更新日期：2013-07-17 00:00:00

abstract：BACKGROUND:Allergic rhinitis is one of the most common health complaints worldwide. Complementary and alternative medical approaches have been employed to relieve allergic rhinitis symptoms and to avoid the side effects of conventional medication. Acupuncture has been widely used to treat patients with allergic rhiniti...

journal_title：Trials

authors： Kim JI,Lee MS,Jung SY,Choi JY,Lee S,Ko JM,Zhao H,Zhao J,Kim AR,Shin MS,Kang KW,Jung HJ,Kim TH,Liu B,Choi SM

更新日期：2009-07-14 00:00:00

abstract：BACKGROUND:Diabetes Mellitus constitutes one of the most important public health problems due to its high prevalence and enormous social and economic consequences. Diabetic foot ulcers are one of the chronic complications of diabetes mellitus and constitute the most important cause of non-traumatic amputation of inferi...

journal_title：Trials

authors： Silva SY,Rueda LC,Márquez GA,López M,Smith DJ,Calderón CA,Castillo JC,Matute J,Rueda-Clausen CF,Orduz A,Silva FA,Kampeerapappun P,Bhide M,López-Jaramillo P

更新日期：2007-09-26 00:00:00

abstract：BACKGROUND:Entertainment-education (E-E) media can improve behavioral intent toward health-related practices. In the era of COVID-19, millions of people can be reached by E-E media without requiring any physical contact. We have designed a short, wordless, animated video about preventive COVID-19 behaviors that can be ...

journal_title：Trials

authors： Vandormael A,Adam M,Greuel M,Bärnighausen T

更新日期：2020-12-15 00:00:00

abstract：BACKGROUND:Frozen shoulder (FS) is a musculoskeletal condition of poorly understood etiology that results in shoulder pain and large mobility deficits. Despite some physical therapy interventions, such as joint mobilization and exercise, having shown therapeutic benefit, a definitive treatment does not currently exist....

journal_title：Trials

authors： Lluch-Girbés E,Dueñas L,Mena-Del Horno S,Luque-Suarez A,Navarro-Ledesma S,Louw A

更新日期：2019-08-13 00:00:00

abstract：BACKGROUND:Subacromial impingement syndrome (SIS) is a painful, and often long lasting, shoulder condition affecting patient function and quality of life. In a recent study, we observed major strength impairments in shoulder external rotation and abduction (~30%) in a population of patients with pronounced and long-las...

journal_title：Trials

authors： Clausen MB,Bandholm T,Rathleff MS,Christensen KB,Zebis MK,Graven-Nielsen T,Hölmich P,Thorborg K

更新日期：2018-03-02 00:00:00

abstract：BACKGROUND:Individual patient data (IPD) meta-analysis is considered the "gold standard" for exploring the effectiveness of interventions in different subgroups of patients. However, obtaining IPD is time-consuming and contact with the researchers responsible for the original trials is usually required. To date, there ...

journal_title：Trials

authors： Veroniki AA,Straus SE,Ashoor H,Stewart LA,Clarke M,Tricco AC

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND:The increasing prevalence and associated cost of treating chronic obstructive pulmonary disease (COPD) is unsustainable, and focus is needed on self-management and prevention of hospital admissions. Telehealth monitoring of patients' vital signs allows clinicians to prioritise their workload and enables pati...

journal_title：Trials

authors： Bentley CL,Mountain GA,Thompson J,Fitzsimmons DA,Lowrie K,Parker SG,Hawley MS

更新日期：2014-08-06 00:00:00

abstract：BACKGROUND:The evidence base to assess the efficacy and effectiveness of alcohol brief interventions (ABI) is weakened by variation in the outcomes measured and by inconsistent reporting. The 'Outcome Reporting in Brief Intervention Trials: Alcohol' (ORBITAL) project aims to develop a core outcome set (COS) and reporti...

journal_title：Trials

authors： Shorter GW,Heather N,Bray JW,Giles EL,Holloway A,Barbosa C,Berman AH,O'Donnell AJ,Clarke M,Stockdale KJ,Newbury-Birch D

更新日期：2017-12-22 00:00:00

abstract：BACKGROUND:In a sham-controlled double-blind trial, we aim to establish the efficacy and safety of the local application of laser therapy in patients with diabetes, onychomycosis and risk factors for diabetes-related foot complications. Onychomycosis leads to thickened and distorted nails, which in turn lead to increas...

journal_title：Trials

authors： Nijenhuis-Rosien L,Kleefstra N,Wolfhagen MJ,Groenier KH,Bilo HJ,Landman GW

更新日期：2015-03-22 00:00:00

abstract：BACKGROUND:Callus is one of the most common foot skin complaints experienced by people of all ages. These painful and unsightly lesions often result in disability. The 'gold standard' of treatment is scalpel debridement by a trained specialist; however, people also seek over-the-counter remedies. There is a lack of cli...

journal_title：Trials

authors： Hashmi F,Nester CJ,Wright CR,Lam S

更新日期：2016-05-17 00:00:00

abstract：BACKGROUND:The oversight and conduct of a randomised controlled trial involves several stakeholders, including a Trial Steering Committee (TSC), Trial Management Group (TMG), Data Monitoring Committee (DMC), funder and sponsor. We aimed to examine how the relationships between these stakeholders affect the trial oversi...

journal_title：Trials

authors： Daykin A,Selman LE,Cramer H,McCann S,Shorter GW,Sydes MR,Gamble C,Macefield R,Lane JA,Shaw A

更新日期：2017-12-22 00:00:00