Radiation-induced toxicity after image-guided and intensity-modulated radiotherapy versus external beam radiotherapy for patients with spinal bone metastases (IRON-1): a study protocol for a randomized controlled pilot trial.

abstract：BACKGROUND:Among patients with hepatocellular carcinoma (HCC), 85% of patients have an advanced disease stage at diagnosis and curative therapies cannot be performed. Prognosis has been quite poor as until recently there was no proven effective chemotherapy. Our group found that all-trans-retinoic acid (ATRA) could imp...

journal_title：Trials

authors： Shi J,Sun J,Liu C,Chai Z,Wang N,Zhang H,Cheng S

更新日期：2019-04-29 00:00:00

abstract：BACKGROUND:Juvenile idiopathic arthritis (JIA)-associated uveitis is a chronic paediatric ocular inflammatory condition that can result in visual impairment. Adalimumab, a tumour necrosis factor (TNF)-alpha inhibitor, effectively controls joint and eye inflammation; however, its long-term use may increase the risk of a...

journal_title：Trials

authors： Acharya NR,Ebert CD,Kelly NK,Porco TC,Ramanan AV,Arnold BF,ADJUST Research Group.

更新日期：2020-10-27 00:00:00

abstract：BACKGROUND:Perioperative complications occur in 30-40% of non-cardiac surgical patients and are the leading cause of early postoperative morbidity and mortality. Regular visits by trained health professionals may decrease the incidence of complications and mortality through earlier detection and adequate treatment of c...

journal_title：Trials

authors： Smit-Fun VM,de Korte-de Boer D,Posthuma LM,Stolze A,Dirksen CD,Hollmann MW,Buhre WF,Boer C

更新日期：2018-10-26 00:00:00

abstract：BACKGROUND:Periprosthetic joint infection (PJI) affects approximately 1% of patients following total hip replacement (THR) and often results in severe physical and emotional suffering. Current surgical treatment options are debridement, antibiotics and implant retention; revision THR; excision of the joint and amputati...

journal_title：Trials

authors： Strange S,Whitehouse MR,Beswick AD,Board T,Burston A,Burston B,Carroll FE,Dieppe P,Garfield K,Gooberman-Hill R,Jones S,Kunutsor S,Lane A,Lenguerrand E,MacGowan A,Moore A,Noble S,Simon J,Stockley I,Taylor AH,Toms A

更新日期：2016-02-17 00:00:00

abstract：:After publication of our article [1] we became aware that several sections of text in our Methods section were copied from a previously published article [2]. ...

journal_title：Trials

authors： Langella LG,Silva PFC,Costa-Santos L,Gonçalves MLL,Motta LJ,Deana AM,Fernandes KPS,Mesquita-Ferrari RA,Bussadori SK

更新日期：2018-12-24 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is a common cause of pain and disability. Currently available analgesics are often insufficiently effective or have unacceptable adverse effects. Tricyclic antidepressants may offer a useful centrally-acting analgesic. Nortriptyline is a readily-available, cheap and comparatively well-tol...

journal_title：Trials

authors： Hudson B,Williman JA,Stamp LK,Alchin JS,Hooper GJ,Mangin D,Thompson BF,Toop L

更新日期：2015-10-09 00:00:00

abstract：OBJECTIVES:To investigate the potential efficacy of Acacia Senegal extract Gum Arabic (GA) supplementation as immunomodulatory and anti-inflammatory dietary intervention among newly diagnosed COVID 19 Sudanese patients. To study the effect of GA on the level of cytokines, TNFα, IL8, IL6 IL10, CRP and the viral load. Se...

journal_title：Trials

authors： Kaddam L,Babiker R,Ali S,Satti S,Ali N,Elamin M,Mukhtar M,Elnimeiri M,Saeed A

更新日期：2020-09-05 00:00:00

abstract：BACKGROUND:Several drugs are being repurposed for the treatment of the coronavirus disease 2019 (COVID-19) pandemic based on in vitro or early clinical findings. As these drugs are being used in varied regimens and dosages, it is important to enable synthesis of existing safety data from clinical trials. However, avail...

journal_title：Trials

authors： Rodgers F,Pepperrell T,Keestra S,Pilkington V

更新日期：2021-01-15 00:00:00

abstract：BACKGROUND:In studies comparing different prosthetic treatment concepts the repeated loss of teeth was chosen as the primary outcome. The resulting data appear to represent a data structure of recurrent events. However, the application of an existing method for recurrent events is far from straightforward. Often only t...

journal_title：Trials

authors： Diebner HH,Marré B,Roeder I,Walter MH

更新日期：2016-05-17 00:00:00

abstract：BACKGROUND:The prevalence of central obesity is constantly increasing, and visceral fat is associated with increased production of inflammatory factors and metabolic risk factors. Lutein might retard the development of metabolic disease through its antioxidant and anti-inflammatory properties. Furthermore, epidemiologi...

