Efficacy of three-dimensionally integrated exercise for scoliosis in patients with adolescent idiopathic scoliosis: study protocol for a randomized controlled trial.

abstract：BACKGROUND:Less invasive surfactant administration (LISA) is a way of giving surfactant without endotracheal intubation and has shown to be promising in reducing the incidence of bronchopulmonary dysplasia (BPD) in preterm infants. However, the mechanism underlying its beneficial effect and variations in the technique ...

journal_title：Trials

authors： Zhu J,Bao Y,Du L,Huang H,Lv Q,Jiang Y,Dai Y,Chen Z,Shi J,Shi Y,Yang C,Mei H,Jiang H,Sun Y,Sun X

更新日期：2020-06-11 00:00:00

abstract：:Tuberculosis (TB) remains a major killer amongst the infectious diseases. Current treatment involves a four-drug regimen for at least 6 months. New drugs and regimens are required to shorten treatment duration, reduce toxicity and combat drug resistance, but the optimal methodology to define the critical path for nove...

journal_title：Trials

authors： Bonnett LJ,Davies GR

更新日期：2015-11-14 00:00:00

abstract：BACKGROUND:The prevalence of depressive disorder in adults with advanced cancer is around 20 %. Although cognitive behavioural therapy (CBT) is recommended for depression and may be beneficial in depressed people with cancer, its use for depression in those with advanced disease for whom cure is not likely has not been...

journal_title：Trials

authors： Serfaty M,King M,Nazareth I,Tookman A,Wood J,Gola A,Aspden T,Mannix K,Davis S,Moorey S,Jones L

更新日期：2016-02-29 00:00:00

abstract：BACKGROUND:Findings suggest approximately one in six people with intellectual disability engage in 'challenging behaviours', which include aggression towards others/property and self-injurious actions. In residential settings, actions of staff members can make challenging behaviours more likely to occur, or make these ...

journal_title：Trials

authors： Randell E,Hastings RP,McNamara R,Knight R,Gillespie D,Taylor Z

更新日期：2017-10-05 00:00:00

abstract：:Data sharing from clinical trials is one way of promoting fair and transparent conduct of clinical trials. It would maximise the use of data and permit the exploration of additional hypotheses. On the other hand, the quality of secondary analyses cannot always be ascertained, and it may be unfair to investigators who ...

journal_title：Trials

authors： Mbuagbaw L,Foster G,Cheng J,Thabane L

更新日期：2017-02-14 00:00:00

abstract：BACKGROUND:Prospective meta-analysis (PMA) is a collaborative research design in which individual sites perform randomized controlled trials (RCTs) and pool the data for meta-analysis. Members of the PMA collaboration agree upon specific research interventions and outcome measures, ideally before initiation but at leas...

journal_title：Trials

authors： Turok DK,Espey E,Edelman AB,Lotke PS,Lathrop EH,Teal SB,Jacobson JC,Simonsen SE,Schulz KF

更新日期：2011-04-29 00:00:00

abstract：BACKGROUND:Extended brief interventions (EBIs) are effective in targeting alcohol misuse in the general population. However, little is known of the effects of EBI in adults with intellectual (also known as learning) disabilities. In this feasibility trial we compared EBI with usual care for alcohol misuse in adults wit...

journal_title：Trials

authors： Kouimtsidis C,Bosco A,Scior K,Baio G,Hunter R,Pezzoni V,Mcnamara E,Hassiotis A

更新日期：2017-05-12 00:00:00

abstract：BACKGROUND:Medications are an effective intervention for managing and preventing health problems but their benefit can be undermined by non-adherence or adverse drug events (ADEs). Since these issues may be interconnected, efforts to improve non-adherence should also include reduction of ADEs. We have developed the IST...

journal_title：Trials

authors： Forster AJ,Erlanger TE,Jennings A,Auger C,Buckeridge D,van Walraven C,Tamblyn R

更新日期：2015-01-08 00:00:00

abstract：BACKGROUND:We aimed to test whether a common set of key data items reported across high-impact neonatal clinical trials could be identified, and to quantify their completeness in routinely recorded United Kingdom neonatal data held in the National Neonatal Research Database (NNRD). METHODS:We systematically reviewed n...

journal_title：Trials

authors： Jawad S,Modi N,Prevost AT,Gale C

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:For the last decade continuous efforts have been made to translate regenerative cell therapy protocols in the cardiovascular field from 'bench to bedside'. Successful clinical introduction, supporting safety, and feasibility of this new therapeutic approach, led to the initiation of the German, Phase III, mu...

journal_title：Trials

authors： Donndorf P,Kaminski A,Tiedemann G,Kundt G,Steinhoff G

更新日期：2012-07-02 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is the most prevalent chronic joint disease, characterized by joint structural deterioration, pain and loss of function among the elders. It is also associated with several extra-articular symptoms (fatigue, sleep disorders, anxiety and depression) and a reduction of life quality. Studies...

