Equine-assisted biographical work (EABW) with individuals in the second half of life: study protocol of a multicentre randomised controlled trial.

abstract：BACKGROUND:Immune function may influence the ability of older adults to maintain or improve muscle mass, strength, and function during aging. Thus, nutritional supplementation that supports the immune system could complement resistance exercise as an intervention for age-associated muscle loss. The current study will d...

journal_title：Trials

authors： Dennis RA,Ponnappan U,Kodell RL,Garner KK,Parkes CM,Bopp MM,Padala KP,Peterson CA,Padala PR,Sullivan DH

更新日期：2015-03-27 00:00:00

abstract：BACKGROUND:Allergic rhinitis is one of the most common health complaints worldwide. Complementary and alternative medical approaches have been employed to relieve allergic rhinitis symptoms and to avoid the side effects of conventional medication. Acupuncture has been widely used to treat patients with allergic rhiniti...

journal_title：Trials

authors： Kim JI,Lee MS,Jung SY,Choi JY,Lee S,Ko JM,Zhao H,Zhao J,Kim AR,Shin MS,Kang KW,Jung HJ,Kim TH,Liu B,Choi SM

更新日期：2009-07-14 00:00:00

abstract：BACKGROUND:Low back pain (LBP) is a major health problem in modern society, with 70-85% of the population experiencing LBP at some time in their lives. Each year, 5-10% of the workforce misses work due to LBP, most for less than 7 days. Almost 10% of all patients are at risk of developing chronic pain and disability. L...

journal_title：Trials

authors： Buselli P,Bosoni R,Busè G,Fasoli P,La Scala E,Mazzolari R,Zanetti F,Messina S

更新日期：2011-10-04 00:00:00

abstract：BACKGROUND:The World Health Organization recommended (in 2010) universal testing for suspected malaria, due to some fundamental changes in malaria trends such as the declining incidence of malaria in high-burden countries, the emergence of parasite resistance to anti-malarial drugs especially artemisinin-based combinat...

journal_title：Trials

authors： Omale UI,Azuogu BN,Alo C,Madubueze UC,Oka OU,Okeke KC,Okafor IM,Utulu R,Akpan UE,Iloke CV,Nnubia AO,Eze II,Anene OC,Nnabu CR,Ibemesi DC

更新日期：2019-10-10 00:00:00

abstract：BACKGROUND:There is currently an absence of high-grade evidence regarding the treatment of chronic sciatica (CS). Whilst gabapentin (GBP) and pregabalin (PGB) are both currently used to treat CS, equipoise exists regarding their individual use. In particular, no head-to-head study of GBP and PGB in CS exists. Despite e...

journal_title：Trials

authors： Robertson K,Marshman LAG,Hennessy M,Harriss L,Plummer D

更新日期：2018-01-09 00:00:00

abstract：BACKGROUND:Standard coronary artery bypass graft surgery uses a single internal mammary artery and supplemental vein or radial artery grafts. Several observational studies have suggested a survival benefit with two internal mammary artery grafts compared to a single internal mammary artery graft, but this has not been ...

journal_title：Trials

authors： Taggart DP,Lees B,Gray A,Altman DG,Flather M,Channon K,ART Investigators.

更新日期：2006-03-30 00:00:00

abstract：BACKGROUND:Recently, clinical observations reported the potential benefit of vagus nerve stimulation (VNS) for pediatric epilepsy. Transcutaneous auricular vagus nerve stimulation (ta-VNS) is a newer non-invasive VNS, making it more accessible for treating pediatric epilepsy, yet there is limited clinical evidence for ...

journal_title：Trials

authors： He W,Wang XY,Zhou L,Li ZM,Jing XH,Lv ZL,Zhao YF,Shi H,Hu L,Su YS,Zhu B

更新日期：2015-08-21 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) is often associated with life-long medical, cognitive, emotional, and behavioral changes. Although long-lasting disabilities are expected, research on effective treatment options in the chronic phase of TBI is scarce. METHODS/DESIGN:This study protocol describes a randomized con...