journal_title：Trials

authors： Zhou J,Zhao D,Wang N,Zeng Z,Wang C,Hao L,Peng X

更新日期：2020-01-06 00:00:00

abstract：:Evidence-based treatment for pregnant women will ultimately require research conducted in the population of pregnant women. Currently, few scholars have addressed the issue of responsible inclusion of pregnant women in drug research. Because of additional risks associated with including pregnant women in drug research...

journal_title：Trials

authors： Roes KCB,van der Zande ISE,van Smeden M,van der Graaf R

更新日期：2018-02-20 00:00:00

abstract：:The period toward the end of patients' participation in late stage blinded clinical trials is highly resource intensive for the sponsor. Consider first a Phase 3 trial. If the trial is a success, the sponsor has to implement the next steps, which might be filing for approval of the drug with the US Food and Drug Admin...

journal_title：Trials

authors： Ganju J

更新日期：2016-07-20 00:00:00

abstract：BACKGROUND:Depression is a common affliction for young adults, and is associated with a range of adverse outcomes. Cognitive-reminiscence therapy is a brief, structured intervention that has been shown to be highly effective for reducing depressive symptoms, yet to date has not been evaluated in young adult populations...

journal_title：Trials

authors： Hallford DJ,Mellor D

更新日期：2013-10-21 00:00:00

abstract：BACKGROUND:Worldwide, prevalence rates of adolescent non-suicidal self-injury (NSSI) range between 13 and 45%. In Germany, lifetime prevalence of NSSI is around 25% in non-clinical samples, and the one-year prevalence for repetitive NSSI is 4%. NSSI is present in the context of several axis I and II disorders (for exam...

journal_title：Trials

authors： Fischer G,Brunner R,Parzer P,Resch F,Kaess M

更新日期：2013-09-13 00:00:00

abstract：BACKGROUND:Rural areas of India exhibit high neonatal mortality, and low literacy and numeracy. We assess the effect of a complex package of health interventions on neonatal survival and the effect of out-of-school-hours teaching on children's literacy and numeracy in rural Madhya Pradesh. METHODS/DESIGN:This is a clu...

journal_title：Trials

authors： Agarwal A,Banerji R,Boone P,Elbourne D,Fazzio I,Frost C,Gopal M,Karnati S,Nair R,Reddy H,Reddy P,Sharma D,Shekhawat SS,Shivalli S

更新日期：2020-06-25 00:00:00

abstract：BACKGROUND:Although conventional laparoscopic and hand-assisted laparoscopic surgery for colorectal cancer is widely used today, there remain many technical challenges especially for right colon cancer in obese patients. Herein, we develop a novel hand-assisted laparoscopic surgery (HALS) with complete mesocolic excisi...

journal_title：Trials

authors： Yang X,Wu Q,Jin C,He W,Wang M,Yang T,Wei M,Deng X,Meng W,Wang Z

更新日期：2017-07-26 00:00:00

abstract：BACKGROUND:The aim of this study is to demonstrate that capecitabine metronomic chemotherapy is non-inferior to capecitabine conventional chemotherapy as maintenance treatment, in patients who have responded to 16-18 weeks first-line chemotherapy in metastatic colorectal cancer (mCRC). METHODS:The study design is a pr...

journal_title：Trials

authors： Shi M,Ma T,Xi W,Jiang J,Wu J,Zhou C,Yang C,Zhu Z,Zhang J

更新日期：2020-03-06 00:00:00

abstract：:Tuberculosis (TB) remains a major killer amongst the infectious diseases. Current treatment involves a four-drug regimen for at least 6 months. New drugs and regimens are required to shorten treatment duration, reduce toxicity and combat drug resistance, but the optimal methodology to define the critical path for nove...

journal_title：Trials

authors： Bonnett LJ,Davies GR

更新日期：2015-11-14 00:00:00

abstract：BACKGROUND:Patients affected by hepatic cirrhosis show reductions in muscle mass and function, with poor quality of life and functional performance. As such, resistance training with blood flow restriction (BFR-RT) could be a useful therapeutic tool for health promotion. Thus, we aim to verify the effects of this inter...

journal_title：Trials

authors： Nóbrega SR,Chachá SGF,Libardi CA

更新日期：2020-05-29 00:00:00

abstract：BACKGROUND:In Switzerland, skin cancer is one of the most common neoplasms. Melanoma is the most aggressive one and can be lethal if not detected and removed on time. Nonmelanoma skin cancer is more frequent as melanoma; it is seldom lethal but can disfigure patients in advanced stages. General practitioners (GPs) are ...