journal_title：Trials

authors： Huang Z,Pan X,Deng W,Huang Z,Huang Y,Huang X,Zhu Z,Han W,Zheng S,Guo X,Ding C,Li T

更新日期：2018-04-17 00:00:00

abstract：BACKGROUND:This study aims to evaluate the feasibility and efficacy of a complex health intervention, based on the combination of conventional Western medicine and traditional Chinese medicine (TCM), in an outpatient department of a university hospital for patients with frequent episodic or chronic tension-type headach...

journal_title：Trials

authors： Schiller J,Kellner T,Briest J,Hoepner K,Woyciechowski A,Ostermann A,Korallus C,Sturm C,Weiberlenn T,Jiang L,Egen C,Beissner F,Stiesch M,Karst M,Gutenbrunner C,Fink MG

更新日期：2019-11-08 00:00:00

abstract：BACKGROUND:Approximately 2 million children are hospitalized each year in the United States, with more than three-quarters of non-elective hospitalizations admitted through emergency departments (EDs). Direct admission, defined as admission to hospital without first receiving care in the hospital's ED, may offer benefi...

journal_title：Trials

authors： Leyenaar JK,McDaniel CE,Acquilano SC,Schaefer AP,Bruce ML,O'Malley AJ

更新日期：2020-11-30 00:00:00

abstract：BACKGROUND:ST-elevation myocardial infarction (STEMI) accounts for nearly one third of acute coronary syndromes. Despite improved STEMI patient care, mortality remains high, contributing significantly to the ischemic heart disease burden. This may partly be related to ischemia-reperfusion injury (IRI). Remote ischemic ...

journal_title：Trials

authors： Gaspar A,Pereira MÁ,Azevedo P,Lourenço A,Marques J,Leite-Moreira A

更新日期：2015-09-08 00:00:00

abstract：BACKGROUND:Surgical site infections (SSI) remain one of the most common complications in conventional abdominal surgery with an incidence between 4% and 19% (Sandini et al., Medicine (Baltimore) 95:e4057, 2016) in the literature. It is unclear whether the use of coated suture material for skin closure reduces the risk ...

journal_title：Trials

authors： Matz D,Teuteberg S,Wiencierz A,Soysal SD,Heizmann O

更新日期：2019-07-02 00:00:00

abstract：:Reviews have repeatedly noted important methodological issues in the conduct and reporting of cluster randomized controlled trials (C-RCTs). These reviews usually focus on whether the intracluster correlation was explicitly considered in the design and analysis of the C-RCT. However, another important aspect requiring...

journal_title：Trials

authors： Ivers NM,Halperin IJ,Barnsley J,Grimshaw JM,Shah BR,Tu K,Upshur R,Zwarenstein M

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Chronic back pain continues to be a costly and prevalent condition. The latest NICE guidelines issued in 2009 state that for patients with persistent back pain (of between six weeks and twelve months duration), who are highly distressed and/or disabled and for whom exercise, manual therapy and acupuncture ha...

journal_title：Trials

authors： Pincus T,Anwar S,McCracken L,McGregor A,Graham L,Collinson M,Farrin AJ,OBI Trial Management Team.

更新日期：2013-06-13 00:00:00

abstract：BACKGROUND:The focus in recent years on physical inactivity and metabolic disturbances in individuals with schizophrenia raises the question of potential effects of physical activity. Physical activity has shown beneficial effects on cognition in healthy older individuals as well as on symptom severity in depression. H...

journal_title：Trials

authors： Engh JA,Andersen E,Holmen TL,Martinsen EW,Mordal J,Morken G,Egeland J

更新日期：2015-12-08 00:00:00

abstract：:Following publication of the original article [1], we have been notified of a few mistakes in the "Sample size calculations" section, second paragraph. ...

journal_title：Trials

authors： van Oostveen RB,Romero-Palacios A,Whitlock R,Lee SF,Connolly S,Carignan A,Mazer CD,Loeb M,Mertz D

更新日期：2019-10-16 00:00:00

abstract：BACKGROUND:Chronic nonspecific low back pain (CNSLBP) troubles approximately 30% of people worldwide. Silver needle therapy (SNT) is a treatment method to relieve soft tissue pain through heating. Therefore, this study aimed to observe the effects of SNT on CNSLBP. METHODS:In this study, 100 patients were randomly div...

journal_title：Trials

authors： Hu X,Dong S,Zhang B,Wang X,Yin Y,Liu C,Yu J,Wu X,Xu F,Meng C

更新日期：2021-01-21 00:00:00

abstract：BACKGROUND:Chronic back pain is a major public health problem and the primary reason patients seek massage treatment. Despite the growing use of massage for chronic low back pain, there have been few studies of its effectiveness. This trial will be the first evaluation of the effectiveness of relaxation massage for chr...

journal_title：Trials

authors： Cherkin DC,Sherman KJ,Kahn J,Erro JH,Deyo RA,Haneuse SJ,Cook AJ

更新日期：2009-10-20 00:00:00

abstract：BACKGROUND:Untreated advanced hepatocellular carcinoma (HCC) is linked to poor prognosis. While sorafenib is the current recommended treatment for advanced HCC, radioembolisation (RE; also called selective internal radiation therapy or SIRT) with yttrium-90 microspheres has shown efficacy in cohort studies. However, th...

journal_title：Trials

authors： Vilgrain V,Abdel-Rehim M,Sibert A,Ronot M,Lebtahi R,Castéra L,Chatellier G,SARAH Trial Group.

