Correction to: Photobiomodulation versus light-emitting diode (LED) therapy in the treatment of temporomandibular disorder: study protocol for a randomized, controlled clinical trial.

abstract：BACKGROUND:Physical exercise interventions have been extensively advocated for the treatment of obesity; however, clinical trials evaluating the effectiveness of exercise interventions on weight control show controversial results. Compensatory mechanisms through a decrease in energy expenditure and/or an increase in ca...

journal_title：Trials

authors： Paravidino VB,Mediano MFF,Silva ICM,Wendt A,Del Vecchio FB,Neves FA,Terra BS,Gomes EAC,Moura AS,Sichieri R

更新日期：2018-03-07 00:00:00

abstract：BACKGROUND:A variety of videolaryngoscopes with angulated blade have been recently introduced into clinical practice. They provide an indirect view of the glottic structures in normal and challenging clinical settings. Despite the very good visualization of the laryngeal structures by these devices, the insertion and a...

journal_title：Trials

authors： Al-Qasmi A,Al-Alawi W,Malik AM,Khan RM,Kaul N

更新日期：2013-09-16 00:00:00

abstract：BACKGROUND:The gap between the level of care recommended by evidence-based clinical practice guidelines and the actual care delivered to patients in practice has been well established. The Canadian Diabetes Association (CDA) created an implementation strategy to improve the implementation of its 2008 guidelines. This s...

journal_title：Trials

authors： Shah BR,Bhattacharyya O,Yu C,Mamdani M,Parsons JA,Straus SE,Zwarenstein M

更新日期：2010-04-23 00:00:00

abstract：BACKGROUND:Earlier vascular healing after drug-eluting stent (DES) implantation may reduce the incidence of late stent thrombosis and provide theoretical evidence to shorten dual antiplatelet therapy duration in patients with high bleeding risks. The BuMA supreme stent is a newly developed DES-coated with the sirolimus...

journal_title：Trials

authors： Li B,Jin QH,Chen YD,Wang CQ,Shi B,Su X,Fu GS,Wu YQ,Zhou XC,Yuan ZY

更新日期：2019-06-07 00:00:00

abstract：BACKGROUND:Loneliness in older people is associated with poor health-related quality of life (HRQoL). We undertook a parallel-group randomised controlled trial to evaluate the effectiveness and cost-effectiveness of telephone befriending for the maintenance of HRQoL in older people. An internal pilot tested the feasibi...

journal_title：Trials

authors： Mountain GA,Hind D,Gossage-Worrall R,Walters SJ,Duncan R,Newbould L,Rex S,Jones C,Bowling A,Cattan M,Cairns A,Cooper C,Edwards RT,Goyder EC

更新日期：2014-04-24 00:00:00

abstract：BACKGROUND:As people live longer, their risk of disability increases. Disability affects quality of life and increases health and social care costs. Preventing or delaying disability is therefore an important objective, and identifying an effective intervention could improve the lives of many older people. Observationa...

journal_title：Trials

authors： Morgan GS,Haase AM,Campbell R,Ben-Shlomo Y

更新日期：2015-03-13 00:00:00

abstract：BACKGROUND:Meta-analyses of randomized controlled trials (RCTs) have shown that exercise has beneficial effects on quality of life (QoL) in patients with breast cancer. However, these effects were often small. Blinding in an exercise trial is not possible, which has the possible disadvantage of difficult accrual, drop-...

journal_title：Trials

authors： Gal R,Monninkhof EM,Groenwold RHH,van Gils CH,van den Bongard DHJG,Peeters PHM,Verkooijen HM,May AM

更新日期：2017-10-27 00:00:00

abstract：BACKGROUND:Current management for men with lower urinary tract symptoms (LUTS) is a pathway that results in prostate surgery in a significant proportion. While helpful in relieving benign prostatic obstruction (BPO), surgery may be ineffective for men suffering from difficulties not relating to BPO. The UPSTREAM trial ...

journal_title：Trials

authors： Young GJ,Lewis AL,Lane JA,Winton HL,Drake MJ,Blair PS

更新日期：2017-10-03 00:00:00

abstract：BACKGROUND:People with severe mental illness (SMI) are two to three times more likely to be overweight and obese than the general population and this is associated with significant morbidity and premature mortality. Although lifestyle interventions can support people with SMI to lose weight, some are unable to make the...

journal_title：Trials

authors： Whicher CA,Price HC,Phiri P,Rathod S,Barnard-Kelly K,Reidy C,Thorne K,Asher C,Peveler R,McCarthy J,Holt RIG

更新日期：2019-11-20 00:00:00

abstract：:Data sharing from clinical trials is one way of promoting fair and transparent conduct of clinical trials. It would maximise the use of data and permit the exploration of additional hypotheses. On the other hand, the quality of secondary analyses cannot always be ascertained, and it may be unfair to investigators who ...

