Effect of electroacupuncture at homotopic and heterotopic acupoints on abdominal pain in patients with irritable bowel syndrome: study protocol for a randomized controlled trial.

abstract：BACKGROUND:Asylum seekers and refugees are at great risk for developing mental disorders. Afghan refugees are a particularly vulnerable group with a low average education and mental health literacy level. Traumatic experiences and hardship before and during migration are predictive of mental health problems. However, p...

journal_title：Trials

authors： Knefel M,Kantor V,Nicholson AA,Schiess-Jokanovic J,Weindl D,Schäfer I,Lueger-Schuster B

更新日期：2020-01-09 00:00:00

abstract：BACKGROUND:Necrotizing enterocolitis (NEC) is the leading cause of death among preterm infants born at < 30 weeks' gestation. The incidence of NEC is reduced when infants are fed human milk. However, in many neonatal intensive care units (NICUs), it is standard practice to freeze and/or pasteurize human milk, which dea...

journal_title：Trials

authors： Sun H,Cao Y,Han S,Cheng R,Liu L,Liu J,Xia S,Zhang J,Li Z,Cheng X,Yang C,Pan X,Li L,Ding X,Wang R,Wu M,Li X,Shi L,Xu F,Yu F,Pan J,Zhang X,Li L,Yang J,Li M,Yan C,Zhou Q,Lu J,Wei M,Wang L,Yang L,

更新日期：2020-02-11 00:00:00

abstract：BACKGROUND:Coronary heart disease (CHD) has become a common cardiovascular disease that seriously threatens the health of people. As reperfusion in the early phase and drug therapy, especially percutaneous coronary intervention (PCI), have become widely used in the clinic, the mortality of acute myocardial infarction i...

journal_title：Trials

authors： Wang Y,Wang X,Wang J,Li B,Yu R,Hu Y,Li X,Peng G,Zhang M,Zhu M

更新日期：2020-03-20 00:00:00

abstract：BACKGROUND:The purpose of clinical trials of acupuncture is to help clinicians and patients make decisions about treatment. Yet this is not straightforward: some trials report acupuncture to be superior to sham (placebo) acupuncture while others show evidence that acupuncture is superior to usual care but not sham, and...

journal_title：Trials

authors： Vickers AJ,Cronin AM,Maschino AC,Lewith G,Macpherson H,Victor N,Sherman KJ,Witt C,Linde K,Acupuncture Trialists' Collaboration.

更新日期：2010-09-28 00:00:00

abstract：BACKGROUND:Chest tube insertion is a standard intervention for management of various injuries of the thorax. Quick and accurate execution facilitates efficient therapy without further complications. Here, we propose a new training concept comprised of e-learning elements as well as continuous rating using an objective ...

journal_title：Trials

authors： Friedrich M,Bergdolt C,Haubruck P,Bruckner T,Kowalewski KF,Müller-Stich BP,Tanner MC,Nickel F

更新日期：2017-02-06 00:00:00

abstract：BACKGROUND:In Switzerland, skin cancer is one of the most common neoplasms. Melanoma is the most aggressive one and can be lethal if not detected and removed on time. Nonmelanoma skin cancer is more frequent as melanoma; it is seldom lethal but can disfigure patients in advanced stages. General practitioners (GPs) are ...

journal_title：Trials

authors： Badertscher N,Rosemann T,Tandjung R,Braun RP

更新日期：2011-06-30 00:00:00

abstract：BACKGROUND:Central sensitization is modulated by the endogenous opioid system and plays a major role in the development and maintenance of pain. Recent animal studies performed following resolution of inflammatory pain showed reinstatement of tactile hypersensitivity induced by administration of a mu-opioid-antagonist,...

journal_title：Trials

authors： Pereira MP,Werner MU,Dahl JB

更新日期：2015-11-10 00:00:00

abstract：BACKGROUND:Approximately 2 million children are hospitalized each year in the United States, with more than three-quarters of non-elective hospitalizations admitted through emergency departments (EDs). Direct admission, defined as admission to hospital without first receiving care in the hospital's ED, may offer benefi...

journal_title：Trials

authors： Leyenaar JK,McDaniel CE,Acquilano SC,Schaefer AP,Bruce ML,O'Malley AJ

更新日期：2020-11-30 00:00:00

abstract：:Data sharing from clinical trials is one way of promoting fair and transparent conduct of clinical trials. It would maximise the use of data and permit the exploration of additional hypotheses. On the other hand, the quality of secondary analyses cannot always be ascertained, and it may be unfair to investigators who ...

journal_title：Trials

authors： Mbuagbaw L,Foster G,Cheng J,Thabane L

更新日期：2017-02-14 00:00:00

abstract：BACKGROUND:Using next-generation sequencing (NGS) in newborn screening (NBS) could expand the number of genetic conditions detected pre-symptomatically, simultaneously challenging current precedents, raising ethical concerns, and extending the role of parental decision-making in NBS. The NC NEXUS (Newborn Exome Sequenc...

