Intratympanic versus intravenous corticosteroid treatment for sudden sensorineural hearing loss in diabetic patients: proposed study protocol for a prospective, randomized superiority trial.

abstract：BACKGROUND:Depression has serious personal, family and economic consequences. It is estimated that it will cost £12.15 billion to the economy each year in England by 2026. Improving access to psychological therapies (IAPT) is the National Health Service talking therapies service in England for adults experiencing anxie...

journal_title：Trials

authors： Strauss C,Arbon A,Barkham M,Byford S,Crane R,de Visser R,Heslin M,Jones AM,Jones F,Lea L,Parry G,Rosten C,Cavanagh K

更新日期：2020-05-04 00:00:00

abstract：BACKGROUND:Chronic nonspecific low back pain (CNSLBP) troubles approximately 30% of people worldwide. Silver needle therapy (SNT) is a treatment method to relieve soft tissue pain through heating. Therefore, this study aimed to observe the effects of SNT on CNSLBP. METHODS:In this study, 100 patients were randomly div...

journal_title：Trials

authors： Hu X,Dong S,Zhang B,Wang X,Yin Y,Liu C,Yu J,Wu X,Xu F,Meng C

更新日期：2021-01-21 00:00:00

abstract：BACKGROUND:Depression and bipolar disorder are associated with reduced neural plasticity and deficits in memory, attention and executive function. Drug treatments for these affective disorders have insufficient clinical effects in a large group and fail to reverse cognitive deficits. There is thus a need for more effec...

journal_title：Trials

authors： Miskowiak KW,Vinberg M,Harmer CJ,Ehrenreich H,Knudsen GM,Macoveanu J,Hansen AR,Paulson OB,Siebner HR,Kessing LV

更新日期：2010-10-13 00:00:00

abstract：BACKGROUND:Hypertension is a risk factor for cardiovascular disease, and the prevalence of hypertension tends to increase with age. Current treatments for hypertension have side effects and poor adherence. Qigong has been studied as an alternative therapy for hypertension; however, the types of qigong used in those stu...

journal_title：Trials

authors： Park JE,Liu Y,Park T,Hong S,Kim JE,Kim TH,Kim AR,Jung SY,Park H,Choi SM

更新日期：2011-11-21 00:00:00

abstract：OBJECTIVES:Primary Objective • To assess the efficacy of herbal extracts in boosting innate immunity of patients with COVID-19 infection. Secondary Objectives • To assess the efficacy of herbal extracts in restoring respiratory health • To assess the efficacy of Cap. IP in early recovery of patients and decline in vira...

journal_title：Trials

authors： Rangnekar H,Patankar S,Suryawanshi K,Soni P

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:Radiation therapy (RT) of bone metastases provides an important treatment approach in palliative care treatment concepts. As a consequence of treatment, the extent of radiation-induced toxicity is a crucial feature with consequences to a patient's quality of life. In this context this study aims at reducing ...

journal_title：Trials

authors： Meyerhof E,Sprave T,Welte SE,Nicolay NH,Förster R,Bostel T,Bruckner T,Schlampp I,Debus J,Rief H

更新日期：2017-03-03 00:00:00

abstract：BACKGROUND:There is evidence to suggest that delivery of diabetes self-management support by diabetes educators in primary care may improve patient care processes and patient clinical outcomes; however, the evaluation of such a model in primary care is nonexistent in Canada. This article describes the design for the ev...

journal_title：Trials

authors： Gucciardi E,Fortugno M,Horodezny S,Lou W,Sidani S,Espin S,Webster F,Shah BR

更新日期：2012-09-13 00:00:00

abstract：BACKGROUND:In rural Ethiopia, 72% of women are exposed to lifetime intimate partner violence (IPV); IPV is most prevalent during pregnancy. As well as adversely affecting women's physical and mental health, IPV also increases the risk of child morbidity and mortality associated with maternal depression, thus making ant...

journal_title：Trials

authors： Keynejad RC,Bitew T,Sorsdahl K,Myers B,Honikman S,Medhin G,Deyessa N,Sevdalis N,Tol WA,Howard L,Hanlon C

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Same-sex attracted young adults have been found to experience higher rates of mental health problems and greater difficulties in accessing specialist mental health care services compared to their heterosexual peers. Internet-based mental health interventions have the potential to be more engaging and accessi...

journal_title：Trials

authors： Abbott JA,Klein B,McLaren S,Austin DW,Molloy M,Meyer D,McLeod B

更新日期：2014-12-23 00:00:00

abstract：BACKGROUND:Generalised anxiety disorder (GAD) is a chronic and debilitating condition characterised by high co-morbidity. Alongside pharmacological treatment, cognitive behavioural therapy (CBT) is an established psychological therapy for GAD. Its effectiveness is limited, however, with only an estimated 50% of clients...