journal_title：Trials

authors： Borgen IMH,Løvstad M,Andelic N,Hauger S,Sigurdardottir S,Søberg HL,Sveen U,Forslund MV,Kleffelgård I,Lindstad MØ,Winter L,Røe C

更新日期：2020-03-27 00:00:00

abstract：BACKGROUND:In cardiac surgery with cardiopulmonary bypass (CPB), large amounts of fluids are administered. CPB priming with crystalloid solution causes marked hemodilution and fluid extravasation. Colloid solutions may reduce fluid overload because they have a better volume expansion effect than crystalloids. The Europ...

journal_title：Trials

authors： Vlasov H,Juvonen T,Hiippala S,Suojaranta R,Peltonen M,Schramko A,Arvonen K,Salminen US,Kleine Budde I,Eränen T,Mazanikov M,Meinberg M,Vähäsilta T,Wilkman E,Pettilä V,Pesonen E

更新日期：2020-02-28 00:00:00

abstract：BACKGROUND:Suffering linked to previous interpersonal trauma is common among patients in mental health care. Diagnostic labels may vary, but the clinical picture is often characterized by long-lasting and complex psychological and somatic symptoms, subjective distress and reduced quality of health and life. A substanti...

journal_title：Trials

authors： Holgersen KH,Brønstad I,Jensen M,Brattland H,Reitan SK,Hassel AM,Arentz M,Lara-Cabrera M,Skjervold AE

更新日期：2020-05-27 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Trials

authors： Eckhardt CM,Cummings MJ,Rajagopalan KN,Borden S,Bitan ZC,Wolf A,Kantor A,Briese T,Meyer BJ,Jacobson SD,Scotto D,Mishra N,Philip NM,Stotler BA,Schwartz J,Shaz B,Spitalnik SL,Eisenberger A,Hod EA,Justman J,Cheung K

更新日期：2020-06-16 00:00:00

abstract：BACKGROUND:The burden of acute gastroenteritis on children and their families continues to be enormous. Probiotics, defined as viable microbial preparations that have a beneficial effect on the health of the host, represent a rapidly expanding field. Although clinical trials in children with gastroenteritis have been p...

journal_title：Trials

authors： Freedman SB,Williamson-Urquhart S,Schuh S,Sherman PM,Farion KJ,Gouin S,Willan AR,Goeree R,Johnson DW,Black K,Schnadower D,Gorelick MH,Pediatric Emergency Research Canada (PERC) Gastroenteritis Study Group.

更新日期：2014-05-14 00:00:00

abstract：BACKGROUND:Chronic subdural haematoma (CSDH) is a common neurosurgical condition, typically treated with surgical drainage of the haematoma. However, surgery is associated with mortality and morbidity, including up to 20% recurrence of the CSDH. Steroids, such as dexamethasone, have been identified as a potential thera...

journal_title：Trials

authors： Kolias AG,Edlmann E,Thelin EP,Bulters D,Holton P,Suttner N,Owusu-Agyemang K,Al-Tamimi YZ,Gatt D,Thomson S,Anderson IA,Richards O,Whitfield P,Gherle M,Caldwell K,Davis-Wilkie C,Tarantino S,Barton G,Marcus HJ,Chari A

更新日期：2018-12-04 00:00:00

abstract：BACKGROUND:Parkinson's Disease is a degenerative neurological condition that causes movement problems and other distressing symptoms. People with Parkinson's disease gradually lose their independence and strain is placed on family members. A multidisciplinary approach to rehabilitation for people with Parkinson's is re...

journal_title：Trials

authors： Gage H,Ting S,Williams P,Bryan K,Kaye J,Castleton B,Trend P,Wade D

更新日期：2011-11-23 00:00:00

abstract：BACKGROUND:Nursing home residents are frequently affected by joint contractures, which impacts their participation and daily activities. A complex intervention, the Participation Enabling Care in Nursing (PECAN), was previously developed and pilot tested to address their needs. Its effectiveness and safety will be eval...

journal_title：Trials

authors： Nguyen N,Thalhammer R,Beutner K,Saal S,Servaty R,Klingshirn H,Icks A,Freyberg K,Vomhof M,Mansmann U,Le L,Müller M,Meyer G