journal_title：Trials

authors： Milko LV,Rini C,Lewis MA,Butterfield RM,Lin FC,Paquin RS,Powell BC,Roche MI,Souris KJ,Bailey DB Jr,Berg JS,Powell CM

更新日期：2018-06-28 00:00:00

abstract：BACKGROUND:Exercise-based cardiac rehabilitation is a beneficial therapy for patients with chronic heart failure. The delivery of exercise-based cardiac rehabilitation should adopt an evidence-based approach, as well as be culturally appropriate and sensitive to individual needs and preferences. The Baduanjin Eight-Sil...

journal_title：Trials

authors： Chen X,Jiang W,Lin X,Lundborg CS,Wen Z,Lu W,Marrone G

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Metabolic syndrome (MetS) has been identified as a major contributor to the development of cardiovascular disease (CVD). Current recommendations for dietary management of people with MetS involve quantitative and qualitative modifications of food intake, such as high consumption of vegetables, fruits, and wh...

journal_title：Trials

authors： Ramprasath VR,Thandapilly SJ,Yang S,Abraham A,Jones PJ,Ames N

更新日期：2015-10-31 00:00:00

abstract：BACKGROUND:Acute kidney allograft rejection is a major cause for declining graft function and has a negative impact on the long-term graft survival. The majority (90%) of acute rejections are T-cell mediated and, therefore, the anti-rejection therapy targets T-cell-mediated mechanisms of the rejection process. However,...

journal_title：Trials

authors： Schiffer L,Schiffer M,Merkel S,Schwarz A,Mengel M,Jürgens C,Schroeder C,Zoerner AA,Püllmann K,Bröcker V,Becker JU,Dämmrich ME,Träder J,Grosshennig A,Biertz F,Haller H,Koch A,Gwinner W

更新日期：2012-10-26 00:00:00

abstract：OBJECTIVES:Patients with diabetes are - compared to people without diabetes - at increased risk of worse outcomes from COVID-19 related pneumonia during hospitalization. We aim to investigate whether telemetric continuous glucose monitoring (CGM) in quarantined hospitalized patients with diabetes and confirmed SARS-CoV...

journal_title：Trials

authors： Klarskov CK,Lindegaard B,Pedersen-Bjergaard U,Kristensen PL

更新日期：2020-11-25 00:00:00

abstract：BACKGROUND:Recently, catheter-based renal sympathetic denervation (RSD) has been verified to be safely used to substantially reduce the levels of blood pressure, left ventricular hypertrophy, sleep apnea severity and norepinephrine spillover, and improve glucose tolerance. All these pathological changes are recognized ...

journal_title：Trials

authors： Qiu M,Yin Y,Shan Q

更新日期：2013-06-11 00:00:00

abstract：BACKGROUND:Recurrent stroke is a major contributor to stroke-related disability and costs. Improving health-risk behaviours and mental health has the potential to significantly improve recovery, enhance health-related quality of life (HRQoL), independent living, and lower the risk of recurrent stroke. The primary aim w...

journal_title：Trials

authors： Guillaumier A,McCrabb S,Spratt NJ,Pollack M,Baker AL,Magin P,Turner A,Oldmeadow C,Collins C,Callister R,Levi C,Searles A,Deeming S,Wynne O,Denham AMJ,Clancy B,Bonevski B

更新日期：2019-08-09 00:00:00

abstract：:Randomised controlled trials are the best research design for decisions about the effect of different interventions but randomisation does not, of itself, promote the applicability of a trial's results to situations other than the precise one in which the trial was done. While methodologists and trialists have rightly...

journal_title：Trials

authors： Treweek S,Zwarenstein M

更新日期：2009-06-03 00:00:00

abstract：BACKGROUND:Patients can struggle to make sense of trials in emergency situations. This study examines patient experience of participating in the United Kingdom, Wound management of Open Lower Limb Fractures (UK WOLLF) study, a trial of standard wound management versus Negative Pressure Wound Therapy (NPWT). METHODS:Th...

journal_title：Trials

authors： Tutton E,Achten J,Lamb SE,Willett K,Costa ML,UK WOLLF Research Collaborators.

更新日期：2018-06-25 00:00:00

abstract：BACKGROUND:Impairment in social functioning is a key component of personality disorder. Therefore psycho-education and problem solving (PEPS) therapy may benefit people with this disorder. Psycho-education aims to educate, build rapport, and motivate people for problem solving therapy. Problem solving therapy aims to h...

journal_title：Trials

authors： McMurran M,Crawford MJ,Reilly JG,McCrone P,Moran P,Williams H,Adams CE,Duggan C,Delport J,Whitham D,Day F

更新日期：2011-08-24 00:00:00

abstract：BACKGROUND:The aim of this study is to demonstrate that capecitabine metronomic chemotherapy is non-inferior to capecitabine conventional chemotherapy as maintenance treatment, in patients who have responded to 16-18 weeks first-line chemotherapy in metastatic colorectal cancer (mCRC). METHODS:The study design is a pr...