journal_title：Trials

authors： Timulak L,Keogh D,Chigwedere C,Wilson C,Ward F,Hevey D,Griffin P,Jacobs L,Irwin B

更新日期：2018-09-19 00:00:00

abstract：BACKGROUND:State of the art sedation concepts on intensive care units (ICU) favor propofol for a time period of up to 72 h and midazolam for long-term sedation. However, intravenous sedation is associated with complications such as development of tolerance, insufficient sedation quality, gastrointestinal paralysis, and...

journal_title：Trials

authors： Soukup J,Selle A,Wienke A,Steighardt J,Wagner NM,Kellner P

更新日期：2012-08-10 00:00:00

abstract：BACKGROUND:Visible light (400 to 700 nm) is common in our environment, comprising 44% of total solar radiation and a large component of environmental light exposure. The effects of visible light on skin remain undefined. The red light portion of the visible spectrum (600 to 700 nm) may be used to treat skin diseases as...

journal_title：Trials

authors： Wang EB,Kaur R,Nguyen J,Ho D,Austin E,Maverakis E,Li CS,Hwang ST,Isseroff RR,Jagdeo J

更新日期：2019-03-20 00:00:00

abstract：BACKGROUND:This randomized controlled clinical trial aims to evaluate the efficacy and safety of opposing needling in patients undergoing unilateral total knee arthroplasty (TKA). Opposing needling is one of the special needling methods used in acupuncture and moxibustion therapy. It involves needling acupoints on the ...

journal_title：Trials

authors： Huang H,Song X,Zhao L,Zheng L,Xiao L,Chen Y

更新日期：2020-05-07 00:00:00

abstract：OBJECTIVES:To assess the effect of prone positioning therapy on intubation rate in awake patients with COVID-19 and acute respiratory failure. TRIAL DESIGN:This is a two-center parallel group, superiority, randomized (1:1 allocation ratio) controlled trial. PARTICIPANTS:All patients admitted to the Hospital Civil de ...

journal_title：Trials

authors： Ibarra-Estrada MÁ,Marín-Rosales M,García-Salcido R,Aguirre-Díaz SA,Vargas-Obieta A,Chávez-Peña Q,López-Pulgarín JA,Mijangos-Méndez JC,Aguirre-Avalos G

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:Atopic dermatitis (AD) is a common pruritic inflammatory skin disease with increasing prevalence. It can manifest with many different clinical phenotypes; however, in its chronic stage, hyperpigmentation, excoriation, lichenification, and dryness are the main symptoms. Jaungo comprises two herbs, Lithospermi...

journal_title：Trials

authors： Yun Y,Ko Y,Ahn JH,Jang BH,Kim K,Ko SG,Choi I

更新日期：2017-04-12 00:00:00

abstract：BACKGROUND:Equine-assisted therapy is more often practiced with children and adolescents than with the elderly, although individuals in the second half of life could also profit from it. This group, from the age of 50, is characterised by increasing emotional, social, health-related and cognitive changes; a critical li...

journal_title：Trials

authors： Schmidt J,Wartenberg-Demand A,Forstmeier S

更新日期：2020-10-15 00:00:00

abstract：BACKGROUND:Generalized anxiety disorder (GAD) is a psychiatric disorder characterized by a constant and unspecific anxiety that interferes with daily-life activities. Its high prevalence in general population and the severe limitations it causes, point out the necessity to find new efficient strategies to treat it. Tog...

journal_title：Trials

authors： Gorini A,Riva G

更新日期：2008-05-05 00:00:00

abstract：BACKGROUND:PaVOS is a randomized controlled trial (RCT) which aims to address the use of whole-body vibration exercise (WBV) in combination with parathyroid hormone 1-34 fragment teriparatide (PTH 1-34) treatment in patients with osteoporosis. PTH 1-34 is an effective but expensive anabolic treatment for osteoporosis. ...

journal_title：Trials

authors： Jepsen DB,Ryg J,Jørgensen NR,Hansen S,Masud T

更新日期：2018-03-16 00:00:00

abstract：BACKGROUND:Tetramethylpyrazine (TMP), an active ingredient in the traditional Chinese herbal medicine Rhizoma Chuanxiong, has been used clinically for the prevention and treatment of cardiovascular disease. The benefits of TMP are largely attributed to its anti-oxidative and vasodilative properties. However, the effica...

journal_title：Trials

authors： Chen Y,He W,Ouyang H,Liu C,Hong C,Wang T,Yang K,Lu W,Wang J

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:Incomplete recovery from facial palsy results in social and physical disabilities, and the medical options for the sequelae of Bell's palsy are limited. Acupuncture is widely used for Bell's palsy patients in East Asia, but its efficacy is unclear. METHODS:We performed a randomized controlled trial includin...