journal_title：Trials

authors： Mbuagbaw L,Foster G,Cheng J,Thabane L

更新日期：2017-02-14 00:00:00

abstract：BACKGROUND:Clinical cancer trials are crucial for the implementation of new treatments in the clinical setting, but it is equally crucial that patients are given the opportunity to make a well-informed decision about participation. The inclusion process is complex, including both oral and written information about the ...

journal_title：Trials

authors： Dellson P,Nilsson K,Jernström H,Carlsson C

更新日期：2018-09-29 00:00:00

abstract：BACKGROUND:Perioperative complications occur in 30-40% of non-cardiac surgical patients and are the leading cause of early postoperative morbidity and mortality. Regular visits by trained health professionals may decrease the incidence of complications and mortality through earlier detection and adequate treatment of c...

journal_title：Trials

authors： Smit-Fun VM,de Korte-de Boer D,Posthuma LM,Stolze A,Dirksen CD,Hollmann MW,Buhre WF,Boer C

更新日期：2018-10-26 00:00:00

abstract：OBJECTIVE:The objective of the Dutch Sildenafil therapy in dismal prognosis early onset fetal growth restriction (STRIDER) randomised clinical trial is to assess the beneficial and harmful effects of sildenafil versus placebo on fetal and neonatal mortality in pregnant women with severe early-onset fetal growth restric...

journal_title：Trials

authors： Pels A,Jakobsen JC,Ganzevoort W,Naaktgeboren CA,Onland W,van Wassenaer-Leemhuis AG,Gluud C

更新日期：2019-01-11 00:00:00

abstract：BACKGROUND:Acute myocardial infarction (AMI) is the leading cause of mortality worldwide. Oxidative stress has been involved in the ischemia-reperfusion injury in AMI. It has been suggested that reperfusion accounts for up to 50% of the final size of a myocardial infarct, a part of the damage likely to be prevented.The...

journal_title：Trials

authors： Rodrigo R,Hasson D,Prieto JC,Dussaillant G,Ramos C,León L,Gárate J,Valls N,Gormaz JG

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:Clavicle fractures account for around 4% of all fractures and up to 44% of fractures of the shoulder girdle. Fractures of the middle third (or mid-shaft) account for approximately 80% of all clavicle fractures. Management of this group of fractures is often challenging and the outcome can be unsatisfactory. ...

journal_title：Trials

authors： Longo UG,Banerjee S,Barber J,Chambler A,Cobiella C,Corbett S,Crowther M,Drew S,Francis A,Lee M,Garlick N,Packham I,Pearse Y,Richards A,Roberts C,Tennent D,Tims E,Ahrens PM

更新日期：2011-02-28 00:00:00

abstract：BACKGROUND:The risk of falling is significantly higher in people with chronic stroke and it is, therefore, important to design interventions to improve mobility and decrease falls risk. Minimum toe clearance (MTC) is the key gait cycle event for predicting tripping-falls because it occurs mid-swing during the walking c...

journal_title：Trials

authors： Begg R,Galea MP,James L,Sparrow WAT,Levinger P,Khan F,Said CM

更新日期：2019-05-31 00:00:00

abstract：BACKGROUND:Suffering linked to previous interpersonal trauma is common among patients in mental health care. Diagnostic labels may vary, but the clinical picture is often characterized by long-lasting and complex psychological and somatic symptoms, subjective distress and reduced quality of health and life. A substanti...

journal_title：Trials

authors： Holgersen KH,Brønstad I,Jensen M,Brattland H,Reitan SK,Hassel AM,Arentz M,Lara-Cabrera M,Skjervold AE

更新日期：2020-05-27 00:00:00

abstract：BACKGROUND:Linezolid, an oxazolidinone, substantially improves treatment outcomes of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis. We started a trial to test whether the use of linezolid instead of ethambutol could increase the rate of sputum culture conversion as of 8 weeks of treatment...

journal_title：Trials

authors： Lee JY,Kim DK,Lee JK,Yoon HI,Jeong I,Heo E,Park YS,Lee JH,Park SS,Lee SM,Lee CH,Lee J,Choi SM,Park JS,Joh JS,Cho YJ,Lee YJ,Kim SJ,Hwang YR,Kim H,Ki J,Choi H,Han J,Ahn H,Hahn S,Yim JJ

更新日期：2017-02-13 00:00:00

abstract：BACKGROUND:Tracheal intubation with the patient in the lateral position is difficult because the laryngeal view is compromised during direct laryngoscopy. Flexible video endoscopes may facilitate intubation even when laryngeal views are poor on direct laryngoscopy because the patients are positioned laterally. Thus, th...

journal_title：Trials

authors： Gao Y,Lin B,Huang J,Lin X,Lin C

更新日期：2019-03-15 00:00:00

abstract：BACKGROUND:Adolescent idiopathic scoliosis (AIS) is one of the most prevalent spinal deformities that may progress sharply during growth. The aim of this study will be to evaluate the efficacy of three-dimensionally integrated exercise on the Cobb angle, angle of trunk rotation, sagittal profile, and quality of life in...