journal_title：Trials

authors： Shi M,Ma T,Xi W,Jiang J,Wu J,Zhou C,Yang C,Zhu Z,Zhang J

更新日期：2020-03-06 00:00:00

abstract：BACKGROUND:People with serious mental illness (SMI) (psychosis, bipolar disorder and major depressive disorder) experience a considerable risk of premature mortality because of cardiovascular disease. Recent research has demonstrated that this population spends almost 13 h per day being sedentary. Sedentary behaviour i...

journal_title：Trials

authors： Williams J,Stubbs B,Gaughran F,Craig T

更新日期：2016-12-12 00:00:00

abstract：BACKGROUND:This descriptive study aimed to investigate adolescents' motivations for participating in a randomised controlled trial (RCT), to explore the understanding that the young people had regarding a number of aspects of the trial design, to examine whether or not they found participation in the trial to be accept...

journal_title：Trials

authors： Midgley N,Isaacs D,Weitkamp K,Target M

更新日期：2016-07-28 00:00:00

abstract：BACKGROUND:Tobacco smoking is a highly prevalent, addictive behaviour and a key public health priority. However available cessation therapies have low quit and high relapse rates, indicating an urgent need for more effective treatments. Predicated on promising preclinical and pilot clinical data, this paper presents a ...

journal_title：Trials

authors： Arancini L,Bortolasci CC,Dodd S,Dean OM,Berk M

更新日期：2019-09-10 00:00:00

abstract：BACKGROUND:At least 40% of people with psychosis have persistent distressing symptoms despite optimal medication treatment. Cognitive behaviour therapy for psychosis (CBTp) is the only NICE-recommended individual therapy for psychosis, with effects on symptoms, distress and quality of life. Yet <10% of service-users re...

journal_title：Trials

authors： Greenwood K,Alford K,O'Leary I,Peters E,Hardy A,Cavanagh K,Field AP,de Visser R,Fowler D,Davies M,Papamichail A,Garety P

更新日期：2018-11-20 00:00:00

abstract：BACKGROUND:Spontaneous recovery from articular cartilage injury is difficult, and the ongoing progression of disease can eventually lead to osteoarthritis. Currently, there is no effective non-surgical treatment for articular cartilage injury. Arthroscopic debridement and microfracture surgery are performed for fibroca...

journal_title：Trials

authors： Ma N,Wang H,Xu X,Wan Y,Liu Y,Wang M,Yu W,Dai Y,Peng J,Guo Q,Yu C,Lu S

更新日期：2017-11-06 00:00:00

abstract：BACKGROUND:There has been longstanding interesting in cognitive training for older adults with cognitive impairment. In this study, we will investigate the effects of working memory training, and explore augmentation strategies that could possibly consolidate the effects in older adults with mild neurocognitive disorde...

journal_title：Trials

authors： Cheng CP,Chan SS,Mak AD,Chan WC,Cheng ST,Shi L,Wang D,Lam LC

更新日期：2015-10-24 00:00:00

abstract：BACKGROUND:Diabetic foot ulcers (DFUs) represent a significant source of morbidity and an enormous financial burden. Standard care for DFUs involves systemic glucose control, ensuring adequate perfusion, debridement of nonviable tissue, off-loading, control of infection, local wound care and patient education, all admi...

journal_title：Trials

authors： Lev-Tov H,Li CS,Dahle S,Isseroff RR

更新日期：2013-01-09 00:00:00

abstract：:In October 2015 we published the paper 'Measurement of HbA1c in multicentre diabetes trials - should blood samples be tested locally or sent to a central laboratory: an agreement analysis'. Chatterjee and Pradhan have submitted a letter to the editor asking critical questions regarding the methods we used. We offer th...

journal_title：Trials

authors： Arch BN,Blair J,McKay A,Gregory JW,Newland P,Gamble C

更新日期：2017-05-26 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated the benefit of early integration of palliative care (PC) in oncology. However, patients continue to receive late referrals to PC even in comprehensive cancer centers. Patients and health professionals may perceive PC as 'a place to die,' and this stigma is a barrier to time...

journal_title：Trials

authors： do Carmo TM,Paiva BS,de Siqueira MR,da Rosa Lde T,de Oliveira CZ,Nascimento MS,Paiva CE

更新日期：2015-04-12 00:00:00

abstract：BACKGROUND:Overt chronic metabolic acidosis in patients with chronic kidney disease develops after a drop of glomerular filtration rate to less than approximately 25 mL/min/1.73 m2. The pathogenic mechanism seems to be a lack of tubular bicarbonate production, which in healthy individuals neutralizes the acid net produ...

journal_title：Trials

authors： Gaggl M,Cejka D,Plischke M,Heinze G,Fraunschiel M,Schmidt A,Hörl WH,Sunder-Plassmann G

更新日期：2013-07-04 00:00:00