journal_title：Trials

authors： Kwon HJ,Choi JY,Lee MS,Kim YS,Shin BC,Kim JI

更新日期：2015-06-03 00:00:00

abstract：BACKGROUND:Juvenile dermatomyositis (JDM) is a rare autoimmune inflammatory disorder associated with significant morbidity and mortality. International collaboration is necessary to better understand the pathogenesis of the disease, response to treatment and long-term outcome. To aid international collaboration, it is ...

journal_title：Trials

authors： McCann LJ,Kirkham JJ,Wedderburn LR,Pilkington C,Huber AM,Ravelli A,Appelbe D,Williamson PR,Beresford MW

更新日期：2015-06-12 00:00:00

abstract：BACKGROUND:In the United Kingdom (UK), there is an extensive market for the class 'A' drug heroin. Many heroin users spend time in prison. People addicted to heroin often require prescribed medication when attempting to cease their drug use. The most commonly used detoxification agents in UK prisons are buprenorphine, ...

journal_title：Trials

authors： Sheard L,Adams CE,Wright NM,El-Sayeh H,Dalton R,Tompkins CN

更新日期：2007-01-08 00:00:00

abstract：BACKGROUND:Chronic thoracic pain after cardiac surgery is prevalent (11 to 56%) and may affect patients' physical and mental health status. Despite its favorable pharmacokinetic and pharmacodynamic properties, high doses of remifentanil administered during surgery are reported to cause acute postoperative pain and incr...

journal_title：Trials

authors： de Hoogd S,Ahlers SJ,van Dongen EP,Tibboel D,Dahan A,Knibbe CA

更新日期：2014-11-27 00:00:00

abstract：BACKGROUND:Systematic use of observational pain tools has been advocated as a means to improve pain management for care home residents with dementia. Pain experts suggest that any observational tool should be used as part of a comprehensive pain management protocol, which should include score interpretation and verific...

journal_title：Trials

authors： Liu JY,Lai C

更新日期：2014-03-13 00:00:00

abstract：BACKGROUND:Dementia is a neurological condition that affects the cognitive and functional ability of the brain and is the leading cause of disability among those aged 65 years and above. More effective ways to manage dementia symptoms are needed because current treatment options (antidepressants and antipsychotics) can...

journal_title：Trials

authors： Timler A,Bulsara C,Bulsara M,Vickery A,Smith J,Codde J

更新日期：2020-02-14 00:00:00

abstract：BACKGROUND:Earlier vascular healing after drug-eluting stent (DES) implantation may reduce the incidence of late stent thrombosis and provide theoretical evidence to shorten dual antiplatelet therapy duration in patients with high bleeding risks. The BuMA supreme stent is a newly developed DES-coated with the sirolimus...

journal_title：Trials

authors： Li B,Jin QH,Chen YD,Wang CQ,Shi B,Su X,Fu GS,Wu YQ,Zhou XC,Yuan ZY

更新日期：2019-06-07 00:00:00

abstract：BACKGROUND:Noncompliance to treatment assignment is an inevitable occurrence in randomized clinical trials (RCTs). Intention to treat (ITT) is generally considered the best method for addressing noncompliance in RCTs. Alternatives to ITT exist, including per protocol (PP), as treated (AT), and instrumental variables (I...

journal_title：Trials

authors： Merrill PD,McClure LA

更新日期：2015-11-17 00:00:00

abstract：BACKGROUND:The aim of this study is to demonstrate that capecitabine metronomic chemotherapy is non-inferior to capecitabine conventional chemotherapy as maintenance treatment, in patients who have responded to 16-18 weeks first-line chemotherapy in metastatic colorectal cancer (mCRC). METHODS:The study design is a pr...

journal_title：Trials

authors： Shi M,Ma T,Xi W,Jiang J,Wu J,Zhou C,Yang C,Zhu Z,Zhang J

更新日期：2020-03-06 00:00:00

abstract：BACKGROUND:Lack of trust in parental support is a transdiagnostic risk factor for the development of psychological problems throughout the lifespan. Research suggests that children's cognitive attachment representations and related information processing biases could be an important target for interventions aiming to b...

journal_title：Trials

authors： Verhees MWFT,Ceulemans E,Bakermans-Kranenburg MJ,van IJzendoorn MH,de Winter S,Bosmans G

更新日期：2017-07-14 00:00:00

abstract：BACKGROUND:Angulated fractures of the distal forearm are very frequent lesions in childhood. Currently, there are no standard guidelines on whether these children should be treated conservatively with a cast; with reduction and a cast; or with reduction, pinning and a cast under anesthesia. Minor prospective and retros...

journal_title：Trials

authors： Adrian M,Wachtlin D,Kronfeld K,Sommerfeldt D,Wessel LM

更新日期：2015-09-30 00:00:00