更新日期：2019-05-29 00:00:00

abstract：BACKGROUND:In Nepal, the burden of noncommunicable, chronic diseases is rapidly rising, and disproportionately affecting low and middle-income countries. Integrated interventions are essential in strengthening primary care systems and addressing the burden of multiple comorbidities. A growing body of literature support...

journal_title：Trials

authors： Schwarz D,Dhungana S,Kumar A,Acharya B,Agrawal P,Aryal A,Baum A,Choudhury N,Citrin D,Dangal B,Dhimal M,Gauchan B,Gupta T,Halliday S,Karmacharya B,Kishore S,Koirala B,Kshatriya U,Levine E,Maru S,Rimal P,Sapkota S

更新日期：2020-01-29 00:00:00

abstract：BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia is a serious infection resulting in 20-50 % 90-day mortality. The limitations of vancomycin, the current standard therapy for MRSA, make treatment difficult. The only other approved drug for treatment of MRSA bacteraemia, daptomycin, has not been...

journal_title：Trials

authors： Tong SY,Nelson J,Paterson DL,Fowler VG Jr,Howden BP,Cheng AC,Chatfield M,Lipman J,Van Hal S,O'Sullivan M,Robinson JO,Yahav D,Lye D,Davis JS,CAMERA2 study group and the Australasian Society for Infectious Diseases Clinical Res

更新日期：2016-03-31 00:00:00

abstract：BACKGROUND:Conventional whole brain radiotherapy (WBRT) has been established as the treatment standard in patients with cerebral metastases from small-cell lung cancer (SCLC), however, it has only modest efficacy and limited prospective data is available for WBRT as well as local treatments such as stereotactic radiosu...

journal_title：Trials

authors： Bernhardt D,Hommertgen A,Schmitt D,El Shafie R,Paul A,König L,Mair-Walther J,Krisam J,Klose C,Welzel T,Hörner-Rieber J,Kappes J,Thomas M,Heußel CP,Steins M,Kieser M,Debus J,Rieken S

更新日期：2018-07-16 00:00:00

abstract：BACKGROUND:Palmoplantar pustulosis is a rare but painful and debilitating disease. It consistently ranks the highest of all psoriasis phenotypic variants in terms of symptoms and functional impairment. Management of plaque-type psoriasis has been revolutionised in the last 10 years with the advent of biologic therapies...

journal_title：Trials

authors： Cornelius V,Wilson R,Cro S,Barker J,Burden D,Griffiths CEM,Lachmann H,McAteer H,Reynolds N,Pink A,Warren RB,Capon F,Smith C

更新日期：2018-08-29 00:00:00

abstract：BACKGROUND:Process evaluations are an important component in the interpretation and understanding of outcomes in trials. The Online Remote Behavioural Intervention for Tics (ORBIT) study is a randomized controlled trial evaluating the effectiveness of an Internet-delivered behavioural intervention (called BIP TIC) comp...

journal_title：Trials

authors： Khan K,Hollis C,Hall CL,Davies EB,Mataix-Cols D,Andrén P,Murphy T,Brown BJ,Murray E,Glazebrook C

更新日期：2020-01-02 00:00:00

abstract：BACKGROUND:Plaque psoriasis is a refractory inflammatory skin disease. The common therapies used to treat plaque psoriasis in traditional Chinese medicine (TCM) and western medicine (WM) have distinct characteristics and advantages. Although a combination of TCM and WM therapies, adjusted to the clinical situation, is ...

journal_title：Trials

authors： Sun X,Zhou X,Wei Y,Yang W,Huang N,Ding Y,Hu R,Guo S,Yang C,Weng H,Zhang Y,Chen X,Ding X,Liu L,Yin Q,Wang R,Li X,Li B

更新日期：2020-03-30 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) is a major contributor to the burden of disease and the number one cause of death worldwide. From 1990 until today, more people died from coronary heart disease than from any other cause. CVD is regularly treated with minimally or non-minimally invasive off- or on-pump cardiothor...