journal_title：Trials

authors： Liang J,Zhou X,Chen N,Li X,Yu H,Yang Y,Song Y,Du Q

更新日期：2018-09-10 00:00:00

abstract：BACKGROUND:Patients with chronic kidney disease (CKD) exhibit increased morbidity and mortality which is associated with an increased systemic inflammatory burden. Identifying and managing comorbid diseases that contribute to this load may inform novel care pathways that could have a beneficial impact on the morbidity/...

journal_title：Trials

authors： Sharma P,Cockwell P,Dietrich T,Ferro C,Ives N,Chapple ILC

更新日期：2017-11-13 00:00:00

abstract：OBJECTIVES:To evaluate the safety of therapeutic plasma exchange (TPE) in adult patients with serious/life-threatening COVID-19 requiring intensive care unit (ICU) admission, and associated 28-day mortality. Serious and life threatening COVID-19 are defined as per published literature (please, refer to the full protoco...

journal_title：Trials

authors： Faqihi F,Alharthy A,Alodat M,Asad D,Aletreby W,Kutsogiannis DJ,Brindley PG,Karakitsos D

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:Compulsory submission of a checklist from the relevant reporting guideline is one of the most widespread journal requirements aiming to improve completeness of reporting. However, the current suboptimal levels of adherence to reporting guidelines observed in the literature may indicate that this journal poli...

journal_title：Trials

authors： Blanco D,Biggane AM,Cobo E,MiRoR network.

更新日期：2018-01-29 00:00:00

abstract：BACKGROUND:Diabetes mellitus is associated with risk of sudden sensorineural hearing loss (SSNHL). Systemic and intratympanic corticosteroids are the two primary treatments for SSNHL in patients with diabetes mellitus. The benefit of intratympanic compared to systemic treatment is the reduced systemic steroid exposure ...

journal_title：Trials

authors： Yang W,Li X,Zhong J,Mei X,Liu H,Yang L,Lu L,Hu H

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:Among patients with hepatocellular carcinoma (HCC), 85% of patients have an advanced disease stage at diagnosis and curative therapies cannot be performed. Prognosis has been quite poor as until recently there was no proven effective chemotherapy. Our group found that all-trans-retinoic acid (ATRA) could imp...

journal_title：Trials

authors： Shi J,Sun J,Liu C,Chai Z,Wang N,Zhang H,Cheng S

更新日期：2019-04-29 00:00:00

abstract：BACKGROUND:Recognizing the value of promoting public access to clinical trial protocols, Trials pioneered the way for their publication over a decade ago. However, despite major advances in the public accessibility of information about trial methods and results, protocol sharing remains relatively rare. MAIN BODY:Prot...

journal_title：Trials

authors： Chan AW,Hróbjartsson A

更新日期：2018-02-17 00:00:00

abstract：BACKGROUND:Chest tube insertion is a standard intervention for management of various injuries of the thorax. Quick and accurate execution facilitates efficient therapy without further complications. Here, we propose a new training concept comprised of e-learning elements as well as continuous rating using an objective ...

journal_title：Trials

authors： Friedrich M,Bergdolt C,Haubruck P,Bruckner T,Kowalewski KF,Müller-Stich BP,Tanner MC,Nickel F

更新日期：2017-02-06 00:00:00

abstract：BACKGROUND:Periprosthetic joint infection (PJI) affects approximately 1% of patients following total hip replacement (THR) and often results in severe physical and emotional suffering. Current surgical treatment options are debridement, antibiotics and implant retention; revision THR; excision of the joint and amputati...

journal_title：Trials

authors： Strange S,Whitehouse MR,Beswick AD,Board T,Burston A,Burston B,Carroll FE,Dieppe P,Garfield K,Gooberman-Hill R,Jones S,Kunutsor S,Lane A,Lenguerrand E,MacGowan A,Moore A,Noble S,Simon J,Stockley I,Taylor AH,Toms A

更新日期：2016-02-17 00:00:00

abstract：BACKGROUND:In cardiac surgery with cardiopulmonary bypass (CPB), large amounts of fluids are administered. CPB priming with crystalloid solution causes marked hemodilution and fluid extravasation. Colloid solutions may reduce fluid overload because they have a better volume expansion effect than crystalloids. The Europ...

journal_title：Trials

authors： Vlasov H,Juvonen T,Hiippala S,Suojaranta R,Peltonen M,Schramko A,Arvonen K,Salminen US,Kleine Budde I,Eränen T,Mazanikov M,Meinberg M,Vähäsilta T,Wilkman E,Pettilä V,Pesonen E

更新日期：2020-02-28 00:00:00

abstract：BACKGROUND:Pyoderma gangrenosum (PG) is a rare inflammatory skin disorder characterised by painful and rapidly progressing skin ulceration. PG can be extremely difficult to treat and patients often require systemic immunosuppression. Recurrent lesions of PG are common, but the relative rarity of this condition means th...

journal_title：Trials

authors： Craig FF,Thomas KS,Mitchell EJ,Williams HC,Norrie J,Mason JM,Ormerod AD,UK Dermatology Clinical Trials Network’s STOP GAP Trial Team.

更新日期：2012-04-28 00:00:00