journal_title：Trials

authors： Badertscher N,Rosemann T,Tandjung R,Braun RP

更新日期：2011-06-30 00:00:00

abstract：BACKGROUND:Exploration and modelling of heterogeneous treatment effects as a function of baseline covariates is an important aspect of precision medicine in randomised controlled trials (RCTs). Randomisation generally guarantees the internal validity of an RCT, but heterogeneity in treatment effect can reduce external ...

journal_title：Trials

authors： Watson JA,Holmes CC

更新日期：2020-05-07 00:00:00

abstract：BACKGROUND:Verrucae are a common, infectious and sometimes painful problem. The optimal treatment for verrucae is unclear due to a lack of high quality randomised controlled trials. The primary objective of this study is to compare the clinical effectiveness of two common treatments for verrucae: cryotherapy using liqu...

journal_title：Trials

authors： Cockayne ES,EVERT Trial Team.

更新日期：2010-02-08 00:00:00

abstract：BACKGROUND:Registration of clinical trials is critical for promoting transparency and integrity in medical research; however, trials must be registered in a prospective fashion to deter unaccounted protocol modifications or selection of alternate outcomes that may enhance favorability of reported findings. We assessed ...

journal_title：Trials

authors： Gopal AD,Wallach JD,Aminawung JA,Gonsalves G,Dal-Ré R,Miller JE,Ross JS

更新日期：2018-08-23 00:00:00

abstract：BACKGROUND:Tackling neonatal mortality is essential for the achievement of the child survival millennium development goal. There are just under 4 million neonatal deaths, accounting for 38% of the 10.8 million deaths among children younger than 5 years of age taking place each year; 99% of these occur in low- and middl...

journal_title：Trials

authors： Kirkwood BR,Manu A,Tawiah-Agyemang C,ten Asbroek G,Gyan T,Weobong B,Lewandowski RE,Soremekun S,Danso S,Pitt C,Hanson K,Owusu-Agyei S,Hill Z

更新日期：2010-05-17 00:00:00

abstract：BACKGROUND:The practice of traditional Chinese medicine (TCM) has a profound history in many Asian countries. TCM syndrome is a set of characteristic physical signs and symptoms shared by a group of patients. Syndrome diagnosis and treatment assignment according to the identified TCM syndrome is a long-held practice of...

journal_title：Trials

authors： Cao H,Zhai J,Mu W,Lei X,Cao H,Liu C,Shang H

更新日期：2014-03-19 00:00:00

abstract：BACKGROUND:Cardiac surgery has been shown to result in a significant decrease of the antioxidant selenium, which is associated with the development of multiorgan dysfunction and increased mortality. Thus, a large-scale study is needed to investigate the effect of perioperative selenium supplementation on the occurrence...

journal_title：Trials

authors： Stoppe C,McDonald B,Rex S,Manzanares W,Whitlock R,Fremes S,Fowler R,Lamarche Y,Meybohm P,Haberthür C,Rossaint R,Goetzenich A,Elke G,Day A,Heyland DK

更新日期：2014-08-28 00:00:00

abstract：BACKGROUND:State of the art sedation concepts on intensive care units (ICU) favor propofol for a time period of up to 72 h and midazolam for long-term sedation. However, intravenous sedation is associated with complications such as development of tolerance, insufficient sedation quality, gastrointestinal paralysis, and...

journal_title：Trials

authors： Soukup J,Selle A,Wienke A,Steighardt J,Wagner NM,Kellner P

更新日期：2012-08-10 00:00:00

abstract：BACKGROUND:Recommendations for good clinical practice have been reported to be difficult to apply in real life by primary care clinicians. This could be because the clinical trials at the origin of the guidelines are based on explanatory trials, conducted under ideal conditions not reflecting the reality of primary car...

journal_title：Trials

authors： Ettori-Ajasse I,Tatin E,Forbes G,Eldridge S,Dibao-Dina C

更新日期：2020-03-19 00:00:00

abstract：BACKGROUND:Transurethral resection of the prostate (TURP) has been the standard operation for benign prostatic obstruction (BPO) for 40 years, with approximately 25,000 procedures performed annually, and has remained largely unchanged. It is generally a successful operation, but has well-documented risks for the patien...

journal_title：Trials

authors： Worthington J,Taylor H,Abrams P,Brookes ST,Cotterill N,Noble SM,Page T,Swami KS,Lane JA,Hashim H

更新日期：2017-04-17 00:00:00

abstract：BACKGROUND:Oral mucositis (OM) is the most frequent and debilitating acute side effect associated with head and neck cancer (HNC) treatment. When present, severe OM negatively impacts the quality of life of patients undergoing HNC treatment. Photobiomodulation is a well-consolidated and effective therapy for the treatm...

journal_title：Trials

authors： Martins AFL,Nogueira TE,Morais MO,Oton-Leite AF,Valadares MC,Batista AC,Freitas NMA,Leles CR,Mendonça EF

更新日期：2019-02-01 00:00:00