更新日期：2014-12-03 00:00:00

abstract：BACKGROUND:Clavicle fractures account for around 4% of all fractures and up to 44% of fractures of the shoulder girdle. Fractures of the middle third (or mid-shaft) account for approximately 80% of all clavicle fractures. Management of this group of fractures is often challenging and the outcome can be unsatisfactory. ...

journal_title：Trials

authors： Longo UG,Banerjee S,Barber J,Chambler A,Cobiella C,Corbett S,Crowther M,Drew S,Francis A,Lee M,Garlick N,Packham I,Pearse Y,Richards A,Roberts C,Tennent D,Tims E,Ahrens PM

更新日期：2011-02-28 00:00:00

abstract：BACKGROUND:Entertainment-education (E-E) media can improve behavioral intent toward health-related practices. In the era of COVID-19, millions of people can be reached by E-E media without requiring any physical contact. We have designed a short, wordless, animated video about preventive COVID-19 behaviors that can be ...

journal_title：Trials

authors： Vandormael A,Adam M,Greuel M,Bärnighausen T

更新日期：2020-12-15 00:00:00

abstract：BACKGROUND:Age-related muscle wasting has been strongly implicated with falls and fractures in the elderly, but it has also been associated with cognitive decline and dementia. Progressive resistance training (PRT) and adequate dietary protein are recognised as important contributors to the maintenance of muscle health...

journal_title：Trials

authors： Daly RM,Gianoudis J,Prosser M,Kidgell D,Ellis KA,O'Connell S,Nowson CA

更新日期：2015-08-08 00:00:00

abstract：OBJECTIVES:Primary Objective: To determine the feasibility of delivering a protocolised, remote, online, Eye Movement Desensitisation and Reprocessing (EMDR) intervention, within 12-weeks of hospital discharge, for adult survivors of Covid-19 related critical illness. Secondary objectives: To investigate whether remote...

journal_title：Trials

authors： Bates A,Rushbrook S,Shapiro E,Grocott M,Cusack R

更新日期：2020-11-17 00:00:00

abstract：BACKGROUND:Graves' hyperthyroidism is an autoimmune disease causing hyperfunction of the thyroid gland. The concentration of selenium is high in the thyroid gland and two important groups of enzymes within the thyroid are selenoproteins, that is, they depend on selenium. Selenium may have beneficial effects on autoimmu...

journal_title：Trials

authors： Watt T,Cramon P,Bjorner JB,Bonnema SJ,Feldt-Rasmussen U,Gluud C,Gram J,Hansen JL,Hegedüs L,Knudsen N,Bach-Mortensen P,Nolsøe R,Nygaard B,Pociot F,Skoog M,Winkel P,Rasmussen AK

更新日期：2013-04-30 00:00:00

abstract：BACKGROUND:Written participant information materials are important for ensuring that potential trial participants receive necessary information so that they can provide informed consent. However, such materials are frequently long and complex, which may negatively impact patient understanding and willingness to partici...

journal_title：Trials

authors： Parker A,Knapp P,Treweek S,Madhurasinghe V,Littleford R,Gallant S,Sullivan F,Schembri S,Rick J,Graffy J,Collier DJ,Eldridge S,Kennedy A,Bower P

更新日期：2018-09-18 00:00:00

abstract：BACKGROUND:Endoscopic ultrasonography (EUS)-guided drainage has become the first-line therapy for late peri-pancreatic fluid collection (PFC). Double pigtail plastic stents (DPPS) and lumen-apposing metal stents (LAMS) are commonly used for PFC drainage. Recently, a multi-institutional consensus on PFC drainage has rec...

journal_title：Trials

authors： Zhu HY,Xie P,Song YX,Li ZS,Jin ZD,Du YQ

更新日期：2018-10-11 00:00:00

abstract：BACKGROUND:Impairment in social functioning is a key component of personality disorder. Therefore psycho-education and problem solving (PEPS) therapy may benefit people with this disorder. Psycho-education aims to educate, build rapport, and motivate people for problem solving therapy. Problem solving therapy aims to h...

journal_title：Trials

authors： McMurran M,Crawford MJ,Reilly JG,McCrone P,Moran P,Williams H,Adams CE,Duggan C,Delport J,Whitham D,Day F

更新日期：2011-08-24 00:00:00