journal_title：Trials

authors： Moza A,Benstoem C,Autschbach R,Stoppe C,Goetzenich A

更新日期：2015-12-02 00:00:00

abstract：BACKGROUND:Written participant information materials are important for ensuring that potential trial participants receive necessary information so that they can provide informed consent. However, such materials are frequently long and complex, which may negatively impact patient understanding and willingness to partici...

journal_title：Trials

authors： Parker A,Knapp P,Treweek S,Madhurasinghe V,Littleford R,Gallant S,Sullivan F,Schembri S,Rick J,Graffy J,Collier DJ,Eldridge S,Kennedy A,Bower P

更新日期：2018-09-18 00:00:00

abstract：BACKGROUND:Haemorrhage remains a leading cause of morbidity and mortality in trauma patients. Fibrinogen is an essential endogenous component of haemostasis and the plasma level is associated with bleeding, transfusion and outcome. Fibrinogen concentrate is widely used to correct acquired hypofibrinogenaemia, recommend...

journal_title：Trials

authors： Steinmetz J,Sørensen AM,Henriksen HH,Lange T,Larsen CF,Johansson PI,Stensballe J

更新日期：2016-07-19 00:00:00

abstract：BACKGROUND:Radiation therapy (RT) of bone metastases provides an important treatment approach in palliative care treatment concepts. As a consequence of treatment, the extent of radiation-induced toxicity is a crucial feature with consequences to a patient's quality of life. In this context this study aims at reducing ...

journal_title：Trials

authors： Meyerhof E,Sprave T,Welte SE,Nicolay NH,Förster R,Bostel T,Bruckner T,Schlampp I,Debus J,Rief H

更新日期：2017-03-03 00:00:00

abstract：BACKGROUND:Chronic non-specific low back pain is the most common medical problem for which patients seek complementary and alternative medical treatment, including bee venom acupuncture. However, the effectiveness and safety of such treatments have not been fully established by randomized clinical trials. The aim of th...

journal_title：Trials

authors： Seo BK,Lee JH,Sung WS,Song EM,Jo DJ

更新日期：2013-01-14 00:00:00

abstract：BACKGROUND:Whiplash-associated disorders (WAD) are an enormous and costly burden to Australian society. Up to 50% of people who experience a whiplash injury will never fully recover. Whiplash is resistant to treatment and no early management approach has yet been shown to prevent chronic pain. The early presence of cen...

journal_title：Trials

authors： Nikles J,Keijzers G,Mitchell G,Schug S,Ware R,McLean SA,Connelly L,Gibson S,Farrell SF,Sterling M

更新日期：2018-01-17 00:00:00

abstract：BACKGROUND:Overt chronic metabolic acidosis in patients with chronic kidney disease develops after a drop of glomerular filtration rate to less than approximately 25 mL/min/1.73 m2. The pathogenic mechanism seems to be a lack of tubular bicarbonate production, which in healthy individuals neutralizes the acid net produ...

journal_title：Trials

authors： Gaggl M,Cejka D,Plischke M,Heinze G,Fraunschiel M,Schmidt A,Hörl WH,Sunder-Plassmann G

更新日期：2013-07-04 00:00:00

abstract：BACKGROUND:Medical training is very demanding and associated with a high prevalence of psychological distress. Compared to the general population, medical students are at a greater risk of developing a psychological disorder. Various attempts of stress management training in medical school have achieved positive result...

journal_title：Trials

authors： Kuhlmann SM,Bürger A,Esser G,Hammerle F

更新日期：2015-02-08 00:00:00

abstract：BACKGROUND:Staphylococcus aureus bacteremia (SAB) is frequently encountered in the hospital setting, and current guidelines recommend at least 14 days of antibiotic treatment for SAB in order to minimize risks of secondary deep infections and relapse. However, evidence to support these treatment recommendations remains...

journal_title：Trials

authors： Thorlacius-Ussing L,Andersen CØ,Frimodt-Møller N,Knudsen IJD,Lundgren J,Benfield TL

更新日期：2019-05-02 00:00:00